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Multi-stage plugging represents a promising strategy for enhancing production and injection rates in medium-and low-permeability oilfields. Despite its potential, the efficacy of current plugging agents, particularly hydrophobically bonded water-soluble polyacrylamide-based gel microspheres, is hindered by notable drawbacks such as low stability and inadequate compressive strength. Therefore, a comprehensive understanding of water plugging mechanisms coupled with the optimization of gel microsphere properties is essential for advancing the development of gel-based plugging agents with superior characteristics or intelligent regulatory capabilities. The P(AA-AM-[PrSO3]Vim) ionic liquid copolymerized gel particles were designed and synthesized by using microfluidic technique and titration gel method with AM, acrylic acid (AA), 1-vinylimidazole (Vim) and 1,3-propylsulfonyl lactone (PrSO3) as the raw materials. The morphology and structure of the copolymer gel particles were characterized, and the effects of [PrSO3]Vim and cross-linker content on the water-absorbing properties and strength of the gel particles were investigated. When the amount of [PrSO3]Vim was 12%, the concentration of crosslinker was 1.5%, and the temperature was 40°C, the water absorption capacity reached the maximum value of 163 g·g−1. The strength of the P(AA–AM–[PrSO3]Vim) spherical gel particles was maximized at a [PrSO3]Vim content of 4%. Furthermore, the chemical and physical roles of the P(AA–AM–[PrSO3]Vim) spherical gel particles were studied in a typical water-plugging environment. This study provides experimental data and a theoretical basis for the application of functional spherical gel-plugging particles in current oilfield environments.

[ Objective ] The study aims to analyze the metabolomic difference in potato roots under NaHCO 3 stress , in order to understand the metabolic mechanism of different potato varieties in response to NaHCO 3 stress , and to provide theoretical basis for optimizing potato breeding , cultivation techniques , and production applications. [ Methods ] The root systems of potato ‘ V 7 ’ and ‘ KANG Nibeike ’ seedlings were selected as materials , and NaHCO 3 solution was used to simulate alkali stress with different concen- trations ( CK , 10 , 20 , 30 , 40 , and 50 mmol / L ) . The root metabolites of these two potato varieties were analyzed by LC-MS and multidimensional statistics combined with non-targeted metabolomics detection. [ Results ] ( 1 ) Under NaHCO 3 stress , 160 metabolites were up-regulated and 91 metabolites were down- regulated in ‘ V 7 ’ roots , and 125 metabolites were up-regulated and 52 metabolites were down-regulated in ‘ KANG Nibeike ’ roots. ( 2 ) 10 differential metabolic pathways were selected for each of the two varieties , among which 4 differential metabolic pathways , namely biosynthesis of plant secondary metabolites , bio- synthesis of unsaturated fatty acids , synthesis of histidine and purine-derived alkaloids , and pyrimidine metabolism , were the key metabolic pathways in response to alkali stress in potato roots. ( 3 ) Differential metabolites , such as carbohydrates , amides , amines , oxy-containing organic compounds , alkaloids , phe- nolic acids , and somatogenin , etc. , were involved in the complex regulatory network in potato in response to NaHCO 3 stress. [ Conclusion ] The key metabolites and metabolic pathways of potato roots in response to NaHCO 3 stress are screened. There are differences in the metabolome of the alkaline tolerant cultivar ‘ V 7 ’ and alkali sensitive cultivar ‘ KANG Nibeike ’ . Also , there are differences between the metabolism of the same variety and CK under different levels of stress. The accumulation of amino acids and their deriva- tives , organic acids , and allantoin is an important feature of the ‘ V 7 ’ root metabolism , which is more ac- tive and alkaline resistant than ‘ KANG Nibeike ’ .

