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138 results on '"Zhang, Min-Jie"'

15. Identification of a novel mutation in the FGF10 gene in a Chinese family with obvious congenital lacrimal duct dysplasia in lacrimo-auriculo-dento-digital syndrome

Author

Zhang, Hong-Yang, Zhang, Chun-Yan, Wang, Fei, Tao, Hai, Tian, Ya-Ping, Zhou, Xi-Bin, Bai, Fang, Wang, Peng, Cui, Jia-Yi, Zhang, Min-Jie, and Wang, Li-Hua

Subjects
Basic Research
Abstract

AIM: To identify the pathogenic gene variant in a family with lacrimo-auriculo-dento-digital syndrome [LADD (MIM 149730)] showing congenital lacrimal duct dysplasia as the main clinical manifestation and lay the foundation for future research on the pathogenic gene. METHODS: Ophthalmological examinations, including slit-lamp biomicroscopy and lacrimal duct probing, and computed tomography dacryocystography (CT-DCG) were performed for all participants. The family pedigree was drawn, genetic features were analyzed, and the genomic DNA of the subjects was extracted. Pathogenic genes were screened via whole exome sequencing (WES) and confirmed using Sanger sequencing. RESULTS: Six patients belonged to this three-generation family, and their clinical manifestations included congenital nasolacrimal duct obstruction, congenital absence of lacrimal puncta and canaliculi, lacrimal fistulae, and limb deformities. This pattern indicates autosomal dominant inheritance. Diagnosis was based on the clinical characteristics of LADD syndrome, which presented in all the patients in this family. A novel frameshift mutation in the FGF10 gene (NM_004465.1), c.234dupC (p.Trp79Leus*15), was identified in all patients via WES. The variant was confirmed by Sanger sequencing and classified as a “pathogenic mutation” according to the American College of Medical Genetics and Genomics (ACMG) variant interpretation guidelines. CONCLUSION: A novel frameshift mutation in the FGF10 gene is found in all patients. This finding helps this family with LADD syndrome receiving a more accurate clinical diagnosis and genetic counseling by extending the mutation range of the FGF10 gene.

Published
2023

18. A New Algorithm of Gray Watermark Embedding

Author

Shen, Yong-zeng, Zhang, Min-jie, Liu, Feng, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Dough, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Pan, Zhigeng, editor, Cheok, Adrian, editor, Haller, Michael, editor, Lau, Rynson W. H., editor, Saito, Hideo, editor, and Liang, Ronghua, editor

Published
2006
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22. Abnormal phenomenon of source-drain current of AlGaN/GaN heterostructure device under UV/visible light irradiation

Author

Liu, Yue-Bo, primary, Shen, Jun-Yu, additional, Xing, Jie-Ying, additional, Yao, Wan-Qing, additional, Liu, Hong-Hui, additional, Dai, Ya-Qiong, additional, Yang, Long-Kun, additional, Wang, Feng-Ge, additional, Ren, Yuan, additional, Zhang, Min-Jie, additional, Wu, Zhi-Sheng, additional, Liu, Yang, additional, and Zhang, Bai-Jun, additional

Published
2021
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39. Antitumor effects and mechanisms of dendritic cells stimulated by sCD40L on ovarian cancer cells in vitro

Author

Zhang,Zheng-mao, Yang,Xue-mei, Zhang,Chao, Zhang,Min-jie, Xia, Feng-hua, Shan, Shi-jie, Shan,Bao-en, Zhang,Zheng-mao, Yang,Xue-mei, Zhang,Chao, Zhang,Min-jie, Xia, Feng-hua, Shan, Shi-jie, and Shan,Bao-en

Abstract

Zheng-mao Zhang,1 Xue-mei Yang,1 Chao Zhang,2 Min-jie Zhang,1 Xia Li,1 Feng-hua Zhang,3 Shan Kang,1 Shi-jie Wang,4 Bao-en Shan21Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, 2Research Center, Fourth Hospital of Hebei Medical University, 3Department of General Surgery, Hebei General Hospital, 4Department of Gastroscopy, Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of ChinaObjective: This study aimed to examine the expression of immune suppression factors and the mechanisms of antitumor effects of cord blood dendritic cells (DCs) stimulated by soluble cluster of differentiation 40 ligand (sCD40L) and cytokines in vitro in ovarian cancer patients.Methods: The expression levels of interleukin (IL)-10 and transforming growth factor (TGF)-β messenger RNA in peripheral blood were detected by reverse transcription polymerase chain reaction; expression levels of CD80 and CD86 in DCs stimulated by sCD40L were detected using flow cytometry and confocal laser scanning microscopy.Results: Expression levels of IL-10 and TGF-β genes in the peripheral blood of ovarian cancer patients were significantly increased compared with patients with benign ovarian tumors (P < 0.05). The expression levels of CD80 and CD86 in DCs cultured in the granulocyte-macrophage colony-stimulating factor + IL-4 + stem cell factor + Flt-3 ligand + sCD40L group were significantly increased compared with those in the control group, as assessed by flow cytometry and confocal laser scanning microscopy (P < 0.05).Conclusion: A variety of cytokines in combination with sCD40L can promote the proliferation of cord blood-derived DCs and induce their maturation as well as stimulating a specific antitumor response.Keywords: antitumor response, cytokine, immunotherapy, cord blood, IL-10, TGF-&beta

Published
2013

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