Search

Obstructive sleep apnea (OSA) is one of the most common sleep disorders, which is closely related to a variety of cardiovascular diseases, and has become one of the key directions for the control and prevention of cardiovascular disease risk factors. In recent years, many clinical studies have confirmed that OSA is closely related to the initiation and evolution of acute coronary syndrome (ACS). Therefore, this article summarized the status quo of clinical studies on OSA and ACS, the shortcomings of current studies, and prospects for future research directions.

【Objective】 The effect of temperature on plant development is often characterized by degree days or accumulated temperature. In this paper, we investigate how planting date affects accumulated temperature and the consequence for the yield of two ratooning rice varieties. 【Method】 The experiment was conducted in a rice field in Changsha, central Hunan province. It included two rice varieties: Y Liangyou 900 (YLY900), which has a long growth period, and Y Liangyou 911 (YLY911), which has a moderate growth period. The seeds of both varieties were sown on March 15 (B1), March 20 (B2), March 25 (B3), March 30 (B4), April 5 (B5), or April 10 (B6) to establish a planting date gradient. In each treatment, we measured physiological parameters including growth duration, yield component, and seed-setting rate to evaluate the physiological development of the crops. 【Result】 The average annual growth period of YLY911 was 215 days. Its first and regeneration seasons were eight and ten days shorter, respectively, than those of YLY900. Delaying the planting date shortened the vegetative growth period of the first season and reduced the total growth period of both seasons in both varieties. The variation in grain yield in the first and regeneration season, as well as annual yield of YLY911, followed a parabolic relationship, peaking in B2. Conversely, the yield of YLY900 decreased steadily as planting date was delayed. Yields in the first and regeneration season, as well as annual yield, were consistently higher in YLY911 than in YLY900. The primary factors affecting grain yields were the number of ears per unit area and the seed-setting rate. With delay in planting dates, the annual accumulated temperature for both varieties first increased and then declined, peaking in B2. The accumulated temperature in the first and annual seasons for YLY900 was significantly higher than for YLY911, while the accumulated temperature in the regeneration season was lower for YLY900 than for YLY911. Such differences in the regeneration season between the two varieties were statistically insignificant (p>0.05). 【Conclusion】 For ratooning rice in our studied area, the optimal planting date was March 15 for varieties with long growth period and March 20 varieties with moderate growth period.

Abstract Background Pueraria is a widely cultivated medicinal and edible homologous plant in Asia, and its tuberous roots are commonly used in the food, nutraceutical, and pharmaceutical industries. “Gange No. 5” is a local variety of Pueraria montana var. thomsonii (Bentham) M.R. Almeida (PMT) in Jiangxi Province, China. After optimizing its cultivation technique, we shortened the cultivation cycle of this variety from two years to one year, suggesting that the regulatory mechanism of the endogenous hormone system during tuberous root expansion may have changed significantly. In this study, we focused on the molecular mechanisms of endogenous hormones in promoting tuberous root expansion during one-year cultivation of “Gange No. 5”. Results The mid-late expansion period (S4) is critical for the rapid swelling of “Gange No. 5” tuberous roots during annual cultivation. At S4, the number of cells increased dramatically and their volume enlarged rapidly in the tuberous roots, the fresh weight of a single root quickly increased, and the contents of multiple nutrients (total protein, total phenol, isoflavones) and medicinal components (puerarin, puerarin apigenin, and soy sapogenin) were at their peak values. We compared the transcriptomes and metabolomes of S1 (the pre-expansion period), S4, and S6 (the final expansion period), and screened 42 differentially accumulated hormone metabolites and 1,402 differentially expressed genes (DEGs) associated with hormone biosynthesis, metabolism, and signaling. Most Auxin, cytokinins (CKs), jasmonic acids (JAs), salicylic acid (SA), melatonin (MLT), and ethylene (ETH), reached their maximum levels at S1 and then gradually decreased; however, abscisic acid (ABA) appeared in S6, indicating that most of the endogenous hormones may play a key role in regulating the initiation of tuberous root expansion, while ABA mainly promotes tuberous root maturation. Notably, multiple key genes of the ‘Tryptophan metabolism’ pathway (ko00380) were significantly differentially expressed, and COBRA1, COBRA2, YUCCA10, IAA13, IAA16, IAA20, IAA27, VAN3, ACAA2, and ARF were also identified to be significantly correlated with the expansion of “Gange No. 5” tuberous roots. Conclusions Our study has revealed how endogenous hormone regulation affects the expansion of “Gange No. 5” tuberous roots. These findings offer a theoretical foundation for improving the yield of PMT tuberous roots.

This study investigates the correlation between 129Xe ventilation functional MRI and CT-detected pulmonary lesion types. We performed 129Xe ventilation functional MRI and CT scans on a sample of 143 patients, subsequently analyzing the relationship between lung ventilation function at the lobe level and CT lesion types. The findings suggest that the ventilation function from 129Xe MRI was consistent with CT results in the majority of lung lobes (74.6%). The ventilation function impairment of lung correlates with CT lesion types, particularly in instances of mixed diseases and emphysema/bullae, which are more prone to induce lung ventilation dysfunction. Moreover, distinct ventilation patterns are observed among different lesion types. That is, the data from both 129Xe ventilation functional MRI and CT provide complementary insights. The preliminary finding of this study offers data support for evaluating lung ventilation function caused by lung lesions, and provides more references for clinical imaging diagnosis, thereby contributing to the refinement of diagnostic and therapeutic strategies for pulmonary diseases.

The paper addresses the issue of fluctuating low-temperature drop-weight tear test （DWTT） performance in 6-8 mm thin-wall pipeline steel， the influencing factors of the control process of low-temperature DWTT of X65 thin-wall pipeline steel have been explored. With microstructure analysis and numerical deconstruction study of different low-temperature DWTT results， ， it reveal that the size of polygonal ferrite grains and the distribution of M/A constituents in the central part of the steel plate significantly affect low-temperature DWTT performance. When the average area of grains with an area ≥200 μm2 is greater than 260 μm2， and the proportion of M/A constituents is greater than 6%， DWTT performance shall deteriorate significantly. By optimizing the composition and continuous casting and rolling processes， control of grain size and M/A constituents can effectively improve the low-temperature DWTT performance of thin-specification pipeline steel. The related product has achieved stable production of more than 80，000 tons， meeting the requirement of -30 ℃ low-temperature DWTT， it is of great significance for the development and production of thin-wall pipeline steel products.

The compatibility of aircraft landing gear and pavement is of great significance to the ground motion ability of aircraft. In this paper, the landing gear load and tire load distribution under different working conditions for a large aircraft are calculated by using the Portland Cement Association method based on Westgard laminate theory and the United States Army Corps of Engineers method based on California bearing ratio（CBR）. The influence of the landing conditions, ground mobility, tire number, tire deflation and track widths on the aircraft classification number（ACN）is analyzed. The aircraft float-ability under rigid and flexible pavement is analyzed. Results show that the increased tire load and uneven load distribution caused by vertical overload and tire deflation can weaken the float-ability of aircraft to varying degrees, especially during turning and landing conditions with tail sinking, therefore, which need to be limited. Increasing the number of tires and the distance between them can improve the float-ability, but the structural design, strength margin and other factors should also be taken into consideration to optimize the design of trolley type landing gear.

