Search

The study aimed to investigate the relationship between the respiratory quotient (RQ), measured by the central venous-arterial carbon dioxide partial pressure difference/arterial-venous oxygenation difference ratio, and the early remission of multi-organ failure (MOF) in sepsis patients with hyperlactatemia. The study observed 49 septic patients with hyperlactatemia in the ICU, obtaining blood samples before and after resuscitation, and dividing the patients into two groups depending on whether the modified Sequential Organ Failure Assessment score improved after 24 hours of treatment. Results showed that lactate clearance was faster and the rate of change in RQ was higher in the improved group than in the unimproved group. Further analysis showed that an RQ ≤0.198 mmHg/mL/L or a change of ≥30.71% in RQ after 24 hours of resuscitation was associated with early improvement in MOF. In conclusion, changes in RQ were associated with early improvement in MOF in septic patients with hyperlactatemia, suggesting that RQ could be used as a potential marker for predicting early remission and guiding clinical interventions. [ABSTRACT FROM AUTHOR]

Natural silk fibroin fiber scaffolds have excellent mechanical properties, but degrade slowly. In this study, we used poly(lactide-co-glycolide) (PLGA, 10:90) fibers to adjust the overall degradation rate of the scaffolds and filled them with collagen to reserve space for cell growth. Silk fibroin-PLGA (36:64) mesh scaffolds were prepared using weft-knitting, filled with type I collagen, and incubated with rabbit autologous bone marrow-derived mesenchymal stem cells (MSCs). These scaffold-cells composites were implanted into rabbit Achilles tendon defects. At 16 weeks after implantation, morphological and histological observations showed formation of tendon-like tissues that expressed type I collagen mRNA and a uniformly dense distribution of collagen fibers. The maximum load of the regenerated Achilles tendon was 58.32% of normal Achilles tendon, which was significantly higher than control group without MSCs. These findings suggest that it is feasible to construct tissue engineered tendon using weft-knitted silk fibroin-PLGA fiber mesh/collagen matrix seeded with MSCs for rabbit Achilles tendon defect repair. [ABSTRACT FROM AUTHOR]

The study aimed to investigate the relationship between the respiratory quotient (RQ), measured by the central venous-arterial carbon dioxide partial pressure difference/arterial-venous oxygenation difference ratio, and the early remission of multi-organ failure (MOF) in sepsis patients with hyperlactatemia. The study observed 49 septic patients with hyperlactatemia in the ICU, obtaining blood samples before and after resuscitation, and dividing the patients into two groups depending on whether the modified Sequential Organ Failure Assessment score improved after 24 hours of treatment. Results showed that lactate clearance was faster and the rate of change in RQ was higher in the improved group than in the unimproved group. Further analysis showed that an RQ ≤0.198 mmHg/mL/L or a change of ≥30.71% in RQ after 24 hours of resuscitation was associated with early improvement in MOF. In conclusion, changes in RQ were associated with early improvement in MOF in septic patients with hyperlactatemia, suggesting that RQ could be used as a potential marker for predicting early remission and guiding clinical interventions.

Objective: To investigate the effect of standardized quality control management on the rehabilitation of children with palsy in Ningbo City., Methods: In this retrospective study, a total of 400 pediatric patients requiring rehabilitation therapy admitted to Ningbo Rehabilitation Hospital from July 2017 to May 2021, were selected as the research subjects. Pediatric patients were divided into an observation group (standardized model) and a control group (routine model) based on the different quality management models. The rehabilitation efficacy, nursing quality, negative emotion, satisfaction, DQ scores, ADL scores, PDI scores, MDI scores, compliance rate, complaint rate of nursing, and incidence of adverse events were compared between the two groups., Results: The rehabilitation efficacy in the observation group was better than that in the control group (P<0.05). Compared to the control group, the nursing quality score and satisfaction rate were higher, and the negative emotion score was lower in the observation group (all P<0.05). DQ scores, ADL scores, PDI scores, and MDI scores in the observation group were higher than the control group (all P<0.05). The statistical differences were observed in the compliance rate, complaint rate in nursing, and incidence of adverse events between the two groups (all P<0.05)., Conclusions: The standardized quality control management enhanced the rehabilitation efficacy, promoted the nursing quality, improved the clinical effects, increased the satisfaction rate, and decreased the negative emotions in pediatric patients., Competing Interests: None., (AJTR Copyright © 2022.)