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346 results on '"Zhan, Xiaoyan"'

11. Guidelines for safe use of Polygoni Multiflori Radix

Author

Xiao, Xiaohe, Wang, Jiabo, Song, Haibo, Ouyang, Dongsheng, Zou, Zhengsheng, Wang, Ruilin, He, Tingting, Jing, Jing, Guo, Yuming, Bai, Zhaofang, Zhan, Xiaoyan, Niu, Ming, Ma, Zhijie, Li, Chunyu, Xiaohe, Xiao, Jiabo, Wang, Haibo, Song, Dongsheng, Ouyang, Zhengsheng, Zou, Ruilin, Wang, Tingting, He, Jing, Jing, Yuming, Guo, Zhaofang, Bai, Ming, Niu, Jianyu, Li, Fengyi, Li, Yun, Zhu, Zhijie, Ma, Chunyu, Li, Jinfa, Tang, Pengyan, Li, Le, Zhang, Chaopeng, Li, and Can, Tu

Published
2024
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30. Icariside I reduces breast cancer proliferation, apoptosis, invasion, and metastasis probably through inhibiting IL-6/STAT3 signaling pathway.

Author

Hou, Manting, Li, Hui, He, Tingting, Hui, Siwen, Dai, Wenzhang, Hou, Xiaorong, Zhao, Jing, Zhao, Jia, Wen, Jincai, Kan, Wen, Xiao, Xiaohe, Zhan, Xiaoyan, and Bai, Zhaofang

Subjects
BREAST cancer, METASTATIC breast cancer, MULTINUCLEATED giant cells, CELLULAR signal transduction, CANCER cell growth, BREAST
Abstract

Objectives: Breast cancer is a common malignancy in women. More than 90% of breast cancer deaths are caused by metastasis. Epimedii Folium (EF) is a commonly used herb with anti-tumor benefits, but its underlying mechanisms and active components for breast cancer prevention are little understood. This study assessed the therapeutic role of Icariside I (ICS I) in Epimedium flavonoids (EF) on lung metastasis of breast cancer, including the underlying mechanism. Methods: Western blot, RT-qPCR, wound healing assay, colony formation assay, and flow cytometry were used to investigate the inhibition of breast cancer cells growth and migration by EF and ICS I through disrupting the IL-6/STAT3 pathway. Combined with 4T1 breast cancer model in mice, Western blot, RT-qPCR, Hematoxylin and Eosin staining, immunohistochemistry were used to evaluate the therapeutic role of ICS I in proliferation, apoptosis, invasion, and metastasis of breast cancer. Key findings: EF can inhibit STAT3 phosphorylation and reduce the colony formation and migration of breast cancer cells. Detecting the active ingredients in EF, we found ICS I can reduce the activation of STAT3 in 4T1 breast cancer cells, impair colony formation and migration. Moreover, ICS I induced cells G1 phase arrest and modulated Cyclin D1, CDK4, bcl-2, and bax to inhibit proliferation and survival of breast cancer cells. Similarly, the in vivo studies demonstrated that ICS I significantly suppressed tumor development and lung metastasis in the 4T1 mouse model. Tumor cells in vehicle group were arranged in a spoke-like pattern with obvious heterogeneity, and multinucleated tumor giant cells were seen. But, the tumor cells in the ICS I group were disorganized and necrotic lysis was seen in some areas. In ICS I-treated group, tumors' STAT3 phosphorylation level, IL-6, Cyclin D1, CDK4, bcl-2, and vimentin expression were downregulated, bax and cleaved caspase 3 expression were upregulated. In the lung tissue, we could find less metastasis of breast cancer cells and less lung injury in the ICS I group. Besides, the expression of metastasis-related genes MMP9 and vimentin was decreased in the lung tissue of ICS I group. Conclusions: These findings suggest that ICS I can inhibit breast cancer proliferation, apoptosis, invasion and metastasis probably via targeting IL-6/STAT3 pathway. Therefore, ICS I has the potential to become an innovative therapeutic candidate to breast cancer prevention and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Serum Exosome–Derived microRNA-193a-5p and miR-381-3p Regulate Adenosine 5'-Monophosphate–Activated Protein Kinase/Transforming Growth Factor Beta/Smad2/3 Signaling Pathway and Promote Fibrogenesis