It is critical to develop the methods and technologies of studying the species and concentration in the processing of adsorption, and diffusion of some important radionuclides in spent fuel waste processing such as Beishan granites in domestic institutions and universities for the geological disposal of high-level radioactive wastes. Enrich the models used or constructed and the calculation procedures developed in the past two decades in this field. In order to evaluate the safety of the repository, chemical speciation analysis of nuclides is the premise of research to accurately predict the migration behavior of nuclides. In view of the rapid development of China's nuclear energy industry and the need to establish the identification of nuclides in the environment, it is of great significance to carry out the study of the chemical forms of nuclides around the repository in China. Aiming at the research requirements of element speciation distribution in the environment, a set of B/S architecture element speciation distribution simulation software is developed with JAVA as the development tool, MySQL as the database, and Tomcat as the container. In order to solve the convergence problem of chemical reaction equilibrium nonlinear equations encountered in simulation calculation, the method based on chemical reaction potential energy is introduced to solve the chemical reaction nonlinear equations quickly, and the multi-phase equilibrium calculation can be expanded. SSCS was used to study the species of U in groundwater and the effects of Eh, pH, different ions and concentrations. The calculation results indicate that neptunium mainly exists as NpO2CO-3(aq) in groundwater. Under strong acidic conditions, neptunium maily exists as NpO+2(aq), while in weak acidic, neutral or weak alkaline conditions, the main species are NpO+2(aq) and NpO2OH.When the solution is in strong alkaline conditions, the species are complicated most of neptunium exists as NpO2(CO3)-3(aq), with the possible generation of NpO2(CO3)3-2 or NpO2(CO3)5-3. Np(Ⅴ) is stable in the reduction condition, while Np(Ⅳ) and Np(Ⅵ) are the possible generation. Comparing the neptunium calculation results of the software in the environment with the PHREEQC calculation results, the relative error is within 10 %. For the distribution of trace elements in the environment, a theoretical calculation solution is provided.

BackgroundWith the rapid development of nuclear energy and the wide application of nuclear technology, the radioactivity level of bodies of water has become a highly concerning issue for the public and governments, especially after the Fukushima nuclear accident in Japan.PurposeThis study aims to develop an online γ radioactivitymonitoring system based on 4G Remote Terminal Unit (4G-RTU) to meet the needs of online and emergency monitoring of water radioactivity.MethodsFirst, the γ-ray monitoring device based on sodium iodide detector, 4G-RTU, an integrated power supply waterproof and compression resistant floating device and corresponding software were employed to compose an online monitoring. Second, Qt programming control software was used to realize the remote control of the system, real-time radioactivity monitoring, and data upload. Finally, the original data obtained by the system were used to test the performance indicators, applicability, accuracy, and software functions to verify the practicability of the system.ResultsWithin the coverage of the 4G network, the system realizes remote control of equipment, real-time online monitoring, and data upload throughout the day. The detectable energy range of the system is 30~3 000 keV, and the energy resolution of the system for 137Cs at 662 keV is 7.3% with minimum detectable activity of 0.75 Bq∙L-1. The spectral drift for 208Tl at 2 614 keV is 0.33%, and the linearity of the spectral energy is 0.999 970. The maximum value of energy spectrum stability is 2.28% for 7 h continuous operating, and the minimum value is -2.36%. The operating temperature range of the system is in the range of -5 ℃ to +50 ℃.ConclusionsThe on-line monitoring system meets the application demand and achieves the expected function. It has important popularization value and application prospects in the field of online radioactive monitoring of bodies of water such as oceans, lakes, and rivers.

The lithology and hardness of the coal seam roof are directly related to the stability and water permeability of the roadway and the safe production of the coal mine. It has become a common method to predict gas content based on AVO inversion, but the conventional AVO inversion formula is a simplified approximation of Zoeppritz equation in different degrees under certain conditions, which affects the inversion accuracy to some extent. On the basis of petrophysical analysis of the roof, the pre-stack inversion of quasi-linear Zoeppritz equation with the smallest overall angle error was employed to lithology and hardness prediction of coal seam roof in Yangquan Mining Area, Shanxi Province. The results show that the expression of quasi-linear Zoeppritz equation is simple, and through the AVO characteristic analysis of different Zoeppritz approximate formulas, found that the precision of quasi-linear Zoeppritz equation is the highest, second only to that of accurate Zoeppritz equation. The analysis of rock mechanics characteristics shows that Young’s modulus multiplied by density is the most sensitive to hardness, and pseudo-gamma P-wave velocity can effectively reflect roof lithology. The lithology and hardness characterization parameters obtained from inversion are combined with the parameter well data and geological data to comprehensively evaluate the roof stability, provide geological evidence for roadway excavation and reduce the coal mine production risk.

