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189 results on '"Zhang, Shu-Yun"'

7. Design of amidobenzimidazole STING receptor agonists with systemic activity

Author

Ramanjulu, Joshi M., Pesiridis, G. Scott, Yang, Jingsong, Concha, Nestor, Singhaus, Robert, Zhang, Shu-Yun, Tran, Jean-Luc, Moore, Patrick, Lehmann, Stephanie, Eberl, H. Christian, Muelbaier, Marcel, Schneck, Jessica L., Clemens, Jim, Adam, Michael, Mehlmann, John, Romano, Joseph, Morales, Angel, Kang, James, Leister, Lara, Graybill, Todd L., Charnley, Adam K., Ye, Guosen, Nevins, Neysa, Behnia, Kamelia, Wolf, Amaya I., Kasparcova, Viera, Nurse, Kelvin, Wang, Liping, Puhl, Ana C., Li, Yue, Klein, Michael, Hopson, Christopher B., Guss, Jeffrey, Bantscheff, Marcus, Bergamini, Giovanna, Reilly, Michael A., Lian, Yiqian, Duffy, Kevin J., Adams, Jerry, Foley, Kevin P., Gough, Peter J., Marquis, Robert W., Smothers, James, Hoos, Axel, and Bertin, John

Published
2018
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8. Mechanism of the Visible-Light-Promoted C(sp3)–H Oxidation via Uranyl Photocatalysis

Author

Zhang, Shu-Yun, Tang, Song-Bai, Jiang, Yan-Xin, Zhu, Ru-Yu, Wang, Zi-Xin, Long, Bo, and Su, Jing

Abstract

Uranyl cation, as an emerging photocatalyst, has been successfully applied to synthetic chemistry in recent years and displayed remarkable catalytic ability under visible light. However, the molecular-level reaction mechanisms of uranyl photocatalysis are unclear. Here, we explore the mechanism of the stepwise benzylic C–H oxygenation of typical alkyl-substituted aromatics (i.e., toluene, ethylbenzene, and cumene) via uranyl photocatalysis using theoretical and experimental methods. Theoretical calculation results show that the most favorable reaction path for uranyl photocatalytic oxidation is as follows: first, hydrogen atom transfer (HAT) from the benzyl position to form a carbon radical ([R•]), then oxygen addition ([R•] + O2→ [ROO•]), then radical–radical combination ([ROO•] + [R•] → [ROOR] → 2[RO•]), and eventually [RO•] reduction to produce alcohols, of which 2° alcohol would further be oxidized to ketones and 1° would be stepwise-oxygenated to acids. The results of the designed verification experiments and the capture of reactive intermediates were consistent with those of theoretical calculations and the previously reported research that the active benzylic C–H would be stepwise-oxygenated in the presence of uranyl. This work deepens our understanding of the HAT mechanism of uranyl photocatalysis and provides important theoretical support for the relevant application of uranyl photocatalysts in organic transformation.

Published
2024
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10. Supplementary Data from The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Author

Liu, Li, primary, Mayes, Patrick A., primary, Eastman, Stephen, primary, Shi, Hong, primary, Yadavilli, Sapna, primary, Zhang, Tianqian, primary, Yang, Jingsong, primary, Seestaller-Wehr, Laura, primary, Zhang, Shu-Yun, primary, Hopson, Chris, primary, Tsvetkov, Lyuben, primary, Jing, Junping, primary, Zhang, Shu, primary, Smothers, James, primary, and Hoos, Axel, primary

Published
2023
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11. Supplementary figure 2 from The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Author

Liu, Li, primary, Mayes, Patrick A., primary, Eastman, Stephen, primary, Shi, Hong, primary, Yadavilli, Sapna, primary, Zhang, Tianqian, primary, Yang, Jingsong, primary, Seestaller-Wehr, Laura, primary, Zhang, Shu-Yun, primary, Hopson, Chris, primary, Tsvetkov, Lyuben, primary, Jing, Junping, primary, Zhang, Shu, primary, Smothers, James, primary, and Hoos, Axel, primary

Published
2023
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12. Supplementary figure 1 from The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Author