An experimental study on the recovery of phosphorus resource was carried out for the resource application of sludge residue. The effects of acid species and different leaching conditions on the leaching of phosphorus from sludge residue were systematically analyzed，and the effects of pH and n（Mg）∶n（N）∶n（P） on the synthesis of struvite from the solution containing phosphorus were investigated. The results showed that the leaching rate of phosphorus from sludge residue could reach 96.9% under the conditions of liquid/solid ratio of 20 mL/g，hydrochloric acid concentration of 0.4 mol/L and leaching time of 4 h. Moreover，the crystallization rate of the phosphorus purification solution purified by cation exchange resin could reach 98.1% at pH=10，n（Mg）∶n（N）∶n（P）=1.2∶1.2∶1，and the heavy metal content in the obtained struvite met the standard limit of Organic and Inorganic Compound Fertilizer （GB/T 18877-2020）. In summary，79% of phosphorus in sludge residue could be recovered after phosphorus extraction，purification and crystallization.

Due to the low oxidation potential and high electrochemiluminescence (ECL) quantum yield, Luminol has been widely applied in analytical and detection fields, especially in immunoassay, food safety and environmental monitoring. However, there is a lack of sufficient experimental evidence on the ECL mechanism of Luminol, which affects the further improvement of its ECL efficiency. Herein, an electrochemistry-micro tube-mass spectrometry (EC-MT-MS) device was constructed for on-line monitoring of Luminol ECL reaction. In this EC-MT-MS device, a high borosilicate glass tube with a nano tip was used as electrochemical cell and electrospray ionization source, a platinum working electrode and a platinum counter electrode were inserted into the tube and connected to a customized power station, which could simultaneously input a low voltage (volt level) for the ECL reaction and a high voltage (kilovolt level) for the formation of electrospray. Prior to the EC-MT-MS experiment, the composition of the reaction solution was optimized to obtain the highest MS signal response, and Luminol was dissolved in acetonitrile-water (4:1, V/V) solvent with ammonium acetate as the electrolyte. The concentrations of Luminol and ammonium acetate in the prepared solution were both 0.1 mmol/L, and the pH was adjusted to 11 using ammonium aqueous. The oxidation potential of Luminol was subsequently studied using a traditional three-electrode system by cyclic voltammetry in the same solution, and the determined oxidation potential for ECL reaction was 0.87 V. During the EC-MT-MS measurements, (2.5 kV+0.87 V) and 2.5 kV were input to the working and counter through the power station, respectively. A series of short-lived intermediates and products such as L1 (m/z 198) and the luminescent precursor AP- (m/z 180) in the Luminol ECL reaction process were successfully captured and analyzed by MS. The molecular structures of these products were characterized by tandem mass spectrometry (MSn) technique. There are mainly two fragments of m/z 163, 136 present in the MS2 spectrum of luminescent precursor AP-, attributed to the (NH2+H) and COO losses, respectively. In addition, the promotion mechanism of hydrogen peroxide (H2O2) for the ECL performance of Luminol was also investigated. A key reaction intermediate LO2H- was found in the MS spectrum at m/z 208. Meanwhile, the peak intensity of luminescent precursor AP- significantly increased from 1.3% to 15.7%, proving that the presence of H2O2 effectively promoted the generation of key luminescent intermediate. Finally, by adding 1,4-benzoquinone to the Luminol-H2O2 system, the central role of the superoxide anion radical (O2·-) derived from H2O2 in the Luminol ECL process was confirmed. The relevant results provide a direct data reference for the study of the Luminol ECL mechanism.

A twelve-channel local-area-network (LAN) wavelength-division multiplexing (LWDM) filter is proposed and demonstrated with a uniform channel spacing of 4.5 nm (800 GHz) in the O-band of 1270–1330 nm by using x-cut lithium-niobate-on-insulator (LNOI) photonic waveguides for the first time. The present LWDM filter consists of twelve single-channel bandpass filters based on multimode waveguide gratings (MWGs) assisted with a TE0/TE1 mode (de)multiplexer. In particular, two stages of MWGs in cascade are introduced for each single-channel bandpass filter, in order to achieve high sidelobe suppression ratios, thus reducing interchannel crosstalk. For the fabricated twelve-channel LWDM filter, all the channels have very excellent box-like spectral responses with low excess losses of ∼0.6 dB, broad 1-dB bandwidths of ∼2.9–3.4 nm (which is close to 75 % of the channel spacing), and ultra-low interchannel crosstalk of

Objective To screen the influencing factors for the poor prognosis in patients with ultra⁃ severe traumatic brain injury (TBI). Methods Total 133 patients with ultra⁃severe TBI [Glasgow Coma Scale (GCS) score 3-5] which admitted to the 909th Hospital of Joint Logistic Support Force; Dongnan Hospital of Xiamen University from January 2012 to June 2017 were included. All cases underwent hematoma removal with either standard craniotomy decompression or oversized craniotomy decompression, even combined with internal decompression. Glasgow Outcome Scale (GOS) was used to evaluate prognosis 6 months after surgery. Univariate and multivariate Logistic regression analyses were adopted to screen the influencing factors for poor prognosis in patients with ultra⁃severe TBI. Results Total 133 patients were divided into favourable prognosis group (GOS score ≥ 4, n = 12) and poor prognosis group (GOS score < 4, n = 121). Logistic regression analysis showed bilateral pupils dilated (OR = 1.779, 95%CI: 1.698-4.531; P = 0.004), postoperative high intracranial pressure (ICP; OR = 12.629, 95%CI: 2.313-68.949, P = 0.007) and volume of secondly cerebral infarction > 75 ml (OR = 2.147, 95%CI: 1.894-5.156; P = 0.009) were the risk factors for poor prognosis, while injury subtyping of isolated epidural hematoma was the protective factor for favourable prognosis (OR = 0.172, 95%CI: 0.032-0.915; P = 0.002). Conclusions GCS score is not reliable in solely predicting the prognosis of patients with ultra ⁃severe TBI. Preoperative bilateral pupil dilation, postoperative high ICP and volume of secondly cerebral infarction > 75 ml were risk factors for poor prognosis of patients with ultra⁃severe TBI, while injury subtyping of isolated epidural hematoma was the protective factor for favourable prognosis.

