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222 results on '"Zhang, Guangsen"'

2. CACA guidelines for holistic integrative management of adult acute myeloid leukemia

Author

Wei, Hui, Mi, Yingchang, Wang, Ying, Jiang, Erlie, Hu, Jianda, Yan, Xiaojing, Han, Yanqiu, Lai, Yongrong, You, Yong, Gao, Sujun, Gao, Chunji, Xu, Bing, Yu, Wenjuan, Chen, Jieping, Chen, Suning, Gong, Tiejun, Yang, Linhua, Yang, Jianmin, Du, Xin, Du, Xin, Li, Wei, Li, Fei, Li, Yan, Li, Jian, Li, Junmin, Jin, Jie, Zhang, Xi, Zhang, Mei, Zhang, Yu, Zhang, Guangsen, Song, Xianmin, Song, Yongping, Jiang, Qian, Wu, Tong, Liu, Ting, Liu, Zhuogang, Liu, Daihong, Ren, Hanyun, Feng, Ru, Fu, Rong, Zhu, Honghu, Sun, Zimin, Wang, Jianmin, Wang, Xin, Wang, Jishi, Wang, Shaoyuan, Fang, Meiyun, Huang, He, Hu, Yu, Liu, Qifa, Ma, Jun, Shen, Zhixiang, Wu, Depei, Huang, Xiaojun, Zhou, Jianfeng, Ji, Chunyan, Qiu, Lugui, Li, Jianyong, and Wang, Jianxiang

Published
2024
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3. Critical role of tripartite fusion and LBD truncation in certain RARA- and all RARG-related atypical APL

Author

Zhou, Xiaosu, Chen, Xue, Chen, Jiaqi, Wen, Lijun, Zhang, Zhanglin, Qin, Ya-Zhen, Cao, Panxiang, Xing, Haizhou, Mi, Yingchang, Wang, Wei, Zhang, Guangsen, Li, Ji, Wu, Huanling, Zhang, Zhifen, Zhang, Jian, Su, Zhan, Wang, Fang, Zhang, Yang, Ma, Xiaoli, Fang, Jiancheng, Wu, Ping, Wang, Tong, Fan, Gaowei, Zhao, Yang, Jin, David, Zhang, Xian, Ma, Xiujuan, Wu, Qisheng, Zhang, Zhihua, Wang, Linya, Ma, Futian, Xiao, Xia, Wu, Chengye, Sun, Kai, Tang, Ruijie, Zhang, Yun, Wu, Sanyun, Gao, Ran, Zhang, Leping, Zheng, Huyong, Zhao, Yanli, Zhu, Hong-Hu, Lu, Daopei, Lu, Peihua, Chen, Suning, and Liu, Hongxing

Published
2024
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12. Effects of Microwave Hybrid Sintering Methods and Nano-HfC Content on Mechanical Properties and Microstructure of TiB2-Based Cermets.

Author

Ji, Wenbin, Wu, Xingchen, Dai, Shijie, and Zhang, Guangsen

Subjects
SOLUTION strengthening, MICROWAVE materials, ELECTRIC furnaces, FRACTURE toughness, DISPERSION strengthening
Abstract

A TiB2-based cermet tool material with excellent mechanical performance was rapidly prepared by microwave hybrid sintering. Microwave hybrid sintering is based on pure microwave sintering with the addition of high microwave absorbing materials (e.g., SiC coating and SiC powder) to assist in the heating of the sample, which has the characteristics of hybrid heating. The effects of two different microwave hybrid sintering methods and nano-HfC content on mechanical properties and microstructure of cermets were investigated. The experimental results indicated that different sintering methods changed the distribution of microwave electric field in the furnace, which affected the sample heating mechanism. SiC-buried powder hybrid sintering was more efficient than SiC coating hybrid sintering, so the sintered material had higher densities and mechanical properties. The fracture toughness and flexural strength of cermets containing 20 wt.% HfC were 36.7% and 45.4%, respectively, higher than those without HfC, and the fracture toughness reached 10.68 MPa·m1/2. With the increase of nano-HfC content, the TiB2 grains changed from coarse irregular shape to fine rectangular shape, and the average grain size can be reduced by 2.6 times. The toughening and strengthening mechanisms of the nano-HfC added phase were mainly fine-grain strengthening, particle dispersion strengthening, solid solution strengthening, crack deflection, and pinning effect. [ABSTRACT FROM AUTHOR]

