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3. Preparation and Oxidation Resistance Mechanism of Silicide Coating on MoNbTaTiW Refractory High-Entropy Alloy

Author

HAN Jie-sheng, SU Bo, ZHANG Ai-jun, MENG Jun-hu, WU You-zhi

Subjects
silicide coating, refractory high-entropy alloy, slurry fusion sintering, anti-oxidation coating, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology
Abstract

Solving the oxidation resistance problem of refractory high-entropy alloy at high temperature is the premise of application in engineering.The preparation of anti-oxidation coating on the surface of refractory metal is an effective way to improve its oxidation resistance.A complex silicide anti-oxidation coating(Si-20Cr-20Fe)was prepared on the surface of MoNbTaTiW refractory high-entropy alloy by slurry fusion sintering method.The microstructure, phase and composition of the initial silicide coating and the coating after oxidation at 1 300 ℃ were studied by SEM, EDS and XRD.The diffusion law of Si, Fe and Cr in the coating and the anti-oxidant mechanism of the coating were explored.Results showed that the initial silicide coating after melting was composed of disilicide, 5/3 silicide and ternary silicide Cr4Nb2Si5 formed by the reaction between metal and silicon.A good diffusion reaction interface was formed between the silicide coating and the substrate.After oxidation at 1 300 ℃, Si, Fe and Cr diffused to the substrate, and the diffusion reaction interface layer moved to the substrate, consequently the coating thickness was increased.The microstructure and composition of the diffusion reaction interface layer were almost the same as the diffusion layer of the complex initial silicide coating.After oxidation, a crack-free, dense oxide layer was formed on the surface of the coating.The layer was composed of CrNbO4, SiO2, WO3 and Fe2SiO4, and it could prevent the further diffusion of oxygen to the inside of substrate.Si, Fe and Cr had different diffusion rates in MoNbTaTiW refractory high-entropy alloy.The diffusion rate of Si was the fastest, Fe was the second, and Cr was the slowest.Therefore, Fe and Cr were enriched in the low silicon content diffusion layer and silicide layer.The complex silicide coating prepared by slurry fusion sintering could provide good anti-oxidation protection for MoNbTaTiW refractory high-entropy alloy at high temperatures.

Published
2022
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41. Development and Validation of an Automatic Image-Recognition Endoscopic Report Generation System: A Multicenter Study

Author

Qu, Jun-yan, primary, Li, Zhen, additional, Su, Jing-ran, additional, Ma, Ming-jun, additional, Xu, Chang-qin, additional, Zhang, Ai-jun, additional, Liu, Cheng-xia, additional, Yuan, Hai-peng, additional, Chu, Yan-liu, additional, Lang, Cui-cui, additional, Huang, Liu-ye, additional, Lu, Lin, additional, Li, Yan-qing, additional, and Zuo, Xiu-li, additional

Published
2020
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50. Comparative proteomics reveal negative effects of gonadotropin-releasing hormone agonist and antagonist on human endometrium

Author

Chen,Qian, Yu,Feng, Li,Yan, Zhang,Ai-Jun, and Zhu,Xiao-Bin

Subjects
endocrine system, Drug Design, Development and Therapy, hormones, hormone substitutes, and hormone antagonists
Abstract

Qian Chen,1,* Feng Yu,2,* Yan Li,1 Ai-Jun Zhang,1 Xiao-Bin Zhu,11Center of Reproductive Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this work Purpose: The two major ovarian-stimulation protocols for in vitro fertilization are gonadotropin-releasing hormone agonist (GnRH-a) protocol or GnRH antagonist (GnRH-ant) protocol; however, comparisons of their relative efficacy remain controversial. Additionally, conflicting data exist regarding their effects on endometrial receptivity. Thus, this study investigated how GnRH-a and GnRH-ant treatments alter the endometrium during the mid-secretory phase.Patients and methods: We compared proteomic profiles across human endometrium tissues of mid-secretory phase from normal control humans (n=5), patients treated with GnRH-a (n=5), and patients treated with GnRH-ant (n=5).Results: We identified 2088 proteins, with 362 that exhibited significantly different expression. Fuzzy c-means clustering (FCM) using the M Fuzz algorithm analysis showed that the same 87 proteins changed significantly in both the GnRH-a and GnRH-ant groups compared with those in the control. Moreover, Gene Ontology (GO) analysis showed that, of these 87, downregulated proteins were associated with energy metabolism and upregulated proteins were linked to cytoskeleton maintenance. Upregulated proteins involved in complement-mediated immunity were present in 151 proteins that exhibited significantly different expression in the GnRH-ant group only.Conclusion: We demonstrated that comparative proteomic analysis is useful for accessing endometrial receptivity, which seemed more strongly impaired by GnRH-ant than GnRH-a treatments. Our findings also revealed that energy metabolism and immunity response may be the key biological mechanisms underlying human endometrial receptivity.Keywords: endometrial receptivity, proteomic profile, energy metabolism, complement-mediated immunity

Published
2019

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