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1,864 results on '"Zhang Deqing"'

1. Multi-heterojunctioned plastics with high thermoelectric figure of merit

Author

Wang, Dongyang, Ding, Jiamin, Ma, Yingqiao, Xu, Chunlin, Li, Zhiyi, Zhang, Xiao, Zhao, Yao, Zhao, Yue, Di, Yuqiu, Liu, Liyao, Dai, Xiaojuan, Zou, Ye, Kim, BongSoo, Zhang, Fengjiao, Liu, Zitong, McCulloch, Iain, Lee, Myeongjae, Chang, Cheng, Yang, Xiao, Wang, Dong, Zhang, Deqing, Zhao, Li-Dong, Di, Chong-an, and Zhu, Daoben

Published
2024
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4. A cross-talk between integrin β4 and epidermal growth factor receptor induces gefitinib chemoresistance to gastric cancer

Author

Jia Huafeng, Zhang Deqing, Ding Yong, Zhang Yulian, and Hu Ailing

Subjects
Integrin β4, EGFR, Gastric cancer, Chemoresistance, Gefitinib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
Abstract

Abstract Background Gastric cancer presents a major health burden worldwide. Therefore, many molecular targeting agents have been evaluated for treatment of gastric cancer. Gefitinib has shown anticancer activity against gastric cancer which work through inhibiting epidermal growth factor receptor (EGFR). However, the effect of gefitinib is limited due to its resistance. Therefore, understanding the mechanisms of gefitinib resistance is desperately needed to formulate novel strategies against gastric cancer. Here, we analyzed resistance mechanism from the crosstalk between EGFR and integrin β4. Methods Integrin β4-expression vector or siRNA were used to analyze the functional effects of integrin β4 on chemoresistance of gastric cancer cells to gefitinib. EGFR and integrin β4 expression, proliferation and apoptosis of gastric cancer cells were assayed by indirect immunofluorescence, western blot, MTT and flow cytometry respectively. EGFR and integrin β4 expression were also assayed on patient samples. Results It was found that the integrin β4 expression was increased in gefitinib-resistant gastric cell line. The upregulated integrin β4 expression was identified to promote gefitinib resistance and proliferation, and inhibit apoptosis, while downregulation of integrin β4 was to inhibit gefitinib resistance and proliferation, and induce apoptosis. Moreover, the overexpression of integrin β4 in SGC7901 cells resulted in the down-regulation of p-EGFR protein levels while down-regulation of integrin β4, significantly resulted in overexpression of p-EGFR. The results of western blot from patients also showed there was obvious negative correlation between p-EGFR and integrin β4 in gastric cancer patients. Conclusion Considering the above results, it is concluded that the interaction of EGFR and integrin β4 may change the sensitivity of gefitinib treatment.

Published
2018
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11. Electric field–catalyzed single-molecule Diels-Alder reaction dynamics

Author

Yang, Chen, Liu, Zitong, Li, Yanwei, Zhou, Shuyao, Lu, Chenxi, Guo, Yilin, Ramirez, Melissa, Zhang, Qingzhu, Li, Yu, Liu, Zhirong, Houk, KN, Zhang, Deqing, and Guo, Xuefeng

Subjects
Organic Chemistry, Chemical Sciences
Abstract

Precise time trajectories and detailed reaction pathways of the Diels-Alder reaction were directly observed using accurate single-molecule detection on an in situ label-free single-molecule electrical detection platform. This study demonstrates the well-accepted concerted mechanism and clarifies the role of charge transfer complexes with endo or exo configurations on the reaction path. An unprecedented stepwise pathway was verified at high temperatures in a high-voltage electric field. Experiments and theoretical results revealed an electric field-catalyzed mechanism that shows the presence of a zwitterionic intermediate with one bond formation and variation of concerted and stepwise reactions by the strength of the electric field, thus establishing a previously unidentified approach for mechanistic control by electric field catalysis.

