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891 results on '"Zhang, Cheng-Cheng"'

2. Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells

Author

Lian, Xizhen, Chatterjee, Sumanta, Sun, Yehui, Dilliard, Sean A., Moore, Stephen, Xiao, Yufen, Bian, Xiaoyan, Yamada, Kohki, Sung, Yun-Chieh, Levine, Rachel M., Mayberry, Kalin, John, Samuel, Liu, Xiaoye, Smith, Caroline, Johnson, Lindsay T., Wang, Xu, Zhang, Cheng Cheng, Liu, David R., Newby, Gregory A., Weiss, Mitchell J., Yen, Jonathan S., and Siegwart, Daniel J.

Published
2024
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5. LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway

Author

Wang, Hongying, Wang, Lei, Luan, Huiwen, Xiao, Jing, Zhao, Zhiling, Yu, Pengfei, Deng, Mi, Liu, Yifan, Ji, Shuhao, Ma, Junjie, Zhou, Yan, Zhang, Jiashen, Meng, Xianhui, Zhang, Juan, Zhao, Xinyu, Li, Chunling, Li, Fangmin, Wang, Dapeng, Wei, Shujuan, Hui, Lijun, Nie, Siman, Jin, Changzhu, An, Zhiqiang, Zhang, Ningyan, Wang, Yaopeng, Zhang, Cheng Cheng, and Li, Zunling

Published
2024
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6. Identification of FDA-approved drugs that induce heart regeneration in mammals

Author

Ahmed, Mahmoud Salama, Nguyen, Ngoc Uyen Nhi, Nakada, Yuji, Hsu, Ching-Cheng, Farag, Ayman, Lam, Nicholas T., Wang, Ping, Thet, Suwannee, Menendez-Montes, Ivan, Elhelaly, Waleed M., Lou, Xi, Secco, Ilaria, Tomczyk, Mateusz, Zentilin, Lorena, Pei, Jimin, Cui, Miao, Dos Santos, Matthieu, Liu, Xiaoye, Liu, Yan, Zaha, David, Walcott, Gregory, Tomchick, Diana R., Xing, Chao, Zhang, Cheng Cheng, Grishin, Nick V., Giacca, Mauro, Zhang, Jianyi, and Sadek, Hesham A.

Published
2024
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30. CAMKs support development of acute myeloid leukemia

Author

Kang, Xunlei, Cui, Changhao, Wang, Chen, Wu, Guojin, Chen, Heyu, Lu, Zhigang, Chen, Xiaoli, Wang, Li, Huang, Jie, Geng, Huimin, Zhao, Meng, Chen, Zhengshan, Müschen, Markus, Wang, Huan-You, and Zhang, Cheng Cheng

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Pediatric Cancer, Pediatric, Childhood Leukemia, Rare Diseases, Hematology, Aetiology, 2.1 Biological and endogenous factors, Animals, Calcium-Calmodulin-Dependent Protein Kinases, Carcinogenesis, Cell Line, Tumor, Disease Models, Animal, Disease Progression, Humans, Leukemia, Myeloid, Acute, Mice, Inbred C57BL, Neoplastic Stem Cells, Receptors, Immunologic, Signal Transduction, Acute myeloid leukemia, CAMK, PirB, LILRB2, CREB, Leukemic stem cell, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology, Oncology and carcinogenesis
Abstract

BackgroundWe recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like receptor (PirB) as receptors for several angiopoietin-like proteins (Angptls). We also demonstrated that PirB is important for the development of acute myeloid leukemia (AML), but exactly how an inhibitory receptor such as PirB can support cancer development is intriguing.ResultsHere, we showed that the activation of Ca (2+)/calmodulin-dependent protein kinases (CAMKs) is coupled with PirB signaling in AML cells. High expression of CAMKs is associated with a poor overall survival probability in patients with AML. Knockdown of CAMKI or CAMKIV decreased human acute leukemia development in vitro and in vivo. Mouse AML cells that are defective in PirB signaling had decreased activation of CAMKs, and the forced expression of CAMK partially rescued the PirB-defective phenotype in the MLL-AF9 AML mouse model. The inhibition of CAMK kinase activity or deletion of CAMKIV significantly slowed AML development and decreased the AML stem cell activity. We also found that CAMKIV acts through the phosphorylation of one of its well-known target (CREB) in AML cells.ConclusionCAMKs are essential for the growth of human and mouse AML. The inhibition of CAMK signaling may become an effective strategy for treating leukemia.