Liu, Li, primary, Mayes, Patrick A., primary, Eastman, Stephen, primary, Shi, Hong, primary, Yadavilli, Sapna, primary, Zhang, Tianqian, primary, Yang, Jingsong, primary, Seestaller-Wehr, Laura, primary, Zhang, Shu-Yun, primary, Hopson, Chris, primary, Tsvetkov, Lyuben, primary, Jing, Junping, primary, Zhang, Shu, primary, Smothers, James, primary, and Hoos, Axel, primary

Published
2023
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13. Supplementary tables S1-S6 from The BRAF and MEK Inhibitors Dabrafenib and Trametinib: Effects on Immune Function and in Combination with Immunomodulatory Antibodies Targeting PD-1, PD-L1, and CTLA-4

Author

Liu, Li, primary, Mayes, Patrick A., primary, Eastman, Stephen, primary, Shi, Hong, primary, Yadavilli, Sapna, primary, Zhang, Tianqian, primary, Yang, Jingsong, primary, Seestaller-Wehr, Laura, primary, Zhang, Shu-Yun, primary, Hopson, Chris, primary, Tsvetkov, Lyuben, primary, Jing, Junping, primary, Zhang, Shu, primary, Smothers, James, primary, and Hoos, Axel, primary

Published
2023
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14. Data from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Author

Rhodes, Nelson, primary, Heerding, Dirk A., primary, Duckett, Derek R., primary, Eberwein, Derek J., primary, Knick, Victoria B., primary, Lansing, Timothy J., primary, McConnell, Randy T., primary, Gilmer, Tona M., primary, Zhang, Shu-Yun, primary, Robell, Kimberly, primary, Kahana, Jason A., primary, Geske, Robert S., primary, Kleymenova, Elena V., primary, Choudhry, Anthony E., primary, Lai, Zhihong, primary, Leber, Jack D., primary, Minthorn, Elisabeth A., primary, Strum, Susan L., primary, Wood, Edgar R., primary, Huang, Pearl S., primary, Copeland, Robert A., primary, and Kumar, Rakesh, primary

Published
2023
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15. Supplementary Figure 2 from Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885

Author

King, Alastair J., primary, Patrick, Denis R., primary, Batorsky, Roberta S., primary, Ho, Maureen L., primary, Do, Hieu T., primary, Zhang, Shu Yun, primary, Kumar, Rakesh, primary, Rusnak, David W., primary, Takle, Andrew K., primary, Wilson, David M., primary, Hugger, Erin, primary, Wang, Lifu, primary, Karreth, Florian, primary, Lougheed, Julie C., primary, Lee, Jae, primary, Chau, David, primary, Stout, Thomas J., primary, May, Earl W., primary, Rominger, Cynthia M., primary, Schaber, Michael D., primary, Luo, Lusong, primary, Lakdawala, Ami S., primary, Adams, Jerry L., primary, Contractor, Rooja G., primary, Smalley, Keiran S.M., primary, Herlyn, Meenhard, primary, Morrissey, Michael M., primary, Tuveson, David A., primary, and Huang, Pearl S., primary

Published
2023
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16. Supplementary Figure 1 from Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885

Author

King, Alastair J., primary, Patrick, Denis R., primary, Batorsky, Roberta S., primary, Ho, Maureen L., primary, Do, Hieu T., primary, Zhang, Shu Yun, primary, Kumar, Rakesh, primary, Rusnak, David W., primary, Takle, Andrew K., primary, Wilson, David M., primary, Hugger, Erin, primary, Wang, Lifu, primary, Karreth, Florian, primary, Lougheed, Julie C., primary, Lee, Jae, primary, Chau, David, primary, Stout, Thomas J., primary, May, Earl W., primary, Rominger, Cynthia M., primary, Schaber, Michael D., primary, Luo, Lusong, primary, Lakdawala, Ami S., primary, Adams, Jerry L., primary, Contractor, Rooja G., primary, Smalley, Keiran S.M., primary, Herlyn, Meenhard, primary, Morrissey, Michael M., primary, Tuveson, David A., primary, and Huang, Pearl S., primary

Published
2023
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17. Supplementary Figures 1-3 from Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

Author

Atkins, Charity, primary, Liu, Qi, primary, Minthorn, Elisabeth, primary, Zhang, Shu-Yun, primary, Figueroa, David J., primary, Moss, Katherine, primary, Stanley, Thomas B., primary, Sanders, Brent, primary, Goetz, Aaron, primary, Gaul, Nathan, primary, Choudhry, Anthony E., primary, Alsaid, Hasan, primary, Jucker, Beat M., primary, Axten, Jeffrey M., primary, and Kumar, Rakesh, primary