With the large-scale application of composite materials in aircraft structures, the threat of visually invisible damage such as internal delamination of composite materials caused by impact from foreign objects is increasing,therefore, impact event monitoring and impact location identification of composite reinforced structures is essential.In order to verify the engineering validity of the impact localization algorithm, based on the piezoelectric sensing signal of the impact test on the composite large wall plate structure, the localization accuracy of the time-reversal focusing,error function and cross-correlation function impact monitoring algorithms is compared. The results show that, in the monitoring area of 2 360 mm×1 260 mm, the error of the cross-correlation function algorithm is smaller than that of the time-reversal focusing algorithm, and the error of the time-reversal focusing algorithm is larger at the truss, which is not suitable for impact positioning of reinforced structures.

Conducting laboratory accelerated simulation tests on the atmospheric environment in which aviation materials are used to obtain their long-term corrosion behavior and life degradation is an important content and foundation for the design, manufacturing, maintenance, life assessment, and life control of related materials and equipment. The laboratory accelerated corrosion tests for simulated coastal atmospheric corrosion of 2A12-T4 aluminum alloy plates is conducted, and the impact of corrosion on the fatigue characteristics of aluminum alloy plates throughout the entire coastal atmospheric corrosion process from initial pitting to later erosion is simulated. Based on the principle of equivalent fatigue life degradation, an accelerated equivalent relationship between 2A12-T4 aluminum alloy plate accelerated corrosion and atmospheric corrosion is established. The results show that the fatigue life degradation law of 2A12-T4 aluminum alloy after accelerated pre-corrosion in laboratory is consistent with that of atmospheric pre-corrosion fatigue life degradation law, which is characterized by "rapid decline period"+"platform period".

In order to develop an environment-friendly natural corrosion inhibitor，betaines in Lycium barbarum were extracted using cellulose.On the basis of single factor experiment，the extraction process was optimized by response surface methodology，and the inhibitory performance and mechanism of betaine crude extracting solution and its compound with polyaspartic acid for Q235 carbon steel in H2SO4 solution were studied.Results showed that the best conditions for the extraction of betaines from Lycium barbarum were an enzymolysis time of 59 min，an enzymolysis temperature of 46 ℃，an enzymolysis pH value of 3，a cellulose dosage of 3 mg/g，a liquid-solid ratio of 25 ∶1 (mL/g) and a methanol concentration of 80%(volume fraction).Under these conditions，the extraction rate of betaines was 20.34%，which was consistent with the predicted extraction rate 20.45%.The corrosion inhibition experiments exhibited that the betaine crude extracting solution of Lycium barbarum had good corrosion inhibition performance for carbon steel in sulfuric acid，and its inhibition efficiency increased with the rise of the concentration of betaine crude extracting solution.The inhibition efficiency reached more than 90%at 30 ℃when the concentration of betaine crude extracting solution reached 250 mg/L.After being combined with polyaspartic acid，the inhibition efficiency was enhanced obviously.Besides，both the betaine crude extracting solution and its complex were mixed-type inhibitors，which could be adsorbed on the surface of carbon steel to form a protective film.The adsorption process could be well described with Langmuir adsorption isolliemi equation.The adsorptions of betaine crude extractive and its complex on carbon steel surface were both spontaneous process dominated by physical adsorption in association with chemical adsorption.

