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Background and purpose: Deep brain stimulation (DBS) has emerged as a promising treatment for movement disorders. This prospective study aims to evaluate the effects of bilateral subthalamic nucleus DBS (STN‐DBS) on motor and non‐motor symptoms in patients with primary Meige syndrome. Methods: Thirty patients who underwent bilateral STN‐DBS between April 2017 and June 2020 were included. Standardized and validated scales were utilized to assess the severity of dystonia, health‐related quality of life, sleep, cognitive function and mental status at baseline and at 1 year and 3 years after neurostimulation. Results: The Burke−Fahn−Marsden Dystonia Rating Scale movement scores showed a mean improvement of 63.0% and 66.8% at 1 year and 3 years, respectively, after neurostimulation. Similarly, the Burke−Fahn−Marsden Dystonia Rating Scale disability scores improved by 60.8% and 63.3% at the same time points. Postoperative quality of life demonstrated a significant and sustained improvement throughout the follow‐up period. However, cognitive function, mental status, sleep quality and other neuropsychological functions did not change after 3 years of neurostimulation. Eight adverse events occurred in six patients, but no deaths or permanent sequelae were reported. Conclusions: Bilateral STN‐DBS is a safe and effective alternative treatment for primary Meige syndrome, leading to improvements in motor function and quality of life. Nevertheless, it did not yield significant amelioration in cognitive, mental, sleep status and other neuropsychological functions after 3 years of neurostimulation. [ABSTRACT FROM AUTHOR]

The determination of multiple per- and poiyfiuoroaikyi substances (PFAS) migrating from food contact material gained in importance as an increasing range of PFAS has been found migrating from food contact [...]

The development of non-noble metal catalysts that exhibit high performance in the dehydrogenation of ammonia borane has been considered a safe and efficient method for hydrogen generation. In this study, a series of CuxCoy alloy nanoparticles with different ratios were highly dispersed on a core–shell microsphere carrier, and the carrier was prepared using carbon spheres as a template. The catalytic activity for H2 from ammonia borane (NH3BH3, AB) hydrolysis was investigated by adjusting the ratio of Cu2+ to Co2+ doping in the catalyst. The Co1Cu1/C@Cu0.76Co2.24O4 core–shell heterostructure catalyst shows excellent catalytic activity with a high turnover frequency (TOF) value of 82.58 molH2 molcat−1 min−1 and a low activation energy (Ea) of 16.06 kJ mol−1. Detailed analysis indicates that the outstanding activity of AB for hydrolytic dehydrogenation could be attributed to the unique core–shell hetero-structures and high dispersion of the CuCo alloy nanoparticles. [ABSTRACT FROM AUTHOR]

In order to ensure the high precision and good dynamic characteristics of the dual‐axis linear motor when machining components, the tracking error and contour error should be reduced with more complex machining trajectory. In this study, the characteristic model of position control of the linear motor is established by using the modelling principle of the characteristic model, and the intelligent adaptive controller is designed. In addition, a new calculation method of the equivalent contour error is proposed innovatively, and the dual axis is compensated by proportional feedback control, to improve the contour accuracy of the permanent magnet synchronous linear motor dual‐axis control system. Finally, through the simulation and experiment of the dual‐axis motor platform, the effectiveness of the proposed contour error calculation method and the intelligent adaptive controller can make the dual‐axis motion control system have higher accuracy and strong robustness and can also make the motor run more smoothly. [ABSTRACT FROM AUTHOR]

Background and Purpose: The role of the cerebellum in olfactory function is not fully understood. In this study, we tried to combine resting state and task functional MRI (fMRI) to improve the understanding of the cerebellum during olfactory processing.Methods: A resting state and a block paradigm of olfactory stimulation fMRI were scanned in 50 subjects. The olfactory stimuli, including phenylethyl alcohol and isovaleric acid, were alternately delivered to the subject using a custom-built olfactometer through air flow. The cerebellar activations elicited by isovaleric acid were subsequently used in the seed-based resting-state functional connectivity study.Results: Phenylethyl alcohol did not induce any cerebellum activation, while isovaleric acid with a more unpleasant smell elicited significant cerebellum activations, primarily in the bilateral posterior lateral hemispheres (bilateral lobule crus I and right lobule VI). Seed-based functional connectivity analysis revealed significant within-cerebellum and corticocerebellar connections.Conclusions: The results imply that the cerebellum is probably involved in olfactory-related responses caused by unpleasant odor but does not directly participate in olfactory perception. Our results may further improve the understanding of the cerebellum in olfactory function. [ABSTRACT FROM AUTHOR]