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NWP (numerical weather prediction) and statistical methods still have limitations in forecasting low visibility. Therefore, enhancing nowcasting techniques is crucial for ensuring the safety of daily life and industrial activities. A short-term visibility forecast model in Jiangsu Province PhyDNet-ATT-VIS is established based on PhyDNet-ATT (physical dynamics network with attention) deep learning method, using high spatial and temporal resolution ground observations and NWP data. Ground observations contain 1 min average horizontal visibility from automatic weather stations in Jiangsu Province, as well as its upstream regions of Anhui Province, Henan Province, and Shandong Province. NWP data are derived from PWAFS (Precision Weather Analysis and Forecast System) gridded meteorological forecast data. Temporal resolution and spatial resolutions of PWAFS forecast products are 1 h and 3 km, respectively. Due to PhyDNet-ATT-VIS's outstanding ability to handle nonlinear problems, visibility forecast from 6 h to 18 h with a spatial resolution of 3 km and a temporal resolution of 1 h is achieved, and model results are tested and evaluated. The visibility forecasting product of ECMWF (European Centre for Medium-Range Weather Forecasts) is selected to evaluate and compare the forecasting skills with that of PhyDNet-ATT-VIS. The initial forecast time of ECMWF is 0800 BT and 2000 BT every day, with the time interval of 3 h and the spatial resolution of 0.125°×0.125°. Compared to ECMWF visibility product, the rootmean square error (RMSE) and mean absolute error (MAE) of PhyDNet-ATT-VIS are reduced by 201% and 310%, respectively. Across different visibility levels, the probability of detection (POD) significantly improves, while the false alarm ratio (FAR) substantially decreases. Threat score (TS) of the forecast demonstrates a clear advantage, although the model's ability to predict low visibility (defined as visibility less than 0.2 km) in 15 h to 18 h range still requires further improvement. In terms of spatial distribution, the forecast error for visibility in lake and coastal areas is significantly lower than that in other regions for NWP. For PhyDNet-ATT-VIS, the error in areas with dense observation sites is significantly lower than that in regions with sparse observation sites. Compared to ECMWF model, PhyDNet-ATT-VIS can more accurately predict key characteristic parameters, such as affected areas, intensity, onset, and dissipation, in both regional and local fog processes. This study can provide a reliable and operationally replicable reference for improving short-term forecasting skills in visibility.

The development of edible vegetable oil is related to food security and people’s quality of life. Literature research method was adopted in this research to analyze the policy and economic environments of edible vegetable oil industry, and on this basis, production scale, sales quantity and brand competition of edible vegetable oil were sorted out. According to the production data of edible vegetable oil from 2013 to 2022, the GM (1,1) model was used to forecast the yields of edible vegetable oil in the next five years. The results revealed that the output of edible vegetable oil will decline in the future. There was a super-large market advantage in the domestic market, and the overall development of edible vegetable oil industry will be stable in the future. It is concluded that the edible vegetable oil industry may face market challenges such as consumer demand reduction, demand structure diversification and complex competition of market players in the future. The study suggested that, first, enterprises need to pay attention to the nutrition and health of edible oil products, which could ensure food quality and safety, and meet the needs of consumers for a healthy life. Second, enterprises should carry out product innovation to develop new oil products with high quality as well as lightweight, and create a new consumption scene. Third, by targeting the niche consumer market, actively expanding the market space of edible oil and stabilizing the market scale of small and medium-sized enterprises, could promote the high-quality development of the edible vegetable oil industry.

Nurses should pay more attention to nursing of patients with infections and infectious diseases, and carry out effective hygiene management and infection care to minimize the infection rate of infectious disease pathogens. This article briefly analyzed the ethical issues of infection and infectious disease care, and explored specific nursing methods for infection and infectious diseases, aiming to provide assistance and reference for modern infection and infectious disease care in China. (在面对传染与感染性疾病患者时, 护理人员需要高度重视, 开展有效的卫生管理和感染护理, 最大限度地降低传染与感染性疾病病原体的感染风险。本文针对传染与感染性疾病护理的伦理问题进行简要分析, 并探讨传染与感染性疾病的具体护理方式, 旨在为临床传染与感染性疾病护理工作提供帮助与参考。)

