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779 results on '"Zhang, Jixian"'

7. Impact of biannual mass azithromycin treatment on enteropathogen carriage in children younger than 5 years in Niger

Author

Platts-Mills, James A, Ayoub, Elias, Zhang, Jixian, McQuade, Elizabeth T Rogawski, Arzika, Ahmed Mamane, Maliki, Ramatou, Abdou, Amza, Keenan, Jeremy D, Lietman, Thomas M, Liu, Jie, and Houpt, Eric R

Subjects
Emerging Infectious Diseases, Infectious Diseases, Clinical Trials and Supportive Activities, Biotechnology, Clinical Research, Good Health and Well Being, Anti-Bacterial Agents, Azithromycin, Child, Child, Preschool, Humans, Infant, Mass Drug Administration, Niger, Prevalence, enteropathogens, Shigella, Shigella, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

We analyzed samples obtained at baseline and 24 months in a mass azithromycin administration trial in Niger using quantitative polymerase chain reaction. In villages randomized to azithromycin, Shigella was the only pathogen reduced at 24 months (prevalence ratio, 0.36 [95% confidence interval: .17-.79]; difference in log quantity, -.42 [-.75 to -.10]).

Published
2022

16. Etiology of acute febrile illness in the peruvian amazon as determined by modular formatted quantitative PCR: a protocol for RIVERA, a health facility-based case-control study

Author

Peñataro Yori, Pablo, Paredes Olórtegui, Maribel, Schiaffino, Francesca, Colston, Josh M., Pinedo Vasquez, Tackeshy, Garcia Bardales, Paul F., Shapiama Lopez, Valentino, Zegarra Paredes, Loyda Fiorella, Perez, Karin, Curico, Greisi, Flynn, Thomas, Zhang, Jixian, Ramal Asayag, Cesar, Meza Sanchez, Graciela, Silva Delgado, Hermann, Casapia Morales, Martin, Casanova, Wilma, Jiu, Bruce, Oberhelman, Richard, Munayco Escate, Cesar, Silver, Rachel, Henao, Olga, Cooper, Kerry K., Liu, Jie, Houpt, Eric R., and Kosek, Margaret N.

Published
2023
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17. A Truthful Revenue-Maximizing Resource Allocation Auction Mechanism in the Internet of Vehicles Cloud-Edge Environment

Author

Zhang, Ziyuan, Zhang, Jixian, Nie, Peng, Yang, Zhe, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Dong, Jian, editor, and Zhang, Long, editor

Published
2023
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38. Cross‐Modal Graph Contrastive Learning with Cellular Images.

Author

Zheng, Shuangjia, Rao, Jiahua, Zhang, Jixian, Zhou, Lianyu, Xie, Jiancong, Cohen, Ethan, Lu, Wei, Li, Chengtao, and Yang, Yuedong

Subjects
CELL imaging, GRAPH neural networks, DRUG discovery, TREATMENT effectiveness, MOLECULAR structure
Abstract

Constructing discriminative representations of molecules lies at the core of a number of domains such as drug discovery, chemistry, and medicine. State‐of‐the‐art methods employ graph neural networks and self‐supervised learning (SSL) to learn unlabeled data for structural representations, which can then be fine‐tuned for downstream tasks. Albeit powerful, these methods are pre‐trained solely on molecular structures and thus often struggle with tasks involved in intricate biological processes. Here, it is proposed to assist the learning of molecular representation by using the perturbed high‐content cell microscopy images at the phenotypic level. To incorporate the cross‐modal pre‐training, a unified framework is constructed to align them through multiple types of contrastive loss functions, which is proven effective in the formulated novel tasks to retrieve the molecules and corresponding images mutually. More importantly, the model can infer functional molecules according to cellular images generated by genetic perturbations. In parallel, the proposed model can transfer non‐trivially to molecular property predictions, and has shown great improvement over clinical outcome predictions. These results suggest that such cross‐modality learning can bridge molecules and phenotype to play important roles in drug discovery. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Trichinella spiralis Infection Inhibits the Efficacy of RBD Protein of SARS-CoV-2 Vaccination via Regulating Humoral and Cellular Immunity.

Author

Zhu, Feifan, Zheng, Wenwen, Gong, Yiyan, Zhang, Jinyuan, Yu, Yihan, Zhang, Jixian, Liu, Mengjun, Guan, Fei, and Lei, Jiahui

Subjects
VACCINE effectiveness, HELMINTHIASIS, ZOONOSES, TRICHINELLA spiralis, CELLULAR immunity
Abstract

Vaccines are the most effective and feasible way to control pathogen infection. Helminths have been reported to jeopardize the protective immunity mounted by several vaccines. However, there are no experimental data about the effect of helminth infection on the effectiveness of COVID-19 vaccines. Here, a mouse model of trichinosis, a common zoonotic disease worldwide, was used to investigate effects of Trichinella spiralis infection on the RBD protein vaccine of SARS-CoV-2 and the related immunological mechanism, as well as the impact of albendazole (ALB) deworming on the inhibitory effect of the parasite on the vaccination. The results indicated that both the enteric and muscular stages of T. spiralis infection inhibited the vaccine efficacy, evidenced by decreased levels of IgG, IgM, sIgA, and reduced serum neutralizing antibodies, along with suppressed splenic germinal center (GC) B cells in the vaccinated mice. Pre-exposure to trichinosis promoted Th2 and/or Treg immune responses in the immunized mice. Furthermore, ALB treatment could partially reverse the inhibitory effect of T. spiralis infection on the efficiency of the vaccination, accompanied by a restored proportion of splenic GC B cells. Therefore, given the widespread prevalence of helminth infections worldwide, deworming therapy needs to be considered when implementing COVID-19 vaccination strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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47. HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy

Author

Zhang, Tuo, primary, Tong, Yuntong, additional, Zhu, Rengguang, additional, Liang, Yaoyun, additional, Zhang, Jixian, additional, Hu, Chujiao, additional, He, Meina, additional, Hu, Zhu, additional, Shen, Zhiyi, additional, Niu, Jin, additional, Zhang, Jingjing, additional, Yu, Yuanyuan, additional, Jin, Bangming, additional, Lei, Shan, additional, Zeng, Zhirui, additional, Wu, Yingmin, additional, Cheng, Zengmei, additional, Xiao, Ziwen, additional, Guo, Bing, additional, Zhao, Shuyun, additional, Xu, Guoqiang, additional, Pan, Wei, additional, and Chen, Tengxiang, additional

Published
2024
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49. Landslide Risk Zoning Method Based on Improved Water Seepage Capacity Model

Author

Wang, Zhaohua, Zhang, Jixian, Zhao, Zheng, Gao, Haiying, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Wang, Liheng, editor, Wu, Yirong, editor, and Gong, Jianya, editor

Published
2020
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50. L 1-Norm Method for Dual-Wavelength Phase Unwrapping

Author

Cheng, Guoqi, Zhang, Jixian, Chen, Huan, Chen, Jiaqi, Lu, Lijun, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Wang, Liheng, editor, Wu, Yirong, editor, and Gong, Jianya, editor

Published
2020
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