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Short-term prediction of liquefied gas concentration is helpful to assisted analysis of storage tank operation status and trend, can discover the potential safety hazards timely inside the storage tank, and then take effective measures to prevent and control the risks, so as to ensure the safety and stability of the oil and gas gathering and transportation industry. Within the limited space, affected by factors such as complexity, high dimension, strong correlation and weak regularity of storage tank operation data, the existing short-term prediction method of liquefied gas concentration is difficult to ensure the real-time performance and accuracy of prediction results. Therefore, we propose a short-term prediction method of liquefied gas concentration based on mixed intelligence. Firstly, we bring in an Extreme Change Function, and calculate the weighted set kurtosis value of the feature curve to realize feature dimension reduction. Secondly, the Convolutional Neural Network is used to mine the correlation between features and extract effective feature vectors. Meanwhile, we use Long Short-Term Memory Network to learn the change law of the data, so as to obtain the predicted value of liquefied gas concentration. Finally, our method is applied to a real scenario to demonstrate that the short-term prediction method of liquefied gas concentration achieves superior results in prediction accuracy, running speed and stability compared with other methods. [ABSTRACT FROM AUTHOR]

Gamma-ray bursts (GRBs) are the most intense explosions in the Universe. GRBs with extended emission (GRBs EE) constitute a small subclass of GRBs. GRBs EE are divided into EE-I GRBs and EE-II GRBs, according to the Amati empirical relationship rather than duration. We test here if these two types of GRB have different origins based on their luminosity function (and formation rate). Therefore, we use Lynden-Bell's c − method to investigate the luminosity function and formation rate of GRBs with EE without any assumption. We calculate the formation rate of two types of GRBs. For EE-I GRBs, the fitting function can be written as ρ(z) ∝ (1 + z)−0.34 ± 0.04 for z < 2.39 and ρ(z) ∝ (1 + z)−2.34 ± 0.24 for z > 2.39. The formation rate of EE-II can describe as ρ(z) ∝ (1 + z)−1.05 ± 1.10 for z < 0.43 and ρ(z) ∝ (1 + z)−8.44 ± 1.10 for z > 0.43. The local formation rate is |$\rho (0) = 0.03\, {\rm Gpc}^{-3} \, {\rm yr}^{-1}$| for some EE-I GRBs and |$\rho (0) = 0.32 \, {\rm Gpc}^{-3} \, {\rm yr}^{-1}$| for EE-II GRBs. Based on these results, we provide new evidence that the origins of EE-I GRBs are different from EE-II GRBs from the perspective of event rate. The EE-I GRB could be produced from the death of the massive star, but EE-II GRB may come from other processes that are unrelated to the star formation rate. Our findings indicate that the GRBs with EE could have multiple production channels. [ABSTRACT FROM AUTHOR]

We investigate the structural, magnetic, dielectric properties, and scaling behaviors of Aurivillius compounds Bi6-x/3Fe2Ti3-2x(WCo)xO18 (0 ⩽ x ⩽ 0.15). The room-temperature weak ferromagnetism is observed for the W/Co co-doped samples. The results of the dielectric constant εr, complex impedance Z", the dc conductivity σdc, and hopping frequency fH manifest that the dielectric relaxation of the x = 0 sample and the doped samples in the dielectric anomaly region (450-750 K) can be ascribed to the trap-controlled ac conduction around the doubly ionized oxygen vacancies and the localized hopping process of oxygen vacancies, respectively. The scaling behaviors reveal that the dynamic process of both electrons in the x = 0 sample and oxygen vacancies in the doped samples is temperature independent. The ferroelectric Curie-temperature Tc decreases slightly from 973K to 947K with increasing the doping level of W/Co. In addition, the dielectric loss exhibits a dielectric relaxation above 800K with the rather large activation energies (1.95 eV ⩽ Ea ⩽ 2.72 eV). [ABSTRACT FROM AUTHOR]

