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349 results on '"Zhang, Chengning"'

3. Learning When to Defer to Humans for Short Answer Grading

Author

Li, Zhaohui, Zhang, Chengning, Jin, Yumi, Cang, Xuesong, Puntambekar, Sadhana, Passonneau, Rebecca J., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wang, Ning, editor, Rebolledo-Mendez, Genaro, editor, Matsuda, Noboru, editor, Santos, Olga C., editor, and Dimitrova, Vania, editor

Published
2023
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13. Association of Mitochondrial Pyruvate Carrier with the Clinical and Histological Features in Lupus Nephritis

Author

Zhu,Huanhuan, Chen,Chen, Geng,Luhan, Li,Qing, Zhang,Chengning, Wu,Lin, Zhang,Bo, Duan,Suyan, Xing,Changying, Yuan,Yanggang, Zhu,Huanhuan, Chen,Chen, Geng,Luhan, Li,Qing, Zhang,Chengning, Wu,Lin, Zhang,Bo, Duan,Suyan, Xing,Changying, and Yuan,Yanggang

Abstract

Huanhuan Zhu, Chen Chen, Luhan Geng, Qing Li, Chengning Zhang, Lin Wu, Bo Zhang, Suyan Duan,* Changying Xing,* Yanggang Yuan* Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanggang Yuan, Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People’s Republic of China, Tel/Fax +86-25-6813-6462, Email ygyuan@njmu.edu.cnBackground: Mounting evidence suggests that mitochondrial dysfunction contributes to lupus nephritis (LN) pathogenesis. Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) mediating pyruvate transport from the cytoplasm to the mitochondrial matrix, determines the cell survival and cellular energy supply. Here, we aimed to investigate the association of mitochondrial pyruvate carrier expression with the clinical and histological features in LN.Methods: Patients with biopsy-proven proliferative LN (class III and class IV, n=18) and membranous LN (class V, n=18) were included. Expression of MPC1 and MPC2 were examined by immunohistochemistry. MPC protein levels in the two groups were evaluated by the Student’s t-test. Correlation analysis between MPC levels and clinicopathological features was performed by Spearman’s rank correlation.Results: Both MPC1 and MPC2 were exclusively expressed in renal tubules of enrolled LN. Significantly lower MPC1 and MPC2 were observed in patients with proliferative LN compared to membranous LN. In addition, the MPC1 and MPC2 were negatively correlated with SLEDAI-2K score, renal function, and renal pathology activity index.Conclusion: Both MPC1 and MPC2 were localized in renal tubules, and decreased MPC content was more pronounced in proliferative LN than membranous LN. MPC l

Published
2024

35. The thickness of glomerular basement membrane predicts complete remission in primary membranous nephropathy.

Author

Duan, Suyan, Sun, Lianqin, Zhang, Chengning, Zeng, Ming, Sun, Bin, Yuan, Yanggang, Mao, Huijuan, Xing, Changying, and Zhang, Bo

Subjects
BASAL lamina, KIDNEY diseases, GLOMERULAR filtration rate, CUBIC curves, ELECTRON microscopes
Abstract

Glomerular basement membrane (GBM) thickening is a typical and essential histopathological characteristic for the diagnosis of primary membranous nephropathy (PMN). The present study aimed to explore the relationship between GBM thickness and treatment response in PMN patients. A total of 128 patients with nephrotic syndrome concurrent with PMN were studied. The highest GBM thickness was measured from at least five glomerular capillary loops using an electron microscope, and the mean value was obtained. Patients were categorized into three groups according to the tertiles of GBM thickness as follows: Group 1 (GBM thickness ≤ 1100 nm, n = 48), Group 2 (1100 nm < GBM thickness ≤ 1300 nm, n = 40), Group 3 (GBM thickness >1300 nm, n = 40). Clinicopathological features and treatment response were compared among the three groups. The associations of GBM thickness with complete remission (CR) were assessed by Cox proportional hazard analyses and a cubic spline curve. During a median follow-up period of 25.80 months, 69 (53.9%) patients achieved CR. Kaplan–Meier analysis showed that the non-CR probability was significantly higher in the highest tertile of GBM thickness (p˂0.001). Univariate Cox proportional hazard analysis indicated that GBM thickness was associated with CR (HR per SD 0.617, 95% CI [0.471–0.809], p˂0.001). After adjusting for age, duration of PMN, estimated glomerular filtration rate (eGFR), urinary protein excretion, grade of C3 deposition, and titer of serum anti-phospholipase A2 receptor (PLA2R) antibody, GBM thickness remained an independent predictor of CR (HR per SD 0.580, 95% CI [0.436–0.772], p˂0.001). Further multivariable-adjusted restricted cubic spline analysis confirmed a significant reverse linear association between GBM thickness and CR (p for nonlinear = 0.1261). GBM thickness is an independent risk factor of CR. PMN patients with an increased level of GBM thickening at diagnosis have a lower probability of achieving CR. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Serum 25-hydroxyvitamin D as a predictive biomarker of clinical outcomes in patients with primary membranous nephropathy

Author

Duan, Suyan, primary, Chen, Si, additional, Lu, Fang, additional, Zhou, Meng, additional, Jiang, Ling, additional, Chen, Chen, additional, Geng, Luhan, additional, Sun, Rui, additional, Xu, Yili, additional, Huang, Zhimin, additional, Zhang, Chengning, additional, Zhang, Bo, additional, Mao, Huijuan, additional, Xing, Changying, additional, and Yuan, Yanggang, additional

Published
2023
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38. A Parameter Robust Finite Control Set Model Predictive Current Control Based on Incremental Prediction Model for SPMSM Drives

Author

Zhao, Mingwei, Zhang, Shuo, Zhang, Chengning, Li, Xueping, and Dong, Yuelin

Abstract

To eliminate the influence of motor parameter mismatch on finite control set model predictive current control (FCS-MPCC), a parameter robust FCS-MPCC for surface permanent magnet synchronous motor (SPMSM) drives is proposed. First, the incremental prediction model (IPM) is introduced, which eliminates the flux linkage parameter; moreover, the parameter sensitivity analysis shows that the influence of resistance parameter mismatch on IPM can be ignored. Second, an inductance information extraction strategy is proposed, which can extract the actual inductance information according to the current prediction errors of IPM. Therefore, the proposed FCS-MPCC based on IPM is robust to all motor parameters. In addition, to ensure the correctness and stability of the inductance information extraction strategy, a parameter update mechanism is introduced, in which the inductance information is updated only when the switching states of the first two control periods are different. Finally, the comparative simulation and experiments are carried out, and the results show that the proposed FCS-MPCC is not influenced by the mismatch of any motor parameters and always has better current tracking performance than traditional FCS-MPCC.

Published
2024
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