Search

Panpan Xu,1,* Di Zhang,2,* Wanqing Zhuo,3 Lin Zhou,4 Yue Du,2 Peipei Zhang,1 Lijuan Ma,4 Yajuan Wang2 1Children’s Hospital Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Neonatology, Children’s Hospital, Capital Institute of Pediatrics, Beijing, People’s Republic of China; 3School of Life Sciences, Peking University, Beijing, People’s Republic of China; 4Department of Clinical Laboratory, Children’s Hospital Affiliated to Capital Institute of Pediatrics, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lijuan Ma; Yajuan Wang, Children’s Hospital Affiliated to Capital Institute of Pediatrics, 2 Yabao Road, Chaoyang District, Beijing, 100020, People’s Republic of China, Email malijuan@shouer.com.cn; cxswyj@vip.sina.comPurpose: Klebsiella michiganensis is an opportunistic pathogen that causes an increasing number of serious infections. This study aimed to investigate the etiology of the severe clinical symptoms of sepsis in preterm infants and the characterization of K. michiganensis isolates.Patients and Methods: Whole-genome sequencing (WGS) was performed on three strains isolated from an infected preterm infant. Additionally, the genomic sequences of 534 K. michiganensis strains were obtained from the NCBI database. To gain deeper insights into these strains, we utilized the Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Clusters of Orthologous Groups (COG), and Pathogen Host Interactions (PHI) database annotation tools for comprehensive gene function analyses. Moreover, the multilocus sequence typing (MLST), EasyCGtree, and virulence factor database (VFDB) were employed to determine the sequence types (STs), construct phylogenetic trees, and identify potential virulence factors.Results: Sequence analysis found that the three isolated strains had identical sequence characteristics and did not correspond to any of the known ST types. Virulence factor analysis revealed that the three strains harbored mrkABCDFHIJ, fimABCDEFGHIK, entABCDEFS, fepABCD, and capsule genes. These virulence factors are likely to play crucial roles in enhancing adhesion and metabolic capabilities, resisting phagocytosis (inducing immune cell damage), and ultimately contributing to prolonged bacteremia. The phylogenetic tree and comparative genomics of virulence factors showed the genetic and virulence factor diversity of the currently reported K. michiganensis strains.Conclusion: We identified a novel strain of K. michiganensis that exhibits high virulence and leads to severe septicemia phenotypes in preterm infants. Furthermore, comparative genomic analysis of previously reported K. michiganensis strains revealed the existence of three clades. This comprehensive analysis provides novel insights into the genetic relationships and virulence factor profiles of diverse strains of K. michiganensis. In future, it will be necessary to investigate the concept of the high virulence of K. michiganensis to determine the treatment method.Keywords: Klebsiella michiganensis, whole-genome sequencing, preterm infant, sepsis

Weiquan Wu,1,* Bing Zhang,1,* Weiqi Wang,2 Qiujin Bu,3 Yuange Li,3 Peihua Zhang,2 Li Zeng1 1Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People’s Republic of China; 2Institute of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China; 3Department of Radiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Peihua Zhang, Institute of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China, Email zhangph@gdmu.edu.cn Li Zeng, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People’s Republic of China, Email lzeng@must.edu.moAbstract: The incidence of chronic wounds is steadily increasing each year, yet conventional treatments for chronic wounds yield unsatisfactory results. The delayed healing of chronic wounds significantly affects patient quality of life, placing a heavy burden on patients, their families, and the healthcare system. Therefore, there is an urgent need to find new treatment methods for chronic wounds. Plant-derived exosome-like nanovesicles (PELNs) may be able to accelerate chronic wound healing. PELNs possess advantages such as good accessibility (due in part to high isolation yields), low immunogenicity, and good stability. Currently, there are limited reports regarding the role of PELNs in chronic wound healing and their associated mechanisms, highlighting their novelty and the necessity for further research. This review aims to provide an overview of PELNs, discussing isolation methods, composition, and their mechanisms of action in chronic wound healing. Finally, we summarize future opportunities and challenges related to the use of PELNs for the treatment of chronic wounds, and offer some new insights and solutions.Keywords: exosomes, exosome-like nanovesicles, plants, chronic wound healing

Geopolymer mortar can be used as an environmentally friendly sustainable construction material for the repair and strengthening of already-existing structures with the utilization of various recycled materials, such as fly ash, slag powder, etc. With mature application of fibers and nanoparticles in construction materials, nano-SiO2 (NS) and polyvinyl alcohol (PVA) fibers have been utilized to enhance the properties of geopolymer mortar, which has a major impact on the rheological properties of geopolymer mortar. The rheological property tests of geopolymer mortar were carried out in this study, and three indices including dynamic yield stress, static yield stress, and plastic viscosity were studied as rheological parameters. The results of the study were used to establish the relationships between PVA fiber content as well as NS content and rheological parameters. The results showed that a tendency of first decreasing and then increasing was observed in the rheological parameters with the addition of NS content from 0 to 2.5%. Compared with the geopolymer mortar without NS addition, the dynamic yield stress, static yield stress, and the plastic viscosity increased by 22.6, 12.4, and 22.9%, respectively, when NS content was 2.5%. The results showed that the rheological parameters of geopolymer mortar increased linearly with the increment in PVA fiber content which was less than 1.2%. In comparison to the geopolymer mortar without PVA fibers, the dynamic yield stress, static yield stress, and plastic viscosity increased by 65, 56, and 161%, respectively, as the PVA fiber content was 1.2%.

Peng Liu,1,2,&ast; Tingting Lv,1,&ast; Yuanwei Liu,1,&ast; Xiaofei Zhang,1 Fei She,1 Rong He,1 Dan Li,1 Lianfeng Liu,1 Ping Zhang1 1Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People’s Republic of China; 2Department of Cardiology, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical University, Inner Mongolia, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ping Zhang, Email zhpdoc@126.comObjective: Atrial fibrillation (AF) is known to increase the risk of thromboembolic events and major adverse cardiovascular events (MACE). The impact of paroxysmal atrial tachycardia (PAT) on these risks remains unclear.Methods: This retrospective cohort study was conducted involving 889 patients diagnosed with PAT and 1106 control patients without PAT, all of whom underwent their initial 24-hour ECG monitoring between 2015 to 2020. Kaplan–Meier survival analysis and Cox regression analysis were used to evaluate the association between PAT and the study endpoints, including thromboembolic events and MACE.Results: Over a mean follow-up period of 50.3 months, the incidence of thromboembolic events and MACE was significantly higher in the PAT group compared to the control group (6.5% vs 1.7% and 19.1% vs 9.9%, respectively). After adjusting for common risk factors and baseline imbalances, the PAT group exhibited a significantly elevated risk of thromboembolic events (hazard ratio [HR] 3.782, 95% confidence interval [CI] 2.212– 6.467; P < 0.001) and MACE (HR 1.795, 95% CI 1.398– 2.305; P < 0.001). However, the frequency of PAT episodes, heart rate, and maximum heart rate were not significantly associated with these outcomes. Within the PAT group, a history of stroke, transient ischemic attack, and chronic renal failure were identified as independent risk factors for thromboembolic events, while hypertension, coronary heart disease, heart failure, and chronic renal failure were independently associated with MACE.Conclusion: PAT, as detected by 24-hour dynamic ECG, is associated with an increased risk of thromboembolic events and MACE.Keywords: paroxysmal atrial tachycardia, thromboembolic events, ischemic stroke, transient ischemic attack, systemic thromboembolism, major adverse cardiovascular events

With its passive characteristics, anti-single point failure characteristics, and simple system, the heat pipe reactor has become a hot research topic in advanced nuclear power. The loading criticality is an essential and important link before the heat pipe reactor is put into operation. Different from the traditional modular design of heat pipe fuel element, the new heat pipe reactor uses bulk fuel, and the traditional extrapolation fuel element/assembly and other extrapolation criticality experimental techniques have poor adaptability. Different from the KRUSTY reactor, the new heat pipe reactor has four side reflectors, and simultaneously lifting four side reflectors does not meet the regulations, which makes the new heat pipe reactor face safety challenges in the process of loading and extrapolation criticality. Therefore, combined with the characteristics of the reactor, the scheme of assembling bulk fuel was firstly determined, and gradually lifting the side reflectors to reach the criticality. Because of the large reactivity of bulk fuel, the core assembly process may face critical safety risks. To solve this problem, the critical safety in the core assembly process was calculated and analyzed by using Monte Carlo calculation program, and the safe and controllable scheme was determined. In the extrapolation process, the neutron fluence rate calculated by the detector is very important, and the size of the new heat pipe reactor is small, and the space available for the arrangement of the neutron source and the detector is limited. At the same time, the new heat pipe reactor is a fast reactor, and the neutron calculated by the detector is a thermal neutron. In order to solve the statistical influence of the neutron source and the detector on the neutron fluence rate in the extrapolation process, the Monte Carlo calculation program was used to determine the arrangement of the neutron source and the detector as well as the thickness of the detector cladding. In order to meet the principle of half addition, the new heat pipe reactor was proposed to use the extrapolation of the side reflector volume to reach the critical point. However, the direct extrapolation of the side reflector volume caused the convex problem on the extrapolation curve. The extrapolation criticality experimental technology was studied, and a modified method was proposed to weight the volume by taking the reactivity value of the side reflector as the weight factor. The extrapolation process was simulated by using this technology, and the feasibility was verified, which provides an important guidance for the loading and extrapolation criticality of the new heat pipe reactor.