Published
2024
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24. A novel germline HAVCR2 (TIM-3) compound heterozygous mutation is related to hemophagocytic lymphohistiocytic syndrome in EBV-positive peripheral T-cell lymphoma (NOS) with down-regulated TIM-3 signaling

Author

Zhang, Yang, primary, Wang, Zhihua, additional, Hu, Guoyu, additional, Li, Jieping, additional, Chen, Yongheng, additional, Jiang, Yi, additional, Zhong, Haiying, additional, Liu, Xianling, additional, Hu, Chunhong, additional, Peng, Honglin, additional, Xu, Yunxiao, additional, Cheng, Zhao, additional, and Zhang, Guangsen, additional

Published
2022
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26. N-Acetylcysteine Enhances the Recovery of Ischemic Limb in Type-2 Diabetic Mice

Author

Zhu, Qiang, primary, Liu, Xuanyou, additional, Zhu, Qingyi, additional, Liu, Zehao, additional, Yang, Chunlin, additional, Wu, Hao, additional, Zhang, Linfang, additional, Xia, Xiujuan, additional, Wang, Meifang, additional, Hao, Hong, additional, Cui, Yuqi, additional, Zhang, Guangsen, additional, Hill, Michael A., additional, Flaker, Gregory C., additional, Zhou, Shenghua, additional, and Liu, Zhenguo, additional

Published
2022
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28. 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy

Author

Zhang, Xiaohui, primary, Chen, Fangping, additional, Chen, Xiequn, additional, Cheng, Yunfeng, additional, Fang, Meiyun, additional, Feng, Jianming, additional, Fu, Haixia, additional, Gao, Hong, additional, Han, Yue, additional, He, Aili, additional, Hou, Ming, additional, Hu, Yu, additional, Huang, Ruibin, additional, Huang, Wenrong, additional, Jing, Zhicheng, additional, Kong, Peiyan, additional, Liang, Aibin, additional, Liang, Meiying, additional, Liu, Daihong, additional, Liu, Junling, additional, Liu, Lin, additional, Liu, Xiaowei, additional, Ma, Liangming, additional, Mei, Heng, additional, Ni, Heyu, additional, Niu, Ting, additional, Peng, Jun, additional, Qiao, Jianlin, additional, Ren, Jinhai, additional, Song, Yongping, additional, Tang, Liang V., additional, Tong, Tong, additional, Wang, Shaoyuan, additional, Wang, Xin, additional, Wang, Zhao, additional, Wei, Hui, additional, Wu, Depei, additional, Wu, Guangsheng, additional, Xu, Caigang, additional, Xu, Xue, additional, Xu, Yajing, additional, Yang, Linhua, additional, Yang, Renchi, additional, Yang, Tonghua, additional, Yin, Chenghong, additional, Yu, Li, additional, Zhang, Guangsen, additional, Zhang, Lei, additional, Zhang, Liansheng, additional, Zhang, Xi, additional, Zhao, Weili, additional, Zhao, Yongqiang, additional, Zhou, Daobin, additional, Zhou, Hu, additional, Zhou, Zeping, additional, Zhu, Tienan, additional, Wang, Jianliu, additional, and Huang, Xiaojun, additional

Published
2022
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29. Coagulation Factor XIII Subunit A Is a Biomarker for Curative Effects and Prognosis in Malignant Solid Tumors, Especially Non-small Cell Lung Cancer

Author

Luo, Yujiao, Li, Bin, Li, Ji, Zhang, Yang, Deng, Mingyang, Hu, Chunhong, Yan, Wenzhe, Zhou, Zhiguang, and Zhang, Guangsen

Subjects
Cancer Research, factor XIII/transglutaminases, curative effect, Oncology, factor XIII subunit A, biomarker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, prognosis, tumor-associated macrophages (TAMs), non-small cell lung cancer, RC254-282, Original Research
Abstract