Background Esophageal cancer is one of the most aggressive gastrointestinal tumors. Advanced esophageal carcinoma is mainly associated with dysphagia. Most elderly patients with severe obstruction esophageal carcinomacannot tolerate anesthesia and invasive treatment due to comorbidities, while the failure to improve dysphagia in the short term will seriously affect the nutritional status, life quality and prognosis of patients. Objective To explore the safety and efficacy of image-guided photodynamic therapy (IGPDT) under local anesthesia for short-term improvement of obstruction and nutritional status in elderly patients with severe obstruction esophageal carcinoma. Methods A total of 24 elderly patients with severe obstruction esophageal carcinoma admitted to Hebei General Hospital from March 2020 to December 2021 were selected for IGPDT in the prospective, single-arm, self-control study. The upper boundary of the lesion was located by endoscopy and marked with metal tissue clips, the lower boundary of the lesion was located by CT and esophagography before treatment. During the treatment, the fiber of laser treatment was delivered to the lesion site under the guidance of X-ray fluoroscopy during treatment. The Stooler dysphagia score was evaluated before, 1 week and 1 month after operation. The nutritional status of patients was evaluated by nutritional risk screening 2002 (NRS 2002) score, hemoglobin, BMI, albumin and prealbumin before and 2 months after operation. The swallowing quality of life scale (SWAL-QOL) was used to evaluate the quality of life in patients. Results All patients achieved partial response (PR) at 1 month postoperative efficacy evaluation. The Stooler dysphagia scores at 1 week and 1 month after IGPDT were significantly lower than that before operation (P

The grain growth behavior of the fourth generation powder metallurgy (PM) superalloys was studied. The results indicate that the grain growth range is small when the heat treatment temperature is below the γ′ solution temperature, which is similar to the initial microstructure (as-forged, 3~4 μm). However, the grain size greatly increases to 30~40 μm when the heat treatment temperature exceeds the γ′ solution temperature, and there is little difference in grain size at the several temperatures over the γ′ solution temperature. The grain size increases significantly at the initial stage of heat treatment, and no longer changes after a certain holding time. The influence of temperature and time on grain size is related to the pinning effect of γ′ on grain boundary migration. A new model is established by modifying the parameters such as the activation energy for boundary migration (Q), the time exponent (n), and the generalized mobility constant (A0) based on the traditional grain growth model. The determination coefficient (R2) and the mean-square error (MSE) between the predicted and the experimental values are 0.9997 and 0.12 μm, respectively, showing the high prediction accuracy, and the various characteristics of the grain growth curves can also be predicted accurately.

The effect of high temperature oxidation on the surface state of FGH96 superalloy powders was studied by simulating the high temperature heating process during hot isostatic pressing (HIP) consolidation. The results indicate that the surface morphology, surface element distribution, and precipitate composition of the FGH96 superalloy powders are significantly changed by high temperature oxidation at near HIP temperature. With the increase of heating temperature and the extension of holding time, the surface solidification structure of cell crystals and dendritic crystals are covered by oxide/carbide layers. The high temperature oxidation process promotes the diffusion of Ni, Ti, Zr, Nb, Al, and C atoms inside the powder matrix to the powder surface. The pre-existing oxides (ZrO2) on the powder surface provide the structural conditions for the nucleation of MC carbides (Ti, Nb)C. Controlling the formation of oxides on the powder surface can effectively limit the formation of prior particle boundaries (PPBs) defects in the alloys.

Nitrogen oxides (NO_x), as one of the main atmospheric pollutants, seriously affect environmental safety and human health. Selective catalytic reduction (NH_3-SCR) is the most effective treatment method for NO_x removal at present, especially low-temperature SCR denitrification technology, which has very important application prospects and research significance. The research showed that VPO/TiO_2 catalyst had excellent low-temperature SCR denitrification activity. The adsorption of NH_3 and NO on V_2O_5 and (VO)_2P_2O_7 surface was simulated by DFT, and the reaction mechanism of VPO catalyst was studied at the micro level. The results showed that NH_3 exhibited stable chemisorption of Brønsted acid and Lewis acid on the surface of V_4P_4O_22H_14 cluster, and the adsorption effect on Brønsted acid sites was more stable. NH_3 adsorption effect on the surface of catalyst was excellent because of the hybridization of 2p orbital of N, 2p of O and 3d electron orbital of V. NO also showed chemisorption on the surface of V_4P_4O_22H_14 cluster. Due to the small amount of electron transfer, which was significantly lower than the adsorption energy of NH_3, NO could not strongly compete with NH_3 molecule. In addition, NO showed stable chemisorption on Brønsted acid and Lewis acid on the surface of V_6O_20H_10 cluster. The adsorption on Brønsted acid sites was more stable. The E-R mechanism and L-H mechanism of VPO/TiO_2 catalyst reaction mechanism were explained.

A method of headspace-solid-phase microextraction-gas chromatography/triple quadrupole mass spectrometry was established for simultaneous determination of 10 types of 51 odorous substances in water. The effects of extraction head, extraction temperature, extraction time, salt content, desorption time and split ratio on detection results were investigated with optimized gas chromatography-mass spectrometry parameters using the multiple reaction monitoring (MRM) mode for triple quadrupole mass spectrometry. The results showed that the optimized conditions were polydimethylsiloxane/divinylbenzene as extraction head, 55 ℃ as extraction temperature, 20 min as extraction time, 300 g/L NaCl as salt content, desorption time of 0.5 min and the split ratio of 10∶1. The detection limits of 51 odorous substances ranged from 0.4 to 183 ng/L, and the linear correlation coefficients were greater than 0.995. The detection limits of indicator substances, such as geosmin, 2-methylisothiol, anisole, dimethyl disulfide, and dimethyl trisulfide were 0.4, 0.9, 1.9, 3.5, 1.7 ng/L, respectively, which met the limit requirement of “Standard for Drinking Water Quality (GB 5749—2022)” of China. The spiked recoveries of the low, medium and high concentration levels were 76.2%-118%, 78.9%-119% and 82.0%-119%, and the relative standard deviations were 2.9%-19.4%, 1.8%-13.4% and 0.9%-13.2%, respectively. This method was used to detect the odorous substances in 29 surface waters, in which 12 odorous substances such as methyl mercaptan, dimethyl sulfide, and DL-sec-butyl acetate were detected with the concentration range of 2.2~1 651 ng/L. There were no apparent interferences in the MRM channels for the detected odorous substances. This method has the characteristics of simple pretreatment, good reproducibility and high accuracy, which is suitable for simultaneous and rapid screening of various types of odorous substances in water bodies.

Centrifugal pump is an important tool for pipeline transportation，and its safety and service life will greatly restrict the cost of pipeline transportation.The centrifugal pump is composed of internal rotor and external diffuser，among which，the external diffuser is welded from steel plates，the weld between the steel plates as the weak link of the diffuser，is a main failure part of the centrifugal pump.Therefore，in this paper，a failed diffuser of an oil transmission station was used as the raw material，scanning electron microscopy (SEM)，energy dispersive spectroscopy (EDS)，and electron back scatter diffraction (EBSD) detection for the welds of the diffuser were conducted，and the failure mechanism of the welds of the diffuser was analyzed from the perspective of microstructure，combining the three detection results and the working environment of the diffuser.Based on EBSD test results，the critical dislocation density ρGND of weld，heat affected zone and substrate was calculated and the strength and toughness of the three positions were quantitatively compared.Results showed that the heat affected zone had the highest strength and toughness，followed by the substrate，and the weld was the lowest.Defects such as slag inclusion，scratch and residual austenite created the initial condition for weld corrosion and cracking.Micro cracks rapidly expanded under the combined action of cyclic stress and corrosive medium，and eventually leading to weld failure of diffuser.The results of this study could provide some reference for the use and manufacture of centrifugal pumps.

