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2. Hash encoding empowered IRON for inverse rendering: Geometry and material reconstruction(哈希编码优化的IRON逆渲染模型：重建几何与材质)

Author

张沛全(ZHANG Peiquan)

Subjects
Electronic computers. Computer science, QA75.5-76.95, Physics, QC1-999
Abstract

将神经网络用于场景几何材质的高效表达，结合逆向渲染在二维光度图的监督下重建高质量的网格和材质贴图，为现有的图形学流水线提供服务——神经渲染已成为近年来计算机图形学新的研究热点。在IRON（inverse rendering by optimizing neural SDFs and materials from photometric images）神经渲染模型基础上，通过引入多分辨率哈希编码，采用冻结训练等方法提高原始模型的训练速度。在多个数据集上的对比实验表明，优化后的IRON逆渲染模型训练速度提升了约40%，且重建结果中包含更多细节。

Published
2023
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13. Synthesis and in vitro anticancer evaluation of novel flavonoid-based amide derivatives as regulators of the PI3K/AKT signal pathway for TNBC treatment

Author

Zha, Dailong, primary, Li, Yuanzhi, additional, Luo, Yingqi, additional, Liu, Yingfan, additional, Lin, Zehong, additional, Lin, Chujie, additional, Chen, Siyue, additional, Wu, Jiangping, additional, Yu, Lihong, additional, Chen, Shaobin, additional, Zhang, Peiquan, additional, Wu, Wenhao, additional, and Zhang, Chao, additional

Published
2022
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20. Synthesis and in vitroanticancer evaluation of novel flavonoid-based amide derivatives as regulators of the PI3K/AKT signal pathway for TNBC treatmentElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00148a

Author

Zha, Dailong, Li, Yuanzhi, Luo, Yingqi, Liu, Yingfan, Lin, Zehong, Lin, Chujie, Chen, Siyue, Wu, Jiangping, Yu, Lihong, Chen, Shaobin, Zhang, Peiquan, Wu, Wenhao, and Zhang, Chao

Abstract

Aberrant activation of the PI3K/AKT pathway is considered in many malignant tumors and plays a crucial role in mediating malignancy progression, metastasis, and chemoresistance. Consequently, development of PI3K/AKT pathway targeted drugs is currently an attractive research field for tumor treatment. In this study, twenty-six flavonoid-based amide derivatives were synthesized and evaluated for their antiproliferation effects against seven cancer cell lines, including MDA-MB-231, MCF-7, HCC1937, A549, HepG2, GTL-16 and HeLa. Among them, compound 7tpossessed the best specific cytotoxicity against triple negative breast cancer MDA-MB-231 cells with an IC50value of 1.76 ± 0.91 μM and also presented inhibitory ability on clonal-formation, migration and invasion of MDA-MB-231 cells. Further cell-based mechanistic studies demonstrated that compound 7tcaused cell cycle arrest of MDA-MB-231 cells at the G0/G1phase and induced apoptosis. Meanwhile, the western blot assay revealed that compound 7tcould down-regulate the expression of p-PI3K, p-AKT, and Bcl-2 and up-regulate the production of PTEN, Bax, and caspase-3. Molecular docking also showed a possible binding mode of 7twith PI3Kα. Together, compound 7twas eligible as a potential TNBC therapeutic candidate for further development.

Published
2022
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25. Preparation of chalcogenide glass fiber using an improved extrusion method