Published
2023
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18. Data from Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

Author

Atkins, Charity, primary, Liu, Qi, primary, Minthorn, Elisabeth, primary, Zhang, Shu-Yun, primary, Figueroa, David J., primary, Moss, Katherine, primary, Stanley, Thomas B., primary, Sanders, Brent, primary, Goetz, Aaron, primary, Gaul, Nathan, primary, Choudhry, Anthony E., primary, Alsaid, Hasan, primary, Jucker, Beat M., primary, Axten, Jeffrey M., primary, and Kumar, Rakesh, primary

Published
2023
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19. Supplementary Material from Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

Author

Atkins, Charity, primary, Liu, Qi, primary, Minthorn, Elisabeth, primary, Zhang, Shu-Yun, primary, Figueroa, David J., primary, Moss, Katherine, primary, Stanley, Thomas B., primary, Sanders, Brent, primary, Goetz, Aaron, primary, Gaul, Nathan, primary, Choudhry, Anthony E., primary, Alsaid, Hasan, primary, Jucker, Beat M., primary, Axten, Jeffrey M., primary, and Kumar, Rakesh, primary

Published
2023
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20. Supplementary Figure 3 from Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885

Author

King, Alastair J., primary, Patrick, Denis R., primary, Batorsky, Roberta S., primary, Ho, Maureen L., primary, Do, Hieu T., primary, Zhang, Shu Yun, primary, Kumar, Rakesh, primary, Rusnak, David W., primary, Takle, Andrew K., primary, Wilson, David M., primary, Hugger, Erin, primary, Wang, Lifu, primary, Karreth, Florian, primary, Lougheed, Julie C., primary, Lee, Jae, primary, Chau, David, primary, Stout, Thomas J., primary, May, Earl W., primary, Rominger, Cynthia M., primary, Schaber, Michael D., primary, Luo, Lusong, primary, Lakdawala, Ami S., primary, Adams, Jerry L., primary, Contractor, Rooja G., primary, Smalley, Keiran S.M., primary, Herlyn, Meenhard, primary, Morrissey, Michael M., primary, Tuveson, David A., primary, and Huang, Pearl S., primary

Published
2023
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21. Supplementary Figure 2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Author

Rhodes, Nelson, primary, Heerding, Dirk A., primary, Duckett, Derek R., primary, Eberwein, Derek J., primary, Knick, Victoria B., primary, Lansing, Timothy J., primary, McConnell, Randy T., primary, Gilmer, Tona M., primary, Zhang, Shu-Yun, primary, Robell, Kimberly, primary, Kahana, Jason A., primary, Geske, Robert S., primary, Kleymenova, Elena V., primary, Choudhry, Anthony E., primary, Lai, Zhihong, primary, Leber, Jack D., primary, Minthorn, Elisabeth A., primary, Strum, Susan L., primary, Wood, Edgar R., primary, Huang, Pearl S., primary, Copeland, Robert A., primary, and Kumar, Rakesh, primary

Published
2023
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22. Supplementary Methods and Figure Legends 1-2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Author

Rhodes, Nelson, primary, Heerding, Dirk A., primary, Duckett, Derek R., primary, Eberwein, Derek J., primary, Knick, Victoria B., primary, Lansing, Timothy J., primary, McConnell, Randy T., primary, Gilmer, Tona M., primary, Zhang, Shu-Yun, primary, Robell, Kimberly, primary, Kahana, Jason A., primary, Geske, Robert S., primary, Kleymenova, Elena V., primary, Choudhry, Anthony E., primary, Lai, Zhihong, primary, Leber, Jack D., primary, Minthorn, Elisabeth A., primary, Strum, Susan L., primary, Wood, Edgar R., primary, Huang, Pearl S., primary, Copeland, Robert A., primary, and Kumar, Rakesh, primary

Published
2023
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25. Constitutive androstane receptor (CAR) mediates pyrene-induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells.