[Objective] Jiaojia-type gold deposit is a new type of gold mine discovered by Shandong geologists in northwestern Jiaodong in the 1960s, and its output is controlled by regional tectonic fracture zones. Pyrite sericitized alteration generally occurred during the ore-forming period, which is characterized by a large scale, distinct alteration zones, concentration of mineralization, simple morphology of the ore body, relatively uniform grade, and simple mineral combinations. The deposit has gone through 12 years of exploration and scientific research, from discovery to establishment. [Methods] This new type of gold deposit has been rapidly promoted since its establishment and has achieved fruitful prospecting results in China. Deep exploration achievements of the Jiaojia-type gold deposit have been coming up in the Jiaodong area since the 21st century. [Results] The accumulated gold resource reserves submitted have been 3617.12 tons by 2020, which has helped the Jiaodong area become the third largest gold cluster in the world, and gold reserves of China have risen to the second rink in the world. Research on the Jiaojia-style gold mine has also made considerable progress, with the age of mineralization accurately limited to 126~120 Ma and formation occurring under a strong regional extension background. The source of mineralization material has multiple origins, with the Archean tholeiite being the initial source rock of gold-bearing minerals. The ore-forming process is divided into four stages, and the “thermo-extension”metallogenic theory and the step metallogenic model are proposed. The metallogenic depth is about 5~10 km, and the post-metallogenic denudation thickness is 5.2±1.2 km, with the deposits well preserved. [Conclusion] The metallogenic prediction study concluded that the total gold resources in the three major metallogenic zones of Sanshandao, Jiaojia, and Zhaoping in the northwestern Jiaozhou area were 7258~10150 tons of metal at a depth of 5000 m, which demonstrates the immense potential of the deeper part of the Jiaojia-type gold deposits for exploration. A set of key exploration techniques was summarized for different exploration stages, from shallow to deep. [Significance] These studies enriched the metallogenic theory of the Jiaojia-type gold deposit, making the metallogenic prediction results highly accurate, reliable, and effective in guiding the gold exploration in the Jiaodong peninsula.

Maoting Zhou, Peng Zhang, Qi Mao, Yue Shi, Lin Yang, Xiaoming Zhang Medical Imaging Key Laboratory of Sichuan Province, Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, People’s Republic of ChinaCorrespondence: Lin Yang, Medical Imaging Key Laboratory of Sichuan Province, Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, People’s Republic of China, Email linyangmd@163.comObjective: To develop a model for predicting the overall survival (OS) of hepatocellular carcinoma (HCC) patients after transarterial chemoembolization (TACE) on the basis of multisequence MRI radiomic features and clinical variables.Methods: The DCE-MRI and clinical data of 116 HCC patients treated with TACE for the first time were retrospectively analyzed. The included patients were randomly divided into training and validation cohorts at a ratio of 7:3. Univariate and multivariate Cox proportional hazards regression models were used to identify independent risk factors that affect the OS of patients with HCC after TACE. Radiomic features were extracted from the sequences of FS-T2W images and arterial-phase (A) and portal venous-phase (P) axial DCE-MR images. The LASSO method was used to select the best radiomic features. Logistic regression was used to establish a radiomic model of each sequence, a joint model of MRI features (M model) combined the radiomic features of all the sequences, and a radiomic-clinical model (M-C model) that integrated the radiomic signatures and clinically independent predictors. The diagnostic performance of each model was evaluated as the area under the receiver operating characteristic (ROC) curve (AUC).Results: The Child–Turcotte–Pugh (CTP) score and neutrophil-to-lymphocyte ratio (NLR) –platelet–to–lymphocyte ratio (PLR) were found to be independent risk factors that affect the OS of patients with HCC treated with TACE. The AUCs of the FS-T2WI, A, P, M, and M-C models for predicting the OS of HCC patients after TACE treatment were 0.779, 0.803, 0.745, 0.858 and 0.893, respectively, in the training group and 0.635, 0.651, 0.644, 0.778 and 0.803, respectively, in the validation group. The M-C model had the best predictive performance.Conclusion: Multiparameter MRI-based radiomic features may be helpful for predicting OS after TACE treatment in HCC patients. The inclusion of clinical indicators such as inflammation scores can improve the predictive performance.Keywords: magnetic resonance imaging, radiomics, hepatocellular carcinoma, transcatheter arterial chemoembolization, inflammatory indices, overall survival

[Objective] The Belt and Road Initiative is the core of China’s foreign policy and future opening-up and international cooperation. It is of great significance to analyze the pattern and efficiency of fossil energy trade between China and countries along the Belt and Road to promote the high-quality development of energy along the Belt and Road and ensure China’s energy security. [Methods] Based on the fossil energy trade data of China’s import countries along the Belt and Road from 2000 to 2020 in the CHRTD resource trade database, this study explored the spatial and temporal change patterns and efficiency of fossil energy trade between China and these countries based on the ordered clustering method, survival analysis model, and stochastic frontier gravity model. [Results] The main results are as follows: From 2000 to 2020, China’s fossil energy import experienced obviously different stages, the number of trading countries was increasing, and the import volume was increasing year by year. Among them, the proportion of natural gas imports increased significantly; energy trade was relatively stable, and the survival rate of trade relations was high, but there were still some low energy trade activities. GDP, economic structure, and spatial distance were important factors that affected China’s energy imports. Energy import efficiency was generally low, and high-value countries was in small number and spatially scattered. Among the energy sources where the time-varying model is applicable, the trade efficiency of coal imports was decreasing year by year, while the import value and volume of natural gas were on the rise. [Conclusion] China’s fossil energy import trade cooperation with countries along the Belt and Road has gradually deepened, but the overall trade efficiency is still low. Further improving regional connectivity and formulating more refined trade management policies are important ways to reduce energy trade risks.

Methoxypolyethylene glycol 1900 and α-bromoisobutanoyl bromide were utilized for alcoholysis reaction to obtain a macromolecular initiator. Then, a simple amphiphilic diblockpolymer (mPEG-PDMAEMA) based on the initiator and dimethylaminoethyl methacrylate was synthesized through the atomic transfer radical polymerization (ATRP) method. The structures of the initiator and diblock polymer were accurately characterized using infrared spectrum and proton nuclear magnetic resonance spectroscopy (1H NMR). Cryo-transmission electron microscopy revealed the self-assembly of mPEG-PDMAEMA into vesicle-like structures in water. Upon injection of CO2 into the solution, the tertiary amine structure within PDMAEMA underwent protonation, resulting in the mPEG-PDMAEMA adopting a hydrophilic structure. Consequently, the vesicles dissociated and dispersed, forming a network-like structure in water. The protonation phenomenon was confirmed by 1H NMR, as evidenced by the shifting of alkyl hydrogen atoms near nitrogen atoms toward downfield positions.

High entropy amorphous alloys (HE AMs) have attracted extensive interest lately due to their superior magnetocaloric properties. However, the critical behavior and mechanical properties have received less research, which restricts their applications. This work presented a comprehensive investigation of the magnetocaloric effect (MCE), critical behavior, and mechanical performance of quinary Gd20Dy20Er20Al20M20 (M = Fe, Co, Ni) HE AMs. All samples exhibited distinct spin glass-like behavior below TC and competitive MCE around hydrogen liquefaction temperature range. Excellent MCE was achieved by the HE AMs through a second-order phase transition from paramagnetic state to ferromagnetic state at 79 K for Fe, 41 K for Co, and 36 K for Ni. Among them, the maximum magnetic entropy change (-ΔSM)max of Gd20Dy20Er20Al20Co20 amorphous alloys was 9.59 J kg−1 K−1 under 0–5 T. Furthermore, RC and RCP of Gd20Dy20Er20Al20Fe20 amorphous alloys were respectively 519 J kg−1 and 613 J kg−1, larger than that of most RE-based amorphous alloys. For all samples, the critical behavior of the phase transition approached the mean field model, and this responded to the long-range ordering of the magnetic interaction. The bending plasticity of Gd20Dy20Er20Al20M20 (M = Fe, Co, Ni) HE AMs were 0.78, 1.03, 0.89, respectively. The adjustable Tc, large (-ΔSM), high RCP, and outstanding mechanical properties suggested Gd20Dy20Er20Al20M20 (M = Fe, Co, Ni) HE AMs may find utility as magnetic refrigerants in low-temperature applications.