BackgroundThe expression of coagulant factor XIII subunit A (FXIII-A) is significantly increased in some types of cancer cells and tumor-associated macrophages (TAMs). However, few studies on plasma FXIII-A in cancer patients have been conducted and have shown contradictory results, so the relationship of plasma FXIII-A with the progression and prognosis of malignant tumors is still unknown. This study explored the association of plasma FXIII-A with a curative effect and the prognosis of patients with malignant solid tumors.MethodsWe monitored plasma FXIII-A before and during systemic therapy and assessed its relationship with the curative effect and prognosis of malignant solid tumors, especially non-small cell lung carcinoma (NSCLC), by propensity-adjusted, multivariable logistic regression analysis and survival curve, in a prospective study of 1147 patients with different types of malignant solid tumors. The influencing factors of plasma FXIII-A were also analyzed.ResultsWe found that D-dimer (D2) = 1 mg/L was the inflection point for the association between FXIII-A and D2: FXIII-A was significantly negatively correlated with D2 (r = -0.39, p < 0.01) and FDP (r = -0.40, p < 0.01) in D2 > 1 mg/L but uncorrelated with D2 or FDP in D2 ≤ 1 mg/L, which provided a method to find a more realistic plasma FXIII-A level. Plasma FXIII-A was positively correlated with age, platelets, lymphocytes, monocytes and carcinoembryonic antigen (CEA). It was found for the first time that plasma FXIII-A was abnormally significantly increased (FXIII-A > 150%) in post-therapy patients, especially in NSCLC and lung metastasis patients, and the incidence of FXIII-A > 150% in lung adenocarcinoma was 16 times higher than that in lung squamous carcinoma. FXIII-A > 150% proved to be an independent risk factor for disease progression in NSCLC patients (OR=5.74, 95% CI: 1.20-27.60, p = 0.029), predicting poor efficacy. The marked decrease in plasma FXIII-A (FXIII-A < 40%) was related to coagulation disorders and poor prognosis with a short survival time (median survival time of 4 months).ConclusionsPlasma FXIII-A has the potential to be a real-time biomarker with bidirectional indicator effects to assess curative effects and prognosis in malignant solid tumors, especially NSCLC.

Published
2021

33. Combination of Antioxidant Enzyme Overexpression and N‐Acetylcysteine Treatment Enhances the Survival of Bone Marrow Mesenchymal Stromal Cells in Ischemic Limb in Mice With Type 2 Diabetes

Author

Zhu, Qiang, primary, Hao, Hong, additional, Xu, Huifang, additional, Fichman, Yosef, additional, Cui, Yuqi, additional, Yang, Chunlin, additional, Wang, Meifang, additional, Mittler, Ron, additional, Hill, Michael A., additional, Cowan, Peter J., additional, Zhang, Guangsen, additional, He, Xiaoming, additional, Zhou, Shenghua, additional, and Liu, Zhenguo, additional

Published
2021
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37. LINC00461 Knockdown Enhances the Effect of Ixazomib in Multiple Myeloma Cells

Author

Deng, Mingyang, Yuan, Huan, Peng, Hongling, Liu, Sufang, Xiao, Xiang, Wang, Zhihua, Zhang, Guangsen, and Xiao, Han

Abstract

Background: LINC00461 has been implicated to be involved in several types of cancer while its roles in multiple myeloma remain unclear. Our study aims to investigate the roles of LINC00461 in multiple myeloma and explore its effects on ixazomib therapy. Methods: LINC00461 and small nuclear ribonucleoprotein polypeptide (SNRP) B2 knockdown stable cell lines were constructed. Cell viability assays including MTT, cell number counting, and colony formation were performed. RNA-pull down and immunoblotting assays were conducted to determine the intramolecular interactions. qRT-PCR and western blotting were conducted to determine the levels of target genes. Kaplan-Meier analysis was used to evaluate overall survival rates. Results: Knockdown of LINC00461 or SNRPB2 enhanced ixazomib's cytotoxicity, as well as affected its regulatory effects on cell apoptosis and cell cycle distribution. Further results showed that LINC00461 knockdown reduced the expression levels of SNRPB2 by their interactions. Additionally, a positive correlation between LINC00461 and SNRPB2 was found in patients with multiple myeloma. Low expression of SNRPB2 was associated with a high survival rate in patients with multiple myeloma. Conclusion: Knockdown of LINC00461 enhanced the therapeutic effects of ixazomib against multiple myeloma in part by the regulation of SNRPB2.