Author

Shi, Zhe, Li, Xue, Zhang, Yu‐Man, Zhou, Yi‐Yao, Gan, Xiu‐Feng, Fan, Qiao‐Ying, He, Chen‐Qing, Shi, Tong, Zhang, Shu‐Yun, Zhang, Yu-Man, Zhou, Yi-Yao, Gan, Xiu-Feng, Fan, Qiao-Ying, He, Chen-Qing, and Zhang, Shu-Yun

Subjects
ANDROSTANE receptors, BLOOD proteins, AMYLOID plaque, HIGH performance liquid chromatography, INFLAMMATION, POLLUTANTS, AMYLOID beta-protein, T helper cells
Abstract

Background and Purpose: The constitutive androstane receptor (CAR), a known xenobiotic sensor, plays an important role in drug metabolism by regulating numerous genes. The polycyclic aromatic hydrocarbon pyrene, an environmental pollutant, is a CAR activator and induces mouse hepatotoxicity via CAR. Here, we investigate the molecular mechanisms of the inflammatory response in pyrene-caused mice liver injury.Experimental Approach: Effects of pyrene on the liver were investigated in wild-type and CAR knockout (KO) mice. Levels of pyrene and its urinary metabolite were analysed by high performance liquid chromatography (HPLC). Inflammatory responses were measured by qRT-PCR, western blotting, and ELISA for cytokines.Key Results: Serum amyloid A proteins (SAAs) were markedly increased in the liver and serum of pyrene-exposed wild-type mice. IL-17-producing helper T cells (Th17 cells) and IL-17 levels were increased in the liver of pyrene-exposed wild-type mice. Hepatic mRNA levels of inflammatory cytokines including IL-1β, IL-6 and TNFα, and serum IL-6 levels were significantly elevated in pyrene-treated wild-type mice. However, these changes were not observed in CAR KO mice.Conclusion and Implications: CAR plays a crucial role in pyrene-caused mice liver inflammatory response with increased SAAs and Th17 cells. Our results suggest that serum SAAs may be a convenient biomarker for early diagnosis of liver inflammatory response caused by polycyclic aromatic hydrocarbons, including pyrene. CAR and Th17 cells may be potential targets for novel therapeutic strategies for xenobiotic-induced liver inflammation. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity

Author

Ramanjulu, Joshi M., Pesiridis, G. Scott, Yang, Jingsong, Concha, Nestor, Singhaus, Robert, Zhang, Shu-Yun, Tran, Jean-Luc, Moore, Patrick, Lehmann, Stephanie, Eberl, H. Christian, Muelbaier, Marcel, Schneck, Jessica L., Clemens, Jim, Adam, Michael, Mehlmann, John, Romano, Joseph, Morales, Angel, Kang, James, Leister, Lara, Graybill, Todd L., Charnley, Adam K., Ye, Guosen, Nevins, Neysa, Behnia, Kamelia, Wolf, Amaya I., Kasparcova, Viera, Nurse, Kelvin, Wang, Liping, Puhl, Ana C., Li, Yue, Klein, Michael, Hopson, Christopher B., Guss, Jeffrey, Bantscheff, Marcus, Bergamini, Giovanna, Reilly, Michael A., Lian, Yiqian, Duffy, Kevin J., Adams, Jerry, Foley, Kevin P., Gough, Peter J., Marquis, Robert W., Smothers, James, Hoos, Axel, and Bertin, John

Published
2019
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34. Chrysene, a four-ring polycyclic aromatic hydrocarbon, induces hepatotoxicity in mice by activation of the aryl hydrocarbon receptor (AhR)

Author

Tao, Li-Ping, primary, Li, Xue, additional, Zhao, Ming-Zhu, additional, Shi, Jing-Ru, additional, Ji, Si-Qi, additional, Jiang, Wen-Yuan, additional, Liang, Qiu-Ju, additional, Lei, Yu-Hang, additional, Zhou, Yi-Yao, additional, Cheng, Rong, additional, Shi, Zhe, additional, Deng, Wenhai, additional, Zhu, Jiayin, additional, and Zhang, Shu-Yun, additional

Published
2021
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43. Study on Mechanical Properties of Submunition's Ribbon Straightening Section.