Haibin Zou,1 Fangfang Xi,1 Yuanyuan Fu,1 Jinhui Xu,1 Ping Zhang,1 Dongge Li,2 Heguo Luo1 1Department of Anesthesiology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People’s Republic of China; 2The Third Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of ChinaCorrespondence: Heguo Luo, Department of Anesthesiology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +86 13807035516, Email ddjy121@163.comPurpose: Ciprofol, a new sedative anesthetic developed in China, offers rapid onset and recovery, reduced injection pain, and stable circulation. However, its effect on blood pressure during anesthesia induction in older adults remains unclear. To compare the effects of propofol and ciprofol on hypotension induced by general anesthesia in older adults.Patients and Methods: This prospective, single-center, double-blind, randomized, controlled clinical study enrolled 117 older adults undergoing surgery. Patients in the ciprofol group (group C) received an intravenous injection of ciprofol (0.3 mg/kg, n=57), while the propofol group (group P) received an intravenous injection of propofol (1.5 mg/kg, n=58). The primary outcome was the incidence of hypotension (mean arterial pressure (MAP) decreased by > 30% from baseline or MAP< 65 mmHg). Secondary outcomes included induction success rate (bispectral index (BIS) value ≤ 60 and Modified Observer’s Assessment of Alertness/Sedation Scale (MOAA/S) score ≤ 1), injection pain, number of drug additions, time to BIS 60, time to eyelash reflex disappearance, blood pressure changes, incidence of hypertension, tachycardia and BIS values before and after administration.Results: The incidence of induced hypotension was 26.3% (15/57) in group C and 48.3% (28/58) in group P (OR=0.383, 95% CI:175– 0.837, P =0.015). Group C had significantly lower injection pain incidence (5.3% vs 20.7%, OR=0.213, 95% CI: 0.057– 0.801, p=0.014). Both groups had a 100% induction success rate, with no significant difference in the number of additional doses. Post-intubation hypertension and tachycardia incidence were not significantly different. Group C showed less blood pressure decrease during induction and a deeper anesthesia level.Conclusion: Compared to propofol, ciprofol reduces the incidence of induced hypotension in older adults and maintains more stable blood pressure during induction. Additionally, ciprofol reduces injection pain and provides a good depth of anesthesia, making it a safe and effective option for anesthesia induction in older adults.Trial Registration ClinicalTrials.gov Identifier: ChiCTR2200066053.Keywords: ciprofol, propofol, bispectral index, BIS, hypotension

Yuchen Tang,1 PingPing Zhang,2 Li Li,1 Jialin Li1 1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 2Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jialin Li, Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Ningbo, Zhejiang Province, 315000, People’s Republic of China, Tel +86 13780008400, Email fyylijialin@nbu.edu.cnPurpose: Diabetic peripheral neuropathy (DPN) is a prevalent chronic complication of diabetes which is linked to chronic hyperglycemia and glycemic variability. This study aimed to investigate the association between the glycemia risk index (GRI) and DPN in patients with type 2 diabetes mellitus (T2DM) using continuous glucose monitoring (CGM) data.Patients and Methods: From 2019 to 2023, 862 adults diagnosed with T2DM were enrolled at a tertiary care diabetes center in Ningbo, China. The medical history and laboratory parameters were recorded. Neurophysiological examinations were performed to evaluate DPN. The CGM data were recorded for 14 days, and the GRI was calculated based on these data. Multivariate logistic regression analyses were conducted to assess the odds ratio (OR) for DPN with an increased GRI.Results: The prevalence of DPN in the ascending GRI quartiles was 41.6%, 47.9%, 49.1%, and 59.5%, respectively (P for trend < 0.001). In the multivariable logistic analysis, the highest GRI quartile exhibited a 63% greater risk of DPN (OR 1.631, 95% CI: 1.071 to 2.484, P = 0.023) than the lowest quartile after adjusted for age, sex, body mass index, diabetes duration, blood pressure, creatinine, urinary albumin-to-creatinine ratio, lipid profile and glycated hemoglobin.Conclusion: High GRI levels, as measured by CGM, were associated with a greater likelihood of DPN in T2DM patients.Keywords: continuous glucose monitoring, glycemia risk index, diabetic peripheral neuropathy, microvascular complications

The value of war heritage is usually reflected in the historical process constituted by the correlation among many heritages rather than a single heritage itself. Traditional heritage protection strategies often focus on ontological protection of heritage, while the inherent relevance between heritage due to their joint participation in historical events is often ignored. Therefore, it is extremely necessary to connect the scattered heritage sites spatially through certain logic, to show the historical process as a whole, and to maximize the integration and protection of the entire resources of the heritage protection mode. Taking the war heritage of Jinzhai as the object, this article analyzes the overall distribution characteristics of the war heritage and the formation process of the war heritage field on the basis of the field theory, and then puts forward the spatial sorting steps based on historical events. The research shows that it is feasible to use key historical events to organize the space of many war heritages to obtain a kind of integrated structure, which can be used as the basic framework for the future use of heritage protection, tourism development, heritage display, and utilization.

In this work, we present necessary and sufficient conditions for the boundedness of the commutators generated by multilinear fractional maximal operators on the products of Morrey spaces when the symbol belongs to Lipschitz spaces.

Abstract Laser wireless energy transmission is a widely utilized method, yet its efficiency is constrained by a variety of factors. In order to improve the conversion efficiency of the receivers of the laser wireless power transmission (LWPT) system, the square elliptic hyperboloid (SEH) concentrating module designed for LWPT system receivers is developed. By analysing the I–V characteristic curves from the results of the experiments and employing non‐linear parameter regression, a corrected battery characteristic curve was derived within a specific laser irradiation range. On this basis, an optical–thermal–electric multi‐field coupling characteristic model was developed. The finite element method is used to simulate the multi‐field coupling characteristics and conversion efficiency of the receiving end under diverse working conditions (including different rotation angles and different divergence angles) of the concentrating photovoltaic module. Research shows: First, the larger the divergence half‐angle β of the laser beam, the more obvious the improvement of the effective optical efficiency of the system by the SEH concentrator. Second, the short‐circuit current and the maximum output power of the PV cell at the receiving end are significantly improved by the SEH concentrator, and the improvement effect is more obvious with the increase of the divergence angle and the rotation angle. Third, SEH concentrators did not significantly affect the fill factor of PV cells.

Hypertensive disorders of pregnancy (HDP) is one of the leading causes of maternal and perinatal mortality worldwide, with increasing incidence and mortality year by year. In 2023, the U.S. Preventive Services Task Force (USPSTF) updated the recommendation statement on screening for hypertensive disorders of pregnancy by evaluating the latest research evidence and analyzing the benefits and harms of screening for HDP. The recommendation, compared with the 2017 version, further affirms the importance of blood pressure measurement in screening for HDP, affirms substantial net benefit, and recommends blood pressure measurement throughout pregnancy to screen for HDP. This article explores and analyzes the key points of this recommendation based on the RIGHT statement for introductions and interpretations of guidelines in Chinese (RIGHT for INT) and its implications for guiding general practitioners in China.

FY-3G precipitation satellite launched in April 2023 is the first dedicated precipitation measurement satellite in China. The dual-frequency precipitation measurement radar (PMR) is the core instrument on the satellite. Because the backscattering performance of the vast ocean area is relatively stable, the calibration accuracy of the on-orbit radar can be tested by studying the backscattering cross-section of the sea surface. FY-3G PMR level 1 data in July 2023 and GPM DPR (global precipitation measurement, dual-frequency precipitation radar) level 2A data are used to analyze the mean value and mean square error of the global sea surface backscattering cross section under no-rain conditions to evaluate the radar performance. At the same time, the theoretical model of ocean surface backscattering is studied to simulate the sea surface backscattering cross-section under the condition of no rain, and the sea surface backscattering cross-section is compared with the actual radar measurement, so as to realize the preliminary evaluation of FY-3G PMR calibration accuracy. Furthermore, the accuracy of FY-3G PMR calibration is evaluated by the ocean calibration test results of GPM DPR data. Test results of ocean calibration accuracy show that when the incidence angle of FY-3G PMR Ku-band is less than 15°, the deviation between the observed value and the model simulation value is small. The deviation of FY-3G PMR ranges from 1.65 to 2.73 dB, while the standard deviation ranges from 0.74 to 1.82 dB. The deviation of FY-3G PMR Ka-band at an 18° incidence is less than 0.27 dB, and the standard deviation of the deviation is 3.49 dB. The calibration deviation of FY-3G PMR and GPM DPR is relatively constant, with the difference is primarily attributed to the backscattering statistical characteristics of the data itself. The stability of the backscattering data of FY-3G PMR Ku- and Ka-band sea surfaces at each incidence angle is comparable to that of GPM DPR. Gas attenuation is not considered at the moment. In the future, the impact of gas attenuation on the Ku- and Ka-band ocean calibration accuracy validation will be further evaluated, and the systematic deviation of FY-3G PMR will be corrected.

Lin Lu,1,* Bing Chen,1,* Xueli Zhao,1 Jie Zhai,1 Pan Zhang,2 Zhen Hua1 1Department of Anesthesiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2Department of Gastroenterology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bing Chen, Department of Anesthesiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dahua Road, DongDan, Beijing, 100730, People’s Republic of China, Tel +8613811295927, Email chenbingbjh@163.comPurpose: We designed this trial to compare the recovery time of remimazolam and propofol in elderly patients undergoing painless gastrointestinal endoscopy.Patients and Methods: In this randomized, non-Inferiority trial, 360 patients aged 65 years or older, scheduled for elective outpatient gastrointestinal endoscopy, were randomly assigned to the remimazolam combined with fentanyl (RF) group or the propofol combined with fentanyl (PF) group. The primary outcome was the post-anesthesia care unit (PACU) stay time, defined as the time from the end of the examination to scoring 9 points using the Modified Post-Anesthetic Discharge Scoring System (MPADSS) criteria. Secondary outcomes included sedation-related adverse events, recall, injection pain, as well as postoperative Quality of Recovery-15 (QoR-15) scores and Pittsburgh Sleep Quality Index (PSQI) scores at 1 day, 1 week, and 1 month postoperatively.Results: A total of 351 patients completed the study, with 174 receiving remimazolam and 177 receiving propofol. The PACU stay time in RF group was non-inferior to that in PF group [14 (11, 18) vs 13 (10, 17), mean difference 1 (95% confidence interval 0, 2), P=0.084 for noninferiority]. However, remimazolam was associated with lower rate of hypoxemia [4.7% (8/180) vs 12.4% (22/180), P=0.011], reduced use of vasoactive drugs [1 (0, 1) vs 1 (1, 2), P< 0.001], less injection pain [2 (1.2%) vs 35 (21.3%), P< 0.001], and lower recall [20 (11.8%) vs 36 (20.3%), P=0.034]. There were no differences in the QoR-15 scores and PSQI scores at postoperative 1 day, 1 week, and 1 month between groups.Conclusion: This non-inferiority study revealed that in elderly outpatients undergoing gastrointestinal endoscopy, remimazolam achieved recovery times comparable to propofol, with fewer associated complications.Keywords: remimazolam, postoperative recovery, older patients, gastrointestinal endoscopy

In response to the issue of infrared ground target tracking failure caused by background occlusion, a novel anti-occlusion tracker for infrared ground targets is proposed based on an enhanced trajectory prediction network. Initially, an occlusion assessment criterion is proposed to accurately assess the occlusion status of infrared ground targets. Subsequently, enhancements are made to the BiTrap trajectory prediction network. On one hand, velocity information is introduced through a Siamese network structure, adopting a unidirectional prediction method, building the SiamTrap trajectory prediction network that improves trajectory prediction accuracy. On the other hand, refining both the training and application methods enables more precise predictions of ground target trajectories. For short-term occlusion, the SiamTrap network uses temporal context information to predict the occluded position of the target. For long-term occlusion, a search expansion strategy is introduced to address prediction errors accumulated due to a lack of real target information. Finally, a "second verification" criterion is introduced, realizing accurate target capture and normal tracking. Comparative tests are conducted on infrared target tracking sequences with occlusion. Compared to baseline trackers, the proposed algorithm shows a 5.2% improvement in success rate and a 5.9% improvement in accuracy under the OPE evaluation metric. This indicates the robustness of the proposed algorithm in handling occlusion scenarios for infrared ground targets.