With the development of nuclear power technology in China, the need for glass vitrification of high-level liquid waste(HLLW) from a power reactor spent fuel has become more and more urgent. In this paper, the application prospect of cold crucible induction melter(CCIM) in the treatment of HLLW from a power reactor spent fuel is reviewed, and the technical advantages, design advantages and technological advantages of CCIM are described in detail. On that basis, some suggestions for the future development of CCIM are proposed.

To study the representative dose coefficients near nuclear facilities in the arid regions of Northwest China, a simplified anatomical model of Sphingonotus insects using computed tomography (CT) scanning is proposed. In addition, a voxel model created by using Photoshop and Python is used to assess the results of the simplified anatomical model. The dose coefficients of internal and external 90Sr and 137Cs irradiation on different organs of Sphingonotus insects in the environmental medium are calculated. To verify the feasibility of the proposed model, the results are compared with the dose coefficients reported in the International Commission on Radiological Protection (ICRP) Publication 108. Based on the simplified model adopted by ICRP to arrive at the results reported in Publication 108, the average value of dose coefficients of each organ of the insect is used to calculate the results presented in this paper. The dose coefficients of internal and external 90Sr irradiation for the simplified anatomical model of Sphingonotus were found to be 6.59×10-4 μGyh-1/Bqkg-1 and 6.74×10-4 μGyh-1/Bqkg-1, respectively. Meanwhile, the dose coefficients of internal and external 137Cs irradiation for the simplified anatomical model were 1.34×10-4 μGyh-1/Bqkg-1 and 4.40×10-3 μGyh-1/Bqkg-1, respectively. The dose coefficients were 7.87×10-4μGyh-1/Bqkg-1 and 6.74×10-4μGyh-1/Bqkg-1, respectively. The dose coefficients were 1.33×10-4μGyh-1/Bqkg-1 and 3.51×10-3μGyh-1/Bqkg-1, respectively. The dose coefficients of internal and external 90Sr radiation for reference insects as reported in the ICRP Publication 108 were 1.00×10-2 μGyh-1/Bqkg-1 and 3.90×10-10 μGyh-1/Bqkg-1, respectively. Moreover, the dose coefficients of internal and external 137Cs radiation in the ICRP Publication 108 were 3.20×10-3 μGyh-1/Bqkg-1 and 2.80×10-3 μGyh-1/Bqkg-1, respectively. The above data indicate that the dose coefficients of internal irradiation reported in the ICRP Publication 108 are larger than those calculated using the proposed dosiological model, whereas those of external irradiation in ICRP Publication 108 are smaller. This trend is probably related to the size of the organism, decay rate, and energy of radionuclides. The adoption of a simplified anatomical model, morphologically similar to the organism, and a voxel model, highly overlapping with the organism, in this study allows a visualization of the real exposure situation for the organism considered with high accuracy, proving the feasibility of the insect dosimetry model established in this study.

Graphene oxide(GO) has attracted extensive attention in the field of water environment treatment due to its large specific surface area and rich oxygen-containing functional groups. Graphene oxide was modified by carboxylation. The effects of solution pH, ionic strength, reaction time and initial concentration on the adsorption performance of carboxylated graphene oxide were systematically studied. It was found that carboxylated graphene oxide has strong adsorption capacity for Nd3+. The adsorption rate of Nd3+ on carboxylated graphene oxide is very fast, and most of Nd3+ can be adsorbed in 10 min. The adsorption equilibrium can be reached in 30 min, which is accord with the pseudo-second-order kinetic model. The adsorption performance is almost not affected by ionic strength. The adsorption isotherm is in accordance with Langmuir model, which indicates that the adsorption process is monolayer chemical adsorption. The study of Nd3+ adsorption behavior by carboxylated GO materials provides a new choice for the separation of rare earth elements in water treatment.

China’s chronic disease management suffers from problems such as unclear institutional function， insufficient information technology application， and weak regulation support. On the basis of current chronic disease management condition in China， this paper proposes to apply the concept of “people-centered” integrated health management to community chronic disease management and discusses the content and procedure of establishing an integrated community-based chronic disease management model driven by massive databases. The model innovatively combines technology integration， data integration and service integration， and can accurately and efficiently realize the "people-centered" full-course health management of various chronic diseases. Shanghai has provided integrated community-based chronic disease management service for 1.98 million citizens through applying this model. The model warrants further effectiveness and economic evaluation. This study provides precious experience for the development of chronic disease prevention and treatment in China.