Author

Zijun Liu, Zhu Minming, Xiang Shen, Qiuhua Nie, Xianghua Zhang, Guangming Tao, Ci Cheng, Xunsi Wang, Qingde Zhu, Zhang Peiquan, Huijuan Xu, Jiang Chen, Fangxing Liao, Peiqing Zhang, Shixun Dai, Ningbo University of Technology (NBUT), Zhejiang University, University of Central Florida [Orlando] (UCF), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Jonchère, Laurent, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
All-silica fiber, Materials science, Optical fiber, Cracks, Glass fibers, Characterization, Utilization rates, Cladding (coating), 02 engineering and technology, 01 natural sciences, law.invention, 010309 optics, law, 0103 physical sciences, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, Fiber design and fabrication, Preforming, Composite material, Plastic optical fiber, Chalcogenide glass fibers, Plastic-clad silica fiber, Extrusion, Germanium, Transmission loss, General Engineering, Infrared fiber optics, Fiber materials, 021001 nanoscience & nanotechnology, Cladding (fiber optics), Atomic and Molecular Physics, and Optics, Fibers, Chalcogenide glass, Reference surface, Glass, 0210 nano-technology, Hard-clad silica optical fiber, Fiber characterizations, Photonic-crystal fiber, Chalcogenides
Abstract

International audience; We developed the extrusion method to prepare arsenic-free chalcogenide glass fibers with glass cladding. By using the double nested extrusion molds and the corresponding isolated stacked extrusion method, the utilization rate of glass materials was greatly improved compared with the conventional extrusion method. Fiber preforms with optimal stability of core/cladding ratio throughout the 160 mm length were prepared using the developed extrusion method. Typical fiber structure defects between the core/cladding interface, such as bubbles, cracks, and core diameter variation, were effectively eliminated. Ge-Sb-Se/S chalcogenide glasses were used to form a core/cladding pair and fibers with core/cladding structure were prepared by thermally drawing the extruded preforms. The transmission loss, fiber bending loss, and other optical characters of the fibers were also investigated. © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).

Published
2016
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26. Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation

Author

Lan, Xiaoying, primary, Zhao, Chong, additional, Chen, Xin, additional, Zhang, Peiquan, additional, Zang, Dan, additional, Wu, Jinjie, additional, Chen, Jinghong, additional, Long, Huidan, additional, Yang, Li, additional, Huang, Hongbiao, additional, Wang, Xuejun, additional, Shi, Xianping, additional, and Liu, Jinbao, additional

Published
2017
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27. Improvements on the optical properties of Ge-Sb-Se chalcogenide glasses with iodine incorporation

Author

Xianghua Zhang, Qiuhua Nie, Xiang Shen, Zhang Peiquan, Shixun Dai, Xunsi Wang, Tiefeng Xu, Ci Cheng, Zijun Liu, Qingde Zhu, Fangxing Liao, Jiang Chen, Zhu Minming, Laboratory of Infrared Material and Devices, Ningbo University (NBU), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), This work was financially supported by the National Program on Key Basic Research Project (973 Program) (Grant No. 2012CB722703), The Natural Science Foundation of China (Grant Nos. 61377099, 61435009 and 61177087), Scientific Research Fund of Zhejiang Provincial Education Department (R1101263), Natural Science Foundation of Ningbo (Grant No. 2013A610118), Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE, P.R.C. Ningbo Optoelectronic Materials and Devices Creative Team (2009B21007), Scientific Research Foundation of the Graduate School of Ningbo University, and the K. C. Wong Magna Fund of Ningbo University., Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Band gap, Chalcogenide, Infrared, [SDV]Life Sciences [q-bio], Analytical chemistry, Chalcogenide glass, Infrared spectroscopy, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, symbols.namesake, Optics, 0103 physical sciences, Absorption (electromagnetic radiation), infrared spectroscopy, 010302 applied physics, Optical properties, business.industry, Glass and other amorphous materials, Fiber materials, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, chemistry, Attenuation coefficient, Raman spectroscopy, symbols, 0210 nano-technology, business
Abstract

International audience; Decreasing glass network defects and improving optical transmittance are essential work for material researchers. We studied the function of halogen iodine (I) acting as a glass network modifier in Ge–Sb–Se–based chalcogenide glass system. A systematic series of Ge20Sb5Se75-xIx (x = 0, 5, 10, 15, 20 at%) infrared (IR) chalcohalide glasses were investigated to decrease the weak absorption tail (WAT) and improve the mid-IR transparency. The mechanisms of the halogen I affecting the physical, thermal, and optical properties of Se-based chalcogenide glasses were reported. The structural evolutions of these glasses were also revealed by Raman spectroscopy and camera imaging. The progressive substitution of I for Se increased the optical bandgap. The WAT and scatting loss significantly decreased corresponding to the progressive decrease in structural defects caused by dangling bands and structure defects in the original Ge20Sb5Se75 glass. The achieved maximum IR transparency of Ge–Sb–Se–I glasses can reach up to 80% with an effective transmission window between 0.94 μm to 17 μm, whereas the absorption coefficient decreased to 0.029 cm-1 at 10.16 μm. Thus, these materials are promising candidates for developing low-loss IR fibers.

