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27 results on '"Zhang, Beilu"'

2. Targeted Lymphoma Therapy Using a Gold Nanoframework-Based Drug Delivery System

Author

Bariana, Manpreet, primary, Zhang, Beilu, additional, Sun, Jingyu, additional, Wang, Weiwei, additional, Wang, Jinping, additional, Cassella, Elena, additional, Myint, Faith, additional, Anuncio, Shaina A., additional, Ouk, Samedy, additional, Liou, Hsiou-Chi, additional, Tan, Ming, additional, Wang, Hongjun, additional, and Zakrzewski, Johannes L., additional

Published
2023
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3. Targeted Nanotherapy of Hematologic Malignancies Using Gold Nanoframework-Based Delivery of a Novel NF-Kb Inhibitor

Author

Bariana, Manpreet, primary, Zhang, Beilu, additional, Sun, Jingyu, additional, Cassella, Elena, additional, Rateshwar, Janice, additional, Tan, Ming Tony, additional, Wang, Weiwei, additional, Wang, Jinping, additional, Feinman, Rena, additional, Siegel, David, additional, Liou, Hsiou-Chi, additional, Ouk, Samedy, additional, Mondello, Patrizia, additional, Wang, Hongjun, additional, and Zakrzewski, Johannes, additional

Published
2022
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6. A Porous Bimetallic Au@Pt Core–Shell Oxygen Generator to Enhance Hypoxia-Dampened Tumor Chemotherapy Synergized with NIR-II Photothermal Therapy

Author

Sun, Jingyu, primary, Wang, Jinping, additional, Hu, Wei, additional, Wang, Yuhao, additional, Zhang, Qiang, additional, Hu, Xiaotong, additional, Chou, Tsengming, additional, Zhang, Beilu, additional, Gallaro, Cosmo, additional, Halloran, Meghan, additional, Liang, Lyu, additional, Ren, Lei, additional, and Wang, Hongjun, additional

Published
2022
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14. Skin Wound Healing: Micelle-Coated, Hierarchically Structured Nanofibers with Dual-Release Capability for Accelerated Wound Healing and Infection Control (Adv. Healthcare Mater. 11/2018)

Author

Albright, Victoria, primary, Xu, Meng, additional, Palanisamy, Anbazhagan, additional, Cheng, Jun, additional, Stack, Mary, additional, Zhang, Beilu, additional, Jayaraman, Arul, additional, Sukhishvili, Svetlana A., additional, and Wang, Hongjun, additional

Published
2018
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16. Engineering a Hollow Nanocontainer Platform with Multifunctional Molecular Machines for Tumor-Targeted Therapy in Vitroand in Vivo

Author

Luo, Zhong, Ding, Xingwei, Hu, Yan, Wu, Shaojue, Xiang, Yang, Zeng, Yongfei, Zhang, Beilu, Yan, Hong, Zhang, Huacheng, Zhu, Liangliang, Liu, Junjie, Li, Jinghua, Cai, Kaiyong, and Zhao, Yanli

Abstract

In order to selectively target malignant cells and eliminate severe side effects of conventional chemotherapy, biocompatible and redox-responsive hollow nanocontainers with tumor specificity were fabricated. The mechanized nanocontainers were achieved by anchoring mechanically interlocked molecules, i.e., [2]rotaxanes, onto the orifices of hollow mesoporous silica nanoparticles viadisulfide bonds as intermediate linkers for intracellular glutathione-triggered drug release. The [2]rotaxane employed was mainly composed of U.S. Food and Drug Administration approved tetraethylene glycol chains, α-cyclodextrin, and folic acid. In this study, folate groups on the mechanized hollow nanocontainers act as both the tumor-targeting agents and stoppers of the [2]rotaxanes. Detailed investigations showed that anticancer drug doxorubicin loaded mechanized nanocontainers could selectively induce the apoptosis and death of tumor cells. The drug-loaded nanocontainers enhanced the targeting capability to tumor tissues in vitroand inhibited the tumor growth with minimal side effects in vivo. The present controlled and targeted drug delivery system paves the way for developing the next generation of nanotherapeutics toward efficient cancer treatment.

