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With the advent of the digital era represented by “cloud, big, material, mobile, intelligent” and 5g, many new concepts and technologies have emerged, which brings both opportunities and challenges to the reform of management system of power enterprises. This paper discusses the internal control system of electric power enterprises, which from the perspective of the reform and construction of internal control system under digital conditions.

Based on the newly developed sinking headframe for the deep and large shaft, the finite element model of the full-scale headframe was established by using SAP2000. Through the calculation, the theoretical stress of the headframe at sinking depths of 40 m, 143 m, 223 m, 518 m, 762 m, 1000 m, 1250 m, and 1503 m was obtained and then compared with the field measured stress. The results show that with the increase of shaft sinking depth, the theoretical stress of finite element simulation and the field measured stress of each member of the sheave wheel platform and the headframe increase linearly, and for the maximum member stress in the upper, middle, and lower layers of the headframe, the numerical simulation value is greater than the field measured value and less than the designed steel strength. In other words, under normal working conditions, headframe members are in the elastic stress stage and meet the design requirements, and instability failure of headframe members will not occur. The end-restraint mode of the supporting bars has a great influence on the force of the top member. The reasonable selection of the restraint mode in the simulation is the key to the accuracy of the calculation results. The simulation results well reflect the actual stress of the headframe and provide a reliable guarantee for the follow-up work of the project.

Hypoxia in the tumour microenvironment is a major limiting factor in photodynamic therapy. The present study employed a novel O 2 -economised photosensitizer, ACSN, to effectively curtail oxygen consumption by impeding the aerobic respiration of tumour cells, thereby increasing the reactive oxygen species (ROS) production in photodynamic therapy. To enhance the efficacy of photodynamic therapy, the active targeting peptide iRGD was employed to facilitate drug accumulation in the tumour tissue. Therefore, we constructed a targeted drug platform, ACSN/Fe 3 O 4 @MSNs-iRGD, that integrates diagnosis and treatment. The drug exhibited excellent active targeting ability towards gastric cancer MGC-803 cells and can efficiently penetrate the mitochondria upon cellular internalisation. The photosensitizer ACSN, released from the drug, effectively suppressed mitochondrial aerobic respiration to conserve oxygen and exhibited robust ROS production upon laser excitation. The core-shell structure comprises Fe 3 O 4 , which offers excellent T2 dark contrast for real-time tumour monitoring through MRI imaging. By incorporating excellent photodynamic therapy and MRI imaging capabilities, this drug can serve as an effective platform for the integration of tumour diagnosis and treatment, thus addressing the limitations associated with conventional tumour therapies. It is anticipated that this approach will soon be clinically translated., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)