The concentrated load endured by the locking system during the weapon mounting and release procedures may lead to mechanical wear in hinges and kinematic pairs, thereby influencing the functional reliability of the weapon rack mechanism system. This study aims to investigate the impact of kinematic pair wear evolution on the reliability of the locking system. Firstly, a rigid-flexible coupling multi-body dynamics model of the locking system was established to simulate the dynamic behaviors of the rack under different loading conditions. Moreover, the wear amounts of the main kinematic pairs were precisely calculated by the Archard wear model to provide data support for the subsequent reliability analysis. Subsequently, the response surface method was employed to design the orthogonal experiments for the reliability analysis of the locking system, and the reliability degradation law of the locking system within the design lifespan was obtained through the Monte Carlo method simulation. The research findings indicate that the wear of kinematic pairs has a significant effect on the motion function and accuracy of the mechanism. The motion reliability of the mechanism can be maintained above 99% within the design lifespan. Nevertheless, when the usage time exceeds twice the design lifespan, the reliability drops significantly to approximately 85%, and the influence degrees of different wear positions on the reliability were obtained through the sensitivity analysis. The research results not only provide a scientific basis for the optimal design of the locking system but also offer a novel perspective and method for the reliability assessment and maintenance strategy of the weapon rack locking system.

Cigarette draw resistance and filter pressure drop are both critical physical indicators for the tobacco industry, which use testing equipment to measure the two parameters. Pressure drop standards are used as transfer standards to ensure the accuracy and reliability of the testing equipment. Pressure drop standards are generally cylindrical rods having a certain number of parallel capillaries. To address the issue of how to design and fabricate pressure drop standards quickly and conveniently, this paper proposes a design method for pressure drop standards based on structural parameters. The method uses a mathematical model of the internal airflow of the standard including the entrance effect into a circular capillary and uses an iterative calculation algorithm accordingly. By iterative calculation, the structural parameters of the pressure drop standard, namely, diameter and length of the capillaries, were obtained, along with the relationship between the draw resistance of the standard and the flow rate in each capillary. The accuracy of the mathematical model was validated by comparing and analyzing the experimental and theoretical draw resistance of standards with different structural parameters. The experimental results showed that the relative error between the measured draw resistance and the calculated draw resistance was below 8%, which proves the reliability and validity of the mathematical model, and provides theoretical support for the design and fabrication of pressure drop standards.

Achieving the best wideband stealth performance under the limited weight constraint is the goal pursued in stealth aircraft radar absorbing coating（RAC） application schemes design. To meet the need for the integrated application of various kinds of RACs on stealth aircraft， an automatic optimization method for the application programme of RAC was established. Firstly， the electromagnetic fields of the model under different frequencies， azimuths and polarizations were simulated based on the finite difference time domain method. The total electromagnetic field was obtained by normalization and weighted calculation of the electromagnetic fields.Then， the total electromagnetic field was divided according to the specific direction and quantity. Each partition was loaded with the corresponding RAC. The reflection coefficient of the RAC was calculated by the transfer matrix method to superimpose the effect of the RAC on the electromagnetic field. The near-far field transformation was performed on the total electromagnetic field after loading with RAC. In this way， fast computation of radar cross section （RCS） was implemented. Based on the improved simplex method and Karush-Kuhn-Tucker condition， an automatic optimization method is established. The objective function was reducing RCS of the target or reducing weight of the absorbing coating. Finally， taking traveling wave plate as an example， the application plan of three thicknesses of RACs was optimized. The goal of optimization was to reduce total weight of the coating. Compared with the 1.5 mm coating plan， the optimization program can reduce the weight by 50%， with the RCS of traveling wave plate increasing by on more than 1 dB. The optimization effect is remarkable.

The accuracy of blood glucose measurement in clinical laboratories is vital for diabetes diagnosis. Trueness Verification Plan was carried out and analyzed for evaluating the standardization of serum glucose among clinical laboratories.

This study investigates the fracture evolution patterns of overlying strata under the mining conditions of close-distance coal seams.Taking the 9305 working face of Anshun Coal Mine as the research object, this study probed into the evolution of displacement field and strain field during the mining process of close-distance coal seams through physical similarity simulation test.The results show that ①with the continuous advancement of distance from the working face, the overburden strata first form separation cracks and longitudinal cracks, and then the middle part of the goaf is gradually compacted.②The displacement field is asymmetrically distributed in the advancing direction of the working face, The displacement of the overlying rock on the side of the working face is obviously smaller than that on the left side of the goaf, and the peak displacement is mainly concentrated in the middle of the goaf.③The maximum principal strain concentration position is asymmetrically transferred from the middle of the goaf to the open-off cut side and the working face side.The concentration degree of the open-off cut side is significantly higher than that of the working face side.This reveals that a potential correlation exists between the maximum principal strain concentration position and the gas enrichment area.

Acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) represents a primary cause of treatment failure in non-small cell lung cancer (NSCLC) patients. Chemokine (C-C motif) ligand 2 (CCL2) is recently found to play a pivotal role in determining anti-cancer treatment response. However, the role and mechanism of CCL2 in the development of EGFR-TKIs resistance have not been fully elucidated. In the present study, we focus on the function of CCL2 in the development of acquired resistance to EGFR-TKIs in NSCLC cells. Our results show that CCL2 is aberrantly upregulated in EGFR-TKIs-resistant NSCLC cells and that CCL2 overexpression significantly diminishes sensitivity to EGFR-TKIs. Conversely, CCL2 suppression by CCL2 synthesis inhibitor, bindarit, or CCL2 knockdown can reverse this resistance. CCL2 upregulation can also lead to enhanced migration and increased expressions of epithelial-mesenchymal transition (EMT) markers in EGFR-TKI-resistant NSCLC cells, which could also be rescued by CCL2 knockdown or inhibition. Furthermore, our findings suggest that CCL2-dependent EGFR-TKIs resistance involves the AKT-EMT signaling pathway; inhibition of this pathway effectively attenuates CCL2-induced cell migration and EMT marker expression. In summary, CCL2 promotes the development of acquired EGFR-TKIs resistance and EMT while activating AKT signaling in NSCLC. These insights suggest a promising avenue for the development of CCL2-targeted therapies that prevent EGFR-TKIs resistance in NSCLC.

The Carboniferous and Permian are important coal-bearing strata in North China， which develop various oil and gas resources such as coalbed methane， coal-bearing shale gas， tight coal-bearing sandstone gas， and coal-formed oil. Massive research and exploration results have shown that coal-bearing strata have good exploration prospects. Compared with those of the Ordos Basin， the exploration and research levels of the Carboniferous and Permian coal-bearing strata in Jiyang-Linqing area are relatively lower. The reservoir formation conditions of coal-bearing strata in Jiyang-Linqing area and Ordos Basin were comparatively analyzed， and the exploration directions for coal-bearing strata in Jiyang-Linqing area were proposed based on systematically summarizing the research progress of oil and gas resource types and enrichment conditions in coal-bearing strata in North China. The research results show that the coal-bearing strata in North China are mainly composed of Taiyuan Formation and Shanxi Formation， formed in the sedimentary environment of the epeiric sea delta. They have strong cyclicity and are developed into symbiotic coalbed methane reservoirs， coal-bearing shale gas reservoirs， and tight coal-bearing sandstone gas reservoirs. Coal， carbonaceous mudstones， and dark mudstones with high organic carbon content are the material basis for the formation of coal-bearing oil and gas resources， and coal-bearing source rock development areas with rich hydrogen have certain exploration potential for coal-formed oil. Preservation conditions are key factors for the enrichment of coalbed methane and coal-bearing shale gas. The high porosity and permeability zones caused by sedimentation and diagenesis are the sweet spot areas for tight coal-bearing sandstone gas. There are good exploration prospects for coal-bearing gas and coal-formed oil in Jiyang-Linqing area. Conducting a systematic evaluation by exploring a set of lithological combinations is an essential technical approach to improving the exploration efficiency of coal-bearing strata. The favorable exploration targets are Taiyuan Formation on the south slope of Dongying Sag and Huimin Sag， the western part of Chezhen Sag， and the Gubei buried hills.