Published
2015
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28. Fabrication and characterization of Ge–Sb–Se–I glasses and fibers

Author

Shixun Dai, Zijun Liu, Guangming Tao, Peiqing Zhang, Jiang Chen, Xianghua Zhang, Xiang Shen, Tiefeng Xu, Qingde Zhu, Xunsi Wang, Zhang Peiquan, Zhu Minming, Fangxing Liao, Ci Cheng, Qiuhua Nie, Laboratory of Infrared Material and Devices, Ningbo University (NBU), Center for Research and Education in Optics and Lasers (CREOL), University of Central Florida [Orlando] (UCF)-School of Optics, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), 61435009, 61377099, and 61177087, National Natural Science Foundation of China, 2012CB722703, The National Program on Key Basic Research Project (973 Program), 2011DFA12040, The International Science & Technology Cooperation Program of China, R1101263, The Scientific Research Fund of Zhejiang Provincial Education Department, 2013A610118, The Natural Science Foundation of Ningbo, 2009B21007, The Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE, P.R.C. Ningbo Optoelectronic Materials and Devices Creative Team, The Scientific Research Foundation of the Graduate School of Ningbo University, The K. C. Wong Magna Fund of Ningbo University, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Optical fiber, Chalcogenide, Glass fiber, Analytical chemistry, Chalcogenide glass, 02 engineering and technology, Porous glass, 01 natural sciences, law.invention, Optical and Electronic Materials, chemistry.chemical_compound, law, 0103 physical sciences, Nanotechnology, [CHIM]Chemical Sciences, General Materials Science, Crown glass (optics), Materials Treatment, 010302 applied physics, Thin Films, General Chemistry, Surfaces and Interfaces, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Characterization and Evaluation of Materials, Amorphous solid, Operating Procedures, chemistry, 0210 nano-technology, Hard-clad silica optical fiber
Abstract

Chalcogenide glasses of the Ge20Sb5Se75−x I x (x = 0, 5, 10, 15, 20 at.%) system were prepared. This study was performed to examine some Ge–Sb–Se–I glass physical and optical properties, the structural evolution of the glass network, and the optical properties of the infrared glass fibers based on our previous studies. The variation process of the glass physical properties, such as transition temperature, glass density, and refractive index, was investigated from the glass of Ge20Sb5Se75 to the Ge20Sb5Se75−x I x glass series. The structural evolutions of these glasses were examined by Raman spectroscopy. The Ge20Sb5Se55I20 composition was selected for the preparation of the IR fiber. The Ge20Sb5Se55I20 glass was purified through distillation, and the intensity of the impurity absorption peaks caused by Ge–O, H2O, and Se–H was reduced or eliminated in the purified glasses. Then, Ge20Sb5Se55I20 chalcogenide glass fiber for mid-infrared transmission was fabricated using high-purity materials. The transmission loss of the Ge20Sb5Se55I20 fiber was greatly reduced compared with that of the Ge20Sb5Se75 glass fiber. The lowest losses obtained were 3.5 dB/m at 3.3 μm for Ge20Sb5Se75I20 fiber, which was remarkably improved compared with 48 dB/m of the unpurified Ge20Sb5Se75 fiber.