Voltage-gated K+ (Kv) channels play a role in the cellular processes of various cancer cells, including lung cancer cells. We previously identified and reported a salivary protein from the Xenopsylla cheopis, FS48, which exhibited inhibitory activity against Kv1.1-1.3 channels when assayed in HEK 293T cells. However, whether FS48 has an inhibitory effect on cancer cells expressing Kv channels is unclear. The present study aims to reveal the effects of FS48 on the Kv channels and the NCI-H460 human lung cancer cells through patch clamp, MTT, wound healing, transwell, gelatinase zymography, qRT-PCR and WB assays. The results demonstrated that FS48 can be effective in suppressing the Kv currents, migration, and invasion of NCI-H460 cells in a dose-dependent manner, despite the failure to inhibit the proliferation. Moreover, the expression of Kv1.1 and Kv1.3 mRNA and protein were found to be significantly reduced. Finally, FS48 decreases the mRNA level of MMP-9 while increasing TIMP-1 mRNA level. The present study highlights for the first time that blood-sucking arthropod saliva-derived protein can inhibit the physiological activities of tumour cells via the Kv channels. Furthermore, FS48 can be taken as a hit compound against the tumour cells expressing Kv channels.

为实现水下滑翔机低功耗、长航程的目标, 提高水下滑翔机升阻比是切实可行的手段之一。采用翼身融合布局设计了一款翼身融合水下滑翔机(blended-wing-body underwater glider, BWBUG), 利用NURBS样条曲线构建BWBUG的精细化参数模型, 以升阻比为优化目标, 运用组合优化算法, 开展BWBUG的多参数优化研究, 建立优化算法与黏流软件接口, 优化过程中直接耦合调用水动力计算, 大大提高了优化效率。结果表明, 优化后的BWBUG模型升力系数提升了0.58%, 阻力系数降低了10.22%, 升阻比提升12.01%, 水动力综合性能提升11.99%。文中所建立的优化方法对提高水下航行器构型优化具有重要的指导意义。

Green finance is closely related to sustainable energy development. Using the NVivo12plus software, a governance model of China's green finance policy was constructed using 22 green finance policy texts at the central level as research objects. Furthermore, based on the csQCA method, Tosmana software was used to develop and verify a theoretical model of 19 policy text cases. The research results demonstrate that policy belief, policy objectives, policy tools, policy feedback, and policy cycle are the main components of China's green finance policy governance. Furthermore, policy instruments are the fundamental factors affecting the governance effectiveness of China's green finance policy. Policy goals and policy feedback dominate the influence pattern of green finance policy in China. There are three modes driving the influence of green finance policies: regulation-oriented, collaborative-driven, and tool-guided. Finally, for the optimization and improvement of green finance policies, three forces must be improved: stimulus force, driving force, and promotion force.

Objective To investigate the correlation between BRAFV600E and different clinical features of Papillary Thyroid Carcinoma (PTC). Methods The clinical and pathological data of 164 patients diagnosed with PTC between December 2016 to December 2019 in Baoding First Central Hospital were selected, detecting the BRAFV600E gene mutation in patients and analyzing the correlation between BRAFV600E mutation rate and different clinicopathological characteristics in order to investigate the effect of BRAFV600E mutation on clinicopathological characteristics and prognosis of PTC patients. Results A total of 164 PTC patients were included, 52 (31.7%) patients had papillary thyroid carcinoma combined with Hashimoto's thyroiditis, 132 (80.5%) patients developed cervical lymph node metastasis, 48 (29.3%) patients were≥55 years old, and 108 (65.9%) patients were detected BRAFV600E mutation. Hashimoto's thyroiditis was associated with the age, lesion location, maximum tumor diameter and nodular calcification in PTC patients (P

Objective The serum levels of iron, zinc, copper and vitamin D in severe early childhood caries (S-ECC) patients were investigated and analyzed to provide reference for primary prevention and diagnosis of S-ECC children. Methods A total of 184 children were enrolled in the Children Health Department of Xinjiang Medical University Health Management Center from June 2018 to June 2019. They were divided into the caries-free (CF) group (n=89) and S-ECC group (n=95). The contents of iron, zinc, copper and vitamin D were detected. Results The serum iron content of the CF group and S-ECC group was (8.36 ± 0.42) mmol/L and (8.13 ± 0.44) mmol/L, respectively, and the difference was statistically significant (t=3.50, P < 0.001); the serum content of zinc was (83.18 ± 7.28) μmol/L and (79.23 ± 6.38) μmol/L, respectively, and the difference was statistically significant (t=3.92, P < 0.001); the serum content of 25-hydroxyvitamin D was (86.72 ± 15.83) nmol/L and (77.75 ± 11.38) nmol/L, respectively, and the difference was statistically significant (t=4.42, P < 0.001). The serum copper content of CF group and S-ECC group was (20.18 ± 4.84) μmol/L and (19.49 ± 4.62) μmol/L, but the difference was not statistically significant (t=0.97, P=0.33). Conclusion The contents of iron, zinc and vitamin D in the serum of S-ECC patients are low, suggesting that iron, zinc and vitamin D supplementation should be emphasized in the prevention and treatment of S-ECC.