Published
2018

35. Gradual or Hysteretic Transition: Anion Effects on Cobalt(II) Spin Crossover Complexes.

Author

Sun, Yu‐Chen, Li, Ying‐Lian, Zhang, Cheng‐Cheng, Chen, Feng‐Li, Shao, Dong, Zhao, Yue, Wei, Hai‐Yan, and Wang, Xin‐Yi

Subjects
SPIN crossover, HYDROGEN bonding, MAGNETIC properties, SINGLE crystals, CRYSTAL structure
Abstract

Comprehensive Summary: To better understand the impact of different anions on the structures and SCO properties of the CoII SCO complexes, six new complexes [Co(terpy‐CH2OH)2]A2·sol (terpy‐CH2OH = 4′‐(hydroxymethyl)‐2,2′;6′,2″‐terpyridine, A = Br– (1, sol = 1.5H2O), I– (2), N3– (3, sol = 2H2O), H3BCN– (4), OTf– (5), and TsO– (6, sol = 4H2O·CH3CN), have been synthesized and characterized. All six compounds consist of mononuclear [Co(terpy‐CH2OH)2]2+ cations and charge‐balancing anions that differ in size, shape, and hydrogen bonding capacity. Complexes 1, 2, 3, and 6 displayed incomplete gradual SCO transitions, whereas 4 and 5 exhibited abrupt hysteretic spin transitions with loops of 12 and 16 K (250.0—262.0 K for 4, and 370.0—386.0 K for 5, respectively), closely resembling our previously reported complexes with SCN– and SeCN– anions. The occurrence of the order‐disorder transition of the CH2OH groups and their transition temperatures are determined by the size and hydrogen bonding capability of the anions. Remarkably, the transition temperatures of complexes with H3BCN–, SCN–, OTf–, and SeCN– anions exhibit an upward trend as the size and mass of the anions increase, as confirmed through detailed single crystal structure analyses conducted in both high‐spin and low‐spin states for all four complexes. [ABSTRACT FROM AUTHOR]

Published
2024
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41. TOP CAR with TMIGD2 as a safe and effective costimulatory domain in CAR cells treating human solid tumors

Author

Nishimura, Christopher D., primary, Corrigan, Devin, additional, Zheng, Xiang Yu, additional, Galbo, Phillip M., additional, Wang, Shan, additional, Liu, Yao, additional, Wei, Yao, additional, Suo, Linna, additional, Cui, Wei, additional, Mercado, Nadia, additional, Zheng, Deyou, additional, Zhang, Cheng Cheng, additional, and Zang, Xingxing, additional

Published
2024
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42. Supplementary Fig. 1B from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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43. Data from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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44. Supplementary Tables from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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45. Supplementary Fig. 2 from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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46. Supplementary Fig. 3 from LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Author

Huang, Ryan, primary, Liu, Xiaoye, primary, Kim, Jaehyup, primary, Deng, Hui, primary, Deng, Mi, primary, Gui, Xun, primary, Chen, Heyu, primary, Wu, Guojin, primary, Xiong, Wei, primary, Xie, Jingjing, primary, Lewis, Cheryl, primary, Homsi, Jade, primary, Yang, Xing, primary, Zhang, Chengcheng, primary, He, Yubo, primary, Lou, Qi, primary, Smith, Caroline, primary, John, Samuel, primary, Zhang, Ningyan, primary, An, Zhiqiang, primary, and Zhang, Cheng Cheng, primary

Published
2024
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