Published
2021

15. Confronting Racism in Chemistry Journals

Author

Burrows, Cynthia J, Huang, Jiaxiang, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J, Schanze, Kirk, Lee, T Randall, Lutkenhaus, Jodie L, Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W, Finn, MG, Blum, Joel D, Kamat, Prashant, Choi, Wonyong, Snyder, Shane, Aldrich, Courtney C, Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S, Zhang, Deqing, Ganesh, Krishna N, Atwater, Harry A, Gooding, J Justin, Allen, David T, Voigt, Christopher A, Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J, Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W, Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F, Brennecke, Joan F, Holme, Thomas A, Merz, Kenneth M, Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I, Wang, Shaomeng, Proteau, Philip, Yates, John R, Stang, Peter, Walker, Gilbert C, Hillmyer, Marc, Taylor, Lynne S, Odom, Teri W, Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J, Shea, Joan-Emma, McCoy, Anne, Zanni, Martin, Hartland, Gregory, Scholes, Gregory, Loo, Joseph A, Milne, James, Tegen, Sarah B, Kulp, Daniel T, and Laskin, Julia

Subjects
Chemical Sciences
Published
2020

16. Update to Our Reader, Reviewer, and Author CommunitiesApril 2020

Author

Burrows, Cynthia J, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J, Schanze, Kirk, Lee, T Randall, Lutkenhaus, Jodie L, Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W, Finn, MG, Blum, Joel D, Kamat, Prashant, Aldrich, Courtney C, Rowan, Stuart, Liu, Bin, Liotta, Dennis, Weiss, Paul S, Zhang, Deqing, Ganesh, Krishna N, Sexton, Patrick, Atwater, Harry A, Gooding, J Justin, Allen, David T, Voigt, Christopher A, Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J, Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W, Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F, Brennecke, Joan F, Holme, Thomas A, Merz, Kenneth M, Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I, Wang, Shaomeng, Proteau, Philip, Yates, John R, Stang, Peter, Walker, Gilbert C, Hillmyer, Marc, Taylor, Lynne S, Odom, Teri W, Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J, McCoy, Anne, Shea, Joan-Emma, Zanni, Martin, Murphy, Catherine, Scholes, Gregory, and Loo, Joseph A

Subjects
Chemical Sciences
Published
2020

17. Update to Our Reader, Reviewer, and Author Communities-April 2020.

Author

Burrows, Cynthia J, Wang, Shu, Kim, Hyun Jae, Meyer, Gerald J, Schanze, Kirk, Lee, T Randall, Lutkenhaus, Jodie L, Kaplan, David, Jones, Christopher, Bertozzi, Carolyn, Kiessling, Laura, Mulcahy, Mary Beth, Lindsley, Craig W, Finn, MG, Blum, Joel D, Kamat, Prashant, Aldrich, Courtney C, Rowan, Stuart, Bin Liu, Liotta, Dennis, Weiss, Paul S, Zhang, Deqing, Ganesh, Krishna N, Sexton, Patrick, Atwater, Harry A, Gooding, J Justin, Allen, David T, Voigt, Christopher A, Sweedler, Jonathan, Schepartz, Alanna, Rotello, Vincent, Lecommandoux, Sébastien, Sturla, Shana J, Hammes-Schiffer, Sharon, Buriak, Jillian, Steed, Jonathan W, Wu, Hongwei, Zimmerman, Julie, Brooks, Bryan, Savage, Phillip, Tolman, William, Hofmann, Thomas F, Brennecke, Joan F, Holme, Thomas A, Merz, Kenneth M, Scuseria, Gustavo, Jorgensen, William, Georg, Gunda I, Wang, Shaomeng, Proteau, Philip, Yates, John R, Stang, Peter, Walker, Gilbert C, Hillmyer, Marc, Taylor, Lynne S, Odom, Teri W, Carreira, Erick, Rossen, Kai, Chirik, Paul, Miller, Scott J, McCoy, Anne, Shea, Joan-Emma, Zanni, Martin, Murphy, Catherine, Scholes, Gregory, and Loo, Joseph A

Subjects
Chemical Sciences, General Chemistry
Published
2020

31. Targeted and Imaging-guided In Vivo Photodynamic Therapy of Tumors Using Dual-functional, Aggregation-induced Emission Nanoparticles

Author

Sun, Xianhe, zebibula, Abudureheman, Dong, Xiaobiao, Li, Gonghui, Zhang, Guanxin, Zhang, Deqing, Qian, Jun, and He, Sailing

Subjects
Quantitative Biology - Tissues and Organs, Physics - Biological Physics, Physics - Medical Physics, Physics - Optics
Abstract