Published
2015
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29. Freely adjusted properties in Ge–S based chalcogenide glasses with iodine incorporation

Author

Guangming Tao, Zhu Minming, Xunsi Wang, Jiang Chen, Xianghua Zhang, Shixun Dai, Zhang Peiquan, Xiang Shen, Tiefeng Xu, Huijuan Xu, Qiuhua Nie, Laboratory of Infrared Material and Devices, Ningbo University (NBU), Center for Research and Education in Optics and Lasers (CREOL), University of Central Florida [Orlando] (UCF)-School of Optics, Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), This work was financially supported by the National Program on Key Basic Research Project (973 Program) (Grant No. 2012CB722703), the Natural Science Foundation of China (Grant Nos. 61377099 and 61177087), the Scientific Research Fund of Zhejiang Provincial Education Department (R1101263), the Natural Science Foundation of Ningbo (Grant No. 2013A610118), the Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE, PRC, the Ningbo optoelectronic materials and devices creative team (2009B21007), the Scientific Research Foundation of Graduate School of Ningbo University, and the K. C. Wong Magna Fund in Ningbo University., Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Optical fiber, Chalcogenide, Infrared, Analytical chemistry, Chalcogenide glass, Physics::Optics, 02 engineering and technology, 01 natural sciences, Condensed Matter::Disordered Systems and Neural Networks, law.invention, chemistry.chemical_compound, law, Impurity, 0103 physical sciences, [CHIM]Chemical Sciences, Fiber, Purification, 010302 applied physics, chemistry.chemical_classification, Polymer, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Condensed Matter::Soft Condensed Matter, chemistry, Halogen, 0210 nano-technology
Abstract

International audience; In this study, we examined the function of halogen iodine acting as a glass network modifier in green chalcogenide glasses based on the Ge–S system. We obtained a series of Ge–S–I glasses and determined their glass-forming region. We then recorded the physical, thermal, and optical properties and studied the effect of halogen iodine on Ge–S–I glasses. Results show that these glasses have relatively wide optical transmission window for infrared (IR) applications. The softening temperature of Ge–S–I glasses varies from 210.54 °C to 321.63 °C, this temperature fits well with some kinds of high-temperature polymers, such as PES and PEI, the polymers serve as protective layers with high strength and flexibility, thus simplifying the fabrication processes of IR chalcogenide glass fiber. Finally, we performed a purification process to eliminate impurities and to improve optical spectra

Published
2015
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30. Preparation of Low-loss Ge15Ga10Te75 chalcogenide glass for far-IR optics applications

Author

Yuju He, Tiefeng Xu, Qiuhua Nie, Zhang Peiquan, Guangming Tao, Xunsi Wang, Huijuan Xu, Xianghua Zhang, Shixun Dai, Laboratory of Infrared Material and Devices, Ningbo University (NBU), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Center for Research and Education in Optics and Lasers (CREOL), University of Central Florida [Orlando] (UCF)-School of Optics, This work was financially supported by the Natural Science Foundation of China (Grant Nos. 61377099 and 61177087), Scientific Research Fund of Zhejiang Provincial Education Department (R1101263), Natural Science Foundation of Ningbo (Grant No. 2013A610118), Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE, P.R.C. Ningbo optoelectronic materials and devices creative team (2009B21007) , Scientific Research Foundation of Graduate School of Ningbo University and sponsored by K.C. Wong Magna Fund in Ningbo University, The Outstanding (Postgraduate) Dissertation Growth Foundation of Ningbo University (Grant PY2012015), the National Program on Key Basic Research Project (973 Program) (Grant No. 2012CB722703)., Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Quenching, Materials science, Analytical chemistry, Chalcogenide glass, Optical loss, [CHIM.MATE]Chemical Sciences/Material chemistry, Condensed Matter Physics, Evaporation (deposition), Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Differential scanning calorimetry, Getter, Impurity, Thermal stability, Absorption (electromagnetic radiation), Purification
Abstract

