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13 results on '"Zhang, Manyan"'

7. Long-term pegylated growth hormone for children with growth hormone deficiency: a large, prospective, real-world study

Author

Hou, Ling, primary, Huang, Ke, additional, Gong, Chunxiu, additional, Luo, Feihong, additional, Wei, Haiyan, additional, Liang, Liyang, additional, Du, Hongwei, additional, Zhang, Jianping, additional, Zhong, Yan, additional, Chen, Ruimin, additional, Chen, Xinran, additional, Pan, Jiayan, additional, Jin, Xianjiang, additional, Zeng, Ting, additional, Liao, Wei, additional, Liu, Deyun, additional, Lan, Dan, additional, Zhu, Shunye, additional, Dong, Zhiya, additional, Ma, Huamei, additional, Yang, Yu, additional, Xiong, Feng, additional, MB, Ping Lu, additional, Cheng, Shengquan, additional, Gu, Xuefan, additional, Jin, Runming, additional, Liu, Yu, additional, Wu, Jinzhun, additional, Xu, Xu, additional, Chen, Linqi, additional, Dong, Qin, additional, Pan, Hui, additional, Su, Zhe, additional, Liu, Lijun, additional, Luo, Xiaoming, additional, Ni, Shining, additional, Chen, Zhihong, additional, Hu, Yuhua, additional, Wang, Chunlin, additional, Liu, Jing, additional, Liu, Li, additional, Lu, Biao, additional, Wang, Xinli, additional, Wang, Yunfeng, additional, Yang, Fan, additional, Zhang, Manyan, additional, Cao, Lizhi, additional, Liu, GeLi, additional, Yao, Hui, additional, Zhang, Yaqin, additional, Dai, Mingjuan, additional, Li, Guimei, additional, Li, Li, additional, Liu, Yanjie, additional, Wang, Kan, additional, Xiao, Yanfeng, additional, Zhang, Xingxing, additional, Dong, Junhua, additional, Gu, Zaiyan, additional, Ying, Lirong, additional, Huang, Feng, additional, Liu, Yanling, additional, Liu, Zheng, additional, Ye, Jin, additional, Zhao, Dongmei, additional, Hu, Xu, additional, Jiang, Zhihong, additional, Ye, Kan, additional, Zhu, Hong, additional, Chen, Shaoke, additional, Chen, Xiaobo, additional, Wan, Naijun, additional, Xu, Zhuangjian, additional, Yin, Qingjin, additional, Zhang, Hongxiao, additional, Huang, Xiaodong, additional, Yin, Jianying, additional, Zhang, Huifeng, additional, Li, Pin, additional, Yin, Ping, additional, Fu, Junfen, additional, and Luo, XiaoPing, additional

Published
2023
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9. Short-term efficacy and safety of a lower dose of polyethylene glycol recombinant human growth hormone in children with growth hormone deficiency: A randomized, dose-comparison study

Author

Jiang, Zhouhong, primary, Chen, Xuefeng, additional, Dong, Guanping, additional, Lou, Yin, additional, Zhang, Jianping, additional, Cheng, Xinran, additional, Pan, Jiayan, additional, Liao, Wei, additional, Wu, Jinzhun, additional, Huang, Xiaodong, additional, Jin, Xianjiang, additional, Liu, Deyun, additional, Zeng, Ting, additional, Zhu, Shunye, additional, Dong, Qin, additional, Luo, Xiaoming, additional, Lan, Dan, additional, Cao, Lizhi, additional, Zhang, Xingxing, additional, Liu, Jing, additional, Dai, Mingjuan, additional, Zhang, Manyan, additional, Liu, Li, additional, Dong, Junhua, additional, Zhao, Dongmei, additional, Ni, Shaoqing, additional, and Fu, Junfen, additional

Published
2022
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11. Role and Mechanism of miR-181a-5p in Mice with Chronic Obstructive Pulmonary Disease by Regulating HMGB1 and the NF-κB Pathway.