Dual-functional nanoparticles, with the property of aggregation-induced emission and the capability of reactive oxygen species, were used to achieve passive/active targeting of tumor. Good contrast in in vivo imaging and obvious therapeutic efficiency were realized with a low dose of AIE nanoparticles as well as a low power density of light, resulting in negligible side effects., Comment: 30 pages, 7 figures

Published
2017

32. Facile fabrication of a nickel hydroxide@carbon nanotube composite for enhanced supercapacitance performance.

Author

Ba, Xuewei, Zhang, Huaikang, Zhou, Xiang, Cheng, Cheng, Lan, Xinyu, Han, Xinyu, Huang, Wenping, Zhang, Deqing, Yu, Yan, and Li, Shuhua

Subjects
CARBON-based materials, CARBON nanotubes, ENERGY density, COMPOSITE materials, METALLIC composites, SUPERCAPACITOR electrodes, NICKEL
Abstract

Carbon-based materials/metal hydroxide composite materials are one type of the most promising electrode materials for improving the performance of supercapacitors. They have the advantages of low cost, controllable morphology, high theoretical capacity, and excellent stability. In this study, nickel hydroxide nanosheets were grown vertically on the surface of carbon nanotubes (Ni(OH)2@CNTs) by a wet chemical method at low temperatures. The unique spatial configuration provides a larger specific surface area and exposes more electrochemically active sites, which is more conducive to improving electrochemical performance. The prominent conductivity of carbon nanotubes can quickly transfer electrons and improve the electrochemical cycling stability of the composite. The Ni(OH)2@CNTs composite exhibits excellent electrochemical performance with a specific capacitance of 1234 F g−1 at a current density of 1 A g−1 under a three-electrode system. In addition, an asymmetric supercapacitor (ASC) assembled using Ni(OH)2@CNTs as a cathode material shows an energy density of 65.63 W h kg−1 at a power density of 752.39 W kg−1 and a capacity retention rate of 85.9% after 10 000 cycles at a current density of 2 A g−1. The results indicate that Ni(OH)2@CNTs has prospects for application as a cathode material in high-performance supercapacitors. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Direct single-molecule dynamic detection of chemical reactions.

Author

Guan, Jianxin, Jia, Chuancheng, Li, Yanwei, Liu, Zitong, Wang, Jinying, Yang, Zhongyue, Gu, Chunhui, Su, Dingkai, Houk, Kendall N, Zhang, Deqing, and Guo, Xuefeng

Abstract

Single-molecule detection can reveal time trajectories and reaction pathways of individual intermediates/transition states in chemical reactions and biological processes, which is of fundamental importance to elucidate their intrinsic mechanisms. We present a reliable, label-free single-molecule approach that allows us to directly explore the dynamic process of basic chemical reactions at the single-event level by using stable graphene-molecule single-molecule junctions. These junctions are constructed by covalently connecting a single molecule with a 9-fluorenone center to nanogapped graphene electrodes. For the first time, real-time single-molecule electrical measurements unambiguously show reproducible large-amplitude two-level fluctuations that are highly dependent on solvent environments in a nucleophilic addition reaction of hydroxylamine to a carbonyl group. Both theoretical simulations and ensemble experiments prove that this observation originates from the reversible transition between the reactant and a new intermediate state within a time scale of a few microseconds. These investigations open up a new route that is able to be immediately applied to probe fast single-molecule physics or biophysics with high time resolution, making an important contribution to broad fields beyond reaction chemistry.

Published
2018

35. Nonhalogenated Solvent Processable and High‐Density Photopatternable Polymer Semiconductors Enabled by Incorporating Hydroxyl Groups in the Side Chains

Author

Gao, Chenying, primary, Li, Cheng, additional, Yang, Yiming, additional, Jiang, Ziling, additional, Xue, Xiang, additional, Chenchai, Kaiyuan, additional, Liao, Junchao, additional, Shangguan, Zhichun, additional, Wu, Changchun, additional, Zhang, Xisha, additional, Jia, Di, additional, Zhang, Fengjiao, additional, Liu, Guoming, additional, Zhang, Guanxin, additional, and Zhang, Deqing, additional

Published
2024
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