International audience; Ge15Ga10Te75 (GGT) glass shows good transparency between 2 and 25 μm wavelengths, good chemical and thermal stability to be drawn into fiber, which appears to be a good candidate for developing far-IR fiber-optics devices, although there are strong absorption peaks caused by impurities in the glass. With the aim of decreasing the content of impurities and micro-crystal particles in prepared \GGT\ glass samples, a rapid heating furnace and the fast distillation method based on vapor evaporation plus deposition under vacuum condition was adopted. Properties measurements including Differential Scanning Calorimeter (DSC), Vis-NIR and \IR\ transmitting spectra were performed on the prepared glass samples. Dependence of optical loss on the types of oxygenic getters and their contents and glass quenching temperature was also studied. All these results show that the average optical losses of distilled glass samples were greatly improved by the designated purification processes. Besides, the quality of the glass samples can be improved with the optimized quenching temperature. In all, the optical loss of the glass can be reduced effectively. Minimum optical losses of 0.042 dB/mm at 9 μm and 0.037 dB/mm at 12 μm are obtained after a right purification process, which are the lowest loss of the \GGT\ chalcogenide glass nowadays.

Published
2014
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31. Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases

Author

Zhao, Chong, primary, Chen, Xin, additional, Yang, Changshan, additional, Zang, Dan, additional, Lan, Xiaoying, additional, Liao, Siyan, additional, Zhang, Peiquan, additional, Wu, Jinjie, additional, Li, Xiaofen, additional, Liu, Ningning, additional, Liao, Yuning, additional, Huang, Hongbiao, additional, Shi, Xianping, additional, Jiang, Lili, additional, Liu, Xiuhua, additional, Dou, Q. Ping, additional, Wang, Xuejun, additional, and Liu, Jinbao, additional

Published
2017
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32. Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Author

Lan, Xiaoying, primary, Zhao, Chong, additional, Chen, Xin, additional, Zhang, Peiquan, additional, Zang, Dan, additional, Wu, Jinjie, additional, Chen, Jinghong, additional, Long, Huidan, additional, Yang, Li, additional, Huang, Hongbiao, additional, Carter, Bing Z., additional, Wang, Xuejun, additional, Shi, Xianping, additional, and Liu, Jinbao, additional

Published
2016
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33. Preparation of chalcogenide glass fiber using an improved extrusion method

Author

Jiang, Chen, primary, Wang, Xunsi, additional, Zhu, Minming, additional, Xu, Huijuan, additional, Nie, Qiuhua, additional, Dai, Shixun, additional, Tao, Guangming, additional, Shen, Xiang, additional, Cheng, Ci, additional, Zhu, Qingde, additional, Liao, Fangxing, additional, Zhang, Peiquan, additional, Zhang, Peiqing, additional, Liu, Zijun, additional, and Zhang, Xianghua, additional

Published
2016
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34. Glass formation and properties of Ge-Ga-Te-ZnI2 far infrared chalcohalide glasses

Author

Tiefeng Xu, Shixun Dai, Qiuhua Nie, Yuju He, Zhang Peiquan, Xunsi Wang, Huijuan Xu, Xianghua Zhang, Laboratory of Infrared Material and Devices, Ningbo University (NBU), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Natural Science Foundation of China (Grant Nos. 60878042, 61111130197, 60908032, 61177087 and 60978058), Scientific Research Fund of Zhejiang Provincial Education Department (20070964, R1101263) Natural Science Foundation of Ningbo (Grant No. 2010A610171), Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE Ningbo Optoelectronic Materials And Devices Creative Team (2009B21007), Scientific Research Foundation of Graduate School of Ningbo University, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Absorption spectroscopy, Chalcogenide, Infrared, Band gap, Te-based, Analytical chemistry, Chalcogenide glass, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, Optics, Far infrared, Differential thermal analysis, 0103 physical sciences, Materials Chemistry, 010302 applied physics, business.industry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, chemistry, Absorption edge, Far-infrared, Ceramics and Composites, 0210 nano-technology, business
Abstract

