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25. 培养基、光照强度和初始氮浓度对克里藻生长 及生物活性代谢产物积累的影响Effects of media, light intensity and initial nitrogen concentration on the growth and bioactive metabolites accumulation of Klebsormidium sp. JNU41

Author

洪建，戴晨明，张虎，高保燕，张成武 HONG Jian, DAI Chenming, ZHANG Hu, GAO Baoyan, ZHANG Chengwu

Subjects
克里藻；培养基；光照强度；氮浓度；油脂；脂肪酸；叶黄素, klebsormidium sp., media, light intensity, nitrogen concentration, lipid, fatty acid, lutein, Oils, fats, and waxes, TP670-699
Abstract

为利用克里藻JNU41高效生产油脂、亚油酸和叶黄素等重要代谢产物，对其进行培养条件的优化及代谢产物积累的评估。采用改良的BG-11（mBG-11）和BBM（mBBM）培养基，设置3组光照强度〔单侧100 μmol/(m2·s)、单侧300 μmol/(m2·s)和双侧300 μmol/（m2·s）〕和6种初始氮浓度（3、6、9、12、15、18 mmol/L）对克里藻JNU41进行培养，并测定其生长曲线、生化组成、总脂产率、脂肪酸组成及叶黄素含量。结果表明：克里藻JNU41在mBBM培养基、双侧光照强度300 μmol/（m2·s）、初始氮浓度6 mmol/L条件下，生物量和总脂产率最高,分别为8.38 g/L和281.71 mg/(L·d)；在mBG-11培养基、双侧光照强度300 μmol/(m2·s)、初始氮浓度3 mmol/L条件下，总脂和总脂肪酸含量最高，分别为5512%和47.10%。克里藻JNU41主要脂肪酸组成为棕榈酸、油酸、亚油酸和亚麻酸，其中亚油酸含量最高，亚油酸最高相对含量为65.87%。此外，克里藻JNU41还积累一定量叶黄素，最高含量可达1.64 mg/g。因此，克里藻JNU41是一株可用于生产多种高附加值产物的潜力藻株。To efficient production of important metabolites such as oil, linoleic acid and lutein by Klebsormidium sp. JNU41, the culture conditions were optimized and the accumulation of metabolites in Klebsormidium sp. JNU41 was evaluated. The growth curve, biochemical composition, total lipid yield, fatty acid composition and lutein content of Klebsormidium sp. JNU41 were studied using modified BG-11 (mBG-11) and BBM (mBBM) as the media, and three sets of light intensities 〔unilateral 100 μmol/(m2·s), unilateral 300 μmol/(m2·s) and bilateral 300 μmol/(m2·s)〕 and six initial nitrogen concentrations (3, 6, 9, 12, 15, 18 mmol/L) were used for culture. The results showed that under the conditions of mBBM media, bilateral light intensity 300 μmol/(m2·s) and initial nitrogen concentration 6 mmol/L, the biomass (8.38g/L) and total lipid yield 〔281.71 mg/(L·d)〕 reached a maximum value. Under the conditions of mBG-11 media, bilateral light intensity 300 μmol/(m2·s) and initial nitrogen concentration 3 mmol/L, the highest total lipid and total fatty acid contents reached 55.12% and 47.10%, respectively. The main components of fatty acids were palmitic acid, oleic acid, linoleic acid and linolenic acid, and linoleic acid content was the highest with the highest relative content of 65.87%. In addition, Klebsormidium sp. JNU41 also accumulated a certain amount of lutein, up to 1.64 mg/g. Therefore, Klebsormidium sp. JNU41 is an algal strain that can be used to produce high value-added products.

Published
2024
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30. Research progress on application of systemic immune inflammatory index in solid cancers

Author

Xu Zhaojun, Zhang Chengwu, Ma Xiaoming

Subjects
systemic immune inflammatory index, lung cancer, gastric cancer, liver cancer, breast cancer, colon cancer, Medicine
Abstract

The top deadly cancer sites in terms of global deaths are lung， stomach， liver， breast and colon cancers. In recent years， more and more studies have shown that cancer-related inflammation plays a crucial role in the development and prognosis of the cancer， such as neutrophil-lymphocyte ratio， monocyte-lymphocyte ratio and platelet-lymphocyte ratio. In 2014， the systemic immune inflammatory index （SII） was first defined. SII combined with peripheral platelets， lymphocytes and neutrophils serves as a comprehensive prognostic parameter， which reflects the balance of immune status and host inflammation more comprehensively than a single inflammatory index. Furthermore， it shows obvious advantages in predicting cancer prognosis. In this article， the application of SII in the prognosis of five common solid cancers was reviewed， aiming to provide the basis for clinical evaluation of cancer prognosis.

Published
2023
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41. Role of Peroxynitrite in the Pathogenesis of Parkinson's Disease and Its Fluorescence Imaging-Based Detection.

Author

Lv, Jiye, Chen, Feiyu, Zhang, Changchan, Kang, Yubing, Yang, Yan, and Zhang, Chengwu

Subjects
PARKINSON'S disease, OXIDATIVE stress, NEURODEGENERATION, PEROXYNITRITE, FLUORESCENCE
Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting the lives of millions of people worldwide. Although the mechanism underlying PD pathogenesis is largely undefined, increasing evidence indicates that oxidative and nitrosative stresses play a crucial role in PD occurrence and development. Among them, the role of oxidative stress has been widely acknowledged, but there is relatively less attention given to nitrosative stress, which is mainly derived from peroxynitrite. In the present review, after briefly introducing the background of PD, we discuss the physiopathological function of peroxynitrite and especially highlight how overloaded peroxynitrite is involved in PD pathogenesis. Then, we summarize the currently reported fluorescence imaging-based peroxynitrite detection probes. Moreover, we specifically emphasize the probes that have been applied in PD research. Finally, we propose perspectives on how to develop a more applicable peroxynitrite probe and leverage it for PD theranostics. Conclusively, the present review broadens the knowledge on the pathological role of peroxynitrite in the context of PD and sheds light on how to develop and utilize fluorescence imaging-based strategies for peroxynitrite detection. [ABSTRACT FROM AUTHOR]

Published
2024
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