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Your search keyword '"Zhang, Jiuwei"' showing total 13 results
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13 results on '"Zhang, Jiuwei"'

4. Efficacy, safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants

Author

Wu, Zhiwei, Li, Qingliang, Liu, Yan, Lv, Huakun, Mo, Zhaojun, Li, Fangjun, Yu, Qingchuan, Jin, Fei, Chen, Wei, Zhang, Yong, Huang, Teng, Hu, Xiaosong, Xia, Wei, Gao, Jiamei, Zhou, Haisong, Bai, Xuan, Liu, Yueyue, Liang, Zhenzhen, Jiang, Zhijun, Chen, Yingping, Zhang, Jiuwei, Du, Jialiang, Yang, Biao, Xing, Bo, Xing, Yantao, Dong, Ben, Yang, Qinghai, Shi, Chen, Yan, Tingdong, Ruan, Bo, Shi, Haiyun, Fan, Xingliang, Feng, Dongyang, Lv, Weigang, Zhang, Dong, Kong, Xiangchu, Zhou, Liuyifan, Que, Dinghong, Chen, Hong, Chen, Zhongbing, Guo, Xiang, Zhou, Weiwei, Wu, Cong, Zhou, Qingrong, Liu, Yuqing, Qiao, Jian, Wang, Ying, Li, Xinguo, Duan, Kai, Zhao, Yuliang, Xu, Gelin, and Yang, Xiaoming

Published
2022
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13. FOXO1 inhibits the invasion and metastasis of hepatocellular carcinoma by reversing ZEB2-induced epithelial-mesenchymal transition.

Author

Dong T, Zhang Y, Chen Y, Liu P, An T, Zhang J, Yang H, Zhu W, and Yang X

Subjects
Animals, Cell Line, Tumor, Cell Movement, DNA-Binding Proteins metabolism, Forkhead Box Protein O1 genetics, Humans, Lung Neoplasms pathology, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Metastasis, Neoplasm Transplantation, Nuclear Proteins metabolism, Promoter Regions, Genetic genetics, RNA Interference, RNA, Small Interfering genetics, Snail Family Transcription Factors metabolism, Transforming Growth Factor beta1 metabolism, Transplantation, Heterologous, Twist-Related Protein 1 metabolism, Zinc Finger E-box Binding Homeobox 2 genetics, Zinc Finger E-box-Binding Homeobox 1 metabolism, Carcinoma, Hepatocellular pathology, Epithelial-Mesenchymal Transition physiology, Forkhead Box Protein O1 metabolism, Liver Neoplasms pathology, Lung Neoplasms secondary, Zinc Finger E-box Binding Homeobox 2 metabolism
Abstract

The epithelial-to-mesenchymal transition (EMT) program is critical for epithelial cell cancer progression and fibrotic diseases. FOXO1 influences a broad range of physiological and pathological processes. However, the mechanism by which FOXO1 inhibits EMT is not fully understood. In this study, we demonstrated that FOXO1 overexpression inhibited cell motility and invasiveness in vitro and inhibited lung metastasis in vivo. In addition, we found that FOXO1 couldreverse the EMT program. FOXO1 silencing by siRNA in hepatocellular carcinoma (HCC) cell lines enhanced the expression of mesenchymal markers and decreased the expression of the epithelial markers. Consistent with these findings, FOXO1 overexpression exerted opposite effects. Furthermore, we found that FOXO1 levels were inversely correlated with the levels of EMT inducers, including Snail, Slug, ZEB1, ZEB2 and Twist1 in HCC cells. Co-immunoprecipitation and immunohistochemistry assays revealed that an interaction between FOXO1 and ZEB2. A dual-luciferase reporter assay and a ChIP assay further demonstrated that FOXO1 binds to the ZEB2 promoter. Together, these findings suggest that FOXO1 overexpression or ZEB2 inhibition might be potential therapeutic strategies for treating HCC.

Published
2017
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