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28 results on '"Zhang, Zhibao"'

10. Epstein‐Barr virus‐encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan‐2 and synaptotagmin‐like‐4 in nasopharyngeal carcinoma cells

Author

Liao, Chaoliang, primary, Zhou, Qin, additional, Zhang, Zhibao, additional, Wu, Xia, additional, Zhou, Zhuan, additional, Li, Bo, additional, Peng, Jinwu, additional, Shen, Liangfang, additional, Li, Dan, additional, Luo, Xiangjian, additional, and Yang, Lifang, additional

Published
2020
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16. Reply

Author

Shen, Ling, primary, You, Qi Sheng, additional, Xu, Xiaolin, additional, Gao, Fei, additional, Zhang, Zhibao, additional, Li, Bin, additional, and Jonas, Jost B., additional

Published
2016
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19. Scleral Thickness in Chinese Eyes

Author

Shen, Ling, primary, You, Qi Sheng, additional, Xu, Xiaolin, additional, Gao, Fei, additional, Zhang, Zhibao, additional, Li, Bin, additional, and Jonas, Jost B., additional

Published
2015
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21. Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Author

Yu,Zhan, Yu,Min, Zhou,Zhimin, Zhang,Zhibao, Du,Bo, Xiong,Qingqing, Yu,Zhan, Yu,Min, Zhou,Zhimin, Zhang,Zhibao, Du,Bo, and Xiong,Qingqing

Abstract

Zhan Yu,1,* Min Yu,2,* Zhimin Zhou,3 Zhibao Zhang,3 Bo Du,3 Qingqing Xiong3 1Second Artillery General Hospital, Beijing, 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical University, Shenyang, 3Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Key Laboratory of Biomedical Material of Tianjin, Tianjin, People’s Republic of China *These authors contributed equallyto this work Abstract: Controlled-release carriers for local drug delivery have attracted increasing attention for inner-ear treatment recently. In this paper, flower-shaped bovine serum albumin (FBSA) particles were prepared by a modified desolvation method followed by glutaraldehyde or heat denaturation. The size of the FBSA particles varied from 10 µm to 100 µm, and most were 50–80 µm. Heat-denatured FBSA particles have good cytocompatibility with a prolonged survival time for L929 cells. The FBSA particles were utilized as carriers to investigate the release behaviors of the model drug – rhodamine B. Rhodamine B showed a sustained-release effect and penetrated the round-window membrane of guinea pigs. We also confirmed the attachment of FBSA particles onto the round-window membrane by microscopy. The FBSA particles, with good biocompatibility, drug-loading capacity, adhesive capability, and biodegradability, may have potential applications in the field of local drug delivery for inner-ear disease treatment. Keywords: bovine serum albumin (BSA), controlled release, local delivery, round-window membrane

Published
2014

25. Prevalence of Otitis Media With Effusion Among Children in Xi'an, China : A Randomized Survey in China's Mainland

Author

Zhang, Qing, Wei, Junrong, Xu, Min, Zhang, Quanan, Zhang, Xiaotong, Zhang, Zhibao, Dang, Shaonong, Huang, Xinsheng, Anniko, Matti, Hellström, Sten, Duan, Maoli, Zhang, Qing, Wei, Junrong, Xu, Min, Zhang, Quanan, Zhang, Xiaotong, Zhang, Zhibao, Dang, Shaonong, Huang, Xinsheng, Anniko, Matti, Hellström, Sten, and Duan, Maoli

Abstract

Objectives: We sought to identify the prevalence of otitis media with effusion (OME) in urban Chinese children in Xi'an, China. Methods: Five kindergartens and 3 primary schools were randomly selected in the urban area of Xi'an. Screening otoscopic and tympanometric examinations were performed on 2,902 children (1,491 boys and 1,411 girls) 2 to 8 years of age. Children with an abnormal tympanogram and simultaneous otomicroscopic signs of effusion were given a diagnosis of OME. Results: The overall prevalence of OME was 4.3%. By age group, the prevalence was 14.0% in 2-year-olds, 8.3% in 3-year-olds, 5.0% in 4-year-olds, 4.9% in 5-year-olds, 2.8% in 6-year-olds, 1.7% in 7-year-olds, and 3.2% in 8-year-olds. The prevalence rate for OME was 4.7% for boys versus 3.9% for girls, and 3.0% in the right ear versus 2.7% in the left, showing no statistically significant difference between genders or between ear sides (p > 0.05). Conclusions: The prevalence of OME in urban areas of Xi'an is not high in comparison with that of the same age group in surrounding areas.

Published
2011

26. Macular thickness in Chinese

Author

Shen, Ling, primary, Gao, Fei, additional, Xu, Xiaolin, additional, Lin, Zhong, additional, Zhang, Zhibao, additional, Zhao, Bowen, additional, Zhang, Xu, additional, Li, Bin, additional, and Jonas, Jost B., additional

Published
2012
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28. [Retinoblastoma spontaneous regression: clinical and histopathologic analysis].

Author

Xu X, Li B, Wang Y, Gao F, and Zhang Z

Subjects
Chemotherapy, Adjuvant, Eye pathology, Female, Humans, Infant, Male, Necrosis, Neoplasm Invasiveness, Optic Nerve, Retinal Neoplasms therapy, Retinoblastoma therapy, Retrospective Studies, Neoplasm Regression, Spontaneous, Retinal Neoplasms pathology, Retinoblastoma pathology
Abstract

Objective: To analyze the clinicopathologic characteristics of retinoblastoma spontaneous regression., Methods: Retrospective case series study. The clinic and pathologic data of 52 cases of retinoblastoma spontaneous regression were analyzed retrospectively. All the cases came from 579 cases of retinoblastoma (without pre-enucleation chemotherapy) archived in Ophthalmic Pathology Laboratory of Beijing Tongren Eye Centre from Jan. 2007 to Dec. 2013. The analyzed factors included tumor activity, tumor invasion, and tissue changes of uveal and lens., Results: In this study, the patients' average age was (14.0 ± 8.7) months. There were 33 (63.5%) male and 19 (36.5%) female patients. The rate of retinoblastoma spontaneous regression was 9.0% (52/579), of which the rate of complete regression was 1.4% (8/579). The most common symptom was leucocoria coupled with red eye 55.8% (29/52). The typical clinicopathologic characteristics were as follows: (1) all or most of all tumor cells suffered coagulation necrosis and only tumor cell remains were left; (2)most eyeballs showed atrophiabulbi or phthisis bulbi; (3) severe atrophy occurred in uvea, especially in iris and ciliary body combined with pigment cells disintegrating; (4) cataract formed coupled with lens swelling, displacement, or wrapped by fibrous connective tissue; (5) in a small number of cases, there were alive tumor cells in the retrolaminar optic nerve or choroid in spite of most tumor cells had suffered regression, indicating the patients had histopathologic high risk factors and had the dispositions of tumor diffusion and metastasis., Conclusions: Some untypical clinical manifestation such as leukocoria coupled with red eye or atrophia bulbi should be paid close attention. The possibility of retinoblastoma spontaneous regression should be considered. Meanwhile, some cases of retinoblastoma spontaneous regression with histopathologic high risk factors should be given post-enucleation systemic adjuvant chemotherapy combined with close observations and follow-ups.

Published
2014

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