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133 results on '"Zhang, Tinghong"'

20. Cover Image, Volume 140, Issue 13

Author

Xu, Yewei, primary, Yang, Chunyan, additional, Deng, Hongyang, additional, Zhong, Chi, additional, He, Peiyu, additional, Zhang, Tinghong, additional, Sun, Yi, additional, Yuan, Rui, additional, Liang, Shuen, additional, Kang, Biao, additional, and Chang, Guanjun, additional

Published
2023
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21. One-step electrodeposition preparation of boron nitride and samarium co-modified Ti/PbO2 anode with ultra-long lifetime: highly efficient degradation of lincomycin wastewater.

Author

Zhao, Maojie, Yang, Mengqi, Yang, Peilin, Su, Rong, Xiao, Feng, He, Ping, Deng, Hongquan, Zhang, Tinghong, and Jia, Bin

Subjects
LEAD oxides, BORON nitride, SAMARIUM, ANTIBIOTIC residues, LINCOMYCIN, SEWAGE, LIQUID chromatography-mass spectrometry, ANODES
Abstract

Lincomycin (LC) is an extensively applied broad-spectrum antibiotic, and its considerable residues in wastewater have caused a series of environmental problems, which makes degradation of LC wastewater extremely urgent. In this work, we have constructed a novel boron nitride (BN) and samarium (Sm) co-modified Ti/PbO2 as anode for high-performance degradation of LC wastewater. Compared with Ti/PbO2, Ti/PbO2-Sm, and Ti/PbO2-BN electrodes, Ti/PbO2-BN-Sm electrode with smaller pyramidal particles possesses higher oxygen evolution potential (2.32 V), excellent accelerated service life (103 h), and outstanding electrocatalytic activity. The single-factor experiments demonstrate that under optimized conditions (current density of 20 mA.cm-2, 6.0 g L-1 Na2SO4, pH 9, and temperature of 30°C), removal rate and COD degradation rate of LC at 3 h have reached 92.85% and 89.11%, respectively. At the same time, degradation of LC is in accordance with the primary kinetic model. Based on the analysis of high-performance liquid chromatography-mass spectrometry (HPLC-MS), four possible degradation pathways are hypothesized. Therefore, efficient electrochemical degradation of LC by using an extremely long-life Ti/PbO2 electrode with high catalytic activity may be a promising method. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Preparation, characterization, and in vitro tumor-suppressive effect of anti-miR-21-equipped RNA nanoparticles.

Author

Zhang, Tinghong, Wu, Yunlong, Yang, Dejun, Wu, Cunzao, and Li, Huaqiong

Subjects
*TRIPLE-negative breast cancer, *EPIDERMAL growth factor receptors, *RNA, *METASTATIC breast cancer, *GENETIC regulation, *APTAMERS, *ANTHRACYCLINES
Abstract

MicroRNAs play an irreplaceable role in gene expression regulation. Upregulation of several miRNAs increases the risk of invasion and metastasis of breast cancer cells. An oncogenic miRNA, miR-21, is highly expressed in triple-negative breast cancer (TNBC) and is associated with tumor proliferation, invasion, carcinogenesis, prognosis, and therapeutic resistance. However, targeted delivery of therapeutic anti-miRNAs into cancer cells remains challenging, especially for TNBC. In this study, we report the application of an RNA nanotechnology-based platform for the targeted delivery of anti-miR-21 by epidermal growth factor receptor (EGFR) aptamer in vitro to TNBC and chemical-resistant breast cancer cells. RNA nanoparticles reduced cell viability and sensitized breast cancer cells to doxorubicin (DOX) treatment in vitro. Inhibition of miR-21 by RNA nanoparticles suppressed TNBC cell invasion, migration, and colony formation. The results indicate the potential application of nanotechnology-based delivery platforms in clinical anti-cancer therapeutics. • A multitude of clinical data revealed the important role of miR-21 in breast cancer. • RNA nanoparticles carrying anit-miR-21 were successfully constructed in the study. • The efficient cellular binding and uptake of 3WJ-EGFRapt/anti-miR-21 NPs were tested. • 3WJ-EGFRapt/anti-miR-21 NPs suppressed cancer cell invasion, migration, and colony formation. • The remarkable synergistic effect of miR-21 knockdown with chemotherapy was revealed. [ABSTRACT FROM AUTHOR]

Published
2021
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