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The possibility of Fe loaded on BP (Fe@BP) as an efficient gas sensor for the detection of toxic gases such as NO2, NO, and CO is studied by the first‐principles calculation, and it is proposed that Fe@BP is an excellent gas‐sensitive material. The adsorption behaviors of gases on Fe@BP were analyzed in terms of adsorption configurations and electronic properties. It is found that all gases adsorbed on Fe@BP exhibit significantly enhanced interactions, and the adsorption intensity is much larger than that of molecules adsorbed on the surface of pure BP. Fe@BP has high selectivity for toxic and ambient gas molecules. In addition, the adsorption strength of NO2 and NO molecules on Fe@BP increases after compression strain is applied (within −3%), while the adsorption strength of CO decreases gradually. After the tensile strain is applied, the adsorption intensity of NO2 and NO is decreased, but that of CO is increased gradually. It is speculated that the strain causes changes in the electronic structure, which affects the adsorption behavior. The adsorption of NO has a stronger strain sensitivity. For these reasons, Fe@BP with high adsorption strength and strain selection is the ideal gas‐sensitive material. [ABSTRACT FROM AUTHOR]

Two-dimensional (2D) semiconductor materials have been extensively studied as excellent candidates for future optoelectronic devices. Cr2Ge2Te6, as a two-dimensional semiconductor material, has attracted extensive interest in the field of photodetectors due to its excellent light absorption properties and suitable band gap. Inspired by biological photosynthesis, this study constructed a high-performance biomimetic self-powered photoelectrochemical-type flexible photodetector using liquid-stripped Cr2Ge2Te6 nanosheets as the photoanode. The device exhibits obvious self-powered photoresponse behavior and excellent photoresponse performance with a responsivity of 54.4 μA/W. Furthermore, the addition of nicotinamide adenine dinucleotide phosphate (NADPH) effectively consumes the photo-excited holes on the Cr2Ge2Te6 nanosheets to inhibit the recombination of photogenerated electron–hole pairs, and the cyclic regeneration of NADPH is realized by adding adenosine triphosphate. In addition, the flexible photodetector also exhibits excellent stability and durability, and it still maintains good photoresponse characteristics after 1000 times of bending and folding. Our work fully confirms that it is an effective means to improve the photoresponse performance of 2D materials by simulating biological photosynthesis, and it also provides theoretical and experimental guidance for the research and development of high-performance biomimetic devices. [ABSTRACT FROM AUTHOR]

Two-dimensional metal carbides (MXene) have become promising candidates for fabricating the supercapacitors. Ti2CTx is more popular in the MXene family due to its lighter mass and excellent electrochemical properties. In this paper, multilayer Ti2CTx is synthesized via choosing the Al layer of etched Ti2AlC raw material. Under the condition of ultrasonic treatment, the as-prepared electrode based on few-layer Ti2CTx nanosheets possess high specific capacitance and strong rate ability. Compared with the etched Ti2CTx, the capacitance performance of ultrasonic Ti2CTx has been greatly improved, which the specific capacitance changes from the initial 133 F g−1 to 284 F g−1 at the current density of 1 A g−1. In addition, the fabricated electrode remains 91% of the initial capacitance after 1000 cycles of constant current charge and discharge at 1 A g−1. This work demonstrates that the fabricated Ti2CTx electrode has excellent capacitive properties and promotes potential use in supercapacitors. [ABSTRACT FROM AUTHOR]

The van der Waals (vdWs) heterostructure retains some excellent properties of monolayer transition metal dichalcogenides (TMDs), and has a significant improvement in performance, which is anticipated to play an important role in optoelectronic devices. S vacancy and interlayer interaction act together to influence the properties of the system. In this work, based on first-principles calculations, the effect of S vacancy on the electronic and optical properties of the MoS2/WSe2 heterostructure were investigated. The calculation demonstrated that a single S vacancy introduces defect states between the conduction band minimum (CBM) and the Fermi level. For optical properties, the formed, built-in electric field of a heterostructure would prevent electron and hole recombination. Both systems show strong light absorption in the visible and ultraviolet regions. The absorption coefficient in the infrared regions of the defected MoS2/WSe2 heterostructure was larger than that of the perfect heterostructure. The defect states were influenced by interlayer distance. The defected MoS2/WSe2 heterostructure experienced a direct-gap semiconductor to metal, and the band gap decreased with decreasing layer distance. Also, all the systems showed strong light absorption in the visible and ultraviolet regions. As for the near-infrared region, light absorption of the defected MoS2/WSe2 heterostructure was more obvious as the interlayer distance decreased, while the smaller the layer distance, the more obvious was the absorption in the near-infrared region. In summary, S vacancy and interlayer interaction have important effects on the electronic structure and optical properties of the MoS2/WSe2 heterostructure, which is helpful for the design of multifunctional high-performance optoelectronic devices. [ABSTRACT FROM AUTHOR]

