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461 results on '"Zhang, Xiang H.-F."'

5. Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal

Author

Hao, Xiaoxin, Shen, Yichao, Chen, Nan, Zhang, Weijie, Valverde, Elizabeth, Wu, Ling, Chan, Hilda L., Xu, Zhan, Yu, Liqun, Gao, Yang, Bado, Igor, Michie, Laura Natalee, Rivas, Charlotte Helena, Dominguez, Luis Becerra, Aguirre, Sergio, Pingel, Bradley C., Wu, Yi-Hsuan, Liu, Fengshuo, Ding, Yunfeng, Edwards, David G., Liu, Jun, Alexander, Angela, Ueno, Naoto T., Hsueh, Po-Ren, Tu, Chih-Yen, Liu, Liang-Chih, Chen, Shu-Hsia, Hung, Mien-Chie, Lim, Bora, and Zhang, Xiang H.-F.

Published
2023
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10. Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Author

Xu, Zhan, primary, Liu, Fengshuo, additional, Ding, Yunfeng, additional, Pan, Tianhong, additional, Wu, Yi-Hsuan, additional, Liu, Jun, additional, Bado, Igor L., additional, Zhang, Weijie, additional, Wu, Ling, additional, Gao, Yang, additional, Hao, Xiaoxin, additional, Yu, Liqun, additional, Edwards, David G., additional, Chan, Hilda L., additional, Aguirre, Sergio, additional, Dieffenbach, Michael Warren, additional, Chen, Elina, additional, Shen, Yichao, additional, Hoffman, Dane, additional, Dominguez, Luis Becerra, additional, Rivas, Charlotte Helena, additional, Chen, Xiang, additional, Wang, Hai, additional, Gugala, Zbigniew, additional, Satcher, Robert L., additional, and Zhang, Xiang H.-F., additional

Published
2024
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11. CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC

Author

Yuan, Xueying, primary, Hao, Xiaoxin, additional, Chan, Hilda L., additional, Zhao, Na, additional, Pedroza, Diego A., additional, Liu, Fengshuo, additional, Le, Kang, additional, Smith, Alex J., additional, Calderon, Sebastian J., additional, Lieu, Nadia, additional, Soth, Michael J., additional, Jones, Philip, additional, Zhang, Xiang H.-F., additional, and Rosen, Jeffrey M., additional

Published
2024
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12. Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity

Author

Monteran, Lea, primary, Ershaid, Nour, additional, Scharff, Ye'ela, additional, Zoabi, Yazeed, additional, Sanalla, Tamer, additional, Ding, Yunfeng, additional, Pavlovsky, Anna, additional, Zait, Yael, additional, Langer, Marva, additional, Caller, Tal, additional, Eldar-Boock, Anat, additional, Avivi, Camila, additional, Sonnenblick, Amir, additional, Satchi-Fainaro, Ronit, additional, Barshack, Iris, additional, Shomron, Noam, additional, Zhang, Xiang H.-F., additional, and Erez, Neta, additional

Published
2024
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13. Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in African American and European American patients with TNBC

Author

Zhu, Qian, primary, Balasubramanian, Akhila, additional, Asirvatham, Jaya Ruth, additional, Piyarathna, Danthasinghe Waduge Badrajee, additional, Kaur, Jaspreet, additional, Mohamed, Nada, additional, Wu, Ling, additional, Chatterjee, Megha, additional, Wang, Stacy, additional, Pourfarrokh, Niloufar, additional, Rasaily, Uttam, additional, Xu, Yitian, additional, Zheng, Junjun, additional, Jebakumar, Deborah, additional, Rao, Arundathi, additional, Chen, Shu-hsia, additional, Li, Yi, additional, Chang, Eric, additional, Li, Xiaoxian, additional, Aneja, Ritu, additional, Zhang, Xiang H.-F., additional, and Sreekumar, Arun, additional

Published
2024
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18. Hormonal modulation of ESR1 mutant metastasis

Author

Gu, Guowei, Tian, Lin, Herzog, Sarah K., Rechoum, Yassine, Gelsomino, Luca, Gao, Meng, Du, Lili, Kim, Jin-Ah, Dustin, Derek, Lo, Hin Ching, Beyer, Amanda R., Edwards, David G., Gonzalez, Thomas, Tsimelzon, Anna, Huang, Helen J., Fernandez, Natalie M., Grimm, Sandra L., Hilsenbeck, Susan G., Liu, Dan, Xu, Jun, Alaniz, Alyssa, Li, Shunqiang, Mills, Gordon B., Janku, Filip, Kittler, Ralf, Zhang, Xiang H. -F., Coarfa, Cristian, Foulds, Charles E., Symmans, W. Fraser, Andò, Sebastiano, and Fuqua, Suzanne A. W.