C44H43N11O12Co2, triclinic, P 1‾ $\overline{1}$ (no. 2), a = 10.7333(11) Å, b = 13.6796(11) Å, c = 16.751(2) Å, α = 113.982(2)°, β = 90.578(2)°, γ = 105.7310(10)°, V = 2142.7(4) Å3, Z = 2, R gt(F) = 0.0460, wR ref(F 2) = 0.1015, T = 296(2) K.

Objective To investigate the expression and clinical significance of H3K27me3 in vascular hemangioma and malformation. Methods Paraffin-embedded tissue blocks from 244 patients with hemangioma and vascular malformation admitted in our hospital from January 2010 and June 2021 were collected. The expression levels of H3K27me3 and smooth muscle actin (SMA) in vascular endothelial and perivascular cells were detected by immunohistochemical SP assay, and its expression differences between hemangioma and vascular malformation was analyzed. Bioinformatics analysis was further applied to explore its potential role in anigodysplasia in combination of the results of SMA immunostaining. Receiver operating characteristic (ROC) curve was drawn to evaluate its diagnostic value in differentiation of hemangioma and vascular malformation. Results In vascular hemangioma, H3K27me3 expression was mainly restricted to vascular endothelial cells, with an expression rate of 50%~90%. However, in vascular malformations, it was expressed in vascular endothelial cells, with an expression rate of 30%~50%, and lost in perivascular cells. There were top 10 endothelium restricted genes derived from GSE21212 dataset based on concerning literatures. According to ChIP-seq data from ENCODE website, H3K27me3 was enriched in the SOX2 promoter of different endothelium lineages, and the molecular interaction of H3K27me3 and SOX2 may be associated with vessel development and differentiation. Conclusion The expression of H3K27me3 in vascular endothelial cells can be used as a candidate marker to distinguish hemangioma and vascular malformation. However, its expression in infantile hemangioma is immunologically heterogeneous.

C19H18N2O4, monoclinic, P21/n (no. 14), a = 8.375(2) Å, b = 22.018(6) Å, c = 9.237(3) Å, β = 106.271(3)∘ $106.271{(3)}^{\circ }$ , V = 1635.1(8) Å3, Z = 4, Rgt ${R}_{gt}$ (F) = 0.0427, wRref ${wR}_{ref}$ (F 2) = 0.1185, T = 296(2) K.

A 61-year-old man developed severe swelling in the left lower extremity after interventional embolization of liver tumor. Ultrasound examination showed a pseudoaneurysm and thrombosis in the upper thigh on the left. To recognize the causes and determine the effective therapy, lower extremity arteriography was performed. The results revealed a pseudoaneurysm arised from deep femoral artery. Considering of the size of cavity and symptoms of patient, a new method was tried instead of traditional treatment using PROGLIDE device. Postoperative angiography showed a powerful blocking effect. This case study provide us a specific treatment for pseudoaneurysm, and this method provide us a new therapeutic strategy in clinical practice.

Human skin can sense the information from the environment and play a significant role in the contact with the outside world. Electronic skins, which mimic the characteristics of human skin and the ability to perceive the environment have a wide range of applications in the fields of medical monitoring, bionic prostheses and robotic tactile perception. Compared with traditional wearable sensors, electronic skin is lighter, more flexible, more malleable, and has the characteristics of wireless, transparent, and compatibility with human skin, therefore, has become one of the emerging research fields. The electronic skin can continuously sense large number of physical and biochemical parameters of the human body, human motion and gas to monitor human health, sports condition and surrounding gases in various environments in real-time. In this review, the state-of-the-art of the materials used to making electronic skins, including zero-dimensional (0D), one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) micro/nano-materials, polymeric materials, hydrogel materials and their composites, were discussed, and the practical applications of the electronic skin constructed based on these core materials were concluded in terms of health monitoring, motion monitoring as well as gas monitoring. It was pointed out that there are still some remaining technical problems in the research process of electronic skin such as high cost and complex process.The development trend of electrode skin was towards multi-function and simultaneous detection of multiple external stimuli, and it had broad application prospects in the fields of medical equipment robbotics and future manufacturing.