Objective To investigate the role and mechanism of lysine acetyltransferase 8(KAT8) on the proliferation of colorectal cancer cells. Methods The expression of KAT8 in cancerous tissues and adjacent tissues of colorectal cancer patients was analyzed by RNA-seq data of TCGA database. Cell proliferation was detected by colony-forming unit assays and CCK8. The GEO database was used to analyze the differential genes of KAT8 knockdown cells and control cells and perform functional pathway enrichment analysis. In the colorectal cancer database hosted on cBioPortal, that conducted an analysis examining the correlation between KAT8 and genes in the regulation of N6-methyladenosine(m6A) modification. Western blot technique was employed to assess the protein expression levels of KAT8 and METTL3. Results Compared to human normal colorectal tissue, KAT8 was highly expressed in colorectal cancer(P＜0.05). Knockdown or selective inactivation of KAT8 inhibited colorectal cancer cells proliferation (P＜0.05). In colorectal cancer cell lines, knocking down KAT8 reduced m6A modification levels (P＜0.05). Knocking down KAT8 inhibited METTL3 expression (P＜0.05). Over-expression of METTL3 reversed cell proliferation which was inhibited by knockdown KAT8(P＜0.05). Conclusions KAT8 facilitates the proliferation of colorectal cancer cell lines through regulation of METTL3-mediated m6A modifications.

Peigang Zhang,1,2,&ast; Lingling Zheng,1,3,4,&ast; Xiaorui Zhang,1,3 Miao Liu,1,3 Mingli Li,2 Mengting Zhang,1 Jian-Lin Wu,4 Martin MF Choi,5 Wei Bian1– 3 1Department of Medical Chemistry, School of Basic Medical Science, Shanxi Medical University, Taiyuan, Shanxi, 030000, People’s Republic of China; 2Department of Cardiothoracic Surgery, People’s Hospital of Lvliang, Lvliang, Shanxi, 033099, People’s Republic of China; 3Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, Shanxi, 030000, People’s Republic of China; 4State Key Laboratory for Quality Research of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, People’s Republic of China; 5Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei Bian, Department of Medical Chemistry, School of Basic Medical Science, Shanxi Medical University, Taiyuan, Shanxi, 030000, People’s Republic of China, Email weibian@sxmu.edu.cnIntroduction: Lung cancer is the most common cancer worldwide, among which non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancers. Chemotherapy, a mainstay modality for NSCLC, has demonstrated restricted effectiveness due to the emergence of chemo-resistance and systemic side effects. Studies have indicated that combining chemotherapy with phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT), can enhance efficacy of therapy. In this work, an aminated mesoporous graphene oxide (rPGO)-protoporphyrin IX (PPIX)-hyaluronic acid (HA)@Osimertinib (AZD) nanodrug delivery system (rPPH@AZD) was successfully developed for combined chemotherapy/phototherapy for NSCLC.Methods: A pH/hyaluronidase-responsive nanodrug delivery system (rPPH@AZD) was prepared using mesoporous graphene oxide. Its morphology, elemental composition, surface functional groups, optical properties, in vitro drug release ability, photothermal properties, reactive oxygen species production, cellular uptake and cell viability were evaluated. In addition, the in vivo therapeutic effect, biocompatibility, and imaging capabilities of rPPH@AZD were verified by a tumor-bearing mouse model.Results: Aminated mesoporous graphene oxide (rPGO) plays a role as a drug delivery vehicle owing to its large specific surface area and ease of surface functionalization. rPGO exhibits excellent photothermal conversion properties under laser irradiation, while PPIX acts as a photosensitizer to generate singlet oxygen. AZD acts as a small molecule targeted drug in chemotherapy. In essence, rPPH@AZD shows excellent photothermal and fluorescence imaging effects in tumor-bearing mice. More importantly, in vitro and in vivo results indicate that rPPH@AZD can achieve hyaluronidase/pH dual response as well as combined chemotherapy/PTT/PDT anti-NSCLC treatment.Conclusion: The newly prepared rPPH@AZD can serve as a promising pH/hyaluronidase-responsive nanodrug delivery system that integrates photothermal/fluorescence imaging and chemo/photo combined therapy for efficient therapy against NSCLC. Keywords: NSCLC, mesoporous graphene oxide, combination therapy, hyaluronidase/pH dual-response, nanodrug delivery system

Li Zhang,1,&ast; Mupeng Li,1,&ast; Lianlian Fan,1 Fangfang Liu,1 Peiwen Zhang,1 Qian Huang,1 Gang Mai,1 Jianzhong Shentu1,2 1Phase 1 Clinical Trial Center, Deyang People′s Hospital, Deyang, Sichuan, People’s Republic of China; 2Research Center for Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jianzhong Shentu, Email stjz@zju.edu.cn Gang Mai, Email stdygcp@163.comPurpose: Estradiol valerate (Progynova®) is used as hormone therapy to supplement estrogen deficiency. This study aimed to assess the bioequivalence of an estradiol valerate tablet and its generic form, under fasting and fed conditions.Methods: A randomized, open-label, single-dose, 2-period crossover study was conducted on healthy postmenopausal Chinese female volunteers under fasting and fed conditions. For each period, the subjects received either a 1 mg tablet of estradiol valerate or its generic. Blood samples were collected before dosing and up to 72 hours after administration. Plasma levels of total estrone, estradiol, and unconjugated estrone were quantified using a validated liquid chromatography-tandem mass spectrometry method.Results: A total of 54 volunteers were enrolled in this study. The primary pharmacokinetic parameters, including Cmax, AUC0-t, and AUC0-∞, were similar for the two drugs under both fasting and fed conditions, with 90% confidence intervals for the geometric mean ratios of these parameters, all meeting the bioequivalence criterion of 80– 125%. A total of 48 adverse events (AEs) were reported in the fed study compared with 24 AEs in the fasting study.Conclusion: Estradiol valerate and its generic form were bioequivalent and well tolerated under both fasting and fed conditions.Keywords: bioequivalence, estradiol valerate, postmenopausal, pharmacokinetics, safety

The superhydrophobic coating can effectively prevent the intrusion, adhesion and condensation of water-containing corrosive media on the surface. However, the poor mechanical and chemical stability of traditional superhydrophobic coatings significantly limits their application in complex and harsh environments. In this study, a superhydrophobic PDMS-EP@SiO2-GO coating was formed on the surface of Q345 steel sheets by using a composite substrate of graphene oxide(GO) and nano silicon dioxide(SiO2) with polydimethylsiloxane(PDMS) and epoxy resin(EP), combined with spraying technology. The superhydrophobic, self-cleaning, anti-fouling, mechanical wear resistance, chemical corrosion resistance and anti-corrosion properties of the coating were studied. Results showed that the water contact angle of PDMS-EP@SiO2-GO was 166.57°, and the sliding angle was less than 3°. Due to the strengthening effect of GO on the coating substrate, the coating maintained a contact angle of more than 155° for liquids with water temperatures ranging from 20 ℃ to 100 ℃ and a contact angle of more than 160° for acidic/alkaline solutions. The sliding angle was less than 4° under the above conditions. After sandpaper friction(total friction length of 40 m) and 30 cycles of tape-peeling tests, the coating still exhibited good superhydrophobic ability, with the contact angle remaining above 152°. In addition, PDMS-EP@SiO2-GO, with excellent water resistance, demonstrated good anti-fouling and self-cleaning properties. In terms of corrosion protection, the lowest frequency impedance of PDMS-EP@SiO2-GO increased by an order of magnitude, and the charge transfer resistance increased by two orders of magnitude, showing excellent corrosion resistance. PDMS-EP@SiO2-GO addressed the problem of weak mechanical and chemical stability in traditional superhydrophobic coatings and enabled the persistent protection of the metal substrate. The as-prepared superhydrophobic coating, with good practicability, contributes to the safe and reliable service of mechanical equipment throughout its life cycle.

【Objective】The objective of this study is to investigate the resource allocation problem in Optical Wireless Communication (OWC) systems using Rate Splitting Multiple Access (RSMA) technique. We propose a joint precoding matrix and rate allocation algorithm based on linear approximation to enhance the system reliability and performance.【Methods】We employ variable transformation and linear approximation techniques to convert the non-convex fractional functions into convex ones. By using the joint precoding matrix and rate allocation algorithm, system resources can be effectively allocated to improve system performance. The optimization problem is solved using a continuous iterative algorithm to obtain the optimal solution.【Results】Simulation results demonstrate that the proposed joint optimization scheme significantly reduces the system outage probability and exhibits a fast convergence rate. This indicates that the proposed method can provide more reliable and efficient communication performance in the RSMA-OWC system, which is based on rate splitting access.【Conclusion】This study provides an effective resource allocation method for RSMA technology in OWC systems, enhancing system reliability and performance. Further research should focus on the challenge of system outage probability in RSMA-OWC systems, as well as resource allocation, precoding design, and application scalability. This study offers valuable insights to promote the application and development of RSMA technology in the field of OWC.