Author

Zhang, Manyan, Lu, Yu, Liu, Lingling, Zhang, Xiaoyan, and Ning, Jiyu

Subjects
*CHRONIC obstructive pulmonary disease, *LEUCOCYTE elastase, *PATHOLOGICAL physiology, *SMOKING
Abstract

Chronic obstructive pulmonary disease (COPD) is a common respiratory disease. This study explored the mechanism of miR-181a-5p in the inflammatory response in COPD mice. COPD mouse models were established by cigarette smoke (CS) exposure following pretreatment with recombinant adeno-associated virus (rAAv)-miR-181a-5p, si-HMGB1 (high mobility group box 1), and NF-κB pathway inhibitor PDTC, respectively. Pathological changes of lung tissues were determined by HE staining. Bronchoalveolar lavage fluid was collected to count total cells, neutrophils, and lymphocytes using a Countess II automatic cell counter. Expressions of neutrophil elastase (NE) and inflammatory factors (TNF-α, IL-6, IL-8, and IFN-γ) were detected by ELISA. Binding relationship between miR-181a-5p and HMGB1 was predicted on starBase and validated by dual-luciferase assay. miR-181a-5p expression was detected by RT-qPCR, and expressions of HMGB1, IκBα, and p-IκBα were detected by western blot. The expression level of miR-181a-5p was lower in lung tissues. miR-181a-5p overexpression alleviated inflammatory response and pathological changes of lung tissues in COPD mice, with decreased pulmonary inflammation scores, total cells, neutrophils, and lymphocytes and expressions of NE and inflammatory factors. HMGB1 expression level was increased in COPD mice. miR-181a-5p targeted HMGB1. si-HMGB1 relieved inflammatory responses in COPD mice. NF-κB was activated in COPD mice, evidenced by degraded IκBα and increased p-IκBα levels. si-HMGB1 significantly restrained the activation of NF-κB pathway. Briefly, miR-181a-5p targets HMGB1 to inhibit the NF-κB pathway, thus alleviating the inflammatory response in COPD mice. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study

Author

Hou, Ling, Huang, Ke, Gong, Chunxiu, Luo, Feihong, Wei, Haiyan, Liang, Liyang, Du, Hongwei, Zhang, Jianping, Zhong, Yan, Chen, Ruimin, Chen, Xinran, Pan, Jiayan, Jin, Xianjiang, Zeng, Ting, Liao, Wei, Liu, Deyun, Lan, Dan, Zhu, Shunye, Dong, Zhiya, Ma, Huamei, Yang, Yu, Xiong, Feng, Lu, Ping, Cheng, Shengquan, Gu, Xuefan, Jin, Runming, Liu, Yu, Wu, Jinzhun, Xu, Xu, Chen, Linqi, Dong, Qin, Pan, Hui, Su, Zhe, Liu, Lijun, Luo, Xiaoming, Ni, Shining, Chen, Zhihong, Hu, Yuhua, Wang, Chunlin, Liu, Jing, Liu, Li, Lu, Biao, Wang, Xinli, Wang, Yunfeng, Yang, Fan, Zhang, Manyan, Cao, Lizhi, Liu, GeLi, Yao, Hui, Zhan, Yaqin, Dai, Mingjuan, Li, Guimei, Li, Li, Liu, Yanjie, Wang, Kan, Xiao, Yanfeng, Zhang, Xingxing, Dong, Junhua, Gu, Zaiyan, Ying, Lirong, Huang, Feng, Liu, Yanling, Liu, Zheng, Ye, Jin, Zhao, Dongmei, Hu, Xu, Jiang, Zhihong, Ye, Kan, Zhu, Hong, Chen, Shaoke, Chen, Xiaobo, Wan, Naijun, Xu, Zhuangjian, Yin, Qingjin, Zhang, Hongxiao, Huang, Xiaodong, Yin, Jianying, Zhang, Huifeng, Li, Pin, Yin, Ping, Fu, Junfen, and Luo, XiaoPing

Published
2023
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