International audience; In order to develop novel far infrared window material, a series of Ge-Ga-Te-ZnI2 chalcohalide glasses were prepared by traditional melt-quenching method and their glass-forming region was determined also. Here, some measurements including X-ray diffraction (XRD), differential thermal analysis (DTA), UV-Vis-NIR absorption spectrum, and infrared optical transmission spectra were carried out. The allowed indirect transition optical band gap was calculated according to the classical Tauc equation. The results show that with the addition of ZnI2, the glass-forming ability and thermal stability are improved gradually. With the contents of ZnI2 increased from 5 to 20 at.%, continued blue-shifting occurs in the cutting-off absorption edge of short-wavelength and the values of indirect optical band gaps were observed with ranges from 0.596 to 0.626 eV in these glasses. These GeTe4.3-GaTe3-ZnI2 glasses show wide optical transmission and the infrared cut-off wavelengths are larger than 25 μm, which implies that the Ge-Ga-Te-ZnI2 chalcogenide glasses possess the potential of far-IR optical window applications.

Published
2014
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36. Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase.

Author

Chen, Xin, Wu, Jinjie, Yang, Qianqian, Zhang, Xiaolan, Zhang, Peiquan, Liao, Siyan, He, Zhimin, Wang, Xuejun, Zhao, Chong, and Liu, Jinbao

Abstract

The ubiquitin-proteasome system (UPS) is indispensable to the protein quality control in eukaryotic cells. Due to the remarkable clinical success of using proteasome inhibitors for clinical treatment of multiple myeloma, it is anticipated that targeting the UPS upstream of the proteasome step be an effective strategy for cancer therapy. Deubiquitinases (DUB) are proteases that remove ubiquitin from target proteins and therefore regulate multiple cellular processes including some signaling pathways altered in cancer cells. Thus, targeting DUB is a promising strategy for cancer drug discovery. Previously, we have reported that metal complexes, such as copper and gold complexes, can disrupt the UPS via suppressing the activity of 19S proteasome-associated DUBs and/or of the 20S proteasomes, thereby inducing cancer cell death. In this study, we found that cadmium pyrithione (CdPT) treatment led to remarkable accumulation of ubiquitinated proteins in cultured cancer cells and primary leukemia cells. CdPT potently inhibited the activity of proteasomal DUBs (USP14 and UCHL5), but slightly inhibited 20S proteasome activity. The anti-cancer activity of CdPT was associated with triggering apoptosis via caspase activation. Moreover, treatment with CdPT inhibited proteasome function and repressed tumor growth in animal xenograft models. Our results show that cadmium-containing complex CdPT may function as a novel proteasomal DUB inhibitor and suggest appealing prospects for cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2018
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37. Fabrication and Optical Properties of Chalcogenide As2S3Suspended-Core Fiber

Author

Zhu Qingde, 祝清德, primary, Wang Xunsi, 王训四, additional, Zhang Peiqing, 张培晴, additional, Peng Tao, 彭涛, additional, Chen Wei, 陈玮, additional, Nie Qiuhua, 聂秋华, additional, Sun Lihong, 孙礼红, additional, Cheng Ci, 程辞, additional, Liu shuo, 刘硕, additional, Pan Zhanghao, 潘章豪, additional, Liao Fangxing, 廖方兴, additional, Zhang Peiquan, 张培全, additional, Liu Zijun, 刘自军, additional, Dai Shixun, 戴世勋, additional, and Guangming Tao, Guangming Tao, additional

Published
2015
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39. A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

Author

Liu, Ningning, primary, Liu, Chunjiao, additional, Li, Xiaofen, additional, Liao, Siyan, additional, Song, Wenbin, additional, Yang, Changshan, additional, Zhao, Chong, additional, Huang, Hongbiao, additional, Guan, Lixia, additional, Zhang, Peiquan, additional, Liu, Shouting, additional, Hua, Xianliang, additional, Chen, Xin, additional, Zhou, Ping, additional, Lan, Xiaoying, additional, Yi, Songgang, additional, Wang, Shunqing, additional, Wang, Xuejun, additional, Dou, Q. Ping, additional, and Liu, Jinbao, additional

Published
2014
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40. Fabrication and Optical Properties of Chalcogenide As2S3Suspended-Core Fiber