C22H22N4O4 ${\mathrm{C}}_{22}{\mathrm{H}}_{22}{\mathrm{N}}_{4}{\mathrm{O}}_{4}$ , monoclinic, C2/c (no. 15), a = 34.315(13) Å, b = 6.701(3) Å, c = 9.105(3) Å, β = 98.510(4)° $98.510(4){}^{\circ}$ , V = 2070.7(13) Å3 ${\mathrm{\mathring{\text{A}}}}^{3}$ , Z = 4, Rgt ${R}_{gt}$ (F) = 0.0461, wRref $w{R}_{ref}$ (F2 ${F}^{2}$ ) = 0.1413, T = 296(2) K.

C14H12Br2O6Zn, monoclinic, C2/c (no. 15), a = 29.43(2) Å, b = 4.774(4) Å, c = 11.658(9) Å, β = 103.194(7)∘ $103.194{(7)}^{\circ }$ , V = 1595(2) Å3, Z = 4, Rgt ${R}_{gt}$ (F) = 0.0235, wRref $w{R}_{ref}$ (F 2) = 0.0647, T = 296(2) K.

The landing maneuver of aircraft is considered to be a feasible way to solve the problem of ultra short distance,precise landing of carrier based fixed wing aircraft. The existing researches mainly focus on aerodynamic modeling,nominal landing trajectory optimization and trajectory tracking control in the process of landing,but few on the overall analysis of the landing mission. Based on the dynamic model of aircraft longitudinal landing maneuver,the concept of landing trajectory reachable region is introduced,and the mathematical description of reachable region is given;On this basis,the Gauss pseudo-spectral method with both computational speed and accuracy is used to solve the reachable region problem,which is divided into three trajectory optimization problems. Firstly,the upper boundary of the terminal height of the perching trajectory is solved. Secondly,the nearest trajectory is solved when the terminal height is fixed. Finally,the farthest trajectory is solved when the terminal height is fixed.The simulation results show that:the model and solution method can quickly get the calculation results,the vertical landing trajectory of unpowered aircraft can reach the asymmetric region of narrow upper and wide lower,and the left and right boundary curves have good linearity.

Aiming at the problem that the surrounding rock of the advancing roadway at the east wing of -550 m level is not easy to be stable when the tunnel is advanced in a short distance under goaf in Liangbei Mine, the stress distribution law and deformation characteristics of the goaf and coal pillar formed by two adjacent working faces at different times on the surrounding rock near the advancing roadway were analyzed by numerical simulation. Based on the support principle of multi-level coupling bearing structure, the corresponding deformation control countermeasures and support schemes were proposed and applied in the field. The results show that with the advance of the working face, the stress recovery zone of the raw rock of the floor strata in the goaf diffuses from the middle of the goaf to the surrounding areas, and the plastic failure zone is distributed in an “inverted saddle” shape; under the influence of the stress produced by the disturbance process of progressive compaction of the adjacent unstable goaf and the stress concentration of the coal pillar, the plastic failure zone of the tunnel is asymmetrically distributed; based on the zoning characteristics of broken zone, plastic zone and elastic zone formed by the failure of roadway surrounding rock, the supporting strategy of making full use of internal and external support to form multi-level coupled bearing structure is put forward. The multi-level coupling control technology of “high strength anchor-mesh-cable + reinforcement of shallow and deep surrounding rock by staged grouting + shotcreting” in shallow and deep surrounding rocks has achieved good application results in the field.

