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Objective To study preliminary research training of eight-year program of clinical medicine through student evaluation. Methods A total of 202 students from the 2016 and 2017 grades of eight-year program of clinical medicine of xiangya school of medicine were given a corresponding questionnaire to describe the relevant problems and conduct analysis. Results Among the students from grade 2017,70.0% believe the course schedule is reasonable, 52.5% think the preliminary research training is meaningful and does stimulate students' interests. 77.5% of students are willing to enter the medical school earlier. However, 57.5% of them disagreed with the evaluation of students learning results by scores and 85.0% believe that the basic course is beneficial. Totally 92.5% of students think that there is little inspiration in the experiment class, 67.5% have little new understanding of the research process. And 50.0% are willing to study non-medical issues. As high as 97.5% of students will re-select eight-year program of clinical medicine. Students believe that it is the most important to focus on experimental ability and that the lack of medical knowledge impedes selecting research fields the most. Among students from grade 2016, 51.2% think the course schedule is unreasonable, 51.2% have little new understanding of the research process. 80.5% are satisfied with the implementation of preliminary research training. Students think that it is most important to build capacity of innovation and that the lack of information about frontier progress impedes selecting research fields interested. Conclusions The combination of the preliminary research training and experimental courses in the same stage is feasible.

Pulmonary arterial hypertension (PAH) is a severe disease characterized by abnormal pulmonary vascular remodeling and increased right ventricular pressure load, posing a significant threat to patient health. While some pathological mechanisms of PAH have been revealed, the deeper mechanisms of pathogenesis remain to be elucidated. In recent years, bioinformatics has provided a powerful tool for a deeper understanding of the complex mechanisms of PAH through the integration of techniques such as multi-omics analysis, artificial intelligence, and Mendelian randomization. This review focuses on the bioinformatics methods and technologies used in PAH research, summarizing their current applications in the study of disease mechanisms, diagnosis, and prognosis assessment. Additionally, it analyzes the existing challenges faced by bioinformatics and its potential applications in the clinical and basic research fields of PAH in the future. [ABSTRACT FROM AUTHOR]

Sphydrofuran is a secondary metabolite produced by Actinomycetes. The first total synthesis of sphydrofuran was achieved by Maliakel and Schmid using a chemoenzymatic approach. A new approach synthesized sphydrofuran and its furan derivative, and secosyrins 1 and syributins 1 and 2, from one precursor. This was achieved beginning from 3-tri-n-butylstannylfuran or 3-bromofuran.

X-ray crystallography was used to characterize a new Schiff base ligand, 2-chlorobenzaldehyde thiosemicarbazone and two cadmium halide complexes, CdL2Br2 and CdL2I2. The results showed that CdL2Br2 has powder SHG efficiencies that is about 20 times that of urea while CdL2I2 does not exhibit any SHG efficiency. The findings appear to support the theory that the intermolecular contact between the cadmium and halide atom is mainly responsible for controlling the SHG efficiencies of the compounds.

Pulmonary arterial hypertension (PAH) is a severe disease characterized by abnormal pulmonary vascular remodeling and increased right ventricular pressure load, posing a significant threat to patient health. While some pathological mechanisms of PAH have been revealed, the deeper mechanisms of pathogenesis remain to be elucidated. In recent years, bioinformatics has provided a powerful tool for a deeper understanding of the complex mechanisms of PAH through the integration of techniques such as multi-omics analysis, artificial intelligence, and Mendelian randomization. This review focuses on the bioinformatics methods and technologies used in PAH research, summarizing their current applications in the study of disease mechanisms, diagnosis, and prognosis assessment. Additionally, it analyzes the existing challenges faced by bioinformatics and its potential applications in the clinical and basic research fields of PAH in the future.

To investigate the relationship between NFAT and C5a/C5aR in C5a/C5aR-mediated kidney Ischemia/reperfusion (I/R) injury, the rats' NRK-52E cell line was used in this study and was distributed into 4 groups, I: the normal control (NC), II: the ischemia/reperfusion (I/R) injury cell model (MG), III: the ischemia/reperfusion (I/R) injury cell model treated with C5a (50 nmol/l) (MG + C5a), IV: the ischemia/reperfusion (I/R) injury cell model treated with C5aR antagonist (2.5 μmol/l) (MG + anti-C5aR). Reverse transcription polymerase chain reaction (RT-PCR), western blot, immunofluorescence and flow cytometry were performed. Nuclear Factor Activated T Cell (NFAT), tumor necrosis factor-α (TNF-α) and interleukin (IL-6) were detected in this study. The results of immunofluorescence showed that NFAT had a nuclear translocation phenomenon during the study. The RT-PCR and WB data indicated that the expression of TNF-α and IL-6 in group III were higher than any other groups. Apoptosis in group III was much serious than other groups. All the results in this study showed that NFAT plays an important role in ischemia/reperfusion injury, it can be induced to up-regulate the inflammatory factor TNF-α and IL-6 by the complement system member C5a/C5aR.

Objective: To improve the recognition of thoracic involvement of Castleman' s disease., Methods: Ten patients with thoracic involvement of Castleman' s disease were retrospectively studied by review of the clinical manifestations, radiology, pathology, differential diagnosis, therapy and prognosis., Results: The 10 patients were all females. Five of the patients, aged from 29 to 49 years, presented with multicentric lesions, manifested by interstitial pneumonia and mediastinal lymphadenopathy on radiology, as well as extrathoracic involvement including peripheral lymphadenopathy, and multiple organ impairment. The pathology was the plasma cell type. Treatment with corticosteroids and chemotherapy achieved partial remission in 4 cases, but 1 died of cardiac and respiratory failure. Localized lesions were found in the other 5 patients, aged from 13 to 49 years. No specific manifestations were revealed in these patients. The major radiological sign was right mediastinal masses, 6-9 cm in diameter, uniformly enhanced by contrast radiology. The pathology revealed vascular hyaline degeneration. Early surgical resection achieved good prognosis. The 5 patients were all alive., Conclusions: Diagnosis of thoracic involvement of Castleman' s disease is not easy. Early, repeated and multiple biopsy of lymph nodes is recommended, especially when the disease is multicentric or when the lymph nodes are massive. Synchronous enhancement with the vessels on contrast radiology is suggestive of the diagnosis.