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246 results on '"Zhang, Shiqian"'

12. Splicing Factor PQBP1 Curtails BAX Expression to Promote Ovarian Cancer Progression

Author

Liu, Xihan, primary, Zhang, Jiaojiao, additional, Wang, Zixiang, additional, Yan, Mingyao, additional, Xu, Meining, additional, Li, Gaoyuan, additional, Shender, Victoria, additional, Wei, Jian‐jun, additional, Li, Jianqiao, additional, Shao, Changshun, additional, Zhang, Shiqian, additional, Kong, Beihua, additional, Song, Kun, additional, and Liu, Zhaojian, additional

Published
2024
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15. Oxidative stress in hair follicle development and hair growth: Signalling pathways, intervening mechanisms and potential of natural antioxidants.

Author

Du, Fanpan, Li, Jingjie, Zhang, Shiqian, Zeng, Xuemei, Nie, Jing, and Li, Zheng

Subjects
HAIR growth, HAIR follicles, CELLULAR signal transduction, OXIDATIVE stress, ENDOCRINE diseases
Abstract

Hair follicle development and hair growth are regulated by multiple factors and multiple signalling pathways. The hair follicle, as an important skin appendage, is the basis for hair growth, and it has the functions of safeguarding the body, perceiving the environment and regulating body temperature. Hair growth undergoes a regular hair cycle, including anagen, catagen and telogen. A small amount of physiological shedding of hair occurs under normal conditions, always in a dynamic equilibrium. Hair loss occurs when the skin or hair follicles are stimulated by oxidative stress, inflammation or hormonal disorders that disrupt the homeostasis of the hair follicles. Numerous researches have indicated that oxidative stress is an important factor causing hair loss. Here, we summarize the signalling pathways and intervention mechanisms by which oxidative stress affects hair follicle development and hair growth, discuss existing treatments for hair loss via the antioxidant pathway and provide our own insights. In addition, we collate antioxidant natural products promoting hair growth in recent years and discuss the limitations and perspectives of current hair loss prevention and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Dendrobium nobile Lindl Polysaccharides Attenuate UVB‐induced Photodamage by Regulating Oxidative Stress, Inflammation and MMPs Expression in Mice Model.

Author

Long, Yunluan, Wang, Wuji, Zhang, Yanyan, Zhang, Shiqian, Li, Zheng, Deng, Jiang, and Li, Jingjie

Subjects
GLUTATHIONE peroxidase, OXIDATIVE stress, STAINS & staining (Microscopy), ANIMAL disease models, TOLUIDINE blue, DENDROBIUM
Abstract

Acute ultraviolet B (UVB) irradiation predominantly leads to various skin disorders caused by photodamage. The major causes of UVB‐induced photodamage include oxidative stress, inflammatory infiltration and collagen degradation. The aim of the study was to elucidate whether DNP had protective effect on the skin of KM mice when exposed to UVB irradiation. The DNP protective properties to skin appearance and histopathological alterations in KM mice were evaluated by hematoxylin–eosin staining, toluidine blue staining, Gomori staining and Masson's trichrome staining and mast cell staining. In this study, DNP pretreatment promoted the activities of antioxidant enzymes, including superoxide dismutase, catalase and glutathione peroxidase, while decreased malondialdehyde level in UVB‐irradiated skin, along with downregulation of proteins expression of matrix metalloproteinases and reduction in the level of the proinflammatory cytokines. Based on these findings, we demonstrated that DNP displayed strong ameliorative effects on UVB‐induced acute photodamage for the first time, indicating that it would be a promoting ingredient candidate that could be used in antiphotodamage. [ABSTRACT FROM AUTHOR]

Published
2023
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