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This paper introduces a system that supports student-centered online one-to-one tutoring and evaluates the practical value of the system by running an experiment with 64 experienced mathematics teachers and 810 students in Grade 7. The experiment lasted for 50 days. A comprehensive evaluation was performed using students' academic performance before and after usage of the system and the system log files. By classifying the students into active and inactive usage groups, it was determined that active students significantly outperformed inactive students on posttests, but with a small effect size. The results also suggested that high prior knowledge students tended to benefit more from using the system than low prior knowledge students. An explanation for this result was that students with a high level of prior knowledge were more likely to have good-quality interactions with their teachers. Therefore, although some advantages of this type of student-centered online one-to-one tutoring are observed, in this system, both the students and the teachers need to be further facilitated to produce more effective tutoring interactions.

Background Oral traditional Chinese medicine (TCM) has been widely used in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD), but the outcome measures of relevant clinical trials have not been standardized and regulated. Objective To screen the published randomized controlled trials (RCTs) of oral TCM in the treatment of AECOPD, summarize the literature characteristics and outcome measures, so as to provide reference for the design of clinical trials and the selection of outcome measures for the treatment of AECOPD with TCM. Methods CNKI, Wanfang Data, VIP, SinoMed, PubMed, Embase, Web of Science, Cochrane Library, ClinicalTrials.gov and Chinese Clinical Trial Registry were systematically searched by computer to obtain RCTs and clinical trial registration protocols for the treatment of AECOPD with oral TCM from January 2018 to October 2022. After independent screening of the literature and extraction of data by 2 researchers, qualitative analysis was used to describe the selection of outcome measures in the enrolled studies. Results A total of 578 studies were enrolled, including 574 RCTs with reported trial results and 4 clinical trial registration protocols. A total of 51 508 patients were involved in 574 RCTs. In the inclusion criteria, 88 studies limited the classification of disease, and 361 studies limited the TCM syndrome type, 6 studies reported the blinding method, and 6 studies mentioned the follow-up. A total of 4 030 outcome measures were covered and the number of outcome measures in a single article ranged from 1 to 24. According to the functional attributes, the outcome measures were classified into 8 measure domains: TCM symptoms/syndromes, symptoms/signs, physical and chemical tests, quality of life, long-term prognosis, economic evaluation, safety evaluation and others. The measure domain with the highest reporting rate was physical and chemical tests, and the top 5 outcome measure items reported in terms of frequency were: response rate (11.5%), forced expiratory volume in 1 s (FEV1) (7.5%), TCM symptom/syndrome score (7.0%), FEV1/Forced Vital Capacity (FVC) (6.8%), FVC (4.6%). Four hundred and forty-five studies reported the composition of response rate, and the top 5 measures with reporting rate were symptoms (423), signs (281), TCM syndrome score (203), laboratory tests (89), and pulmonary function (71) . Conclusion The RCTs of oral TCM in the treatment of AECOPD involved a large number and a wide range of outcome measures. The included literature focused on the effects of oral TCM on the symptoms and signs, physical and chemical test indicators, quality of life, long-term prognosis, economic evaluation and safety outcomes of patients with AECOPD in varying degrees. However, the selection of outcome measures remains problematic in multiple ways: unclear prioritization of outcome measures; focusing on clinical endpoints with insufficient attention to clinical endpoints; insufficient attention to health economics indicators; different sources and judgment criterias of reference of response. In the future studies, researchers can design the rational outcome measures by refering to the published core outcome set (COS) to improve the quality of TCM clinical research.

Automatic short-answer grading has been studied for more than a decade. The technique has been used for implementing auto assessment as well as building the assessor module for intelligent tutoring systems. Many early works automatically grade mainly based on the similarity between a student answer and the reference answer to the question. This method performs well for closed-ended questions that have single or very limited numbers of correct answers. However, some short-answer questions ask students to express their own thoughts based on various facts; hence, they have no reference answers. Such questions are called semi-open-ended short-answer questions. Questions of this type often appear in reading comprehension assessments. In this paper, we developed an automatic semi-open-ended short-answer grading model that integrates both domain-general and domain-specific information. The model also utilizes a long-short-term-memory recurrent neural network to learn the representation in the classifier so that word sequence information is considered. In experiments on 7 reading comprehension questions and over 16,000 short-answer samples, our proposed automatic grading model demonstrates its advantage over existing models.

Objective To evaluate the efficacy and safety of yinqiao qingre tablet in treating common cold with wind-heat type.Methods The randomized, double-blind, placebo, parallel control research were applied to this study. The eligible subjects were divided into a experimental group, a positive control group and a placebo control group. The test drug was yinqiao qingre tablet, positive control drug was yinqiao jiedu tablet, and simulation drugs were yinqiao qingre simulation tablet and yinqiao jiedu simulation tablet. The experimental group was given yinqiao qingre tablet and yinqiao jiedu simulation tablet, the positive control group was given yinqiao qingre simulation tablet and yinqiao jiedu tablet, and the placebo control group was given yinqiao qingre simulation tablet and yinqiao jiedu simulation tablet.The course of treatment for each group was 3 days. Before and after treatment, the disappearance rate of major symptoms, individual symptom scores, efficacy of TCM syndrome, change of temperature, used of antipyretic analgesics and safety were evaluated. Results The disappearance rate of major symptoms was 62.12% in experimental group, was the highest among three groups(P

Despite their drawback, multiple-choice questions are an enduring feature in instruction because they can be answered more rapidly than open response questions and they are easily scored. However, it can be difficult to generate good incorrect choices (called "distractors"). We designed an algorithm to generate distractors from a semantic network for four types of multiple choice questions in biology. By recruiting 200 participants from Amazon Mechanical Turk, the machine-generated distractors were compared to human-generated distractors in terms of question difficulty, question discrimination and distractor usefulness. The machine-generated and human-generated distractors performed very closely on all the three measures, suggesting that generating distractors from a semantic network for simple multiple choice questions is a viable method.