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9 results on '"Zhang, Zhongzi"'

6. Biomechanical analysis and clinical effects of bridge combined fixation system for femoral fractures

Author

Daxing Wang, Qi Pu, Ying Xiong, Zhang Zhongzi, Fu Jia, Shao Gu, Hong Deng, Bailian Liu, and Qunhui Li

Subjects
Adult, Male, medicine.medical_treatment, Bone Screws, Finite Element Analysis, Walking, Bone healing, Fracture Fixation, Internal, Young Adult, Fixation (surgical), Flexural strength, Bone plate, Humans, Medicine, Displacement (orthopedic surgery), Femur, Bridge (dentistry), Aged, Orthodontics, business.industry, Mechanical Engineering, General Medicine, Middle Aged, Biomechanical Phenomena, Bending stiffness, Female, Stress, Mechanical, Implant, business, Bone Plates, Femoral Fractures
Abstract

This work aimed to compare the stress distribution and mechanical properties of our bridge combined fixation system and commonly used metal locking plate screw system by finite element analysis and by using the Zwick/Z100 testing machine. In addition, we also investigated the clinical outcome of our bridge combined fixation system for femoral fractures in 59 patients from June 2005 to January 2013. As a result, the stress distribution in the bone plate and screws of metal locking plate screw system during walking and climbing stairs was significantly lower than that of metal locking plate screw system. No significant difference in the displacement was observed between two systems. The equivalent bending stiffness of bridge combined fixation system was significantly lower than that of metal locking plate screw system. There were no significant differences in the bending strength, yield load, and maximum force between two systems. All the cases were followed up for 12–24 months (average 18 months). The X-ray showed bone callus was formed in most patients after 3 months, and the fracture line was faint and disappeared at 6–9 months postoperatively. No serious complications, such as implant breakage and wound infection, occurred postoperatively. According to self-developed standard for bone healing, clinical outcomes were rated as excellent or good in 55 out of 59 patients (success rate: 93.2%). Therefore, our findings suggest that our bridge combined fixation system may be a promising approach for treatment of long-bone fractures.

Published
2014

8. Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies

Author

Fu Jia, Qi Pu, Qunhui Li, Bailian Liu, Zhang Zhongzi, Junmin Li, Ying Xiong, Daxing Wang, Zhao Feng, Rui-Fen Sun, and Jin Yan

Subjects
medicine.medical_specialty, Genotype, Osteoporosis, Calcitriol receptor, vitamin D deficiency, Bone Density, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Amplified Fragment Length Polymorphism Analysis, Deoxyribonucleases, Type II Site-Specific, Genetics (clinical), Osteoporosis, Postmenopausal, Bone mineral, Polymorphism, Genetic, biology, business.industry, General Medicine, Odds ratio, Middle Aged, medicine.disease, Endocrinology, Meta-analysis, Osteocalcin, biology.protein, Receptors, Calcitriol, Female, business, Polymorphism, Restriction Fragment Length
Abstract

Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs).The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (bb vs. BB: OR=0.61, 95% CI, 0.40-0.92; bb vs. BB/Bb: OR=0.70, 95% CI, 0.52-0.95, respectively). Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in postmenopausal women (bb vs. BB/Bb: OR=0.68, 95% CI, 0.46-0.98) and Africans (Bb/bb vs. BB: OR=0.18, 95% CI, 0.09-0.37).The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.

Published
2012

9. [Modified retrograde rotative-type interlocking intramedullary nail for humeral shaft fractures].

Author

Wang D, Xiong Y, Deng H, Liu B, Li Q, Zhang Z, and Jia F

Subjects
Adolescent, Adult, Aged, Bone Nails, Female, Fracture Fixation, Intramedullary methods, Humans, Internal Fixators, Male, Middle Aged, Young Adult, Fracture Fixation, Intramedullary instrumentation, Humeral Fractures surgery
Abstract

Objective: To improve the retrograde rotative-type interlocking intramedullary nail based on humeral bone dissection and clinical application, and investigate the clinical values of modified retrograde rotative-type interlocking intramedullary nail for humeral shaft fracture., Methods: Between March 2006 and March 2010, 146 patients with humeral shaft fractures were treated and fractures were fixed with the modified retrograde rotative-type interlocking intramedullary nail (the modified group, n=73) and with the retrograde rotative-type interlocking intramedullary nail (the original group, n=73). In the original group, there were 40 males and 33 females with an average age of 41 years; 41 cases were classified as transverse fracture, 18 as oblique fracture, 8 as spiral fracure, and 6 as comminuted fracture; the median disease duration was 11 days (range, 3 hours to 2 months); and close reduction fixation was performed in 27 cases and open reduction fixation in 46 cases. In the modified group, there were 39 males and 34 females with an average age of 40 years; 43 cases were classified as transverse fracture, 16 as oblique fracture, 10 as spiral fracure, and 4 as comminuted fracture; the median disease duration was 13 days (range, 3 hours to 3 months); and close reduction fixation was performed in 31 cases and open reduction fixation in 42 cases. There was no significant difference in sex, age, fracture type, and disease duration between 2 groups (P > 0.05). The fracture healing and functional recovery of affected limbs were compared between 2 groups after operation., Results: The operation time and intraoperative blood loss in the modified group were significantly less than those in the original group (P < 0.05). Iatrogenic fracture occurred in 3 cases of the original group, which were cleavage fracture of supracondylar. No iatrogenic fracture occurred in the modified group. All incisions of 2 groups healed by first intention without complications of postoperative infections, metal fracture, and loosening of internal fixation, etc. A total of 116 patients were followed up more than 12 months in 2 groups with 58 patients in each group. The fracture healing time was (15 +/- 3) weeks (fresh fracture) and (30 +/- 12) weeks (old fracture and nonunion) in the modified group, and was (16 +/- 4) weeks (fresh fracture) and (35 +/- 14) weeks (old fracture) in the original group, showing significant differences between 2 groups (P < 0.05). The results of Neer shoulder score were excellent in 65 cases and good in 8 cases, and the results of Aitken and Rorabeck elbow function score were excellent in 61 cases and good in 12 cases in the original group; the results of Neer shoulder score were excellent in 67 cases and good in 6 cases, and the results of Aitken and Rorabeck elbow function score were excellent in 63 cases and good in 10 cases; and the excellent and good rates were 100% in 2 groups., Conclusion: The modified retrograde rotative-type interlocking intramedullary nail has the advantages of easy operation and less complication, which is an effective and reliable internal fixator.

Published
2011

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