Author

Wang, Sihao, primary, Chen, Yan, additional, Lei, Guanglin, additional, Ma, Xuemei, additional, An, Linjing, additional, Wang, Han, additional, Song, Zheng, additional, Lin, Li, additional, He, Quanwei, additional, Xu, Ran, additional, Zhan, Xiaoyan, additional, Bai, Zhaofang, additional, and Yang, Yongping, additional

Published
2023
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32. Liuwei Wuling Tablet relieves the inflammatory transformation of hepatocellular carcinoma by inhibiting the PI3K/AKT/NF-κB signalling pathway

Author

Chen, Yuanyuan, primary, Song, Zheng, additional, Hou, Xiaorong, additional, Liu, Jia, additional, Zheng, Congyang, additional, Zhao, Xiaomei, additional, Lv, Guiji, additional, Li, Junjie, additional, Xiu, Ye, additional, Shi, Wei, additional, Zhao, Jia, additional, Yang, Huijie, additional, Wang, Yan, additional, Zhao, Jun, additional, Zhan, Xiaoyan, additional, Niu, Ming, additional, Zou, Wenjun, additional, Bai, Zhaofang, additional, and Xiao, Xiaohe, additional

Published
2023
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37. Comparing the effects of GBA variants and onset age on clinical features and progression in Parkinson's disease.

Author

Ren, Jingru, Zhan, Xiaoyan, Zhou, Hao, Guo, Zhiying, Xing, Yi, Yin, Hangxing, Xue, Chen, Wu, Jun, and Liu, Weiguo

Subjects
*PARKINSON'S disease, *DISEASE progression, *AGE of onset, *MONTREAL Cognitive Assessment
Abstract

Objective: Glucosylceramidase (GBA) variants and onset age significantly affect clinical phenotype and progression in Parkinson's disease (PD). The current study compared clinical characteristics at baseline and cognitive and motor progression over time among patients having GBA‐related PD (GBA‐PD), early‐onset idiopathic PD (early‐iPD), and late‐onset idiopathic PD (late‐iPD). Methods: We recruited 88 GBA‐PD, 167 early‐iPD, and 488 late‐iPD patients in this study. A subset of 50 GBA‐PD, 81 early‐iPD, and 223 late‐iPD patients was followed up at least once, with a 3.0‐year mean follow‐up time. Linear mixed‐effects models helped evaluate the rate of change in the Unified Parkinson's Disease Rating Scale motor and Montreal Cognitive Assessment scores. Results: At baseline, the GBA‐PD group showed more severe motor deficits and non‐motor symptoms (NMSs) than the early‐iPD group and more NMSs than the late‐iPD group. Moreover, the GBA‐PD group had more significant cognitive and motor progression, particularly bradykinesia and axial impairment, than the early‐iPD and late‐iPD groups at follow‐up. However, the early‐onset GBA‐PD (early‐GBA‐PD) group was similar to the late‐onset GBA‐PD (late‐GBA‐PD) group in baseline clinical features and cognitive and motor progression. Conclusion: GBA‐PD patients exhibited faster cognitive and motor deterioration than early‐iPD and late‐iPD patients. Thus, subtype classification based on genetic characteristics rather than age at onset could enhance the prediction of PD disease progression. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Region search evolutionary algorithm with constraint handling for multi-objective short-term wind-solar-hydro-thermal scheduling

Author

Liu Yongqi, Zhan Xiaoyan, Lyu Hao, and Qin Hui

Subjects
Environmental sciences, GE1-350
Abstract

Due to the depletion of fossil energy and environmental pollution, renewable clean energy has been paid more and more attention. This paper researches a multi-objective wind-solar-hydro-thermal scheduling model (MOSWS), whose objectives are to minimize the economic cost and minimize the environmental pollution caused by thermal power generation. The region search evolutionary algorithm (RSEA) with constraint handling method is proposed to solve the constrained multi-objective problems and applied to MOSWS model. From the experimental results, we find that RSEA with constraint handling is able to solve the constrained multi-problems and outperforms MODE-ACM in terms of both convergence and diversity. The RSEA is also applied to hydro-thermal system. The results show that wind-solar-hydro-thermal system can not only increase economic benefits, but also reduce the impact of thermal power generation on the atmospheric environment.