Published
2021
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20. Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions

Author

Xu, Longyong, Liu, Xia, Peng, Fanglue, Zhang, Weijie, Zheng, Liting, Ding, Yao, Gu, Tianpeng, Lv, Kaosheng, Wang, Jin, Ortinau, Laura, Hu, Tianyuan, Shi, Xiangguo, Shi, Guojun, Shang, Ge, Sun, Shengyi, Iwawaki, Takao, Ji, Yewei, Li, Wei, Rosen, Jeffrey M., Zhang, Xiang H.-F., Park, Dongsu, Adoro, Stanley, Catic, Andre, Tong, Wei, Qi, Ling, Nakada, Daisuke, and Chen, Xi

Published
2020
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22. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression

Author

Arnold, James M., Gu, Franklin, Ambati, Chandrashekar R., Rasaily, Uttam, Ramirez-Pena, Esmeralda, Joseph, Robiya, Manikkam, Mohan, San Martin, Rebeca, Charles, Christy, Pan, Yinghong, Chatterjee, Sujash S., Den Hollander, Petra, Zhang, Weijie, Nagi, Chandandeep, Sikora, Andrew G., Rowley, David, Putluri, Nagireddy, Zhang, Xiang H.-F., Karanam, Balasubramanyam, Mani, Sendurai A., and Sreekumar, Arun

Published
2020
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36. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression

Author

Arnold, James M., Gu, Franklin, Ambati, Chandrashekar R., Rasaily, Uttam, Ramirez-Pena, Esmeralda, Joseph, Robiya, Manikkam, Mohan, Martin, Rebeca San, Charles, Christy, Pan, Yinghong, Chatterjee, Sujash S., Den Hollander, Petra, Zhang, Weijie, Nagi, Chandandeep, Sikora, Andrew G., Rowley, David, Putluri, Nagireddy, Zhang, Xiang H.-F., Karanam, Balasubramanyam, Mani, Sendurai A., and Sreekumar, Arun

Published
2020
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37. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms

Author

Kim, Ik Sun, Gao, Yang, Welte, Thomas, Wang, Hai, Liu, Jun, Janghorban, Mahnaz, Sheng, Kuanwei, Niu, Yichi, Goldstein, Amit, Zhao, Na, Bado, Igor, Lo, Hin-Ching, Toneff, Michael J., Nguyen, Tuan, Bu, Wen, Jiang, Weiyu, Arnold, James, Gu, Franklin, He, Jian, Jebakumar, Deborah, Walker, Kimberly, Li, Yi, Mo, Qianxing, Westbrook, Thomas F., Zong, Chenghang, Rao, Arundhati, Sreekumar, Arun, Rosen, Jeffrey M., and Zhang, Xiang H.-F.

Published
2019
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38. RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Author

Yue, Zhiying, Niu, Xin, Yuan, Zengjin, Qin, Qin, Jiang, Wenhao, He, Liang, Gao, Jingduo, Ding, Yi, Liu, Yanxi, Xu, Ziwei, Li, Zhenxi, Yang, Zhengfeng, Li, Rong, Xue, Xiwen, Gao, Yankun, Yue, Fei, Zhang, Xiang H.-F., Hu, Guohong, Wang, Yi, Li, Yi, Chen, Geng, Siwko, Stefan, Gartland, Alison, Wang, Ning, Xiao, Jianru, Liu, Mingyao, and Luo, Jian

Subjects
Bone cancer -- Development and progression -- Genetic aspects, Metastasis -- Development and progression -- Genetic aspects, Cellular signal transduction -- Genetic aspects -- Health aspects, Osteoclasts (Biology) -- Genetic aspects -- Health aspects, Cell receptors -- Genetic aspects -- Health aspects, Health care industry
Abstract

Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how osteoclasts regulate premetastatic niche and bone tropism are largely unknown. In this study, we report that osteoclast precursors (OPs) can function as a premetastatic niche component that facilitates breast cancer (BCa) bone metastasis at early stages. At the molecular level, unbiased GPCR ligand/agonist screening in BCa cells suggested that R-spondin 2 (RSPO2) and RANKL, through interaction with their receptor LGR4, promoted osteoclastic premetastatic niche formation and enhanced BCa bone metastasis. This was achieved by RSPO2/RANKL-LGR4 signal modulating the WNT inhibitor DKK1 through G[[alpha].sub.q] and [beta]-catenin signaling. DKK1 directly facilitated OP recruitment through suppression of its receptor LDL receptor-related protein 5 (LRP5) but not LRP6, upregulating Rnasek expression via inhibition of canonical WNT signaling. In clinical samples, RSPO2, LGR4, and DKK1 expression showed a positive correlation with BCa bone metastasis. Furthermore, soluble LGR4 extracellular domain (ECD) protein, acting as a decoy receptor for RSPO2 and RANKL, significantly alleviated bone metastasis and osteolytic lesions in a mouse bone metastasis model. These findings provide unique insights into the functional role of OPs as key components of the premetastatic niche for BCa bone metastasis and identify RSPO2/RANKL-LGR4 signaling as a promising target for inhibiting BCa bone metastasis., Introduction Accumulating evidence demonstrates that target organs of cancer metastasis are not just the passive receivers of disseminated tumor cells, but instead are selectively and positively groomed by the primary [...]

Published
2022
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39. Correction to: Hormonal modulation of ESR1 mutant metastasis

Author

Gu, Guowei, Tian, Lin, Herzog, Sarah K., Rechoum, Yassine, Gelsomino, Luca, Gao, Meng, Du, Lili, Kim, Jin-Ah, Dustin, Derek, Lo, Hin Ching, Beyer, Amanda R., Edwards, David G., Gonzalez, Thomas, Tsimelzon, Anna, Huang, Helen J., Fernandez, Natalie M., Grimm, Sandra L., Hilsenbeck, Susan G., Liu, Dan, Xu, Jun, Alaniz, Alyssa, Li, Shunqiang, Mills, Gordon B., Janku, Filip, Kittler, Ralf, Zhang, Xiang H. -F., Coarfa, Cristian, Foulds, Charles E., Symmans, W. Fraser, Andò, Sebastiano, and Fuqua, Suzanne A. W.

Published
2022
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43. Supplementary Video 2 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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44. Supplementary Figure S1-S7 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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45. Supplementary Video 1 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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46. Data from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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47. Supplementary Video 4 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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48. Supplementary Raw Data from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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49. Supplementary Video 3 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Author

Zhang, Weijie, primary, Xu, Zhan, primary, Hao, Xiaoxin, primary, He, Tiancheng, primary, Li, Jiasong, primary, Shen, Yichao, primary, Liu, Kai, primary, Gao, Yang, primary, Liu, Jun, primary, Edwards, David G., primary, Muscarella, Aaron M., primary, Wu, Ling, primary, Yu, Liqun, primary, Xu, Longyong, primary, Chen, Xi, primary, Wu, Yi-Hsuan, primary, Bado, Igor L., primary, Ding, Yunfeng, primary, Aguirre, Sergio, primary, Wang, Hai, primary, Gugala, Zbigniew, primary, Satcher, Robert L., primary, Wong, Stephen T.C., primary, and Zhang, Xiang H.-F., primary

Published
2023
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50. Supplementary Methods from Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone

Author

Sawant Dessai, Abhisha, primary, Dominguez, Mayrel Palestino, primary, Chen, Uan-I, primary, Hasper, John, primary, Prechtl, Christian, primary, Yu, Cuijuan, primary, Katsuta, Eriko, primary, Dai, Tao, primary, Zhu, Bokai, primary, Jung, Sung Yun, primary, Putluri, Nagireddy, primary, Takabe, Kazuaki, primary, Zhang, Xiang H.-F., primary, O'Malley, Bert W., primary, and Dasgupta, Subhamoy, primary

Published
2023
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