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This study aims to identify key regulators of paraptosis in gastric cancer (GC) and explore their potential in guiding therapeutic strategies, especially in stomach adenocarcinoma (STAD). Genes associated with paraptosis were identified from the references and subjected to Cox regression analysis in the TCGA-STAD cohort. Using machine learning models, LPAR1 consistently ranked highest in feature importance. Multiple sequencing data showed that LPAR1 was significantly overexpressed in cancer-associated fibroblasts (CAFs). LPAR1 expression was significantly higher in normal tissues, and ROC analysis demonstrated its discriminative ability. Copy number alterations and microsatellite instability were significantly associated with LPAR1 expression. High LPAR1 expression correlated with advanced tumor grades and specific cancer immune subtypes, and multivariate analysis confirmed LPAR1 as an independent predictor of poor prognosis. LPAR1 expression was associated with different immune response metrics, including immune effector activation and upregulated chemokine secretion. High LPAR1 expression also correlated with increased sensitivity to compounds, such as BET bromodomain inhibitors I-BET151 and RITA, suggesting LPAR1 as a biomarker for predicting drug activity. FOXP2 showed a strong positive correlation with LPAR1 transcriptional regulation, while increased methylation of LPAR1 promoter regions was negatively correlated with gene expression. Knockdown of LPAR1 affected cell growth in most tumor cell lines, and in vitro experiments demonstrated that LPAR1 influenced extracellular matrix (ECM) contraction and cell viability in the paraptosis of CAFs. These findings suggest that LPAR1 is a critical regulator of paraptosis in GC and a potential biomarker for drug sensitivity and immunotherapy response. This underscores the role of CAFs in mediating tumorigenic effects and suggests that targeting LPAR1 could be a promising strategy for precision medicine in GC.

In order to study the change rules of mineral composition, micro-structure evolution characteristics and their relationship with dynamic properties of granite after high temperature treatment, the high temperature tests on Beishan granite in Gansu Province, China, were carried out at 20−1 000 ℃. Microscopic images of granite after high temperature treatment were obtained by slicing technique and polarizing microscope. The evolution of mineral composition, mineral content and micro-structure characteristic parameters of granite with temperature were studied through mineral composition analysis, micro-cracks characteristic identification and parameters calculation. Subsequently, dynamic impact compression tests of high temperature treated granite were carried out by split Hopkinson pressure bar (SHPB) system, to analyze the effects of temperature, impact rate and micro-structure characteristics on dynamic peak stress. On this basis, the quantitative relationship between micro-structure characteristics and macroscopic dynamic properties was established. The results show that high temperature has a significant effect on the mineral composition, micro-structure and impact compressive strength of granite, and 600 ℃ is taken as the threshold temperature. The loading rate also significantly affects the impact compressive strength, and the larger the loading rate is, the less the influence of temperature on the macroscopic dynamic properties is. The evolution process of the micro-structure of granite after high temperature treatment is the internal mechanism for the change of its macroscopic dynamic properties with temperature. The microcrack characteristics have a significant correlation with the dynamic peak stress, and the average crack width is the main factor affecting the dynamic peak stress of granite.

Revise ISO 22768∶2017 based on China′s industrial standards, and expand the scope of application to latex. The effects of sample preparation method, gas flow rate, heating rate and sample amount on the determination results of glass transition temperature were investigated, and the precision of the method was established. The results showed that, when the drying method was selected, the gas flow rate was 20 mL/min, the sample amount was 5-20 mg, and the heating rate was 20 ℃/min, the method had good precision, the standard deviation of repeatability was less than 0.30 ℃ and the standard deviation of reproducibility was less than 1.01 ℃.

All-inorganic cesium lead halide perovskite materials have potential applications in mini/micro-LED display applications due to their excellent photoelectric properties. However, these materials have an uncontrollable tendency to form large-sized crystals and poor stability, which is not conducive to miniaturized optoelectronic applications. Herein, a novel Cs4PbBr6@KBr color conversion film (Cs4PbBr6@KBr CCFs) with both excellent luminescence properties and high stability was in situ constructed by using inkjet printing technology. The improvement in performance is attributed to the reduction in perovskite defects within the structure and the isolation of oxygen and water by the surface modification layer, which is related to the higher solubility product of KBr. The Cs4PbBr6@KBr CCFs printed on a PET flexible substrate present a high-resolution dot matrix of 16.7 μm and a homogeneous and bright green emission with a high photoluminescence quantum yield of 94%. Moreover, the Cs4PbBr6@KBr CCFs retain 65% of their initial intensity after being aged at 70 °C for 16 h, which is superior to that of perovskite CCFs without the coating of KBr. These results indicate that the Cs4PbBr6@KBr composite has excellent potential in realizing mini/micro-LED displays with high resolution and anti-counterfeiting lables. [ABSTRACT FROM AUTHOR]