We investigate the magnetic, dielectric, and magnetodielectric properties of rare-earth-substituted Aurivillius phase Bi6Fe1.4Co0.6Ti3O18. The room-temperature ferromagnetic behavior is observed in all samples, and the rare-earth-substituted samples exhibit an enhanced magnetization. The weak ferromagnetism can be ascribed to the spin canting of the antiferromagnetic coupling of the Fe-based and Co-based sublattices via Dzyaloshinsky-Moriya interaction. The dielectric loss of all samples exhibits two dielectric relaxation peaks corresponding to two different relaxation mechanisms. One relaxation process with Ea = 0.5 eV is related to the hoping process of oxygen vacancies and the other one with Ea = 1.6 eV can be ascribed to the intrinsic conduction. The Gd-doped sample exhibits a remarkable magnetodielectric effect (9.4%) at RT implying this Aurivillius phase may be the potential candidate for magnetodielectric applications. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Increasing studies have indicated the important functions of long non-coding RNAs (lncRNAs) in tumorigenesis and progression including hepatocellular carcinoma (HCC). The study aims to explore the role of long non-coding RNA AK001796 in HCC progression. PATIENTS AND METHODS: Quantitative Real- time polymerase chain reaction (QRT-PCR) analysis was performed to examine the lncRNA AK001796 expression in 73 cases of human HCC tissue samples and matched adjacent normal tissues. Besides, the relationship between lncRNA AK001796 expression and clinicopathologic characteristics was analyzed. Overall survival (OS) curves of patients were constructed by the Kaplan-Meier methods. Multivariate Cox regression analysis was used to evaluate independent risk factors affecting HCC prognosis. Cell proliferation and invasion abilities are analyzed by cell counting kit-8 (CCK-8) and transwell invasion assays. RESULTS: We showed that the lncRNA AK001796 expression was significantly up-regulated in HCC tissues and cell lines, compared to their controls, respectively. Higher lncRNA AK001796 expression closely correlated with tumor size (p<0.05), TNM stage (p<0.05) and the poor overall survival (OS) rate of HCC patients (p<0.05). Besides, multivariate Cox regression analysis found that lncRNA AK001796 expression was identified as an independent risk factor for HCC prognosis. In vitro, we showed that lncRNA AK001796 knockdown markedly suppressed cell proliferation and cell invasion abilities. CONCLUSIONS: Our results suggested that lncRNA AK001796 acts as a predictor of HCC prognosis and may provide an important clinical value for HCC treatment. [ABSTRACT FROM AUTHOR]

A temperature gradient in a liquid mixture causes a concentration gradient through the Soret effect. We have developed an instrument to measure the Soret effect by observing the bending of a laser beam propagating horizontally through the liquid mixture subjected to a temperature gradient in the vertical direction. Our design of the liquid cell, with a long path length and controlled temperature uniformity, enables us to measure Soret coefficients with an accuracy of 1–3 %, higher than that obtained by previous investigators. In addition, by measuring the dynamic response of the beam deflection after imposition of the temperature gradient, we can also determine the mutual diffusion coefficient. We have applied the technique to mixtures of toluene and n-hexane over the temperature range 5–45 °C and to mixtures of ethanol and water at 25 °C. We have verified that the measured value of the Soret coefficient is independent of the magnitude of the temperature gradient imposed up to 14 K/cm. The Soret coefficients obtained for mixtures of toluene and n-hexane differ from the values obtained by previous investigators with a thermogravitational column method, but they are in good agreement with the results recently obtained by Köhler and Müller with a forced Rayleigh scattering method. For mixtures of ethanol and water, our Soret coefficients agree with the results obtained earlier by Kolodner et al., also with an optical beam-bending technique. © 1996 American Institute of Physics. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Propofol is one of the most commonly used intravenous anesthetic agents used in cancer resections, but the effect of propofol on non-small cell lung cancer (NSCLC) remains unclear. Previous researches have reported that propofol can inhibit extracellular signal-regulated kinase (ERK) 1/2 phosphorylation or activate p53-upregulated modulator of apoptosis (PUMA) signaling, resulting in apoptosis. In addition, PUMA is negatively regulated by ERK1/2 activation. In the present work, we determined the effect of propofol on NSCLC A549 cells and explored its signaling pathway. MATERIALS AND METHODS: A549 cells were treated with different concentrations of propofol (1-10 µg/mL) for 6 h. After washing, cells were cultured in Dulbecco's Modified Eagle Medium supplemented with 10% fetal bovine serum and antibiotics for another 72 h. Cell survival and apoptosis were determined by MTT, flow cytometry, and TUNEL analyses. To assess whether propofol functions via ERK1/2 and PUMA signaling pathways, A549 cells were transfected with small interfering RNA (siRNA) to target PUMA, or treated with human recombinant ERK1/2 (hrERK1/2) to activate ERK1/2. RESULTS: Propofol treatment inhibited viability and induced apoptosis of A549 cells in a dose-dependent manner in vitro. Propofol inhibited phosphorylation of ERK1/2 (pERK1/2) and increased ERK1/2-dependent PUMA expression. Knockdown of PUMA by siRNA or treatment with hrERK1/2 to activate ERK1/2 blocked propofol-induced apoptosis and cell viability. Upregulation of PUMA expression by propofol requires pERK1/2 inactivation. CONCLUSIONS: Propofol inhibits viability and induces apoptosis of A549 cells via an ERK1/2-dependent PUMA signaling. [ABSTRACT FROM AUTHOR]