Published
2021
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41. Disrupted topologic efficiency of brain functional connectome in de novo Parkinson's disease with depression.

Author

Wang, Hui, Zhan, Xiaoyan, Xu, Jianxia, Yu, Miao, Guo, Zhiying, Zhou, Gaiyan, Ren, Jingru, Zhang, Ronggui, and Liu, Weiguo

Subjects
*PARKINSON'S disease, *FUNCTIONAL magnetic resonance imaging, *LARGE-scale brain networks, *TEMPORAL lobe, *MENTAL depression
Abstract

Growing evidence supports that depression in Parkinson's disease (PD) depends on disruptions in specific neural networks rather than regional dysfunction. According to the resting‐state functional magnetic resonance imaging data, the study attempted to decipher the alterations in the topological properties of brain networks in de novo depression in PD (DPD). The study also explored the neural network basis for depressive symptoms in PD. We recruited 20 DPD, 37 non‐depressed PD and 41 healthy controls (HC). The Graph theory and network‐based statistical methods helped analyse the topological properties of brain functional networks and anomalous subnetworks across these groups. The relationship between altered properties and depression severity was also investigated. DPD revealed significantly reduced nodal efficiency in the left superior temporal gyrus. Additionally, DPD decreased five hubs, primarily located in the temporal‐occipital cortex, and increased seven hubs, mainly distributed in the limbic cortico‐basal ganglia circuit. The betweenness centrality of the left Medio Ventral Occipital Cortex was positively associated with depressive scores in DPD. In contrast to HC, DPD had a multi‐connected subnetwork with significantly lower connectivity, primarily distributed in the visual, somatomotor, dorsal attention and default networks. Regional topological disruptions in the temporal‐occipital region are critical in the DPD neurological mechanism. It might suggest a potential network biomarker among newly diagnosed DPD patients. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway

Author

Wen, Jincai, primary, Qin, Shuanglin, additional, Li, Yurong, additional, Zhang, Ping, additional, Zhan, Xiaoyan, additional, Fang, Mingxia, additional, Shi, Ce, additional, Mu, Wenqing, additional, Kan, Wen, additional, Zhao, Jia, additional, Hui, Siwen, additional, Hou, Manting, additional, Li, Hui, additional, Xiao, Xiaohe, additional, Xu, Guang, additional, and Bai, Zhaofang, additional

Published
2023
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44. Additional file 1 of Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Author

Mu, Wenqing, Xu, Guang, Wang, Zhilei, Li, Qiang, Sun, Siqiao, Qin, Qin, Li, Zhiyong, Shi, Wei, Dai, Wenzhang, Zhan, Xiaoyan, Wang, Jiabo, Bai, Zhaofang, and Xiao, Xiaohe

