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The aim of this study is to explain the effects of miRNA-186 in renal injury induced by sepsis.

The Heifangtai, known as the modern natural landslide laboratory, is an independent loess tableland formed, which is located in northwest China. Agricultural irrigation in Heifangtai leads to a substantial rise in groundwater table. The loess landslides induced by irrigation and frozen stagnant water effect are a common geologic hazard in this area. However, in the existing researches, less attention was paid to the influencing factors of the frozen stagnant water effect, and the groundwater table lacked long-term data monitoring. In the numerical simulation, the seasonal variation of irrigation and the preferential channels of loess caves are not considered simultaneously. The response relationships among irrigation, frozen stagnant water effect, groundwater table, and slope stability are not yet clear. Based on field monitoring and numerical simulation, this paper studied the variation law of groundwater table under the irrigation and frozen stagnant water effect. The influence laws between irrigation, frozen stagnant water effect, and slope stability are discussed. Field monitoring found that the soil in the slope unsaturated area has longer freezing time and thicker freezing depth. Under the combination of irrigation and frozen stagnant water effect, the groundwater table kept rising from May 2019 to February 2020. Irrigation led to the increase of groundwater level by 0.35–0.45 m in 1 year. During the freezing period, the minimum slope safety stability coefficient caused by frozen stagnant water effect is 1.64. During the thawing period, the minimum slope safety stability coefficient caused by irrigation is 1.7. The slope failure is most prone to occur in February. [ABSTRACT FROM AUTHOR]

Iodine treatment administered before the end of the second trimester of pregnancy appears to provide effective protection from iodine deficiency in the fetal brain. Iodine deficiency causes endemic cretinism and is the most common preventable cause of mental retardation. Iodine treatment before conception is known to prevent cretinism, but the effects of treatment during pregnancy and after birth are less well known. Pregnant women and young children in an iodine-poor region were given iodine treatment. The children of women who received iodine treatment before the end of the second trimester of pregnancy showed a 2% rate of neurologic abnormalities, compared to 9% of the children who were treated during or after the third trimester. At about two years of age, the mean development score of the children whose mothers received iodine treatment before the end of the second trimester of pregnancy was 90, compared to a mean score of 75 in their untreated counterparts.