OBJECTIVE: We have recently reported that therapies targeting TGF-β1 signaling were effective to prevent the anaplastic thyroid cancer (ATC) cell growth, but not the invasion. Phosphatidylinositol 3-kinase (PI3K)/AKT signaling are activated in ATC and play a major role in ATC invasion. Herein, we examined the effects of targeting TGF-β1 by shRNA in combination with pan-AKT inhibitor, MK-2206 on growth and metastasis of ATC xenografts implanted in severe combined immunodeficient mice. MATERIALS AND METHODS: 8505C cells or 8505C/shRNA cells or 8505C/TGF-β1 shRNA cells were implanted sc in 5-week-old female nude mice. Upon establishment of palpable tumours, MK-2206 was administered at 60 mg/kg, orally, three times a week for 6 weeks. RESULTS: The results showed that TGF-β1/shRNA alone only prevents anaplastic thyroid cancer (ATC) tumor formation, but not lung metastasis. MK-2206 alone only inhibits lung metastasis, but not tumor formation. The combined treatment with TGF-β1/shRNA and MK-2206 led to an approximately 71% growth inhibition compared with TGF-β1/shRNA (44%) and MK-2206 (15%). The combined treatment with TGF-β1/shRNA and MK- 2206 significantly inhibits lung metastasis. CONCLUSIONS: These findings demonstrated that targeting TGF-β1 in combination with MK-2206 was the effective method for treatment of ATC. [ABSTRACT FROM AUTHOR]

We investigate the effect of high magnetic-field annealing on the microstructural, ferroelectric, and magnetic properties of Bi6Fe1.4Co0.6Ti3O18 thin films. The magnetic field can lower the energy barrier for nucleation and improve the grain connectivity. The application of magnetic field of 6T parallel to the film plane can substantially enhance the remnant polarization Pr from 18.1 to 29 μC/cm² as a result of the variation in grain size and growth orientation caused by magnetic field annealing. Moreover, the remnant magnetization Mr is substantially improved from 2.48 to 4.56 emu/cm³ arising from the enhanced exchange coupling due to the better grain connectivity. These results demonstrate that high magnetic-field annealing is an effective way to optimize multiferroic properties of the Aurivillius compounds. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Vascular endothelial growth factor (VEGF) is the most potent inducer of neovasculature, and its increased expression has been related to a worse clinical outcome in many disease. Angiogenesis from thyroid cancer cell plays the important roles in post-surgical persistent, recurrent, and metastatic papillary thyroid cancer (PTC). Vascular endothelial growth factor (VEGF) Trapon is a newly developed VEGF-blocking agent with stronger affinity and broader activity than the anti-VEGF antibody bevacizumab. In this study, we tested the activity of VEGF Trapon on a PTC model in vivo. MATERIALS AND METHODS: BC-PAP (derived from papillary carcinomas) transfected with a luciferase-expressing vector were injected into the back to mice. I.p. treatment with VEGF Trapon or control protein (25 mg/kg twice weekly) was started shortly after tumor injection to prevent tumor development (prevention model) or after established tumors were formed to inhibit tumor growth and metastasis formation (intervention model). RESULTS: In the prevention model, VEGF Trapon inhibited tumor growth by 73 ± 12% compared with control (p = 0.014) and significantly prolonged survival. In the intervention model, VEGF Trapon inhibited tumor growth by 68 ± 7% (p < 0.01). Microvascular density was reduced by 56% due to VEGF Trapon treatment (p<0.01). CONCLUSIONS: VEGF Trapon is a potent inhibitor of BC-PAP tumor growth, angiogenesis and blocks the biological function of VEGF in vivo. These results support further clinical development of VEGF Trapon for PTC and other cancer types. [ABSTRACT FROM AUTHOR]

Electrical transport properties of La2/3Sr1/3VO3 (LSVO) thin films grown on LaAlO3 (LAO) and SrTiO3 (STO) substrates have been investigated. It is found that the LSVO/LAO show metal-insulator transition when decreasing the temperature, while the LSVO/STO exhibit metallic behavior. The difference in transport properties of LSVO thin films has been discussed based on the variation of oxygen content and can be attributed to different oxygen substrate-to-film transfer. These results highlight the crucial role of oxygen stoichiometry in determining the physical properties of LSVO and the importance of oxygen-substrate contribution in LSVO thin films. [ABSTRACT FROM AUTHOR]

The effect of compressive strain on the transport and magnetic properties of epitaxial LaMnO3+δ thin films has been investigated. It is found that the transport and magnetic properties of the LaMnO3+δ thin films grown on the LaAlO3 substrates can be tuned by the compressive strain through varying film thickness. And the insulator-metal transition, charge/orbital ordering transition, and paramagnetic-ferromagnetic transition are suppressed by the compressive strain. Consequently, the related electronic and magnetic transition temperatures decrease with an increase in the compressive strain. The present results can be explained by the strain-controlled lattice deformation and the consequent orbital occupation. It indicates that the lattice degree of freedomis crucial for understanding the transport and magnetic properties of the strongly correlated LaMnO3+δ. [ABSTRACT FROM AUTHOR]