Abstract Background Pueraria is a dry root commonly used in Traditional Chinese Medicine or as food and fodder, and tuberous root expansion is an important agronomic characteristic that influences its yield. However, no specific genes regulating tuberous root expansion in Pueraria have been identified. Therefore, we aimed to explore the expansion mechanism of Pueraria at six developmental stages (P1–P6), by profiling the tuberous roots of an annual local variety “Gange No.1” harvested at 105, 135, 165, 195, 225, and 255 days after transplanting. Results Observations of the tuberous root phenotype and cell microstructural morphology revealed that the P3 stage was a critical boundary point in the expansion process, which was preceded by a thickening diameter and yield gain rapidly of the tuberous roots, and followed by longitudinal elongation at both ends. A total of 17,441 differentially expressed genes (DEGs) were identified by comparing the P1 stage (unexpanded) against the P2–P6 stages (expanded) using transcriptome sequencing; 386 differential genes were shared across the six developmental stages. KEGG pathway enrichment analysis showed that the DEGs shared by P1 and P2–P6 stages were mainly involved in pathways related to the “cell wall and cell cycle”, “plant hormone signal transduction”, “sucrose and starch metabolism”, and “transcription factor (TF)”. The finding is consistent with the physiological data collected on changes in sugar, starch, and hormone contents. In addition, TFs including bHLHs, AP2s, ERFs, MYBs, WRKYs, and bZIPs were involved in cell differentiation, division, and expansion, which may relate to tuberous root expansion. The combination of KEGG and trend analyses revealed six essential candidate genes involved in tuberous root expansion; of them, CDC48, ARF, and EXP genes were significantly upregulated during tuberous root expansion while INV, EXT, and XTH genes were significantly downregulated. Conclusion Our findings provide new insights into the complex mechanisms of tuberous root expansion in Pueraria and candidate target genes, which can aid in increasing Pueraria yield.

Abstract Permeability tests are performed by using the flexible wall permeameter to study the influence of bentonite-HDTMA (hexadecyl trimethyl ammonium bromide) on the permeability performance of Loess as a lining material in the solid waste landfill. Results show, the impermeability of compacted Loess in the middle and lower reaches of the Yellow River in China does not meet the standard requirement as the landfill liner. The permeability of Loess mixed with more than 10% bentonite ratio is less than 1.0 × 10−7 cm·s−1. The permeability of Loess increases slightly after mixing a small amount of HDTMA. The impermeability of Loess mixed with some bentonite-HDTMA ratio still meet the standard requirement. The HDTMA may destroy the soil aggregate structure and increase the soil permeate channel. The SEMs show that the bentonite clay particle can fill the pores between Loess coarse particles and improve the impermeability performance of the material. The digital photos show that HDTMA can effectively resist the development of soil macro-cracks induced by wetting–drying cycles, better for liner to maintain good impermeability. On this basis, the relationship between the hydraulic conductivity of bentonite-HDTMA modified Loess and dry density is constructed. From this study, Loess can be used as a lining material for landfills, when mixed with bentonite/HDTMA at ratios of 10%/0% or 14%/2%.

The shimmy of the front landing gear of an aircraft usually occurs in the process of taking off or landing,which endangers the stability and maneuverability of the aircraft and is a serious aircraft fault. In this paper,based on the theorem of moment of momentum,a mathematical model of shimmy considering landing gear side bending and torsion is established for a certain type of UAV. The different dynamic models when using traditional oil damping damper and electromagnetic damping damper are discussed. For the traditional oil damping damper,the equivalent linear model is used to obtain the upper and lower boundaries of the critical stability damping curve. For the nonlinear model of electromagnetic damping damper,the bifurcation analysis theory is used to determine the shimmy stability area. Results show that excessive shimmy damping can not suppress shimmy,and the stable region of shimmy on the parameter plane can be obtained. It can provide some references for the design of landing gear shimmy reduction.

ObjectiveTo observe the effect of hot and cold Chinese medicine whirlpool bath combined with motor control training on patients with shoulder-hand syndrome (SHS) after stroke.MethodsA total of 40 patients with SHS after stroke in the Xuzhou Rehabilitation Hospital and Xuzhou Central Hospital from January to December 2020 were randomly divided into control group and observation group according to random number table method, with 20 cases in each group. Both groups received routine rehabilitation training such as physical agent modalities and occupational therapy. The control group received motor control training on the basis of routine rehabilitation training, 40 minutes a time, once a day, five times a week, lasting for four weeks; the observation group received hot and cold Chinese medicine whirlpool bath on the basis of control group, 40 minutes a time, once a day, five times a week, lasting for four weeks. Before and after four weeks of treatment, visual analogue scale (VAS) was used to evaluate the severity of shoulder pain; overflow method was used to evaluate the degree of hand swelling; Fugl-Meyer assessment upper extremity (FMA-UE) was used to evaluate motor function of the affected limb; modified Barthel index (MBI) was used to evaluate the activities of daily living; motor activity log-amount of use (MAL-AOU) and motor activity log-quality of movement (MAL-QOM) were recorded by the motor activity record sheet.ResultsCompared with those before treatment, VAS score and hand swelling value of both groups decreased significantly after treatment, while FMA-UE, MBI, MAL-AOU and MAL-QOM scores increased significantly after treatment, and the differences were statistically significant (PP

【Objective】 Transplant is a cultivation commonly used in ratooning rice production in southern China and other eastern Asian countries. Its impact on rice growth and yield depends on a range of factors. This paper presents an experimental study of the effect of transplanting density on yield composition of different panicle-typed varieties. 【Method】 The field experiment compared three rice varieties: Tianyou Huazhan, Huiliangyou 898 and Yliangyou 900. The transplanting density treatments for all three varieties were the same: 1.5×104 points/hm2 (D1), 187 500 points/hm2 (D2), 225 000 points/hm2 (D3), 262 500 points/hm2 (D4), 300 000 points/hm2 (D5), and 337 500 points/hm2 (D6). In the experiment, we measured rice growth and its ultimate yield formation in each treatment. 【Result】 Transplanting density affected composition of both seasonal and annual rice yields significantly, but the effect varied with rice varieties. There was a lack of variety-planting density interaction on the yield. The variety Huiliangyou 898 had the highest seasonal and annual yields, strong coordination ability among yield factors, high seed setting rate; variety Tianyou Huazhan had strong tillering ability, high ear-setting rate and full panicle numbers per unit area. All these were significantly higher than those of the variety YLY900. The variety YLY900 had fast population growth rate and high grain numbers per panicle, but its tillering ability was poor, and ear-setting rate and low harvest index were low; it hence produced the lowest seasonal and annual yields. On average, the optimal transplanting density for the three varieties was D5, producing highest seasonal and annual yields, faster tillering rate and more tillers per unit area; it also significantly increased the panicle numbers and sink capacity, population growth rate, and dry matter accumulation. 【Conclusion】 Selecting rice varieties with panicle and grain for the initial season in ratooning rice production should consider its tillering ability to achieve high yield. For the three rice varieties we compared, the optimal transplanting density is 300 000 holes/hm2.