This paper studies the total flavonoids extraction and activity in vitro of Rose rugosa cv. Plena residues from Shandong province. Single factor experiment and orthogonal experiment are designed to determine the optimal extraction conditions for flavonoids. The antioxidant and antimicrobial activities of total flavonoids in vitro are evaluated by free radical scavenging method and Oxford cup method. Results show that the optimal extraction process for flavonoids are as follows: set the ethanol concentration to 60%and the solid-liquid ratio of 1∶30, then shake the rose residues at 80 ℃ for 1.5 hours, after which run it ultrasonic treatment for 45 minutes at 140 W and 60 ℃. This process gives us the total flavonoids content of 58.53 mg/g. The extracted flavonoids from rose residues demonstrates good antioxidant activity. The scavenging rates of DPPH· radical, ABTS+ radical and hydroxyl radical are 91.58%, 73.71% and 467.91 U/mL respectively. The total flavonoids have good antimicrobial activity on Staphylococcus aureus and Bacillus cereus. The flavonoids could significantly inhibit Staphylococcus aureus. This study would laid a solid foundation for the comprehensive utilization of Rose rugosa cv. Plena residues.

C17H15NO3, monoclinic, P21/n (no. 14), a = 4.3970(3) Å, b = 13.8942(8) Å, c = 22.0484(14) Å, β = 91.099(6)°, V = 1346.75(15), Z = 4, Rgt (F) = 0.0412, wRref (F2) = 0.1003, T = 150 K.

Environmental supervision and government subsidy are important tools for government to promote green innovation. The influence of these two policy orientations on green innovation performance is spreading widely, but the specific indirect mechanism of policy orientation inducing green innovation needs further exploring.This paper introduces the knowledge-dynamic ability (knowledge production ability, knowledge acquisition ability, knowledge integration ability) into the analysis framework of enterprise green innovation, and studies the mediating effect of the knowledge-dynamic ability on policy orientation and green innovation. Based on the panel data of 30 provinces in China from 2000 to 2015, the empirical findings are as follows: Firstly, the knowledge-dynamic ability plays a remarkable mediating role in promoting between policy orientation and green innovation, which indicates that improving the knowledge-dynamic ability is a core mechanism of policy orientation to induce enterprise green innovation. Secondly, the knowledge-dynamic ability plays a complete mediating role in the relationship between environmental supervision and green innovation. Environmental supervision promotes green process innovation by enhancing knowledge acquisition ability and induces green product innovation by enhancing knowledge production ability. Thirdly, the knowledge-dynamic ability plays a partial mediating role in the relationship between government subsidy and green innovation. Government subsidy improves enterprise green process innovation by enhancing knowledge acquisition ability and knowledge integration ability, and induces enterprise green product innovation by enhancing knowledge production ability and knowledge integration ability

Objective: This study aimed to investigate the protective effect and mechanism of solid beverage with vine tea combined with and cassia on alcoholic liver injury in rats. Methods: SD rats were given 43%vol aging by gavage to establish model of alcoholic liver injury. The model was fed with low, medium and high doses of solid beverage. The appropriate ratio of solid beverages was detected by cell test, the physiological and biochemical indicators of rats were detected by using kits, and the expression of related differential genes was studied by transcriptomic analysis to assessing the effect of vine tea extract combined with cassia extract solid beverage on alcoholic liver injury in rats and revealing the mechanism of action. Results: Compared with the model group, the activities of ALT, AST and LDH in the solid beverage group were significantly decreased; the levels of IL-6 and TNF-α was significantly reduced; the activities of GSH and SOD in the liver were significantly increased, while the contents of MDA and TG were significantly decreased; finally the oxidative stress and inflammatory response in rat liver were significantly improved. Compared to the model group, the inflammatory cell infiltration and vacuolar degeneration of liver cells in the liver pathological sections of the solid beverage group were significantly reduced; transcriptomic analysis speculated that the regulation of genes such as spermidine synthase, Sirt7, RT1-A2, RT1-CE1 and other pathways and amino acid metabolism are related to vine tea extract combined with cassia extract solid beverage to alleviate alcoholic liver injury. Conclusion: Vine tea extract combined with cassia extract solid beverage can alleviate alcohol-induced liver injury by improving liver function, reducing liver inflammation and oxidative stress.

