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Inflammation is closely associated with cerebrovascular diseases, cardiovascular diseases, diabetes, and cancers, and it is accompanied by the development of autoantibodies in the early stage of inflammation-related diseases. Hence, it is meaningful to discover novel antibody biomarkers targeting inflammation-related diseases. In this study, Jumonji C-domain-containing 6 (JMJD6) was identified by the serological identification of antigens through recombinant cDNA expression cloning. In particular, JMJD6 is an antigen recognized in serum IgG from patients with unstable angina pectoris (a cardiovascular disease). Then, the serum antibody levels were examined using an amplified luminescent proximity homogeneous assay-linked immunosorbent assay and a purified recombinant JMJD6 protein as an antigen. We observed elevated levels of serum anti-JMJD6 antibodies (s-JMJD6-Abs) in patients with inflammation-related diseases such as ischemic stroke, acute myocardial infarction (AMI), diabetes mellitus (DM), and cancers (including esophageal cancer, EC; gastric cancer; lung cancer; and mammary cancer), compared with the levels in healthy donors. The s-JMJD6-Ab levels were closely associated with some inflammation indicators, such as C-reactive protein and intima–media thickness (an atherosclerosis index). A better postoperative survival status of patients with EC was observed in the JMJD6-Ab-positive group than in the negative group. An immunohistochemical analysis showed that JMJD6 was highly expressed in the inflamed mucosa of esophageal tissues, esophageal carcinoma tissues, and atherosclerotic plaques. Hence, JMJD6 autoantibodies may reflect inflammation, thereby serving as a potential biomarker for diagnosing specific inflammation-related diseases, including stroke, AMI, DM, and cancers, and for prediction of the prognosis in patients with EC. [ABSTRACT FROM AUTHOR]

The mushy zone refers to the region of the solid-liquid system where the temperature is between the liquidus and solidus temperatures. In this zone, the turbulence of the interdendritic flow is reduced by blockage of dendrites. The mushy zone coefficient (Amush) is an important calculating parameter in the continuous casting numerical simulation process, which strongly affects the prediction of fluid flow and solidification behavior in the mold zone. However, most researchers have neglected the influence of the mushy zone coefficient, and the correct expression of this coefficient is rarely found in the literature. Generally, the lower default value of 1×105 kg·m-3·s-1 is used in the model, which leads to unrealistic results. In this study, the relationship between the mushy zone coefficient and permeability was analyzed, and the expression of the mushy zone coefficient was proposed. A coupled flow and solidification numerical model was developed to evaluate the effect of the mushy zone coefficient on the melt flow and solidification phenomena in a bloom continuous casting mold. Results show that the higher the value of the mushy zone coefficient, the stronger the damping becomes, and the faster the velocity drops as melt solidifies. A relatively high value of the mushy zone coefficient generates a "banded" form of mushy zone sandwiched between the solid and liquid phases in the mold zone. When the mushy zone coefficient is at a lower value, a wider mushy zone is obtained and the melt cools down rapidly in the mold region. In addition, the temperature at free surface is relatively low with supercooling, and the solidified shell remelts locally. The model is validated through comparison with measurements of shell thickness on a breakout shell. The value of the mushy zone coefficient ranging from 1×108 to 5×108 kg·m-3·s-1 is suggested.

In this work, the effects of in-plane shear stress on the thermal conductivities of two important kinds of graphene configurations (rectangular graphene and annular graphene) are investigated using molecular dynamics simulations. The various strain angles are set as θ = 0°, 3°, 5°, 10°, and 15° for rectangular graphene and θ = 0°, 3°, 5°, and 8° for annular graphene. A spectral energy density approach is applied to carry out phononic analyses of the two configurations under in-plane shear stress for the first time. It is found that for rectangular graphene, the thermal conductivity shows a significant decreasing trend from 239.6 to 79.1 W m−1 K−1 with the θ increasing from 0° to 15°. Besides, the application of shear stress can significantly widen the energy bands of branches, which indicates shorter phonon lifetimes. Further phononic analysis shows that most of the phonon scattering caused by in-plane shear stress emanates from the in-plane mode, which is an updated conclusion in this field. On the other hand, the thermal conductivity of annular graphene also shows a decreasing evolution with the increasing strain angles, but phonon transport in rectangular graphene is more susceptible to shear stress than in annular graphene due to a stronger phonon-boundary scattering in the latter configuration. In this work, the monotonically decreasing trends of the thermal conductivities of both graphene configurations with the increasing strain angle are different from the V-shape trend reported in the literature. Based on phononic analyses, it can be concluded that an abnormal increase of the thermal conductivities at a low shear stress can be attributed to the application of the AIREBO potential model in the literature. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate the clinical, radiographic, and esthetic outcomes of immediate implant placement with buccal bone dehiscence in the anterior maxilla. Methods: In this case series, implants were inserted immediately after tooth extraction in sockets with buccal bone dehiscence. Guided bone regeneration (GBR) with a papilla preservation flap and simultaneous connective tissue grafting (CTG) was used. The following outcome variables were measured: mid‐facial mucosal recession, probing depth, bleeding on probing, Pink Esthetic Score (PES), marginal bone loss, and thickness of buccal bone plate (TBP). Results: 12 patients were recruited. Stable mid‐facial mucosal level (−0.03 ± 0.17 mm) and excellent soft‐tissue esthetic outcomes (PES, 9.17 ± 0.72) were achieved at 1 year. The TBP at platform level was 2.01 ± 0.31 mm at 1‐year follow up with a resorption rate of 28.90% ± 15.14%. Conclusions: Immediate implant placement using GBR performed with a papilla preservation approach and simultaneous CTG is a feasible treatment procedure in compromised extraction sockets in the anterior region. Favorable esthetic outcomes and buccal bone thickness were obtained. Further studies were needed to evaluate the long‐term tissue alteration. [ABSTRACT FROM AUTHOR]