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Pile-supported wharf (PSW) is widely used in the deep-water port engineering construction, most of which are located in liquefiable ground. The effect of wave action on the working performance of PSW in liquefiable ground cannot be ignored, but few studies have been reported. This study performs the wave flume test of PSW in liquefiable ground considering the soil-structure-wave interaction. This test really reproduces the operating condition of PSW, and explores the internal response difference of wharf structure under wave. The influence of wave height on dynamic response of the PSW system is discussed systematically. The result shows that the acceleration and displacement of the PSW deck gradually increase first and finally remain relatively stable with the increase of wave action. The hydrodynamic pressure and deformation of each pile in pile group are obviously different, and the response variation is related to the pile position. The pore pressure of the soil layer in the free field and around the pile decreases with the increase of depth, and the existence of the pile group can reduce the pore pressure in the soil layer around the pile, and increase the acceleration of the soil layer. The effect of wave height on the soil layer decreases with the increase of depth. The above results can provide reference for the similar PSW test under wave and the support for the design and wave protection of PSW.

Recent research results show that great progress has been made in improving the generation rate of physical random numbers. However, there are still some defects such as complex generation process and large volume. To solve these problems, this paper theoretically proposes a scheme for generating random numbers using mode hopping of Vertical Cavity Surface Emitting Laser (VCSEL) with optical feedback. The VCSEL is perturbed by the optical feedback to generate the mode hopping. The square wave signal then modulates the injection current, periodically restarts the VCSEL to switch from the non-emitting state to the mode hopping state, and finally outputs a random pulse sequence to realize the random number generation. The results of this paper show that unbiased random numbers with verified randomness can be generated continuously at a rate of the order of Gbit/s. Our scheme eliminates the need for optoelectronic conversion and post-processing operations, simplifing the current random number generation structure, which has the potential to realize a low-cost photonic integrated random number generator.

Several studies reported that the expression of SIRT1 was associated with the clinical features of patients with esophageal squamous cell carcinoma (ESCC), but the function remains inconsistent. We conducted this study to illustrate the clinical value of SIRT1 expression in the early diagnosis and prediction of prognosis of ESCC. In this study, PubMed, Embase, and Web of Science were searched by two independent researchers and STATA14.0 software was used to conduct meta-analysis. The odds ratio with 95% confidence interval was used to estimate the pooled effect. Egger’s test and Begg’s funnel were used to assess publication bias. Sensitivity analysis was used to evaluate the reliability and stability of meta-analysis results. According to the inclusion and exclusion criteria, six studies were enrolled, including 811 cases of ESCC. Results of the meta-analysis indicated that SIRT1 was overexpressed in ESCC and the SIRT1 expression was closely related to the clinicopathological features of ESCC, such as tumor infiltration, tumor node metastasis (TNM) stage, and lymph node metastasis. In the survival analysis, high expression of SIRT1 represented a poor prognosis in ESCC patients. Our study demonstrated that SIRT1 was overexpressed in ESCC, and it might be a potential biomarker for progress of ESCC.

Dansyl chloride has been widely used in metal ion recognition as a fluorescent sensing molecule. The interaction between fluorescent probes and metal ions is summarized, and the research progress in the structural design of dansyl group receptors in the field of metal ion fluorescent probes since 2010 is discussed. Its sensing mechanism involves intramolecular induced photoelectron transfer, charge transfer, dimethylamino deprotonation/protonation, formation of monomer-excitation complex, chelate-enhanced fluorescence transfer, complexation reaction, fluorescence resonance energy transfer, and other ones. The rules of the fluorescent responses of dansyl group under various mechanisms are also discussed, such as fluorescence quenching induced by intramolecular charge transfer and chelation triggered fluorescence enhancement. The future application trends of dansyl group in the field of fluorescent probe design are proposed as well. [ABSTRACT FROM AUTHOR]

p-Hydroxyacetophenone (p-HAP) has been used as a preservative in cosmetics, however, its new efficacy has rarely been reported. Herein, the soothing and oil control efficacy of p-HAP was evaluated by cellular in vitro method to provide new efficacy basis for application in cosmetics. The content of nitric oxide (NO), tumor necrosis factor a (TNF-α) and interleukin-6 (IL-6) was determined in LPS-induced RAW264.7. The lipid content was determined in testosterone-induced SZ95. The results revealed that p-HAP could significantly inhibit these pro-inflammatory cytokines, including NO, TNF-α and IL-6 (P < 0.01). In addition, 0.05 mg/mLp-HAP could inhibit the formation of lipid droplets in human sebocytes, with inhibition rate of 17.64% (P < 0.001). These findings might imply the potential application of p-HAP as a functional ingredient in cosmetics, which might have soothing and oil control efficacy according to the inhibition of pro-inflammatory cytokines and lipid content. [ABSTRACT FROM AUTHOR]