Typhoons are among the most significant natural disasters affecting the eastern and southern coastal regions of China, inflicting substantial annual damage on both coastal and inland areas. Since the initiation of the reform and opening-up policy, the socioeconomic development of the coastal regions of China has been swift, leading to increased exposure to typhoons. In the context of global climate change, typhoons are expected to increase in frequency and intensity in China. Therefore, researching on the spatiotemporal pattern characteristics of typhoons impacting China is of critical importance for understanding the impact patterns and risk changes of typhoon disasters, as well as for formulating policies on disaster response, prevention, and mitigation. This study aims to provide valuable insights into the formulation of such policies. Based on these objectives, this study utilized a comprehensive dataset, including county-level socioeconomic and disaster statistics, historical typhoon wind and rainfall data, and high-precision topographic data. Using county-level administrative regions as spatial units, this study employed various methods, such as time-series statistical analysis, gravity model, geographical detector, spatial correlation analysis, and geographically weighted regression, to analyze the spatiotemporal distribution patterns and influencing factors of typhoon disaster conditions in China from 1978 to 2020. The findings of this study are as follows: (1) The number of deaths and missing persons, quantity of damaged housing, death, and missing rate per million people, and proportion of direct economic loss to GDP caused by typhoon disasters have all shown a declining trend, indicating significant achievements in disaster prevention and mitigation efforts. (2) The center of gravity of typhoon disaster-related losses has shifted southward, corresponding with the economic development of coastal regions, demonstrating a reduced disaster impact in coastal areas and an increased impact in inland areas. (3) Wind and rain induced by typhoons are the primary driving factors of disaster conditions, and topographical factors are also drivers of casualties and crop loss. (4) The two major regions, Zhejiang-Northern Fujian and Western Guangdong-Eastern Guangxi, exhibit significant characteristics of disaster condition agglomeration, closely related to typhoon activity patterns and levels of economic development. (5) There is a negative correlation between the gross local product and disaster conditions in some areas, reflecting the role of socioeconomic development in enhancing the capacity for disaster prevention and mitigation.

Objective To analyze the reasons of high-risk medication extravasation in the ICU and investigate prevention measures. Methods A total of 213 critically ill patients admitted to the hospital's intensive care unit from October 2022 to November 2023 were selected. The risk factors for high-risk medication extravasation in hospitalized patients were analyzed. The reasons for high-risk medication extravasation were studied, and measures to prevent high-risk medication extravasation and clinical management of high-risk medication extravasation were summarized. Results Among the 213 patients, 19 patients experienced high-risk medication extravasation, with an incidence rate of 8. 92%. Among the 19 patients, 9 cases were attributed to nurse-related factors, accounting for 47. 37% of the cases; 5 cases were due to patient-related factors, accounting for 26. 32%; 3 cases resulted from inappropriate vascular access selection, representing 15. 79% of the cases; and 2 cases were attributed to environmental factors, accounting for 10. 53%. Conclusion When administering intravenous fluids to patients in the intensive care unit, it is essential to be familiar with the types of high-risk extravasation-prone medications. Nurses should conduct a comprehensive assessment of patients' vasculature. Prevention is the primary approach, and targeted preventive measures can effectively prevent high-risk medication extravasation. (目的 分析重症监护室(ICU)患者常见高危药物外渗发生原因, 探讨应对措施。方法 回顾性分析医院ICU 2022 年 10 月— 2023 年 11 月收治的 213 例重症患者的临床资料, 探讨住院期间发生高危药物外渗的风险问题, 分析药物外渗的原因, 总结临床药物外渗预防和应对措施。结果 213 例患者中发生高危药物外渗19 例, 发生率为8. 92%。分析原因: 9(47. 37%)例由护士因素导致, 5(26. 32%)例由患者因素导致, 3(15. 79%)例由药物因素导致, 2(10. 53%)例由环境因素导致。结论 针对ICU患者输液治疗时, 护士需要熟知高危外渗药物种类, 对患者的血管状况进行全面评估, 以预防为主, 通过实施针对性的防范措施降低药物外渗的发生风险。)

Jiyang Depression， as one of the mature exploration areas in Bohai Bay Basin， has been explored and developed for over 60 years. It is urgent to solve the theoretical understanding problems such as oil and gas resource potential， exploration direction， and accumulation law to realize the sustainable development of oil and gas exploration. The evolution process of hydrocarbon generation and hydrocarbon generation potential of different types of source rocks were compared based on the analysis and testing of the sedimentary environment and organic geochemical characteristics of a large number of source rock samples in the primary hydrocarbon-generating strata and the hydrocarbon generation simulation experiment. It is found that the source rocks in the saline environment have the characteristics of high ancient productivity and low activation energy， and a “saline and hydrocarbon-rich” of hydrocarbon generation and expulsion mode was established in the continental lake basin. It breaks through the traditional understanding that source rock in freshwater environments is the primary source of oil and gas. It is pointed out that “strong cementation in early stage and strong dissolution in late stage” are the essential reasons for the formation of a large number of secondary dissolution pores in the deep reservoirs by analyzing the relationship between porosity and acid-base properties of formation fluid during diagenetic evolution of deep reservoirs. The genetic problem of effective reservoirs of deep clastic rocks under a high geothermal background is solved. The paper summarizes and puts forward the orderly distribution of lithology， structure-lithology， lithology-structure， and tectonic reservoirs from subsag to slope zones based on the exploration practice in Jiyang Depression. Therefore， the theoretical understanding of refined oil and gas exploration in mature exploration areas of “saline and hydrocarbon-rich， acid-base control， and orderly accumulation” has been innovated， and the potential of remaining resources has been defined. The direction of deep exploration has been pointed out， so oil and gas exploration has changed from passive transfer to active exploration. The division and optimization method of the “exploration layer unit” suitable for the refined exploration stage is innovatively established， and a “seven-step” refined exploration and evaluation process is formed for mature exploration areas. The paper points out the critical exploration directions and fields with increasing reserves in the future， which provide essential guarantees for the long-term benefit and sustainable development of the oilfield based on the new geological understanding of Jiyang Depression and the results of the latest round of oil and gas resource evaluation.

Yuru He,1,2 Xing Wang,1,2 Zuowei Wang,3,4 Ping Zhang,5 Xiaojia Huang,3,4 Meihong Yu,5 Jill K Murphy,6 Erin E Michalak,6 Jing Liu,6 Tao Yang,1,2 Xiaorui Yang,7 Yiru Fang,1,8,9 Raymond W Lam,6 Jun Chen1,2 1Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People’s Republic of China; 3Division of Mood Disorders, Shanghai Hongkou Mental Health Center, Shanghai, People’s Republic of China; 4Clinical Research Center for Mental Health, School of Medicine, Shanghai University, Shanghai, People’s Republic of China; 5Fengxian District Mental Health Center, Shanghai, People’s Republic of China; 6Department of Psychiatry, University of British Columbia, Vancouver, Canada; 7Department of Psychology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 8Department of Psychiatry & Affective Disorders Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 9CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, People’s Republic of ChinaCorrespondence: Jun Chen, Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People’s Republic of China, Tel +86 21-34773367, Email doctorcj2010@gmail.com Raymond W Lam, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1, Canada, Tel +1 604-822-7325, Email r.lam@ubc.caPurpose: To validate the efficacy of enhanced measurement-based care against standard measurement-based care in patients with major depressive disorder.Patients and Methods: In this pilot study of an ongoing multicenter cluster randomized controlled trails, 160 patients diagnosed with major depressive disorder were enrolled from 2 mental health centers, with a plan to include 12 centers in total. One hundred patients engaged in a six-month evaluation using a technology-enhanced measurement-based care tool, including assessments of clinical symptoms, side effects, and functionality at baseline, two months, four months and six months. Simultaneously, the remaining 60 patients underwent standard paper-based measurement-based care, utilizing the same set of scales over the same six-month period, with assessments at the same time points.Results: Patients utilizing the enhanced measurement-based care tool demonstrated a significantly higher reduction rate in PHQ-9 scores compared to those using standard paper-based measurement-based care during the two-month follow-up. Additionally, a notable positive correlation was observed between the frequency of enhanced measurement-based care tool usage and the quality of life during the two-month follow-up.Conclusion: Enhanced measurement-based care has the effect of reducing depressive symptoms. Our study emphasized that using enhanced measurement-based care via smartphones is a feasible tool for patients with major depressive disorder. Our future study, including results from additional research centers, may further validate the effectiveness of enhanced measurement-based care.Keywords: major depressive disorder, measurement-based care, enhanced measurement-based care, smartphone-based intervention

Abstract To study the seepage law and sectional morphological characteristics in splitting sandstones of different grain sizes, three‐dimensional morphological scanning tests and seepage characteristics tests are conducted on the splitting rock samples of siltstone, fine‐, medium‐ and coarse‐grained sandstone, and the differences in morphological characteristics and seepage law in different grain size sandstones are compared and analyzed. The test results show that the sections of siltstone and fine‐grained sandstone have the overall morphological characteristics of “one high and one low” with large undulation, while the sections of medium‐ and coarse‐grained sandstone have a more uniform distribution and less undulation. In the relationship between pressure gradient and flow velocity, siltstone and fine‐grained sandstone are precisely characterized by the Forchheimer formula, and medium‐ and coarse‐grained sandstone are well characterized by the Izbash formula, and the fitting effect is good. The results of the study are of great reference significance for improving the cross‐sectional morphological characteristics and seepage law of the splitting rock samples.