Author

Qin, Dong-ze, Zhang, Wei, Zhang, Shu-Yun, Guo, Tian-Ji, Pei, Shui-Yuan, and Zhang, Jin-Shi

Abstract

The humanitarian damage caused by the unexploded submunitions is one of the hot issues of concern to the international community at present. A portion of the submunition that did not explode was caused by a break at the connection between the ribbon riveting and the fuze. According to the physical structure of the submunition and the trajectory into which it was ejected, we analyzed the forces of the submunition in flight, deduced the related mathematical models, and clarify the key elements of the mechanics. In this paper, the commercial simulation software was used to calculate the mechanical properties of the ribbon. And the variation regularity between drop velocity and straightening force of ribbon are revealed. And the response characteristics of different material ribbon with different sizes of riveting holes and riveting joints under tensile action were simulated. The simulation results show that, in the trajectory environment with 30 m/s~55 m/s typical stream speed, the tensile force of the ribbon is less than 300 N, and the application concentration of the connecting parts of the riveting joint and the ribbon will not cause the failure of the kevlar ribbon, but it will cause the failure of the nylon ribbon. In order to verify the variation of the tension of kevlar ribbons in different trajectory environments, we designed the experimental scheme of tension test of the ribbon straightening section of submunition and conducted experiments. Experimental results and numerical simulation results revealed the same law. This paper provides effective technical support for solving the problem of unexploded submunitions. [ABSTRACT FROM AUTHOR]

Published
2020
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45. Synergy of TLR4 agonist GSK1795091, an innate immune activator, with agonistic antibody against co-stimulatory immune checkpoint molecule OX40 in cancer immunotherapy.

Author

Gao, Hua-Xin, primary, Bhattacharya, Sabyasachi, additional, Matheny, Christopher Jon, additional, Yanamandra, Niranjan, additional, Zhang, Shu-Yun, additional, Emerich, Heidi, additional, Li, Yufeng, additional, Bojczuk, Paul, additional, Shi, Hong, additional, Wang, Wei, additional, Hopson, Christopher, additional, Fu, Tihui, additional, Allison, James Patrick, additional, Sharma, Padmanee, additional, Smothers, James F ., additional, Srinivasan, Roopa, additional, and Hoos, Axel, additional

Published
2018
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46. Abstract 1637: ICOS agonism induces potent immune activation and anti-tumor response in non-clinical models

Author

Yadavilli, Sapna, primary, Zhang, Tianqian, additional, Hahn, Ashleigh, additional, Seestaller-Wehr, Laura M., additional, Shi, Hong, additional, Liu, Yao-Bin, additional, DeYoung, M.Phillip, additional, Kilian, David J., additional, Bi, Meixia, additional, Adam, Michael P., additional, Zhang, Shu-Yun, additional, Bhattacharya, Sabyasachi, additional, Katlinskaya, Yuliya, additional, Blackwell, Christina, additional, Hopson, Christopher B., additional, Yanamandra, Niranjan, additional, Srinivasan, Roopa, additional, Mayes, Patrick A., additional, and Hoos, Axel, additional

Published
2017
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47. Abstract IA22: Targeting inducible T cell co-stimulator (ICOS) promotes effector T cell function and antitumor response

Author

Mayes, Patrick A., primary, Yadavilli, Sapna, additional, Liu, Yao-Bin, additional, Bi, Meixia, additional, Zhang, Tianqian, additional, Sendeyo, Kelhia, additional, Willoughby, Jane, additional, Seestaller-Wehr, Laura, additional, Hahn, Ashleigh, additional, Bhattacharya, Sabyasachi, additional, DeYoung, M. Phillip, additional, Blackwell, Christina, additional, Shi, Hong, additional, Killian, David, additional, Adam, Michael, additional, Zhang, Shu-Yun, additional, Jing, Junping, additional, Hopson, Chris, additional, Marodon, Gilles, additional, Cragg, Mark S., additional, and Hoos, Axel, additional

Published
2016
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49. Abstract A149: Evaluating immune contexture in syngeneic mouse models of cancer

Author

Yadavilli, Sapna, primary, Bhattacharya, Sabyasachi, additional, Hahn, Ashleigh, additional, Seestaller-Wehr, Laura, additional, Kilian, David, additional, Bi, Meixia, additional, Zhang, Shu-Yun, additional, Vitali, Nicholas, additional, Adam, Michael, additional, Li, Yufeng, additional, Yanamandra, Niranjan, additional, Srinivasan, Roopa, additional, and Hoos, Axel, additional

Published
2016
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