Abstract

Additional file 1: Supplementary information on liver injury induced by TCAs by triggering NLRP3 inflammasome activation. Fig. S1. Cell viability of BMDMs administrated with nortriptyline was assessed using CellTiter-Glo Assay, which is according to quantitation of ATP. Fig. S2. Tricyclic antidepressantnortriptyline triggers the inflammasome activation in the absence of agonists.LPS-primed BMDMs were treated with carbamazepine and nortriptyline for 12 h or treated with them for 1 h followed by ATP stimulation, respectively. Western blotting was used to assess the expression of caspase-1 and IL-1β in SN. Fig. S3. Nortriptyline has no effect on Ca2+ mobilization.LPS-primed BMDMs were pretreated with EDTAand then stimulated with nortriptyline. Western blotting was used to assess the expression of caspase-1 in SN. Fig. S4. Nortriptyline activates NLRP3 inflammasome by inducing the accumulation of mtROS.LPS-primed BMDMs were pretreated with NACfor 1 h and then treated with nortriptyline for 6 h. The content of mtROSwas measured by flow cytometry. Western blotting was used to assess the expression of IL-1β and caspase-1 in cell SN as well as pro-IL-1β, pro-caspase-1, and NLRP3in WCL. The level of caspase-1activity. The levels of IL-1βand TNF-αin SN using ELISA. Data are presented as mean ± SEM; *P < 0.05, ***P < 0.001; One-Way ANOVA followed by Dunnett's post hoc test. Fig. S5. Multiple TCAs specifically trigger the aberrant activation of NLRP3 inflammasome.LPS-primed BMDMs were pretreated with MCC950 and then stimulated with Imi, Ami, Pro, and Nor for 12 h, the levels of IL-1βand TNF-αwere detected by ELISA kits.WT and Nlrp3-/- BMDMs were primed with LPS and then stimulated with Imi, Ami, Pro and Nor, the levels of IL-1βand TNF-αwere evaluated by ELISA kits. Data are expressed as the mean ± SEM,; *P < 0.05, **P < 0.01, ***P < 0.001 vs. the control; ns, not significant; unpaired Student’s t-testfollowed by the Dunnett's post hoc test. Fig. S6. Multiple TCAs induce the NLRP3 inflammasome activation by triggering upstream signaling events.LPS-primed BMDMs were pretreated with MCC950, NAC, and KCl for 1 h followed by these TCAs stimulation, respectively. Western blotting was used to assess the expression of caspase-1in SN. Fig. S7. Nortriptyline directly triggered activation of the NLRP3 inflammasome in both hepatocytes and Kupffer cells.LPS-primed BMDMs and hepatocytes were pretreated with MCC950 and then stimulated with nortriptyline for 12 h. The levels of IL-1β in SN were detected using ELISA kits.BMDMs and Kupffer cells were primed with LPS and then pretreated with MCC950 followed by nortriptyline stimulation for 12 h. The levels of IL-1β in SN were detected using ELISA kits. Data are presented as the mean ± SEM; ***P < 0.001; One-Way ANOVA followed by the Dunnett's post hoc test. Fig. S8. Nortriptyline induces IDILI by triggering the activation of NLRP3 inflammasome.Female WT C57BL/6 mice were pretreated with LPSand then treated with different doses of nortriptyline. The serum levels of TNF-α were detected by ELISA kits.WT or Nlrp3-/- mice were pretreated with LPS and then treated with nortriptyline. ELISA kits were used to determine the levels of IL-6and TNF-αin mouse sera. Data are shown as the mean ± SEM; ***P < 0.001; ns, not significant. Statistics differences were analyzed using an unpaired Student’s t-test.

Published
2023
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47. Polysaccharide extract fromIsatidis Radixinhibits multiple inflammasomes activation and alleviate gouty arthritis

Author

Ren, Lutong, primary, Li, Qiang, additional, Li, Hui, additional, Zhan, Xiaoyan, additional, Yang, Ruichuang, additional, Li, Zhiyong, additional, Fang, Zhie, additional, Liu, Tingting, additional, Wei, Ziying, additional, Zhao, Jia, additional, Lin, Li, additional, Mou, Wenqing, additional, Dai, Wenzhang, additional, Bai, Zhaofang, additional, Xu, Guang, additional, and Cao, Junling, additional

Published
2022
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48. Structural mapping of antibody landscapes to human betacoronavirus spike proteins

Author

Bangaru, Sandhya, primary, Antanasijevic, Aleksandar, additional, Kose, Nurgun, additional, Sewall, Leigh M., additional, Jackson, Abigail M., additional, Suryadevara, Naveenchandra, additional, Zhan, Xiaoyan, additional, Torres, Jonathan L., additional, Copps, Jeffrey, additional, de la Peña, Alba Torrents, additional, Crowe, James E., additional, and Ward, Andrew B., additional

Published
2022
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49. Tanshinone I Specifically Suppresses NLRP3 Inflammasome Activation by Disrupting the Association of NLRP3 and ASC

Author

Zhao, Jia, primary, Liu, Hongbin, additional, Hong, Zhixian, additional, Luo, Wei, additional, Mu, Wenqing, additional, Hou, Xiaorong, additional, Xu, Guang, additional, Fang, Zhie, additional, Ren, Lutong, additional, Liu, Tingting, additional, Li, Qiang, additional, Wen, Jincai, additional, Shi, Wei, additional, Wei, Ziying, additional, Hui, Siwen, additional, Wang, Jiabo, additional, Guo, Yuming, additional, Zhao, Xu, additional, Zou, Wenjun, additional, Yang, Yongping, additional, Zhao, Jun, additional, Xiao, Xiaohe, additional, Bai, Zhaofang, additional, and Zhan, Xiaoyan, additional

Published
2022
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