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430 results on '"Zhang, Mingkai"'

23. Giant duplication of the transverse colon in an adult: A case report and literature review

Author

Peng Zhihao, Zhang Mingkai, Wang Ruixue, Huang Hai, Sun Zongke, and Li Yanbin

Subjects
transverse colonic duplication, adult, ileus, emergency surgery, previous laparotomy, Biology (General), QH301-705.5
Abstract

Intestinal duplication is a rare congenital malformation that can occur in any segment of the digestive tract. It is most commonly found in the ileum of infants and is rarely reported in adults, especially in the colon. Diagnosing intestinal duplication can be extremely challenging due to its diverse clinical manifestations and complex anatomical structure. Surgical intervention is currently considered the mainstay of treatment. In this report, we presented a case of giant duplication of the transverse colon in an adult.

Published
2023
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36. Coupling coordination degree and influencing factors of green science and technology innovation efficiency and digital economy level: Evidence from provincial panel data in China

Author

Zhang Mingkai, Chen Xinlan, and Yang Guangming

Subjects
green science and technology innovation, digital economy, coupling coordination, condition configuration, fsQCA, Environmental sciences, GE1-350
Abstract

Green innovation and the digital economy are the new engine and driving force for Chinese high-quality development and will become the mainstream of China’s high-quality development. Therefore, it is of great significance to explore the interaction between the two for the formulation of economic development policies. This paper constructed an evaluation system of green science and technology innovation efficiency (GSTIE) and digital economy level (DEL) based on 30 provinces in China. Through the corrected coupling coordination degree (CCD) model, this paper measured the coupling coordination degree of green science and technology innovation efficiency and DEL and analyzed its provincial differences and spatial effects. By employing the fuzzy set Qualitative Comparative Analysis (fsQCA) method, this paper further explored the influencing factors configuration affecting the coupling coordination degree of GSTIE and DEL. The research results are as follows. Compared with the development of green science and technology innovation, the development of the digital economy was relatively backward. The coupling coordination degree between China’s provincial GSTIE and DEL showed an overall increasing trend year by year, and there was obvious spatial heterogeneity in which the eastern region was the highest, followed by the western and central regions. A single influencing factor does not constitute a necessary condition for a high coupling coordination degree. There were four paths that improve the coordinated development level between GSTIE and DEL: HC + RD + OP-jointly driven, RD + OP-dual driven, HC + GS-dual driven, and GS-oriented. Finally, based on the research conclusions, this paper proposed corresponding policy suggestions.

Published
2023
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44. Catalytic asymmetric synthesis of metabenzene isosteres

Author

Zhang, Mingkai, Chapman, Matthew, Sarode, Bhagyesh R., Xiong, Bingcong, Liang, Hao, Chen, James K., Weerapana, Eranthie, and Morken, James P.

Abstract

Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug1. Nonoptimal potency, metabolic stability, solubility and lipophilicity in pharmaceutical compounds can be improved by replacing aromatic rings with non-aromatic isosteric motifs2. Moreover, whereas aromatic rings are planar and lack three-dimensionality, the binding pockets of most pharmaceutical targets are chiral. Thus, the stereochemical configuration of the isosteric replacements may offer an added opportunity to improve the affinity of derived ligands for target receptors. A notable impediment to this approach is the lack of simple and scalable catalytic enantioselective syntheses of candidate isosteres from readily available precursors. Here we present a previously unknown palladium-catalysed reaction that converts hydrocarbon-derived precursors to chiral boron-containing nortricyclanes and we show that the shape of these nortricyclanes makes them plausible isosteres for metadisubstituted aromatic rings. With chiral catalysts, the Pd-catalysed reaction can be accomplished in an enantioselective fashion and subsequent transformation of the boron group provides access to a broad array of structures. We also show that the incorporation of nortricyclanes into pharmaceutical motifs can result in improved biophysical properties along with stereochemistry-dependent activity. We anticipate that these features, coupled with the simple, inexpensive synthesis of the functionalized nortricyclane scaffold, will render this platform a useful foundation for the assembly of new biologically active agents.

Published
2024
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47. Novel framework for dialogue summarization based on factual-statement fusion and dialogue segmentation.

Author

Zhang, Mingkai, You, Dan, and Wang, Shouguang

Subjects
*TEXT summarization
Abstract

The explosive growth of dialogue data has aroused significant interest among scholars in abstractive dialogue summarization. In this paper, we propose a novel sequence-to-sequence framework called DS-SS (Dialogue Summarization with Factual-Statement Fusion and Dialogue Segmentation) for summarizing dialogues. The novelty of the DS-SS framework mainly lies in two aspects: 1) Factual statements are extracted from the source dialogue and combined with the source dialogue to perform the further dialogue encoding; and 2) A dialogue segmenter is trained and used to separate a dialogue to be encoded into several topic-coherent segments. Thanks to these two aspects, the proposed framework may better encode dialogues, thereby generating summaries exhibiting higher factual consistency and informativeness. Experimental results on two large-scale datasets SAMSum and DialogSum demonstrate the superiority of our framework over strong baselines, as evidenced by both automatic evaluation metrics and human evaluation. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Dual-Frequency ISB Estimation and Stability Analysis of BDS/GPS

Author

Zhang, Mingkai, Liu, Zhiping, Yu, Jieqing, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Sun, Jiadong, editor, Yang, Changfeng, editor, and Yang, Yuanxi, editor

Published
2019
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