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Your search keyword '"Zhan, Shoubin"' showing total 15 results
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15 results on '"Zhan, Shoubin"'

6. Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47

Author

Hu, Huanhuan, Cheng, Rongjie, Wang, Yanbo, Wang, Xiaojun, Wu, Jianzhuang, Kong, Yan, Zhan, Shoubin, Zhou, Zhen, Zhu, Hongyu, Yu, Ranran, Liang, Gaoli, Wang, Qingyan, Zhu, Xiaoju, Zhang, Chen- Yu, Yin, Rong, Yan, Chao, and Chen, Xi

Subjects
Gene mutations -- Research, Oncology, Experimental, Immune response -- Genetic aspects, Lung cancer -- Genetic aspects -- Development and progression, Cellular signal transduction -- Research, Oncogenes -- Health aspects, Cancer -- Research, Health care industry
Abstract

KRAS is one of the most frequently activated oncogenes in human cancers. Although the role of KRAS mutation in tumorigenesis and tumor maintenance has been extensively studied, the relationship between KRAS and the tumor immune microenvironment is not fully understood. Here, we identified a role of KRAS in driving tumor evasion from innate immune surveillance. In samples of lung adenocarcinoma from patients and Kras- driven genetic mouse models of lung cancer, mutant KRAS activated the expression of cluster of differentiation 47 (CD47), an antiphagocytic signal in cancer cells, leading to decreased phagocytosis of cancer cells by macrophages. Mechanistically, mutant KRAS activated PI3K/STAT3 signaling, which restrained miR-34a expression and relieved the posttranscriptional repression of miR-34a on CD47. In 3 independent cohorts of patients with lung cancer, the KRAS mutation status positively correlated with CD47 expression. Therapeutically, disruption of the KRAS/CD47 signaling axis with KRAS siRNA, the [KRAS.sup.G12C] inhibitor AMG 510, or a miR-34a mimic suppressed CD47 expression, enhanced the phagocytic capacity of macrophages, and restored innate immune surveillance. Our results reveal a direct mechanistic link between active KRAS and innate immune evasion and identify CD47 as a major effector underlying the KRAS-mediated immunosuppressive tumor microenvironment., Introduction Mutations of the KRAS gene are the most common drivers of tumor development across a spectrum of human cancers, such as cancers of the lung, colon, and pancreas (1-3). [...]

Published
2023
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10. PLOD2 high expression associates with immune infiltration and facilitates cancer progression in osteosarcoma

Author

Wang, Zhen, primary, Fan, Gentao, additional, Zhu, Hao, additional, Yu, Lingfeng, additional, She, Diankun, additional, Wei, Yanting, additional, Huang, Jianhao, additional, Li, Tianhang, additional, Zhan, Shoubin, additional, Zhou, Shenkai, additional, Zhu, Yan, additional, Wang, Yicun, additional, Chen, Xi, additional, Zhao, Jianning, additional, and Zhou, Guangxin, additional

Published
2022
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12. Evaluating adipose‐derived stem cell exosomes as miRNA drug delivery systems for the treatment of bladder cancer

Author

Liu, Tianyao, primary, Li, Tianhang, additional, Zheng, Yufeng, additional, Xu, Xinyan, additional, Sun, Rui, additional, Zhan, Shoubin, additional, Guo, Xu, additional, Zhao, Zihan, additional, Zhu, Wenjie, additional, Feng, Baofu, additional, Wei, Fayun, additional, Jiang, Ning, additional, Wang, Jin, additional, Chen, Xi, additional, Fang, Feng, additional, Guo, Hongqian, additional, and Yang, Rong, additional

Published
2022
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14. Sperm microRNAs confer depression susceptibility to offspring

Author

Wang, Yanbo, primary, Chen, Zhang-Peng, additional, Hu, Huanhuan, additional, Lei, Jieqiong, additional, Zhou, Zhen, additional, Yao, Bing, additional, Chen, Li, additional, Liang, Gaoli, additional, Zhan, Shoubin, additional, Zhu, Xiaoju, additional, Jin, Fangfang, additional, Ma, Rujun, additional, Zhang, Jun, additional, Liang, Hongwei, additional, Xing, Ming, additional, Chen, Xiao-Rui, additional, Zhang, Chen-Yu, additional, Zhu, Jing-Ning, additional, and Chen, Xi, additional

Published
2021
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