Author

祝清德 Zhu Qingde, 王训四 Wang Xunsi, 张培晴 Zhang Peiqing, 彭涛 Peng Tao, 陈玮 Chen Wei, 聂秋华 Nie Qiuhua, 孙礼红 Sun Lihong, 程辞 Cheng Ci, 刘硕 Liu shuo, 潘章豪 Pan Zhanghao, 廖方兴 Liao Fangxing, 张培全 Zhang Peiquan, 刘自军 Liu Zijun, 戴世勋 Dai Shixun, and Guangming Tao Guangming Tao

Subjects
Materials science, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published
2015
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41. Novel Ge-Ga-Te-KBr Far InfraredTransmitting Chalcogenide Glasses System

Author

ZHU Minming, 朱敏鸣, primary, WANG Xunsi, 王训四, additional, XU Huijuan, 徐会娟, additional, NIE Qiuhua, 聂秋华, additional, JIANG Chen, 姜晨, additional, ZHANG Peiquan, 张培全, additional, DAI Shixun, 戴世勋, additional, SHEN Xiang, 沈祥, additional, XU Tiefeng, 徐铁峰, additional, and XianghuaZhang, Xianghua Zhang, additional

Published
2014
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46. A new gold(I) complex-Au(PPh 3 )PT is a deubiquitinase inhibitor and inhibits tumor growth.

Author

Li X, Huang Q, Long H, Zhang P, Su H, and Liu J

Subjects
A549 Cells, Animals, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Enzyme Inhibitors pharmacology, Gene Expression Regulation, Neoplastic, Gold, Humans, Leukemia, Myeloid, Acute enzymology, Lung Neoplasms enzymology, Mice, Mice, Nude, Organogold Compounds chemistry, Organogold Compounds pharmacology, Xenograft Model Antitumor Assays, Deubiquitinating Enzymes antagonists & inhibitors, Enzyme Inhibitors administration & dosage, Leukemia, Myeloid, Acute drug therapy, Lung Neoplasms drug therapy, Organogold Compounds administration & dosage, Organophosphorus Compounds chemistry, Organoplatinum Compounds chemistry
Abstract

Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases. Through counteracting ubiquitination, deubiquitinases (DUBs) can either positively or negatively regulate UPS function, thereby representing attractive targets of cancer therapies. Previous studies have shown that metal complexes can inhibit tumor growth through targeting the UPS; however, novel metal complexes with higher specificity for cancer therapy are still lacking., Methods: We synthesized a new gold(I) complex, Au(PPh 3 )PT. The inhibitory activity of Au(PPh 3 )PT on the UPS and the growth of multiple cancer cell types were tested in vitro, ex vivo, and in vivo. Furthermore, we compared the efficacy of Au(PPh 3 )PT with other metal compounds in inhibition of UPS function and tumor growth., Findings: Here we report that (i) a new gold(I) complex-pyrithione, i.e., Au(PPh 3 )PT, induced apoptosis in two lung cancer cell lines A549 and NCI-H1299; (ii) Au(PPh 3 )PT severely impaired UPS proteolytic function; (iii) Au(PPh 3 )PT selectively inhibited 19S proteasome-associated DUBs (UCHL5 and USP14) and other non-proteasomal DUBs with minimal effects on the function of 20S proteasome; (iv) Au(PPh 3 )PT induced apoptosis in cancer cells from acute myeloid leukemia patients; (v) Au(PPh 3 )PT effectively suppressed the growth of lung adenocarcinoma xenografts in nude mice; and (vi) Au (PPh 3 )PT elicited less cytotoxicity in normal cells than several other metal compounds., Interpretation: Together, this study discovers a new gold(I) complex to be an effective inhibitor of the DUBs and a potential anti-cancer drug. FUND: The National High Technology Research and Development Program of China, the project of Guangdong Province Natural Science Foundation, the projects from Foundation for Higher Education of Guangdong, the project from Guangzhou Medical University for Doctor Scientists, the Medical Scientific Research Foundation of Guangdong Province, and the Guangzhou Key Medical Discipline Construction Project Fund., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2019
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