Objective·To investigate the role of methyltransferase like 3 (METTL3) acting on N6-methyladenosine (m6A) and regulating pri-miR-21 methylation in the renal fibrosis of diabetic nephropathy (DN).Methods·Eight-week-old male db/db mice were used as DN models, and db/m mice were used as controls. The mice were randomly divided into 4 groups according to whether they received the treatment of 3-deazaadenosine (DAA) by tail vein injection or not (5 mice/group): db/m group, db/db group, db/m+DAA group and db/db+DAA group. From the age of 8 weeks, DAA was injected once per 5 d for a total of 8 times. After the DAA intervention, the mice were kept until they were 19 weeks old. The blood, the urine and the kidney tissue samples of the mice were collected, and blood glucose (BG), serum creatinine (Scr), and urinary albumin-to-creatinine ratio (ACR) were detected. The kidneys were stained with hematoxylin-eosin (H-E), Masson and sirius red to observe the pathological changes. The methylation level of m6A in total RNAs of the kidney was detected with the kit. The expression levels of METTL3 and fibrosis-related proteins in the kidney were detected by Western blotting. The overall pri-miR-21 and the mature miR-21 were detected by real-time quantitative PCR. After enrichment of the m6A-methylated RNAs in the kidney by immunomagnetic beads, the methylated pri-miR-21 at m6A was detected by PCR.Results·Compared with the db/m group, the levels of BG, Scr, and ACR, and METTL3, m6A methylation level, fibrosis-related proteins, overall pri-miR-21, m6A-methylated pri-miR-21 and mature miR-21 in the kidney in the db/db group significantly increased (P

Objective To explore the CT imaging features and differentiation of thymic squamous cell carcinoma to improve the recognition and diagnosis level of it. Methods Of 39 patients with thymic tumor confirmed by surgery or puncture pathology from June 2014 to June 2021 in Sengong Hospital of Shannxi Province, 25 patients with thymic squamous cell carcinoma were collected as observation group and 14 patients with high-risk thymoma were served as control group. The clinical manifestations, Masaoka staging and CT signs were summarized and compared between two groups. Results The Masaoka staging system showed that most of thymic squamous cell carcinoma were stage Ⅲ(28.0%, 7/25) and stage Ⅳ(52.0%, 13/25) in observation group, which were significantly different from those in control group( χ2=9.762, P=0.021). The incidences of lobulated tumor, blurred boundaries, pericardial invasion, mediastinal fat infiltration in observation group were statistical higher than those in control group(P＜0.05). There was no significant difference in tumor internal partition, density, degree of enhancement, calcification and cystic, perfusion type growth, invasion of large vessels, pleural invasion, lymph node metastasis, pulmonary metastasis and pleural implantation between two groups(P＞0.05). Conclusion There is no obvious specificity in the clinical manifestations of thymic squamous cell carcinoma. CT manifestations are mostly characterized by anterior middle and upper mediastinal lobular mass with blurred boundaries and perfusion growth along macrovascular shape in some of them. The tumor is highly invasive to surrounding tissues and can invade macrovascular, pleura and pericardium. Mediastinal fat infiltration are common, and Masaoka staging is mostly stage Ⅲ and Ⅳ.

This review article focused on the mechanical properties of sisal, coir and hemp fiber-reinforced concrete composites and several factors affecting the mechanical properties of natural fiber-reinforced concrete (NFRC) composites. Several treatments were applied to improve the surface of natural fiber for improving the strength and durability of composites. Recently researchers have investigated the mechanical properties by using NaOH treatments effects of sisal, coir and hemp fibers-reinforced concrete composite are highlighted in this study. A variety of recent studies showed that sodium hydroxide (NaOH) treatment plays a significant role in the adhesion of fiber concrete composites. It was found that NaOH improves the mechanical properties of the natural fiber-reinforced composites. Further, the treatment techniques for the modification of these natural fibers by improving the surface of these natural fibers are discussed. In the same way, previous research has investigated the effect of thermal stability and water absorption on the mechanical properties. Generally, this review article was aimed to highlight, gather, and explore the previous reported research studies leading the mechanical properties of sisal, coir and hemp fiber and its polymer composites to deliver a basis source of data and literature to expose it as composite materials like synthetic fibers.

Ectopic thyroid is a rare malformation induced by a migration defect in the developing gland during embryogenesis. In 90% of cases, the ectopic thyroid is located in the lingual region, whereas it is extremely rare in the abdominal cavity, particularly in the pancreas. A 50-year-old female patient presented to the Taizhou First People’s Hospital with a complaint of recurrent mid-lower abdominal pain and diarrhea for approximately a month. The abdominal computed tomography scan revealed a space-occupying lesion with abundant blood supply in the head of the pancreas during the consultation. This led to the suspicion of a neuroendocrine tumor. The doctor considered that this lesion in the head of the pancreas could be responsible for the patient’s incontinence. A laparoscopic pancreaticoduodenectomy was performed after relevant tests were undertaken and contraindications were ruled out. The patient was diagnosed with ectopic thyroid of the pancreas through postoperative pathology. Ectopic thyroid can be considered in middle-aged and elderly women who present with a mass with abundant blood supply and an unknown diagnosis. Subsequent treatments should be decided after fine-needle aspiration cytology.

Inserting a prestressed high-intensity concrete pipe pile into a cement–soil mixing pile can form a new composite pile named the composite foundation with stiffened deep cement mixing (SDCM) pile. The Huanghuai alluvial stratum in China is selected to carry out the in situ test for the SDCM pile, and the bearing capacity of the SDCM pile is tested by the slow-speed maintenance load method. The results show that for an SDCM pile with dense silt and fine sand as the bearing layer, the characteristic value of bearing capacity can reach 2,300 kN, which means an SDCM pile with a length of 8.0 m meets the load requirement of a general high-rise building. Further analysis shows that the SDCM pile saves more than 40% of the cost compared with the traditional CFG pile and has better quality control advantages at the same time. This research can provide basic data and design references for similar site foundation projects.

Objective To explore the influencing factors of long⁃term prognosis of patients with spontaneous cerebellar hemorrhage (SCH) after surgery. Methods Total 121 patients with SCH admitted to the Second Affiliated Hospital of Air Force Military Medical University from January 2012 to September 2019 were included. The prognosis was assessed by the modified Rankin Scale (mRS) 12 months after surgery, and the risk factors related to dismal prognosis were screened by univariate and multivariate Logistic regression analysis. Results The age (P=0.001), proportion of Glasgow Coma Scale (GCS) score≤8 (P=0.000), activated partial thromboplastin time (P=0.003), random blood glucose level (P=0.044) and ventilator assisted ventilation ratio (P=0.015) of patients with poor prognosis (mRS score 4-6, n=79) were higher than those of patients with good prognosis (mRS score 0-3, n=42), while platelet count was lower than those of patients with good prognosis (P=0.017). There was significant difference in surgery modes between 2 groups (P=0.001). Logistic regression analysis showed that older age (OR=1.090, 95%CI: 1.032-1.151; P=0.002), high serum D⁃dimer level (OR=1.339, 95%CI: 1.034-1.735; P=0.027), craniotomy hematoma removal (OR=4.949, 95%CI: 1.310-18.691; P=0.018) and hematoma puncture drainage (OR=6.789, 95%CI: 1.249-36.912; P=0.027) were the main risk factors for long⁃term dismal prognosis after surgery for SCH. Conclusions Older age, high serum D⁃dimer level and surgery modes are the risk factors for long⁃term dismal prognosis after surgery for SCH.

