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In the United States, coal, natural gas, and oil stand as primary contributors to carbon emissions. The transition toward carbon-free energy sources has significantly reduced the demand for conventional fossil fuels while also significantly altering its labor market environment. This concurrently opens a good number of job prospects in low-carbon energy production sectors. Consequently, navigating this labor force transition requires informed decisions. This research aims to explore the economic impacts of this transition using the state of Wyoming as a case study, a state at the forefront of moving from fossil fuel reliance to embracing low-carbon energy sources. Through an in-depth analysis, including autoregressive integrated moving average (ARIMA) modeling, this paper explored the retraining needs of workers in each sector, the associated costs, and the current state of Wyoming's workforce. The results of the analysis showed that the coal mine sector and oil and gas industries face significant workforce migration pressures with a relatively higher number of workers who need to be migrated, whereas coal power plants are less affected. With Wyoming found to be at the "take-off" phase, ready to accelerate into a new energy paradigm, a relatively modest investment ranging from $3,060 to $7,201, per worker, can facilitate this transition. This research provides critical insights into managing workforce transitions, informing strategic decisions for a sustainable shift from fossil fuels energy production to low-carbon energy production. This research could assist government agencies in the establishment of workforce transition initiatives in the energy production industries and beyond. This research potentially offers a practical framework for understanding the intricacies of workforce transitioning that could be utilized for other sectors such as the architecture, engineering, and construction (AEC) sector. [ABSTRACT FROM AUTHOR]

Aimed to explore the mechanisms and targets of Diwu Yanggan Capsule (DWYG), a traditional Chinese medicine in liver regeneration, we used the TCMSP to obtain the active ingredients and targets of DWYG and the GEO database to obtain the DEGs related to liver regeneration. We also searched for liver regeneration-related genes in disease databases and integrated them with the herbal and GEO data to screen for potential targets of DWYG in liver regeneration. Enrichment analysis using R language and molecular docking of the key targets and active ingredients were constructed. We found 73 potential targets of DWYG in liver regeneration and revealed that DWYG may act through pathways such as MAPK, TNF, and IL-17. We also found that quercetin was a major component of DWYG with low binding energy to three key targets. Our results suggest that DWYG can facilitate liver regeneration and quercetin may be its core ingredient. [ABSTRACT FROM AUTHOR]

The United States Army Corps of Engineering Manual 385 (EM 385) has become a vital part of construction operations on all Department of Defense (DOD) construction projects to create a safer work environment. With tremendous effort on developing and enforcing the EM 385, the question of whether the EM 385 provides any value for project safety is critical to the construction industry at large. This study looks for causation between the EM 385 and mishap reduction by isolating three dependent variables and a variety of explanatory variables. The data was compiled using both the OSHA Data Initiative (ODI) and the Federal Spending Database. A structural equation is developed to conduct multiple regression analysis assuming EM 385 will reduce the number of mishaps and the severity of mishaps. However, the result shows the effectiveness of EM 385 on reducing the number and severity of mishaps is not significant. Key words: construction safety, Engineer Manual 385, predictive analytics. Le manuel d'ingenierie 385 (EM 385) du << United States Army Corps of Engineers >> est devenu une partie essentielle des activites de construction sur tous les projets de construction du departement de la Defense (DOD) pour creer un environnement de travail plus securitaire. Compte tenu des efforts considerables deployes pour elaborer et appliquer la norme EM 385, la question a savoir si la norme EM 385 offre une valeur pour la securite du projet est essentielle pour l'industrie de la construction dans son ensemble. La presente etude examine la causalite entre le EM 385 et la reduction des incidents en isolant trois variables dependantes et une variete de variables explicatives. Les donnees ont ete compilees a l'aide de l'Initiative de donnees de l'<< Occupational Safety and Health Administration >> (OSHA) et de la Base de donnees sur les depenses federales (<< Federal Spending Database >>). Une equation structurelle est elaboree pour effectuer une analyse de regression multiple en supposant que la methode EM 385 reduira le nombre d'incidents et leur gravite. Toutefois, le resultat montre que l'efficacite de la methode EM 385 pour reduire le nombre et la gravite des incidents n'est pas significative. [Traduit par la Redaction] Mots-cles : securite des chantiers, manuel d'ingenierie 385 (<< EM 385 >>), analyse predictive., Introduction The Engineer Manual 385 (EM 385) is composed of extensive safety planning guidelines that have cost millions of dollars to develop and implement over its 73-year history. The EM [...]