Published
2024
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21. Engineering a Hollow Nanocontainer Platform with Multifunctional Molecular Machines for Tumor-Targeted Therapy in Vitro and in Vivo

Author

Luo, Zhong, primary, Ding, Xingwei, additional, Hu, Yan, additional, Wu, Shaojue, additional, Xiang, Yang, additional, Zeng, Yongfei, additional, Zhang, Beilu, additional, Yan, Hong, additional, Zhang, Huacheng, additional, Zhu, Liangliang, additional, Liu, Junjie, additional, Li, Jinghua, additional, Cai, Kaiyong, additional, and Zhao, Yanli, additional

Published
2013
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23. Surface functionalized mesoporous silica nanoparticles with natural proteins for reduced immunotoxicity.

Author

Luo, Zhong, Hu, Yan, Xin, Renlong, Zhang, Beilu, Li, Jinghua, Ding, Xingwei, Hou, Yanhua, Yang, Li, and Cai, Kaiyong

Abstract

Mesoporous silica nanoparticles (MSNs) present themselves as one of the most promising nano-carriers for drug delivery. To reduce their immunotoxicities, in this study, natural proteins of gelatin (Gel), bovine serum albumin (BSA), and lysozyme (Lys) were employed as end-caps of MSNs by using succinic anhydride as an intermediate linker, thus leading to fabrication of MSNs/protein nanocomposites, respectively. Furthermore, combined techniques of SEM, TEM, FTIR, and zeta potential instruments were utilized to monitor the construction processes of MSNs/protein nanocomposites, respectively. Finally, the immunotoxicities of those nanocomposites to macrophage cells (RAW264.7 cells) were investigated in detail, i.e., cell morphology, cell viability, nitric oxide (NO) production, reactive oxygen species (ROS), and acid phosphatase activity (ACP) as well as inflammation cytokine expressions (tumor necrosis factor-α and interleukin-1β). All results suggest that macrophages were activated after uptaking nanoparticles of SiO2 and MSNs, which subsequently induced severe inflammation responses in vitro. In contrast, the inflammation responses of MSNs nanocomposites were reduced dramatically after end-capping with those natural proteins. Overall, this study accumulates knowledge for the development of MSNs-based drug delivery systems with reduced immunotoxicity. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3781-3794, 2014. [ABSTRACT FROM AUTHOR]

Published
2014
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27. A Porous Au@Rh Bimetallic Core-Shell Nanostructure as an H 2 O 2 -Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy.

Author

Wang J, Sun J, Hu W, Wang Y, Chou T, Zhang B, Zhang Q, Ren L, and Wang H

Subjects
Animals, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Biocompatible Materials chemistry, Cell Line, Tumor, Cell Membrane Permeability, Humans, Hydrogen Peroxide chemistry, Hydrogen Peroxide pharmacology, Indicators and Reagents chemistry, Indocyanine Green chemistry, Metal Nanoparticles administration & dosage, Metal Nanoparticles adverse effects, Mice, Multimodal Imaging, Optical Imaging, Photoacoustic Techniques, Photochemotherapy, Photosensitizing Agents chemistry, Porosity, Alloys chemistry, Gold chemistry, Metal Nanoparticles chemistry, Neoplasms diagnostic imaging, Neoplasms therapy, Rhodium chemistry, Tumor Hypoxia drug effects
Abstract

In treatment of hypoxic tumors, oxygen-dependent photodynamic therapy (PDT) is considerably limited. Herein, a new bimetallic and biphasic Rh-based core-shell nanosystem (Au@Rh-ICG-CM) is developed to address tumor hypoxia while achieving high PDT efficacy. Such porous Au@Rh core-shell nanostructures are expected to exhibit catalase-like activity to efficiently catalyze oxygen generation from endogenous hydrogen peroxide in tumors. Coating Au@Rh nanostructures with tumor cell membrane (CM) enables tumor targeting via homologous binding. As a result of the large pores of Rh shells and the trapping ability of CM, the photosensitizer indocyanine green (ICG) is successfully loaded and retained in the cavity of Au@Rh-CM. Au@Rh-ICG-CM shows good biocompatibility, high tumor accumulation, and superior fluorescence and photoacoustic imaging properties. Both in vitro and in vivo results demonstrate that Au@Rh-ICG-CM is able to effectively convert endogenous hydrogen peroxide into oxygen and then elevate the production of tumor-toxic singlet oxygen to significantly enhance PDT. As noted, the mild photothermal effect of Au@Rh-ICG-CM also improves PDT efficacy. By integrating the superiorities of hypoxia regulation function, tumor accumulation capacity, bimodal imaging, and moderate photothermal effect into a single nanosystem, Au@Rh-ICG-CM can readily serve as a promising nanoplatform for enhanced cancer PDT., (© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2020
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