Min Yang,1– 3,&ast; Wenfei Wang,3,&ast; Peize Zhang,4 Guizhen Liu,5 Hailin Lu,6 Mingjie He,5 Guofang Deng,2,3 Xiaoyou Chen1,7 1Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Second Department of Pulmonary Medicine and Tuberculosis, the Third People’s Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, Guangdong, People’s Republic of China; 3National Clinical Research Center for Infectious Disease, the Third People’s Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, Guangdong, People’s Republic of China; 4Fourth Department of Pulmonary Medicine and Tuberculosis, the Third People’s Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, Guangdong, People’s Republic of China; 5The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China; 6Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China; 7Infectious Diseases Department, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaoyou Chen; Guofang Deng, Email chenxy1998@hotmail.com; jxxk1035@yeah.netObjective: We aimed to investigate dysregulated metabolic pathways and identify diagnostic and therapeutic targets in patients with tuberculosis-diabetes (TB-DM).Methods: In our prospective cohort study, plasma samples were collected from healthy individuals, diabetic (DM) patients, untreated TB-only (TB-0)/TB-DM patients (TB-DM-0), and cured TB (TB-6)/TB-DM patients (TB-DM-6) to measure the levels of amino acids, fatty acids, and other metabolites in plasma using high-throughput targeted quantification methods.Results: Significantly different biological processes and biomarkers were identified in DM, TB-DM-0, and TB-DM-6 patients. Moreover, quinolinic acid (QA) showed excellent predictive accuracy for distinguishing between DM patients and TB-DM-0 patients, with an AUC of 1 (95% CI 1– 1). When differentiating between TB-DM-0 patients and TB-DM-6 patients, the AUC was 0.9297 (95% CI 0.8460– 1). Compared to those in DM patients, the QA levels were significantly elevated in TB-DM-0 patients and decreased significantly after antituberculosis treatment. We simultaneously compared healthy controls and untreated tuberculosis patients and detected an increase in the level of QA in the plasma of tuberculosis patients, which decreased following treatment.Conclusion: These findings improve the current understanding of tuberculosis treatment in patients with diabetes. QA may serve as an ideal diagnostic biomarker for TB-DM patients and contribute to the development of more effective treatments.Keywords: pulmonary tuberculosis, diabetes, metabolomics, quinolinic acid, biomarker

Objective AAC (luminum alloy conductive) rails are widely used in rail transit power supply systems. However, a significant deviation often exists between the calculated and tested values of the permissible current carrying capacity of AAC rails, which poses inconvenience to engineering design. Therefore, it is necessary to study the relationship between the permissible current carrying capacity and the calculated current carrying capacity of AAC rails. Method Based on the Chapoulie-Rols formula and the thermal balance equation, and the permissible current carrying capacities are calculated for six common AAC rails with different shapes and cross-sections respectively. Subsequently, experiments are conducted to test the permissible current carrying capacities of these six AAC rails. A comparative analysis of the difference is performed between theoretical calculated and experimental test values of the conductive rail current carrying capacity. Result & Conclusion Correction coefficients are introduced into the Chapoulie-Rols formula, which allows for the calculated current carrying capacity closer to the actual permissible current carrying capacity of AAC rails. The rail temperature of AAC rails basically stabilizes after 3 hours of current loading test.

Objective There is limited research on the impact of mechanical method connecting passage construction on mainline tunnels and surrounding soil of metro shield interval in water-rich sandy stratum. Method Taking a metro shield tunnel interval project with mechanical method connecting passage construction in water-rich sandy stratum as example, a numerical model is established using ABAQUS finite element software to simulate and analyze the entire process of this engineering. The effects of mechanical method connecting passage construction on mainline tunnels and surrounding soil are investigated. The calculation results are compared with actual engineering monitoring data to verify the reliability of the proposed numerical model. Result & Conclusion Land subsidence along the longitudinal direction of the mainline tunnel and connecting passage caused by mechanical method connecting passage construction exhibits a U-shaped curve, with a maximum land subsidence value of 4.60 mm. The effects of the construction on mainline tunnel deformation are mainly vertical deformation and horizontal deformation along the mainline tunnel. The maximum vertical deformation of the mainline tunnel is 1.08 mm, and the maximum horizontal deformation is 1.28 mm. During construction, the maximum stress in the mainline tunnel suddenly increases with the breakthrough of the connecting passage portal, reaching 52.54 MPa upon completion of the construction. Actual monitoring data show that the fitted land subsidence monitoring data aligns with the trend of numerical calculation results, validating the reliability of the numerical calculations.

Weijian Liu,&ast; Liangzi Yang,&ast; Hongjuan Qin, Peize Zhang Department of Pulmonary Medicine and Tuberculosis, The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Peize Zhang, Email 82880246@qq.comAbstract: Tuberculosis(TB) is a serious infection that affects transplant recipients, particularly in high TB burden countries. Clinical presentation of these patients is atypical, and the care and management are frequently tricky as multi-drug interaction and intolerable adverse effects. Contezolid, a novel oxazolidinone antibacterial agent, had been demonstrated to be effective for TB in vitro and had been shown in some clinical cases with a more favorable safety profile than linezolid, the first-generation oxazolidinone, which had a commonly seen myelosuppression and neuropathy. Additionally, Contezolid has a unique metabolic mechanism that leads to less drug interaction. Here, we report a case of multi-system TB in a transplant recipient with chronic kidney allograft dysfunction. She was intolerant to most first and second-line anti-TB drugs and repeatedly developed ascites and nocturnal low-grade fever. She finally achieved good efficacy and safety results after enhanced anti-TB treatment with the addition of contezolid. Given the increased risk of TB in patients with organ transplantation and multi-drug interaction in patients with severe comorbidities, further clinical studies are needed to investigate the application and appropriate dosage of contezolid in patients with active TB.Keywords: tuberculosis, contezolid, kidney dysfunction, kidney transplantation, tuberculous peritonitis

Peipei Wu,1 Panpan Zhang,1 Jing Xu,1 Wenhui Ma,1 Longfei Li,2 Haifeng Xu1 1Department of Uveitis, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People’s Republic of China; 2College of Energy and Mining Engineering, Shandong University of Science and Technology, Qingdao, People’s Republic of ChinaCorrespondence: Haifeng Xu, Qingdao Eye Hospital, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Science, 5 Yanerdao Road, Qingdao, 266071, People’s Republic of China, Tel +86 13906391451, Fax +86 0532 85891110, Email chxhf@126.comBackground: To compare the efficacy of intravitreal injections of Conbercept combined with dexamethasone (DEX) for macular edema (ME) following central retinal vein occlusion (CRVO).Methods: This was a prospective, single-masked, randomised, controlled clinical trial. Patients with ME following CRVO were randomised into groups to receive intravitreal injections of 0.5 mg Conbercept plus 0.2 mg DEX or 0.5 mg Conbercept alone on day 0 followed by repeat injections as indicated. The primary outcome measure was the change in best-corrected visual acuity (BCVA) from baseline to month 12. Secondary outcome measures included decrease in central retinal thickness (CRT), injection frequency and interval and percentage of patients who gained more than 15 ETDRS letters or achieved a CRT of < 250 μm at month 12.Results: 33 males (51%) and 32 females (49%) were initially recruited with an average age of 56.64 ± 13.88 years. Patients in the Conbercept and Conbercept + DEX groups gained an average of 14.55 ± 19.19 and 14.88 ± 17.68 ETDRS letters, respectively, at months 12 (t = 4.221, P = 0.000; and t = 4.834, P = 0.000) with no significant difference between the two groups (t = 0.071, P = 0.943). In the Conbercept group, the mean reduction in CRT from baseline to month 12 was 435.26 ± 293.37 μm (t = 8.261, P = 0.000) compared to 431.36 ± 294.55 (t = 8.413, P = 0.000) in the Conbercept + DEX group. There was no significant difference between the two groups (t = 0.053, P = 0.958). The Conbercept + DEX group received fewer intravitreal injections. No major complications occurred.Conclusion: Conbercept, alone or with DEX, can improve BCVA and reduce CRT in ME following CRVO without serious adverse events. The treatment interval was longer in the Conbercept + DEX group.Trial Registration: The study was registered with the Chinese Clinical Trial Registry at 5 July 2017. (http://www.chictr.org.cn, 05/07/2017 Registration Number: ChiCTR-INR-17011877).Keywords: conbercept, dexamethasone, macular edema, retinal vein occlusion

To address the issue of wear failure in Inconel 718 nickel-based alloy under wide temperature conditions, two different contents of Al2O3+TiO2 particles(10%, 20%, mass fraction) were selected as ceramic reinforcement phases. Two types of Inconel 718-MoS2-Al2O3-TiO2 high-temperature wear-resistant lubricating composite coatings were prepared using laser cladding technology. The microstructure, mechanical properties and tribological behavior of the composite coatings were systematically investigated to provide data support for their application in the field of tribology. Results showed that the composite coatings were primarily composed of γ-Ni solid solution, γ'-Ni3(Ti, Al) intermetallic compounds, Ti3O5 and Al2O3 ceramic reinforcement phases, as well as MoS2 lubricating phase. When the content of TiO2 and Al2O3 reached 20%, higher levels of Ti3O5 and Al2O3 contributed to increased hardness and elastic modulus of the coatings, with a maximum microhardness of up to 455 HV0.3. However, this led to coarser grains of Ti3O5 and Al2O3 phases, which were unfavorable for enhancing the elastic modulus and resistance to plastic deformation. At friction temperatures ranging from room temperature to 200 ℃, the friction coefficient and wear rate of the composite coatings with 10% TiO2 and Al2O3 content significantly increased, reaching maximum values. Wear mechanisms were mainly attributed to abrasive wear and delamination. As the temperature increased to 400 ℃, the formation of a continuous oxide film on the coating abrasion surface led to a significant reduction in wear rate. When the temperature reached 600～800 ℃, both types of composite coatings formed continuous smooth oxide films on the friction surfaces, exhibiting lubricating effects and significantly improving tribological performance, especially with a reduction in wear rate by one order of magnitude compared to Inconel 718 alloy coatings. When the content of TiO2 and Al2O3 reached 20%, the composite coatings demonstrated superior tribological performance at intermediate to high temperatures. A comparative analysis revealed that the Inconel 718-MoS2-Al2O3-TiO2 composite coatings exhibited better tribological performance than Inconel 718 alloy coatings across temperatures ranging from room temperature to 800 ℃.