Objective To investigate the effect of esmolol, a short-acting, highly selective β-blocker, on cardiomyocyte apoptosis in septic rats and its possible mechanism. Methods A total of 63 male Wistar rats were randomly divided into sham operation group (Sham group), sepsis group (CLP group), and esmolol group (ES group). Each group was further divided into 6-, 12-, and 24-hour subgroups. The rats of the Sham group were given sham surgery only, and those of the CLP and ES groups underwent cecal ligation and puncture (CLP) to establish sepsis model. The Sham group and the CLP group were continuously infused with 0.9% sodium chloride solution at a speed of 1 mL/h by micropump for 6 h, while the ES group was continuously infused with 15 mg/kg·h esmolol diluted solution at 1 mL/h for 6 h. Then the rats were sacrificed at 6, 12 and 24 h after successful modeling, and the heart specimens were collected. Serum TNF-α and BNP levels were measured by ELISA. Water soluble tetrazolium (WST-1) method was used to detect SOD activity, and spectrophotometry to determine MDA content in myocardial tissue. The expression levels of Caspase-3, Bcl-2, Bax and other proteins in myocardial tissue were detected by Western blotting. Transmission electron microscopy was performed to observe the morphology and structure of myocardial mitochondria. Results Compared with the levels at the same time points in Sham group, the serum TNF-α and BNP levels, MDA content, and expression levels of apoptotic proteins such as Caspase-3 and Bax were significantly increased in the CLP and ES groups (P < 0.05). Except the level of BNP in ES24h group was not significantly different than that in CLP24h group (P>0.05), ES group had obviously decreased serum TNF-α and BNP levels, MDA content, and expression levels of Caspase-3 and Bax when compared with those in the CLP group at same time points (P < 0.05). The SOD activity and Bcl-2 level were remarkably higher in the CLP and ES groups at the same time points (P < 0.05), and the activity and levels were increased in the ES group than the CLP group at all time points (P < 0.05). Under a transmission electron microscope, myocardial fibers and mitochondria were almost intact in the Sham group at all time points; the damages were the most severe in the CLP group, and the severity was deteriorated gradually with time elapse, while the conditions became alleviated in the ES group at each time point. Conclusion Esmolol partially improves cardiac function in septic rats by inhibiting cardiomyocyte apoptosis. The mechanism may be due to its inhibition in apoptosis initiation factor TNF-α and regulation in the expression of apoptosis-related proteins such as Bcl-2, Bax, and Caspase-3, and reduction of the oxidative stress response as well. It mediates both the accompanying process of apoptosis and an important initiator of apoptosis, and protects the mitochondrial structure of target organelles damaged by apoptosis and oxidative stress.

Objective To assess the diagnostic value of whole body 18F-fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT imaging) in cancer of unknown primary (CUP) and provide references for the detecting strategy of patients with unknown primary metastases. Methods The studies concerning diagnostic value of whole body 18F-FDG PET/CT imaging in the search for primary lesions of CUP were retrieved and screened from the published English and Chinese literatures from January 2010 to March 2019. After data extraction and quality evaluation, the calculation of summary receiver operating pooled sensitivity, specificity and 95%CI, and demonstrated the plots based on the calculation. Summary receiver operating characteristic (SROC) and a funnel graph were drawn. Finally, heterogeneity of the included studies was tested and exploration of the source of the heterogeneity was also included if necessary. Results Eighteen studies were finally included. The pooled sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (-LR), diagnostic odds ratio and the corresponding 95%CI, for diagnosis of CUP were 0.88 (95%CI: 0.81~0.92), 0.76 (95%CI: 0.65~0.84), 3.61 (95%CI: 2.4~5.4), 0.16 (95%CI: 0.10~0.27), and 22 (95%CI: 11~46), respectively. The area under the SROC curve (AUC) was 0.89 (95%CI: 0.86~0.92). Conclusion 18F-FDG PET/CT shows sound diagnostic efficiency in detection of primary lesion site in patients with CUP, and is worthy of extensive application and promotion in clinical practice. It is worth noting that future studies should clear the definition of CUP.