C30H48O5, orthorhombic, P212121 (no. 19), a = 11.6608(10) Å, b = 14.8098(15) Å, c = 15.9975(16) Å, V = 2762.7(5) Å3, Z = 4, Rgt(F) = 0.0586, wRref (F2) = 0.1580, T = 293(2) K.

Objective To investigate the clinical features, endoscope diagnosis, and treatment of cases of colorectal foreign bodies. Methods A retrospective analysis of colorectal foreign body cases admitted to the Digestive Endoscope Center from June 2005 to September 2018 were completed. The information of gender, age, source and location of foreign bodies, complications, and methods of removal was collected so that characteristics and management experience were summarized. Results A total of 14 cases of colorectal foreign bodies were included, among which there were 10 males (71%) with an average age of 49 years old (21-80 years old). The origin of foreign body included iatrogenic (5 cases), oral (3 cases), anal (5 cases) and one case of unknown reason. As to the position of foreign bodies, iatrogenic and oral foreign bodies might distribute in the whole colon, while anal foreign bodies located in sigmoid-rectum mainly. In total 6 cases suffered from foreign body-related complications, including mucosal injury (1 case), intestinal wall injury (2 cases), intestinal obstruction (2 cases) and liver abscess (1 case). We attempted to remove foreign bodies under endoscopy in 12 cases, with success in 11 cases; the instruments used were foreign body forceps (7 cases) and snares (5 cases). The main reason of failure was big size of foreign bodies. Conclusions The distribution of colorectal foreign bodies is related to its origin; colorectal foreign bodies may cause colonic mucosal injury, intestinal obstruction or intestinal perforation, and even severe peritoneal infection; when attempting to remove colorectal foreign body under endoscope, foreign body forceps and snares can be used. After the foreign body's removal, it is necessary to be alert of the colon perforation.

Objective To detect the expression of 4 progesterone receptor (PR) antibodies (EP2, SP2, 1E2, and 16) in non-specific invasive breast cancer (NSIBCs) and identify the optimal antibody for PR analysis and treatment planning for NSIBCs. Methods Immunohistochemistry was used to detect the expression of the 4 PR antibodies in a tissue microarray consisting of 195 tissue specimens of NSIBCs, and their constituent ratios with the expression of estrogen receptor (ER), the percentages of stained cells, staining intensity, Allred score (A-score) and consistency were compared. Results The constituent ratios of the 4 PR antibodies with ER (ER±/PR±) did not differ significantly in the 195 cases of NSIBCs (P>0.05). Regardless of the status of ER expression, the cases showed high rates of positivity or negativity for all the 4 PR antibodies at the same time (81.54%~90.77%) with good consistencies among the 4 antibodies (κ=0.634~0.804). Further analysis of the average number of stained cells, percentage of positive cells, staining intensity, and A-score of the 4 PR antibodies showed that all these indicators were significantly higher for 1E2 than for EP2, SP2, and 16 (P < 0.05), and were not significantly different among the latter 3 antibodies (P>0.05). Conclusion 1E2 has a higher positivity rate and expression intensity in NSIBCs than EP2, SP2 and RP16, and thus can serve as an ideal PR antibody for clinical pathology tests.

C19H14F4O2${\text{C}}_{19}{\text{H}}_{14}{\text{F}}_{4}{\text{O}}_{2}$, triclinic, P1‾$P‾{1}$ (no. 2), a = 8.1539(7) Å, b = 8.8584(6) Å, c = 11.8025(9) Å, α = 73.186(7)°, β = 76.184(7)°, γ = 69.512(7)°, V = 755.39(11) Å3, Z = 2, Rgt${R}_{gt}$(F) = 0.0436, wRref$w{R}_{\text{ref}}$(F2) = 0.0965, T = 100 K.