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389 results on '"Zhang, Weihan"'

1. High-Throughput Discovery of Kagome Materials in Transition Metal Oxide Monolayers

Author

Wang, Renhong, Wang, Cong, Guo, Deping, Dai, Jiaqi, Zong, Canbo, Zhang, Weihan, and Ji, Wei

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Kagome materials have been found to exhibit exotic physical properties such as spin frustration, charge density waves, and unconventional superconductivity. However, the number of materials with kagome lattice-related properties discovered so far is relatively small, limiting the exploration of the physical phenomena associated with kagome materials. Due to the weaker interlayer coupling in two-dimensional kagome materials, they are more likely to exhibit kagome lattice-related physical properties. Therefore, the search for potential two-dimensional kagome materials is crucial for understanding the underlying physics of kagome lattices. In this work, we performed high-throughput workflow to discover thermodynamically stable kagome transition metal oxide monolayers based on "1+3" strategy. Starting from a pool of 349 candidate materials, we identified 12 globally stable kagome monolayers, including both magnetic and non-magnetic structures. These monolayers were classified into four categories based on their electronic structures, lattice types, symmetry, band gaps, and magnetic properties. A detailed analysis was performed on kagome structures exhibiting band features near the Fermi level. This study demonstrates the feasibility of the "1+3" strategy in constructing kagome lattices, providing a pathway for further theoretical and experimental exploration of kagome materials and their potential quantum phenomena.

Published
2024

6. Intralayer Negative Poisson's Ratio in Two-Dimensional Black Arsenic by Strain Engineering

Author

Zhang, Jingjing, Zhang, Weihan, Zhang, Leining, Du, Guoshuai, Yu, Yunfei, Xia, Qinglin, Wu, Xu, Wang, Yeliang, Ji, Wei, Qiao, Jingsi, Ding, Feng, and Chen, Yabin

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Negative Poisson's ratio as the anomalous characteristic generally exists in artificial architectures, such as re-entrant and honeycomb structures. The structures with negative Poisson's ratio have attracted intensive attention due to their unique auxetic effect and many promising applications in shear resistant and energy absorption fields. However, experimental observation of negative Poisson's ratio in natural materials barely happened, although various two-dimensional layered materials are predicted in theory. Herein, we report the anisotropic Raman response and the intrinsic intralayer negative Poisson's ratio of two-dimensional natural black arsenic (b-As) via strain engineering strategy. The results were evident by the detailed Raman spectrum of b-As under uniaxial strain together with density functional theory calculations. It is found that b-As was softer along the armchair than zigzag direction. The anisotropic mechanical features and van der Waals interactions play essential roles in strain-dependent Raman shifts and negative Poisson's ratio in the natural b-As along zigzag direction. This work may shed a light on the mechanical properties and potential applications of two-dimensional puckered materials., Comment: 23 pages, 4 figures

Published
2023

20. Classification of COVID-19 X-ray Images Using a Combination of Deep and Handcrafted Features

Author

Zhang, Weihan, Pogorelsky, Bryan, Loveland, Mark, and Wolf, Trevor

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Coronavirus Disease 2019 (COVID-19) demonstrated the need for accurate and fast diagnosis methods for emergent viral diseases. Soon after the emergence of COVID-19, medical practitioners used X-ray and computed tomography (CT) images of patients' lungs to detect COVID-19. Machine learning methods are capable of improving the identification accuracy of COVID-19 in X-ray and CT images, delivering near real-time results, while alleviating the burden on medical practitioners. In this work, we demonstrate the efficacy of a support vector machine (SVM) classifier, trained with a combination of deep convolutional and handcrafted features extracted from X-ray chest scans. We use this combination of features to discriminate between healthy, common pneumonia, and COVID-19 patients. The performance of the combined feature approach is compared with a standard convolutional neural network (CNN) and the SVM trained with handcrafted features. We find that combining the features in our novel framework improves the performance of the classification task compared to the independent application of convolutional and handcrafted features. Specifically, we achieve an accuracy of 0.988 in the classification task with our combined approach compared to 0.963 and 0.983 accuracy for the handcrafted features with SVM and CNN respectively., Comment: 5 pages, 5 figures

Published
2021

21. Species-Shared and -Specific Brain Functional Connectomes Revealed by Shared-Unique Variational Autoencoder

Author

Yang, Li, Zhang, Songyao, Zhang, Weihan, Zhou, Jingchao, Zhong, Tianyang, Wei, Yaonai, Jiang, Xi, Liu, Tianming, Han, Junwei, Yuan, Yixuan, Zhang, Tuo, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Frangi, Alejandro, editor, de Bruijne, Marleen, editor, Wassermann, Demian, editor, and Navab, Nassir, editor

Published
2023
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33. Origins and Genetic Characteristics of Egyptian Peach.