The large-scale application of coal gasification technology produces a large amount of coal gasification slag that is difficult to handle. As a kind of coal gasification ash rich in aluminosilicate minerals, coal gasification coarse slag has the characteristics of pozzolanic activity and low carbon content, and can be used as supplementary cementitious material. In order to explore the activity characteristics of coal gasification coarse slag under different modification effects and its influence mechanism on the hydration and hardening performance of cement, this paper analyzed the hydration exotherm, compressive strength, composition and structure of hydration products of the blended cement paste mixed with modified gasification slag, which were compared from macroscopic and microscopic perspectives. The results show that the addition and modification of diethanol monoisopropanolamine (DEIPA) can significantly improve the grinding efficiency and potential hydration activity of gasification coarse slag, effectively reduce the extension of hydration induction period and reduce the retarding effect of gasification coarse slag on cement hydration. The addition order of DEIPA has little effect on the hydration hardening properties of blended cement. The coal gasification coarse slag modified by chemical and physical coordination can be used as the admixture of Portland cement and concrete, and the mechanical properties of blended cement can be improved under the appropriate dosage (10 %).

Ion erosion and carbonization in concrete are the key factors leading to the deterioration of durability. Layered double hydroxides (LDHs) are a kind of functional material with layered structures and ion exchange properties, which can capture a variety of harmful anions in concrete pore solutions. Therefore, LDHs exhibit great potential in improving the durability of concrete as new modified material. This article reviews the recent progress of LDHs. Based on the structural characteristics of LDHs, this work discusses the binding effect of LDHs on Cl−, SO42−{\text{SO}}_{4}^{2-}, and CO32−{\text{CO}}_{3}^{2-} in cement-based materials. We also analyze the influence of LDHs on the physical, mechanical, and hydration properties of cement-based materials and describe the modification mechanisms. Further, the improved durability of concrete and the corrosion inhibition of reinforcement by LDHs were summarized. Finally, we briefly point out some problems in the current research and development trends in the future on LDHs modified cement-based materials.

为了分析起落架支柱柔性和机身柔性对飞机地面运动载荷的影响, 应用动力学基本原理, 建立了六轮小车式起落架动力学模型及全机模型。对活塞杆与外筒柔性化处理, 并在对称水平着陆、机尾下沉着陆和滚转着陆3种着陆工况下, 分析了小车式起落架的载荷分配情况, 研究了着陆工况及支柱柔度对小车式起落架载荷分配的影响。对机身进行柔性化处理, 分析机身柔性对地面载荷的影响。结果表明: 支柱柔度对起落架航向载荷影响较大, 对垂向载荷影响较小; 考虑机身柔性后, 弹性机身变形吸收能量, 有助于减弱机体振动, 起落架及轮胎上的载荷也明显减小。

The aberrant changes of fussion/fission-related proteins can trigger mitochondrial dynamics imbalance, which cause mitochondrial dysfunctions and result insulin resistance (IR). However, the relationship between the inner mitochondrial membrane fusion protein optic atrophy 1 (Opa1) and hepatic IR as well as the specific molecular mechanisms of signal transduction has not been fully elucidated. In this study, we explore whether abnormalities in the Opa1 cause hepatic IR and whether berberine (BBR) can prevent hepatic IR through the SIRT1/Opa1 signalling pathway. High-fat diet (HFD)-fed mice and db/db mice are used as animal models to study hepatic IR in vivo. IR, morphological changes, and mitochondrial injury of the liver are examined to explore the effects of BBR. SIRT1/Opa1 protein expression is determined to confirm whether the signalling pathway is damaged in the model animals and is involved in BBR treatment-mediated mitigation of hepatic IR. A palmitate (PA)-induced hepatocyte IR model is established in HepG2 cells in vitro. Opa1 silencing and SIRT1 overexpression are induced to verify whether Opa1 deficiency causes hepatocyte IR and whether SIRT1 improves this dysfunction. BBR treatment and SIRT1 silencing are employed to confirm that BBR can prevent hepatic IR by activating the SIRT1/Opa1 signalling pathway. Western blot analysis and JC-1 fluorescent staining results show that Opa1 deficiency causes an imbalance in mitochondrial fusion/fission and impairs insulin signalling in HepG2 cells. SIRT1 and BBR overexpression ameliorates PA-induced IR, increases Opa1, and improves mitochondrial function. SIRT1 silencing partly reverses the effects of BBR on HepG2 cells. SIRT1 and Opa1 expressions are downregulated in the animal models. BBR attenuates hepatic IR and enhances SIRT1/Opa1 signalling in db/db mice. In summary, Opa1 silencing-mediated mitochondrial fusion/fission imbalance could lead to hepatocyte IR. BBR may improve hepatic IR by regulating the SIRT1/Opa1 signalling pathway, and thus, it may be used to treat type-2 diabetes.

How to reasonably allocate unmanned aerial vehicle(UAV)search and rescue tasks in low-altitude rescue has been the focus of research for a long time.The multi-object UAV mission assignment model based on level and distribution assignment method is established.In the model,the search and rescue cost,the number of UAVs used,and the balance of completed tasks are used as objective functions,and solved with the improved NSGA-Ⅱalgorithm.The results show that the established model is effective,and the reasonable and effective allocation schemes can be given in different search and rescue environments.When the highest rescue efficiency are oriented,it will lead the cost and number of UAVs increase.As the actual search UAVs are very limited,the investment of time cost is required.When economic interests are oriented,it will lead to the conclusion that search and rescue time will increase.

During pregnancy, women experience substantial changes in physiology, morphology, and hormonal systems. These changes have profound effects on the biomechanics of the human body, particularly the musculoskeletal system, resulting in discomfort, pain, and decreased body stability. Sufficient biomechanical knowledge is critical for understanding the etiology and precautions of musculoskeletal disorders. With awareness of health problems in the pregnant cohort, identification, intervention, and precaution of problems have garnered attention. Researchers have conducted studies to determine the biomechanics of pregnancy. There have been review studies on summarization. However, to the best of our knowledge, few studies have comprehensively described biomechanical changes throughout pre-, in-, and postpartum periods. This review analyzed available studies on biomechanical changes during these three periods in the electronic databases of PubMed, Scopus, and Cochrane from inception until June 2, 2021. Synthesized the general information, age of the studied subjects, investigated periods, sample size, objectives, measurement tools, and outcomes of reviewed studies. And Using National Institutes of Health quality assessment tool for observational cohort and cross-sectional studies to assessment the quality of the reviewed articles. These studies revealed biomechanical deviations in body stability, motion patterns, and gait modes during these three periods. Regarding research content, there are insufficient studies on certain critical biomechanical aspects, such as the kinetic parameters of the inner body, which are the most direct factors related to musculoskeletal problems. According to the National Institutes of Health quality assessment tool for observational cohort and cross-sectional studies, a more comprehensive and explicit understanding of pregnancy biomechanics can be expected.