Background: Cellular senescence (CS) is believed to be a major factor in the evolution of cancer. However, CS-related lncRNAs (CSRLs) involved in colon cancer regulation are not fully understood. Our goal was to create a novel CSRLs prognostic model for predicting prognosis and immunotherapy and exploring its potential molecular function in colon cancer., Methods: The mRNA sequencing data and relevant clinical information of GDC TCGA Colon Cancer (TCGA-COAD) were obtained from UCSC Xena platform, and CS-associated genes was acquired from the CellAge website. Pearson correlation analysis was used to identify CSRLs. Then we used Kaplan-Meier survival curve analysis and univariate Cox analysis to acquire prognostic CSRL. Next, we created a CSRLs prognostic model using LASSO and multivariate Cox analysis, and evaluated its prognostic power by Kaplan-Meier and ROC curve analysis. Besides, we explored the difference in tumor microenvironment, somatic mutation, immunotherapy, and drug sensitivity between high-risk and low-risk groups. Finally, we verified the functions of MYOSLID in cell experiments., Results: Three CSRLs (AC025165.1, LINC02257 and MYOSLID) were identified as prognostic CSRLs. The prognostic model exhibited a powerful predictive ability for overall survival and clinicopathological features in colon cancer. Moreover, there was a significant difference in the proportion of immune cells and the expression of immunosuppressive point biomarkers between the different groups. The high-risk group benefited from the chemotherapy drugs, such as Teniposide and Mitoxantrone. Finally, cell proliferation and CS were suppressed after MYOSLID knockdown., Conclusion: CSRLs are promising biomarkers to forecast survival and therapeutic responses in colon cancer patients. Furthermore, MYOSLID, one of 3-CSRLs in the prognostic model, could dramatically regulate the proliferation and CS of colon cancer., Competing Interests: LC, FC, SZ, HZ and YB were employed by Shenzhen Nucleus Gene Technology Co., Ltd., and Shanghai Nucleus Biotechnology Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Cao, Chen, Xu, Zeng, Wang, Zhang, Ba and Zhang.)

Purpose: The intratumoral microorganisms participates in the progression and immunotherapy of colorectal cancer (CRC). However, due to technical limitations, the impact of microorganisms on CRC has not been fully understood. Therefore, we conducted a systematic analysis of relationship between bacterial lipopolysaccharide (LPS)-associated genes and immune cells to explore new biomarkers for predicting the prognosis of CRC., Methods: The single-cell RNA sequencing data and the Comparative Toxicogenomics Database were used to screen T cells-associated LPS-related genes (TALRGs). Then, we established and validated the TALRGs risk signature in The Cancer Genome Atlas Colon Adenocarcinoma (TCGA-COAD) cohort and GSE39582 cohort. Besides, we compared the differences in tumor-infiltrating immune cell types, immunotherapeutic response, somatic mutation profiles, and tumor mutation burden (TMB) between high-risk group and low-risk group. In addition, the immunotherapeutic cohort (Imvigor210) treated with an anti-PD-L1 agent was performed to explore the potential value of the TALRGs signature on immunotherapy., Results: Five prognostic TALRGs were identified and selected to build the prognostic model. The high-risk group had poor prognosis in both TCGA-COAD cohort ( P < 0.0001) and GSE39582 cohort ( P = 0.00019). The areas under the curves (AUCs) of TALRGs signature were calculated (TCGA-COAD cohort: 0.624 at 1 years, 0.639 at 3 years, 0.648 at 5 years; anti-PD-L1 cohort was 0.59). The high-risk group had advanced pathological stages and higher TMN stages in both TCGA-COAD cohort and GSE39582 cohort. The high-risk group had the higher infiltration of immunosuppressive cells, the expressions of immune checkpoint molecules, the IC50 values of chemotherapy drugs, and TP53 mutation rate ( P < 0.05). In addition, patients with high TMB had worse prognosis ( P < 0.05). Furthermore, the Imvigor210 also showed patients with high-risk scores had poor prognosis (platinum-treated cohort: P = 0.0032; non-platinum-treated cohort: P = 0.00017)., Conclusions: Microorganisms are closely related to the tumor microenvironment to influence the progression and immune response of CRC via stimulating T cells through LPS-related genes. The TALRGs signature contributed to predict the prognosis and immunotherapy of CRC, and became new therapeutic targets and biomarkers of CRC.