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Objective To screen the risk factors for ventriculoperitoneal shunt (VPS) after tumor resection in children with supratentorial neoplasms due to new hydrocephalus or progression of existing hydrocephalus. Methods Total 199 children who underwent supratentorial neoplasms resection at Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, from January 2011 to January 2021 were included. Socio-demographic data, course of disease and imaging data, tumor resection- related indicators and hydrocephalus occurrence and progression were collected. The risk factors for the occurrence or progression of existing hydrocephalus after supratentorial neoplasms resection were analyzed by univariate and multivariate Logistic regression. Results Fifteen of 199 children (7.54%) with supratentorial tumors required VPS after surgery, of which 14 had new hydrocephalus or progression of existing hydrocephalus within 2 weeks after surgery. Logistic regression analysis showed the presence of preoperative coexisting hydrocephalus (OR = 14.756, 95%CI: 3.451-63.089; P = 0.000), tumor adjacent to the midline (OR = 5.466, 95%CI:1.409-21.203; P = 0.014), and large intraoperative bleeding (OR = 1.295, 95%CI: 1.016-1.650; P = 0.037) were risk factors for the need of VPS in children with supratentorial tumors. Conclusions Development or progression of hydrocephalus after tumor resection in children with supratentorial neoplasms occurs mostly within 2 weeks after surgery. Children with preoperative coexisting hydrocephalus, tumor adjacent to the midline, and large intraoperative bleeding should be alerted to development and acute progression of hydrocephalus after surgery.

Objective To analyze the epidemiological status of bladder cancer incidence and mortality in Gansu Province from 2010 to 2019. Methods The cancer registry data from Gansu Province during 2010 and 2019 was analyzed to calculate the crude incidence and mortality rates of bladder cancer, as well as the age-standardized rates for the Chinese population (AS- RC), the world population (ASRW), and the average annual percentage change (AAPC). Results In 2019, the crude incidence rate of bladder cancer in Gansu Province was 5.34 per 100 000, with the age-standardized rate for China at 3.44 per 100 000 and the world standard rate at 3.35 per 100 000. The incidence rates for males and females were 8.2 per 100 000 and 2.38 per 100 000, respectively; the urban and rural incidence rates were 5.38 per 100 000 and 5.27 per 100 000, respectively. The crude mortality rate was 1.62 per 100 000, with the age-standardized rates at 0.96 per 100 000 for China and 0.94 per 100 000 for the world. The mortality rates for males and females were 2.54 per 100 000 and 0.66 per 100 000, respectively; the urban and rural mortality rates were 1.68 per 100 000 and 1.52 per 100 000, respectively. The peak incidence and mortality rates were observed in the age groups of 75-79 years and 85 years and older, respectively. From 2010 to 2019, the incidence of bladder cancer in Gansu Province showed a yearly increase, with an AAPC of 5.06% (95%Cl: 2.58-7.58) for crude incidence and an AAPC of 5.18% (95%Cl: 2.48-7.95) for age-standardized incidence; the AAPC for mortality was 0.18% (95%Cl: -7.34-8.32) for crude mortality and -2.76% (95%Cl: -12.32-5.62) for age-standardized mortality. Conclusion In 2019, the incidence and mortality rates of bladder cancer in Gansu Province were lower than the national average. However, there was an upward trend in incidence from 2010 to 2019, with significant gender differences. Greater attention should be paid to bladder cancer prevention and control strategies in the future. [ABSTRACT FROM AUTHOR]