Objective: To solve the problem that the thickness and tightness of the rhizopus brick by traditional mechanical stamping JIUQU starter press were different, so as to achieve the effect of manual trampling on the liquor. Methods: Through the analysis of the existing JIUQU starter press machine in the distillery, the transmission mechanism of the mechanical stamping JIUQU starter press machine was optimized, the original crank connecting rod mechanism that controlled the movement of the JIUQU starter die was replaced by the groove cam mechanism, and the cam profile curve was inversely calculated according to the relationship between the JIUQU starter press force and the compression amount of the JIUQU starter press material, and the eleventh degree polynomial cam profile curve that conforms to the compression deformation of the JIUQU starter press material was constructed. Results: Compared with the original mechanism, it can reduce the movement time of non working stage by 75.09% and increase the movement time of working stage by 192.60%. Conclusion: After the optimization design, the JIUQU starter press force is matched with the compression amount of JIUQU starter and the effect of the optimal of best JIUQU starter press is achieved.

The fusion neutron source is of great significance for conducting material testing for future fusion reactors, as it can genuinely reflect the change of material properties under fusion neutron irradiation. The International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-driven neutron source. It still has some differences from the ideal fusion neutron source in terms of fusion neutron energy spectrum, which has led to the reconsideration of the fusion neutron source approach. In this paper, the magnetic field configuration, heating scheme design, and related calculations are carried out regarding the fusion neutron source. The plasma temperature, density evolution process, and the corresponding neutron yield of the field reversed configuration (FRC) plasma after two-stage cascade magnetic compression are analyzed, and the suppression of the magnetic fluid instabilities such as tilted and rotating modes of the FRC plasma after considering the two-fluid effect and the finite Larmor radius effect are studied. The fundamental physical parameters of the fusion neutron source are finally given. The calculation results show that the neutron source is expected to obtain fusion neutrons with an annual average power density higher than 2 MW/m2, which can meet the requirements of material testing of the demonstration reactors (DEMO). The power estimation also shows that the scheme has the potential to become an energy source based on the pulsed deuterium-deuterium fusion.

In order to solve the problems of low drilling efficiency and poor target-hitting accuracy of ground life support hole, Meihua Mine was selected as the test site of rapid and accurate drilling technology project, through the analysis of geological conditions, the adaptability of complex strata and drilling technology, and the optimization of drilling technology, the construction technology is determined as compound drilling. The hydraulic truck-mounted drilling rig and large displacement mud pump are the key equipment, which are optimized from five aspects: well structure, PDC bit, bottom hole assembly, drilling parameters and trajectory control, rapid and accurate drilling technology for complex formation with large dip angle, medium soft rock and water inrush by optimizing PDC bit, adding hydraulic single-bend auger and using wireless MWD as key bottom hole assembly. The field test shows that the life support hole reaches the well depth of 670.5 m, takes 46.83 hours, the average drilling speed is 14.32 m/h and the horizontal displacement of bottom hole is 0.27 m, which meets the requirements of drilling hole in the golden rescue time of 72 hours for 600 m deep drilling, it has the important demonstration significance of mine emergency rescue.

ObjectiveTo establish the ultra-performance liquid chromatography-tandem mass spectrometry （UPLC-MS/MS） method to detect ethanol metabolites phosphatidylethanol （PEth） in whole blood.MethodsAn appropriate amount of aqueous solution including 1% formic acid was added to 100 μL whole blood, the protein was precipitated with acetone, centrifuged and the supernatant was purified and enriched by using Bond Elut Certify column. The eluent was redissolved with 1/1 isopropanol/acetonitrile （v/v） solution after nitrogen blowing and then tested by UPLC-MS/MS. Selective reaction monitoring scanning was carried out in negative ionization mode, and quantitative analysis was performed by external standard method.ResultsPEth showed a linear relationship over the concentration range of 1-160 ng/mL in whole blood （r=0.999 9） with peak area. The detection limit was 0.2 ng/mL, the quantification limit was 1 ng/mL, the recovery rate was 97.43%-103.61%, the accuracy was 0.99%-1.77%, the intra-day precision was 0.4%-2.4%, and the inter-day precision was 1.1%-3.3%, and the matrix effect was 91.00%-99.55%. PEth was not detected in the in vitro blood samples supplemented with ethanol. PEth was detected positive in three drunk driving cases, and the concentration were 195.49， 83.67 and 876.12 ng/mL, respectively.ConclusionThe established method has high sensitivity and specificity and the analysis results are accurate. It is suitable for the qualitative and quantitative analysis of PEth in whole blood.

The spatial distribution of land use at different terrain gradients has been used as an important index for the land management and ecological restoration in the Loess Plateau of China. Based on the land use data surveyed in 2015 and digital elevation model data with a resolution of 30 m from typical village transects in the Loess Plateau area in Yan’an City, Shaanxi Province, this study analyzed the terrain niche index, distribution index, land utilization comprehensive index, and land use equilibrium degree for four village transects. The results demonstrated that the land use types in the four village transects were mainly grassland, forest land, and cropland. Land use types showed obvious differences in respect to topographical gradient with built-up land, traffic land, water bodies, cropland, and orchard distributed in low terrain gradient areas, forest land, and grassland distributed in medium- and high-terrain areas. As terrain gradient increased, the land utilization comprehensive index and land use equilibrium degree showed a generally decreasing trend. These findings may provide a useful reference for land use planning and land resource allocation in the Loess Plateau region.

Under the background of China's rapid economic development and accelerated urbanization process, the construction industry has been fully developed. However, due to the characteristics of extensive production in the construction industry, a large amount of construction waste is generated. This paper relies on the centralized resettlement project of Zhanjie Town in Gongyi City. Through the research on the key technologies such as the reuse of pile head, the reuse of steel bar head and the recycling of construction waste in engineering practice, the practical methods of construction waste recycling are analyzed, so as to better carry out the recycling of construction waste.

This paper presents a framework utilising digital twins for predictive maintenance planning of fuel cells in electric vehicles, focusing on real-time condition monitoring and Remaining Useful Lifetime (RUL) prediction. By integrating advanced algorithms, it optimises maintenance schedules to reduce downtime and extend fuel cell lifetime. Despite relying on simulated data, the findings highlight the potential of digital twins to improve fuel cell reliability, and sustainability, illustrating their transformative impact on smart urban transportation systems.

Large-scale agent-based social simulation is gradually proved to be an effective method for the study of human society.It can contribute to decision-making in social science, distributed artificial intelligence and agent technology in computer science, theory and modeling practice of computer simulation system, etc.However, the existing research practice has difficulties in balancing model complexity and simulation performance.In view of the existing problems, this paper proposes a conceptual model framework of large-scale social simulation based on agent and big data driving, and provides the reference implementation of mo-del components.Taking the epidemic prediction and control in a large-scale artificial city as an example, it illustrates how to use the proposed conceptual framework to model the large-scale social system with complex human behavior and social interaction.It also points out the potential applications in other social science fields, such as micro transportation system and urban evacuation planning.