Author

Ezzat, Mohamed, Zhang, Weihan, Amar, Mohamed, Nishawy, Elsayed, Zhao, Lei, Belal, Mohammad, Han, Yuepeng, and Liao, Liao

Subjects
*FRUIT trees, *GERMPLASM, *COLD (Temperature), *PEACH, HAN dynasty, China, 202 B.C.-220 A.D., SILK Road
Abstract

Peach (Prunus persica), a significant economic fruit tree in the Rosaceae family, is extensively cultivated in temperate and subtropical regions due to its abundant genetic diversity, robust adaptability, and high nutritional value. Originating from China over 4000 years ago, peaches were introduced to Persia through the Silk Road during the Han Dynasty and gradually spread to India, Greece, Rome, Egypt, Europe, and America. Currently grown in more than 80 countries worldwide, the expansion of peach cultivation in Egypt is mainly due to the development and utilization of peach varieties with low chilling requirements. These varieties exhibit unique phenotypic characteristics such as early maturity, reduced need for winter cold temperatures, low water requirements, and high economic value. In this study, a systematic analysis was conducted on the genetic characteristics and kinship relationships of peaches with low chilling requirements in Egypt. We conducted a comprehensive evolutionary and Identity-by-Descent (IBD) analysis on over 300 peach core germplasm resources, including Egyptian cultivars with low chilling requirements, to investigate their origin and genetic characteristics. The evolutionary analysis revealed that 'Bitter almond' is closely related to China's wild relative species Prunus tangutica Batal, while 'Early grand' shares one branch with Chinese ornamental peach cultivars, and 'Nemaguard' clusters with some ancient local varieties from China. The IBD analysis also indicated similar genetic backgrounds, suggesting a plausible origin from China. Similarly, the analysis suggested that 'Swelling' may have originated from the Czech Republic while 'Met ghamr' has connections to South Africa. 'Desert red', 'Early swelling', and 'Florida prince' are likely derived from Brazil. These findings provide valuable insights into the genetic characteristics of Egyptian peach cultivars. They offer a significant foundation for investigating the origin and spread of cultivated peaches worldwide and serve as a valuable genetic resource for breeding low chilling requirement cultivars, which is of considerable significance for the advancement of peach cultivation in Egypt. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages.

Author

Li, Lirong, Qin, Runkuan, Liu, Yunbo, Tseng, Yu-Shan, Zhang, Weihan, Yu, Lin, Mietzsch, Mario, Zou, Xinkai, Liu, Haizhou, Lu, Guangwen, Hu, Hongbo, Mckenna, Robert, Yang, Jinliang, Wei, Yuquan, Agbandje-Mckenna, Mavis, Hu, Jiankun, and Yang, Lin

Subjects
ADENO-associated virus, GENE therapy, GENETIC recombination, GENETIC variation, HUMAN genes, ADENOVIRUSES
Abstract

Adeno-associated virus (AAV) serotypes from primates are being developed and clinically used as vectors for human gene therapy. However, the evolutionary mechanism of AAV variants is far from being understood, except that genetic recombination plays an important role. Furthermore, little is known about the interaction between AAV and its natural hosts, human and nonhuman primates. In this study, natural AAV capsid genes were subjected to systemic evolutionary analysis with a focus on selection drives during the diversification of AAV lineages. A number of positively selected sites were identified from these AAV lineages with functional relevance implied by their localization on the AAV structures. The selection drives of the two AAV2 capsid sites were further investigated in a series of biological experiments. These observations did not support the evolution of the site 410 of the AAV2 capsid driven by selection pressure from the human CD4+ T-cell response. However, positive selection on site 548 of the AAV2 capsid was directly related to host humoral immunity because of the profound effects of mutations at this site on the immune evasion of AAV variants from human neutralizing antibodies at both the individual and population levels. Overall, this work provides a novel interpretation of the genetic diversity and evolution of AAV lineages in their natural hosts, which may contribute to their further engineering and application in human gene therapy. Author summary: Adeno-associated virus (AAV) is a viral vector that is universally applied in human gene therapy. Despite their versatile applications in gene therapy, the origin and evolution of AAV serotypes have not been extensively studied. In this study, positive selection upon diversification of AAV capsid genes was carefully investigated by evolutionary analysis. Numerous diversifying selected sites were dispersed among the AAV lineages, and evolutionary pathways were inferred for two selected sites of the AAV2 capsid gene. Furthermore, the putative immunological drives underlying the selection of AAV2 capsid genes were experimentally dissected. This work provides a novel interpretation of the evolution and diversity of AAV serotypes and might be helpful for their engineering and application in gene therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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