The concept of low-carbon green development has become a global consensus, and the servitization of manufacturing is a feasible path to achieving green development in manufacturing. This paper takes manufacturing enterprises in 27 provinces and cities in China from 2006 to 2019 as samples, and empirically analyzes the effects of manufacturing servitization to promote carbon emission reduction in a low-carbon economy, which shows that: manufacturing servitization can reduce carbon emissions, and informatization, urbanization and energy structure optimization promote carbon emission reduction; in the less developed and backward central and western regions of the economy, manufacturing servitization promotes carbon emission reduction The effect is obvious. In the future, China should give full play to the digital economy's new advantages, optimize the manufacturing industry's energy use structure, and take the lead in promoting the servitization of the manufacturing industry in less economically developed regions.

Since the outbreak of a large-scale epidemic can trigger fear and uncertainty, disease and death, and cause a great disruption to daily life while having a significant negative impact on the national and world economies, effective planning and research to deal with the spread of epidemics are of great importance. Since the outbreak of COVID-19 in 2019, applied mathematical-statistical models have been widely used in the control and research of world epidemics. In their response to the COVID-19 pandemic, countries and the World Health Organization (WHO) have used a variety of statistical tools and mathematical models to respond to and combat pandemic diseases. The continuing threat posed by infectious diseases has led to renewed research efforts around the world. This paper analyzed 13 relevant articles from 2010 to 2022, summarized and analyzed the main contributions of statistical and mathematical models in epidemic prevention and control, and put forward suggestions for future research directions, to increase the significance of data-based statistics for the study of infectious diseases, emphasizes the role and advantages of statistical and mathematical models in the control of infectious diseases, and advocates expanding the use of mathematical modelling of epidemics and encouraging increased cross-border collaboration in epidemiology among other related disciplines. This will bring a lot of benefits to future epidemiological research.

In order to study the influence of different incline angles on the shape of top coal caving body, and the influence of different strike angles and different caving styles on the top coal caving rate of large angle fully mechanized top coal caving face, this paper carried out the numerical simulation of caving process based on the engineering geological conditions of No.10 fully mechanized top coal caving face in Pangpangta Coal Mine. It is found that: with the increase of dip angle, the flow speed of top coal accelerates and the discharge amount of coal increases, and the top coal develops at the upper end of dip angle, and the coal rock interface tends to be asymmetrical from symmetry on both sides of the coal caving mouth; with the increase of dip angle, the rate of coal released from top coal decreases continuously, and the rate of coal released from top coal mining is higher than that from top coal mining; the step distance of coal released is 0.8 m, 1.6 m, 2.4 m, when the strike angle is 0°, the top coal caving rate reaches the maximum value; when the strike angle is fixed, the caving rate is the highest when the step distance of caving is 1.6 m; when the mining caving ratio is 1∶2, 1∶2.5, 1∶3, the larger the mining caving ratio is, the higher the top coal caving rate will be; multi-round sequential caving has obvious advantages, and the coal caving rate of working face reaches 86.33%.

Advancements in deep neural networks have led to significant progress in computer vision and natural language processing. These networks, trained on real-world stimuli, develop high-level feature representations of stimuli. It is hypothesized that these representations, stemming from different inputs, should converge into similar conceptual systems, as they reflect various perspectives of the same underlying reality. This paper examines the degree to which different conceptual systems can be aligned in an unsupervised manner, using feature-based representations from deep neural networks. Our investigation centers on the alignment between the image and word representations produced by diverse neural networks, emphasizing those trained via self-supervised learning methods. Subsequently, to probe comparable alignment patterns in human learning, we extend this examination to models trained on developmental headcam data from children. Our findings reveal a more pronounced alignment in models trained through self-supervised learning compared to supervised learning, effectively uncovering higher-level structural connections among categories. However, this alignment was notably absent in models trained with limited developmental headcam data, suggesting more data, more inductive biases, or more supervision are needed to establish alignment from realistic input.

On the basis of theoretical analysis of the working mechanism of traditional magnetic field modulation gear,a cylinder type linear magnetic gear is designed,whose transmission ratio is 2. 67. Its air- gap flux density and static thrust characteristics and dynamic thrust characteristics are calculated by using the finite element analysis method. The correctness of the design is validated through the calculate results. Based on the above,the influence of magnetic field modulate ring size on the gear static thrust and the change rule of the influence are analyzed,and a basis for parameter optimization of a linear magnetic gear is provided. At the last,the optimization of relative width of magnetic field modulate ring is to 0. 6 and the thickness to 3 mm,the air gap width of high- speed side to 1. 2 mm.