The effect of topographic correction (TOC) has a profound influence on the quantitative application of remote sensing image. With regard to the invalid evaluation of the TOC model with such a single topographic correction assessment (TCA) method, we have selected five TCA indexes from five different perspectives: the difference in mean radiance radiometry between sunlit and shaded slopes, the cosine empirical relationship, stability, heterogeneity, and outlier ratio. The entropy weight method was used to assign weight to each TCA indexes, and the comprehensive evaluation value (CEV) of TOC for each band of remote sensing image was obtained by weighted superposition. After that, the weight of each band of the remote sensing image is determined by the entropy weight method, and the CEV of the TOC of the remote sensing image is obtained by weighting and superposition, so as to realize the effect evaluation of the six TOC models of C, SCS + C, VECA, Teillet, Minnaert, and Minnaert + SCS. The results indicate that the proposed method can effectively evaluate the correction effect of the TOC model. Results indicate that the SCS + C model has the best correction effect, while the Minnaert model performs the worst. The results generated from the Minnaert + SCS, Teillet, and Minnaert models typically show inferior quality. The SCS + C, VECA, and C models are better suited for generating images with high spectral fidelity, and these three correction models are recommended for TOCs over mountainous areas.

Background: Glioma is the result of malignant transformation of glial cells in the white matter of the brain or spinal cord and accounts for approximately 80% of all intracranial malignancies. Cathepsin A (CTSA) is highly expressed in a variety of tumor tissues, but its role in glioma is poorly studied. This study analyses the relationship between CTSA, and glioma based on The Cancer Genome Atlas (TCGA). Methods: Data for glioma patients were collected from TCGA. The expression level of CTSA was compared between paired glioma tissues and normal tissues with Wilcoxon rank-sum test. In addition, the Wilcoxon ranksum test was also applied to analyze the relationship between clinicopathologic features and CTSA expression. Kaplan-Meier Plotter was applied to analyze OS, DSS and PFI. Immuno-infiltration analysis of BLCA was performed by single sample gene set enrichment analysis (ssGSEA) in the "GSVA" R package. Results: The CTSA was overexpressed in glioma tissues compared to normal tissues (P

Background: To investigate the efficacy and safety of intravenous thrombolysis combined with mechanical stent interventional thrombectomy in the treatment of acute ischemic stroke. Methods: A retrospective analysis was carried out for clinical data of 118 patients with acute ischemic stroke. The patients enrolled were divided into control group (recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis) and thrombectomy group (mechanical stent interventional thrombectomy based on rt-PA intravenous thrombolysis). The vascular recanalization rate and clinical efficacy after treatment were compared between the two groups. National Institutes of Health Stroke Scale (NIHSS) was used to identify the degree of neurological impairment in all patients before and after treatment, and Barthel Index was used to assess their activity of daily living. Moreover, the changes in the levels of T-lymphocyte subpopulation in peripheral blood and immuno-inflammatory factors before and after treatment were compared, and prognosis of patients and incidence of adverse reactions were recorded. Results: The response rate inthrombectomy group (93.2%) was significantly better than that in control group (76.3%). The NIHSS sore and modified Rankin scale (mRS) score after treatment were significantly lower than those before treatment, while the Barthel Index after treatment was distinctly higher than that before treatment. The NIHSS score and mRS score in thrombectomy group obviously declined compared with those in control group at 1 month after treatment. The Barthel Index in thrombectomy group was obviously higher than that in control group at 1 month and 2 months after treatment. Levels of cluster of differentiation 3 (CD3)+, CD3+CD4+, CD4+/CD8+ and natural killer (NK) cells in peripheral blood at 6 months after treatment evidently rose compared with those before treatment, while level of CD3+CD8+ evidently declined compared with that before treatment. In thrombectomy group, levels of CD3+, CD3+CD4+, CD4+/CD8+ and NK cells were markedly higher than those in control group, while the level of CD3+CD8+ was markedly lower than that in control group. Besides, in thrombectomy group, levels of serum osteopontin (OPN), malondialdehyde (MDA) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were evidently lower than those in control group at 1 month after treatment, while the level of serum superoxide dismutase (SOD) was evidently higher than that in control group. Compared with that in control group, the acute vascular reocclusion rate in thrombectomy group was significantly decreased at 3 months after treatment (10.2% vs. 22.0%). Conclusions: Intravenous thrombolysis combined with mechanical stent interventional thrombectomy can effectively promote the vascular recanalization, improve the neurological function and activity of daily living of patients, reinforce the immunological function, inhibit the oxidative stress response and improve the prognosis of patients.

Coal gasification slag is a kind of solid coal chemical waste which mainly contains aluminosilicate minerals.The gasification slag modified by mechanical grinding and chemical excitation can be used as active admixture of composite Portland cement, which can effectively reduce the carbon footprint in the production and preparation of cement building materials.In order to clarify the working performance of modified gasification slag cement fresh paste, the compatibility of gasification slag-cement binary system with superplasticizer was evaluated by studying the fluidity, ζ-potential and particle size distribution of gasification slag-cement composite paste.The results show that the coal gas slag modified by diethyl alcohol monoisopropanolamine is a kind of mesoporous material, and it has good workability when the content is not more than 30 %.Polycarboxylic acid superplasticizer is beneficial to the dispersibility and fluidity of modified gas slag cement paste, and the fresh coal gas slag cement paste mixed with polycarboxylic acid superplasticizer shows modified Bingham fluid characteristics.The experimental results have high theoretical reference value for studying the workability of gas slag-cement binary system and its compatibility with superplasticizer.

ObjectiveTo investigate the inhibitory effect of cholecystokinin octapeptide （CCK-8） binding to cholecystokinin 2 receptor （CCK2R） on methamphetamine （METH）-induced neuronal apoptosis, and to explore the signal transduction mechanism of β-arrestin 2 in CCK-8 inhibiting METH-induced neuronal apoptosis.MethodsSH-SY5Y cell line was cultured, and HEK293-CCK1R and HEK293-CCK2R cell line were constructed by lentivirus transfection. Small interfering RNA （siRNA） was used to knockdown the expression of β-arrestin 2. Annexin Ⅴ-FITC/PI staining and flow cytometry were used to detect the apoptotic rate of cells, and Western blotting was used to detect the expression of apoptosis-related proteins.ResultsThe apoptosis of SH-SY5Y cells was induced by 1 mmol/L and 2 mmol/L METH treatment, the number of nuclear fragmentation and pyknotic cells was significantly increased, and the expression of apoptosis-related proteins Bax and cleaved caspase-3 were increased. CCK-8 pre-treatment at the dose of 0.1 mmol/L and 1 mmol/L significantly reversed METH-induced apoptosis in SH-SY5Y cells, and inhibited cell nuclear fragmentation, pyknosis and the changes of apoptosis-related proteins induced by METH. In lentivirus transfected HEK293-CCK1R and HEK293-CCK2R cells, the results revealed that CCK-8 had no significant effect on METH-induced changes of apoptosis-related proteins in HEK293-CCK1R cells, but it could inhibit the expression level of apoptosis-related proteins in HEK293-CCK2R cells induced by METH. The inhibitory effect of CCK-8 on METH-induced apoptosis was blocked by the knockdown of β-arrestin 2 expression in SH-SY5Y cells.ConclusionCCK-8 can bind to CCK2R and exert an inhibitory effect on METH-induced apoptosis by activating the β-arrestin 2 signal.