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Background The occurrence and development of osteoporosis experience a long process, therefore, attention should be paid to bone health throughout the whole life cycle of human, early prevention and treatment of osteoporosis is of positive significance. There is a relative lack or insufficiency of research on TCM symptom assessment in the high risk population of osteoporosis in Ling-nan region.Objective To conduct expert questionnaire analysis on the assessment of TCM symptoms in high risk population of osteoporosis in Ling-nan region and form expert consensus opinions.Methods Based on the previous literature review and the first round of "Questionnaire for TCM symptom assessment in high risk population of osteoporosis in Ling-nan region", the Delphi method was adopted to optimize the second round of expert questionnaire from October 2021 to September 2022, in combination with the expert opinions of the first academic conference of Ling-nan bone and joint disease in December 2021 and the expert group of Guangdong Provincial Association of Chinese Medicine concerned Specialist Committee on Bone and Joint Degeneration and Injury. The experts in the department of orthopedics in Ling-nan region were consulted for their opinions, and the data of the investigation results were statistically analyzed.Results 192 experts with solid theoretical knowledge and clinical diagnosis and treatment skills in TCM or Chinese and western integrative medicine were selected from various provinces and cities in the Ling-nan region. The research fields of the surveyed experts included orthopedics and traumatology of Chinese medicine, orthopedics and traumatology of Chinese and western integrative medicine and clinical rehabilitation, etc. involving TCM clinical practice, Chinese and western integrative medicine clinical practice and scientific research, etc. Among them, there were 115 male experts, 77 female experts, 31 experts with senior professional titles, 76 experts with associate senior professional titles and 85 experts with intermediate professional titles, with the duration of carrying out specialty not less than 6 years. The expert positive coefficient was 100%, and the average authority coefficient was (0.81±0.04) . The concentration and coordination degree of the surveyed experts' opinions were relatively higher, that is, the sample mean±coefficient variation of the TCM symptom items of high risk population of osteoporosis in Ling-nan region included " humpback deformity" (88.93±13.46, 15.14%) , "generalized bone pain" (89.45±14.56, 16.28%) , "fracture occurred in recent 5 years" (85.68±17.44, 20.36%) , "low back pain" (84.51±15.27, 18.07%) , "shortened height" (82.94±16.14, 19.46%) , "heavy joints unable to bend or extend" (80.21±14.43, 17.99%) , "heavy body trapped" (76.17±17.22, 22.60%) , "tiredness" (75.26±14.69, 19.52%) , "tooth shaking and hair loss" (74.87±15.87, 21.20%) , etc.Conclusion The motivation and professionalism of experts surveyed by "Questionnaire for TCM symptom assessment in high risk population of osteoporosis in Ling-nan region" are good with a wide distribution region and good representation. The preferred items of TCM symptoms of high risk population of osteoporosis in Ling-nan region were "humpback deformity" , "generalized bone pain" , "fracture occurred in recent 5 years" , "low back pain" , "shortened height" , "heavy joints unable to bend or extend" , "heavy body trapped" , "tiredness" , "tooth shaking and hair loss" , etc. The recommendations of experts in this field on the TCM symptoms assessment in high risk population of osteoporosis in Lingnan region can be better summarized based on Delphi method, which can provide references for the subsequent early diagnosis of osteoporosis and the development of the assessment scale.

Immune checkpoint inhibitors significantly improves the prognosis of patients with advanced malignancy, but it is also associated with off-target toxicity caused by activation of the immune system, known as immune-related adverse events (irAEs). Severe irAEs will lead to temporary or permanent termination of immunotherapy, which greatly affects its clinical application. At present, glucocorticoids are mainly used to treat irAEs clinically. On one hand, severe adverse reactions will cause serious damage to patients' health; on the other hand, the extensive application of glucocorticoids will affect the efficacy of immune checkpoint inhibitors. In recent years, TNF-α inhibitors have shown significant effect in reducing toxic and side effects. This paper reviews the progress of TNF-α in preventing and treating irAEs.

This paper proposes a novel video hashing with tensor robust Principal Component Analysis (PCA) and Histogram of Optical Flow (HOF) for copy detection. In the proposed hashing, a video is divided into some video groups. For each video group, a low-rank secondary frame is constructed from the low-rank component decomposed by applying tensor robust PCA to the video group. Since the low-rank component can well indicate spatial-temporal intrinsic structure of the video group and it is slightly disturbed by digital operations, feature extraction from the low-rank secondary frames is discriminative and stable. Next, spatial features and temporal features are extracted from low-rank secondary frames by Charlier moments and HOF, respectively. Since the Charlier moments are robust to geometric transform and they can efficiently distinguish video frames with different contents, the use of Charlier moments can make robust and discriminative spatial features. As the HOF can measure the distribution of motion information between frames, the temporal features formed by HOFs can provide good discrimination. Hash is ultimately determined by quantizing the spatial and temporal features and concatenating the quantized results. Numerous experiments on open video datasets indicate that the proposed hashing is superior to some hashing baseline schemes in terms of classification and copy detection. [ABSTRACT FROM AUTHOR]