Published
2023
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39. Back Cover: Targeting lactate dehydrogenase A ( LDHA ) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia

Author

Yu, Haizhi, Yin, Yafei, Yi, Yifang, Cheng, Zhao, Kuang, Wenyong, Li, Ruijuan, Zhong, Haiying, Cui, Yajuan, Yuan, Lingli, Gong, Fanjie, Wang, Zhihua, Li, Heng, Peng, Hongling, and Zhang, Guangsen

Subjects
Cancer Research, Oncology, Cover Image
Abstract

The cover image is based on the Original Article Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia by Haiying Zhong, Ya‐fei Yin, Yifang Yi et al., https://doi.org/10.1002/cac2.12080. [Image: see text]

Published
2020

43. Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study

Author

Liu, Jiheng, primary, Li, Heng, additional, Luo, Ming, additional, Liu, Jiyang, additional, Wu, Lingzhen, additional, Lin, Xianfeng, additional, Li, Ruijuan, additional, Wang, Zhihua, additional, Zhong, Haiying, additional, Zheng, Wenli, additional, Zhou, Yan, additional, Jiang, Dixuan, additional, Tan, Xin, additional, Zhou, Zhiguo, additional, Peng, Hongling, additional, and Zhang, Guangsen, additional

Published
2020
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45. Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia

Author

Yu, Haizhi, primary, Yin, Yafei, additional, Yi, Yifang, additional, Cheng, Zhao, additional, Kuang, Wenyong, additional, Li, Ruijuan, additional, Zhong, Haiying, additional, Cui, Yajuan, additional, Yuan, Lingli, additional, Gong, Fanjie, additional, Wang, Zhihua, additional, Li, Heng, additional, Peng, Hongling, additional, and Zhang, Guangsen, additional

Published
2020
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46. Lymphopenia acted as an adverse factor for severity in patients with COVID-19: a single-centered, retrospective study

Author

Liu, Jiheng, primary, Li, Heng, additional, Luo, Ming, additional, Liu, Jiyang, additional, Wu, Lingzhen, additional, Lin, Xianfeng, additional, Li, Ruijuan, additional, Wang, Zhihua, additional, Zhong, Haiying, additional, Zheng, Wenli, additional, Zhou, Yan, additional, Jiang, Dixuan, additional, Tan, Xin, additional, Zhou, Zhiguo, additional, Peng, Hongling, additional, and Zhang, Guangsen, additional

Published
2020
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48. Recent progress in study of circRNAs and its role in leukemia.

Author

Fu, Lei, Tang, Doudou, Sun, Ailian, Zhu, Dengqin, Zhang, Guangsen, and Wang, Yewei

Subjects
LINCRNA, CIRCULAR RNA, NON-coding RNA, LEUKEMIA, GENE expression
Abstract

Circular RNAs (circRNAs) are a class of newly identified noncoding RNA and are considered as a new feature of eukaryotic gene expression. Hundreds of thousands of endogenous circRNAs have been found in mammalian cells, which we knew little before. CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. Researchers with RNA‐Seq technology have identified that the expression of circRNAs is developmentally regulated, tissue‐ and cell‐type specific. Like long noncoding RNAs (lncRNAs), circRNAs are becoming a new research hotspot in the RNA field, and aberrant expression of circRNAs could contribute to carcinogenesis. Recent studies have demonstrated that circRNAs play important roles in the development, maintenance, and progression of leukemia. Herein, we describe the biologic characteristics and functions of circRNAs, with a focus on circRNAs that play essential roles in leukemia. [ABSTRACT FROM AUTHOR]

Published
2021
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