The construction scale of a wastewater centralized treatment facility in a printing and dyeing cluster improvement park in Zhejiang Province was 30 000 m3/d. According to the characteristics of wastewater in the park, the main process of “regulation tank+cooling system+reaction initial sedimentation tank+anaerobic hydrolysis tank+A/O biochemical tank+secondary sedimentation tank+high-efficiency sedimentation tank” was adopted. The results showed that the process was stable and efficient. When the average COD, BOD5, and total antimony in the influent were 1 370, 360 and 1.17 mg/L, the COD, BOD5, and total antimony in effluent were respectively reduced to 88, 7.4, and 0.049 mg/L, with the corresponding removal rates of 94%, 98% and 96%. The effluent met the indirect discharge requirements in Table 2 of “Discharge Standards of Water Pollutants for Dyeing and Finishing of Textile Industry”(GB 4287-2012). The project adopted a coagulation agent enhanced initial sedimentation process to achieve effective carbon capture of wastewater and indirectly export energy, which was conducive to the reduction of carbon emissions. The main treatment unit adopted intensive combination and deep pool design to save land, which could be used as a reference for land limited wastewater plants.

To evaluate the mechanical property of concrete materials rapidly, a fast prediction model of the concrete equivalent modulus is proposed based on the random aggregate model and scaled boundary finite element method (SBFEM). First, a random aggregate model of meso-concrete is employed to construct the representative volume element (RVE) according to the aggregate content, gradation, shape, etc. Second, the RVE model is transformed to be a grayscale image and stored as a digital matrix. The quadtree mesh is partitioned automatically for simulation by SBFEM. There are only six types of unique subdomains, and the hanging node does not affect the simulation accuracy. The global stiffness matrix can be assembled directly according to the six subdomain stiffness matrices. Finally, the equivalent modulus is predicted by using the numerical homogenization method. Several numerical examples are employed to verify this model, and the results are compared with that of other methods. The result indicates that the proposed model can efficiently determine the equivalent modulus. Furthermore, the effect of the aggregate gradation, shape, porosity, and pore water are studied and analysed in this work. The proposed model is potential and helpful in predicting the mechanical properties of concrete or other composite materials.

Myopia is one of the leading causes of visual impairment and has become a major global public health concern with the rapidly increasing prevalence worldwide. Due to the trend of myopia towards younger age groups, accurate prediction of the occurrence and progression of myopia could help to provide targeted interventions for high-risk population and myopia patients in children and adolescents, in order to delay myopia onset or slow myopia progression. In recent years, various myopia prediction models have been built based on evidence-based medicine such as baseline ocular biometric data, refractive status, environment factors, genetic factors, and lifestyle have been established. The interaction of genetic and environmental effects on etiology of myopia have been established, with the continuous innovation of genetic research methods, specific genes with higher predictive power in the future will also be applied in the prediction, prevention and control of myopia. This article summarize the content, performance and research progress of myopia prediction models, which could serve as a useful reference and guidance for the prevention and control of myopia in children and adolescents.

PurposeTo explore the percutaneous minimally invasive treatment of pubic symphysis and its adjacent fractures.MethodSince May 2021, 13 cases of fractures involving the pubic symphysis and its adjacent parts were treated with x-ray fluoroscopic localization and percutaneous cannulated screw fixation across the symphysis pubis, the guide pin pierced the symphysis pubis and the fracture end and stopped at the inner edge of the acetabulum. Visual analogue scale (VAS) was used to evaluate the effect of the operation, and the patients were followed up.ResultThe screw insertion operation time was 25–40 min, with an average of 31.45 min; The number of perspectives is 20–40, with an average of 28.75. The average intraoperative blood loss was 10 ml, and there were no puncture complications such as nerve or vascular damage. The initial stability of the fractured end of the patient after surgery was good. The VAS score decreased from preoperative 8–10 points to postoperative 1–2 points (average of 1.5 points). The follow-up time was 3–25 months, with an average of 8.5 months. At the last follow-up, the excellent and good rate of pelvic function according to Majeed pelvic function scoring system was 100%. One patient had screws removed 1.5 years after surgery, while the remaining twelve patients did not have screws removed. All patients did not experience any discomfort symptoms caused by pubic symphysis fixation.ConclusionPercutaneous hollow nail internal fixation is an effective method for treating fractures of the pubic symphysis and its adjacent parts.

Objective To explore the neurophysiological responses of patients′ fear in real treatment scenarios, and to construct a assessment model of children′s dental fear and anxiety (DFA) based on physiological data. Methods Totally 166 children under the age of 14 who received treatment at the Beijing Children′s Hospital Department of Stomatology were included in the study. The Chinese version of the modified Children′s Fear Survey Schedule-Dental Subscale (CFSS-DS) was used to assess dental fear and anxiety scores in children. A wrist-worn physiological data collection device was used to continuously measure subjects′ heart rate (HR) and galvanic skin response (GSR) during the treatment. Repeated measures analysis of variance was used to test for differences in physiological data before, during and after treatment. Pearson′s correlation analysis was used to analyze the relationship between physiological data and CFSS-DS scores before, during, and after treatment. A Least Absolute Shrinkage and Selection Operator(LASSO) regression model was established to assess dental fear and anxiety among children, and Leave-One-Out (LOO) was used for cross-validation. Results There were significant differences in the changes of each dimension of physiological data before, during, and post treatment(P＜0.05). The Pearson′s correlation coefficient (r) between the LASSO model predictive values and the CFSS-DS scores was 0.30 (P＜0.05), which indicated a good predictive accuracy of the model. Conclusions The assessment model might achieve objective and automated measurement of dental fear and anxiety in children.

Epidermal stem cells (EpSCs) play a vital role in skin wound healing through re-epithelialization. Identifying chemicals that can promote EpSC proliferation is helpful for treating skin wounds. This study investigates the effect of morroniside on cutaneous wound healing in mice and explores the underlying mechanisms. Application of 10‒50 μg/mL of morroniside to the skin wound promotes wound healing in mice. In vitro studies demonstrate that morroniside stimulates the proliferation of mouse and human EpSCs in a time- and dose-dependent manner. Mechanistic studies reveal that morroniside promotes the proliferation of EpSCs by facilitating the cell cycle transition from the G1 to S phase. Morroniside increases the expression of β-catenin via the glucagon-like peptide-1 receptor (GLP-1R)-mediated PKA, PKA/PI3K/AKT and PKA/ERK signaling pathways, resulting in an increase in cyclin D1 and cyclin E1 expression, either directly or by upregulating c-Myc expression. This process ultimately leads to EpSC proliferation. Administration of morroniside to mouse skin wounds increases the phosphorylation of AKT and ERK, the expressions of β-catenin, c-Myc, cyclin D1, and cyclin E1, as well as the proliferation of EpSCs, in periwound skin tissue, and accelerates wound re-epithelialization. These effects of morroniside are mediated by the GLP-1R. Overall, these results indicate that morroniside promotes skin wound healing by stimulating the proliferation of EpSCs via increasing β-catenin expression and subsequently upregulating c-Myc, cyclin D1, and cyclin E1 expressions through GLP-1R signaling pathways. Morroniside has clinical potential for treating skin wounds.

Yonggui Zhang,1 Xianzhong Lin,2 Chen Ye,2 Peiling Zhang3 1Department of Anesthesiology, The Second Hospital of Longyan, Fujian, People’s Republic of China; 2Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China; 3Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, People’s Republic of ChinaCorrespondence: Xianzhong Lin, Department of Anesthesiology, the First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, People’s Republic of China, Email lxzyjs@fjmu.edu.cnBackground: With the aging of the population and the increasing incidence of neurological diseases, amnestic mild cognitive impairment (aMCI) has attracted attention. Hyperbaric oxygen (HBO) has gradually shown the potential in the treatment of aMCI as an emerging treatment method in recent times. This study is to observe the effect of HBO on the long-term learning memory of aMCI rats, and investigate the associated mechanisms.Methods: Seventy-two male rats (4-month-old) were randomly divided into control (CON) group, aMCI group, HBO group, 24 rats in each group. Each group was randomly divided into CON1, CON7, CON28; aMCI1, aMCI7, aMCI28; HBO1, HBO7, HBO28, 8 rats in each group. The aMCI model rats were established in aMCI and HBO groups. HBO group was treated with HBO for 7 days. The ethological and cytopathology which include Morris water maze (MWM) test, HE staining, TUNEL staining and the expression of Fas/FasL on neuron membrane were conducted to evaluate the effects of HBO on day 1, day 7 and day 28 after HBO treatment.Results: MWM test showed that the spatial learning and memory ability of the rats decreased in aMCI group, and recovered in HBO group; Compared with aMCI group, the pathological damage of hippocampal nerve cells was alleviated, the number of apoptotic cells was significantly reduced (P < 0.05), and the expression of Fas/FasL on the surface of nerve cell membrane was significantly weakened in HBO group (P < 0.05). There were no significant changes in the spatial learning and memory ability, pathological damage of hippocampal neurons, the number of apoptotic cells, and the changes of Fas/FasL on the surface of hippocampal neurons in HBO1, HBO7, and HBO28 groups (P > 0.05). However, in aMCI1, aMCI7, and aMCI28 groups gradually aggravated (P < 0.05).Conclusion: 1. HBO can improve the long-term learning and memory impairment by attenuating neuronal apoptosis in aMCI rats. 2. Fas/FasL mediated cell receptor death pathway is involved in the apoptosis of hippocampal neurons.Keywords: amnesic mild cognitive impairment, hyperbaric oxygen, apoptosis, learning and memory impairment