1. Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus Aspergillus fumigatus GXIMD00544.
- Author
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Zhang, Geng-Si, Li, Hai-Yan, Liang, Li-Fen, Fu, Chun-Qing, Yu, Qin, Liu, Kai, Su, Zhi-Wei, Zhou, Dong-Mei, Gao, Cheng-Hai, Xu, Xin-Ya, and Liu, Yong-Hong
- Subjects
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ANTIFUNGAL agents , *ALKALOIDS , *MICROBIAL sensitivity tests , *FUNGI , *PLANT extracts , *PHYSICAL & theoretical chemistry , *FERMENTATION , *ASPERGILLUS , *MOLECULAR structure , *MEDICINAL plants , *MOLECULAR biology , *PHARMACODYNAMICS - Abstract
A pair of atropisomers secofumitremorgins C (1a) and D (1b), together with fifteen known alkaloids (2-16), were isolated from a saltern-derived fungus Aspergillus fumigatus GXIMD00544. The structures of atropisomers 1a and 1b were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds 1 and 8 displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane Fusarium sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers 1 also exhibited antifouling potential against Balanus amphitrite larval settlement with an inhibitory rate of 96% at the concentration of 100 µM. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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