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Contrastive dimension reduction methods have been developed for case-control study data to identify variation that is enriched in the foreground (case) data X relative to the background (control) data Y. Here, we develop contrastive regression for the setting when there is a response variable r associated with each foreground observation. This situation occurs frequently when, for example, the unaffected controls do not have a disease grade or intervention dosage but the affected cases have a disease grade or intervention dosage, as in autism severity, solid tumors stages, polyp sizes, or warfarin dosages. Our contrastive regression model captures shared low-dimensional variation between the predictors in the cases and control groups, and then explains the case-specific response variables through the variance that remains in the predictors after shared variation is removed. We show that, in one single-nucleus RNA sequencing dataset on autism severity in postmortem brain samples from donors with and without autism and in another single-cell RNA sequencing dataset on cellular differentiation in chronic rhinosinusitis with and without nasal polyps, our contrastive linear regression performs feature ranking and identifies biologically-informative predictors associated with response that cannot be identified using other approaches

As automation technologies advance, the need for compact and multi-modal sensors in robotic applications is growing. To address this demand, we introduce CompdVision, a novel sensor that employs a compound-eye imaging system to combine near-field 3D visual and tactile sensing within a compact form factor. CompdVision utilizes two types of vision units to address diverse sensing needs, eliminating the need for complex modality conversion. Stereo units with far-focus lenses can see through the transparent elastomer for depth estimation beyond the contact surface. Simultaneously, tactile units with near-focus lenses track the movement of markers embedded in the elastomer to obtain contact deformation. Experimental results validate the sensor's superior performance in 3D visual and tactile sensing, proving its capability for reliable external object depth estimation and precise measurement of tangential and normal contact forces. The dual modalities and compact design make the sensor a versatile tool for robotic manipulation., Comment: Accepted to IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) 2024

While advanced machine learning (ML) models are deployed in numerous real-world applications, previous works demonstrate these models have security and privacy vulnerabilities. Various empirical research has been done in this field. However, most of the experiments are performed on target ML models trained by the security researchers themselves. Due to the high computational resource requirement for training advanced models with complex architectures, researchers generally choose to train a few target models using relatively simple architectures on typical experiment datasets. We argue that to understand ML models' vulnerabilities comprehensively, experiments should be performed on a large set of models trained with various purposes (not just the purpose of evaluating ML attacks and defenses). To this end, we propose using publicly available models with weights from the Internet (public models) for evaluating attacks and defenses on ML models. We establish a database, namely SecurityNet, containing 910 annotated image classification models. We then analyze the effectiveness of several representative attacks/defenses, including model stealing attacks, membership inference attacks, and backdoor detection on these public models. Our evaluation empirically shows the performance of these attacks/defenses can vary significantly on public models compared to self-trained models. We share SecurityNet with the research community. and advocate researchers to perform experiments on public models to better demonstrate their proposed methods' effectiveness in the future., Comment: To appear in the 33rd USENIX Security Symposium, August 2024, Philadelphia, PA, USA

Building advanced machine learning (ML) models requires expert knowledge and many trials to discover the best architecture and hyperparameter settings. Previous work demonstrates that model information can be leveraged to assist other attacks, such as membership inference, generating adversarial examples. Therefore, such information, e.g., hyperparameters, should be kept confidential. It is well known that an adversary can leverage a target ML model's output to steal the model's information. In this paper, we discover a new side channel for model information stealing attacks, i.e., models' scientific plots which are extensively used to demonstrate model performance and are easily accessible. Our attack is simple and straightforward. We leverage the shadow model training techniques to generate training data for the attack model which is essentially an image classifier. Extensive evaluation on three benchmark datasets shows that our proposed attack can effectively infer the architecture/hyperparameters of image classifiers based on convolutional neural network (CNN) given the scientific plot generated from it. We also reveal that the attack's success is mainly caused by the shape of the scientific plots, and further demonstrate that the attacks are robust in various scenarios. Given the simplicity and effectiveness of the attack method, our study indicates scientific plots indeed constitute a valid side channel for model information stealing attacks. To mitigate the attacks, we propose several defense mechanisms that can reduce the original attacks' accuracy while maintaining the plot utility. However, such defenses can still be bypassed by adaptive attacks., Comment: To appear in the 32nd USENIX Security Symposium, August 2023, Anaheim, CA, USA

Stem cell-derived organoids are a promising tool to model native human tissues as they resemble human organs functionally and structurally compared to traditional monolayer cell-based assays. For instance, colon organoids can spontaneously develop crypt-like structures similar to those found in the native colon. While analyzing the structural development of organoids can be a valuable readout, using traditional image analysis tools makes it challenging because of the heterogeneities and the abstract nature of organoid morphologies. To address this limitation, we developed and validated a deep learning-based image analysis tool, named D-CryptO, for the classification of organoid morphology. D-CryptO can automatically assess the crypt formation and opacity of colorectal organoids from brightfield images to determine the extent of organoid structural maturity. To validate this tool, changes in organoid morphology were analyzed during organoid passaging and short-term forskolin stimulation. To further demonstrate the potential of D-CryptO for drug testing, organoid structures were analyzed following treatments with a panel of chemotherapeutic drugs. With D-CryptO, subtle variations in how colon organoids responded to the different chemotherapeutic drugs were detected, which suggest potentially distinct mechanisms of action. This tool could be expanded to other organoid types, like intestinal organoids, to facilitate 3D tissue morphological analysis., Comment: Lab on a Chip (2022)

In this paper, we present a spatio-temporal tendency reasoning (STR) network for recovering human body pose and shape from videos. Previous approaches have focused on how to extend 3D human datasets and temporal-based learning to promote accuracy and temporal smoothing. Different from them, our STR aims to learn accurate and natural motion sequences in an unconstrained environment through temporal and spatial tendency and to fully excavate the spatio-temporal features of existing video data. To this end, our STR learns the representation of features in the temporal and spatial dimensions respectively, to concentrate on a more robust representation of spatio-temporal features. More specifically, for efficient temporal modeling, we first propose a temporal tendency reasoning (TTR) module. TTR constructs a time-dimensional hierarchical residual connection representation within a video sequence to effectively reason temporal sequences' tendencies and retain effective dissemination of human information. Meanwhile, for enhancing the spatial representation, we design a spatial tendency enhancing (STE) module to further learns to excite spatially time-frequency domain sensitive features in human motion information representations. Finally, we introduce integration strategies to integrate and refine the spatio-temporal feature representations. Extensive experimental findings on large-scale publically available datasets reveal that our STR remains competitive with the state-of-the-art on three datasets. Our code are available at https://github.com/Changboyang/STR.git., Comment: Accepted by BMVC2022