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154 results on '"Zhai, Xiangjun"'

3. Hepatitis B virus infection and risk of non‐alcoholic fatty liver disease: A population‐based cohort study

Author

Zhu, Liguo, Jiang, Jie, Zhai, Xiangjun, Baecker, Aileen, Peng, Hong, Qian, Jiao, Zhou, MingHao, Song, Ci, Zhou, Yan, Xu, Jianfang, Liu, Hongjian, Hang, Dong, Hu, Zhibin, Shen, Hongbin, Zhang, Zuo‐Feng, and Zhu, Fengcai

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Substance Misuse, Prevention, Hepatitis, Digestive Diseases, Nutrition, Chronic Liver Disease and Cirrhosis, Clinical Research, Infectious Diseases, Diabetes, Liver Disease, Alcoholism, Alcohol Use and Health, Obesity, Metabolic and endocrine, Oral and gastrointestinal, Cancer, Infection, Good Health and Well Being, Adult, Age Distribution, Body Mass Index, China, Comorbidity, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Hepatitis B, Chronic, Humans, Incidence, Male, Middle Aged, Multivariate Analysis, Non-alcoholic Fatty Liver Disease, Overweight, Proportional Hazards Models, Risk Factors, Sex Distribution, BMI, diabetes mellitus, HBsAg carriers, NAFLD, BMI, NAFLD, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsAlthough non-alcoholic fatty liver disease (NAFLD) has been studied extensively, the potential risk factors for NAFLD among chronic hepatitis B (CHB) patients have not been fully known.MethodsA population-based cohort of adult CHB patients without a history of alcohol drinking or NAFLD were recruited and followed up from October 2012 to January 2015 in Jiangsu province, China. Using Cox proportional hazards regression model, potential risk factors including viral and metabolic factors for NAFLD were evaluated.ResultsTwo thousand three hundred and ninety-three adult CHB patients (mean age 50.7 ± 13.2 years) were included in the cohort. With 4429 person-years of follow-up, 283 individuals progressed to NAFLD with an incidence rate of 63.89/1000 person-years. Overweight and obese CHB patients had an increased risk of NAFLD (overweight adjusted hazard ratio [HR], 3.10; 95% CI, 2.29-4.18; obese HR, 8.52; 95%CI, 5.93-12.25) compared to normal weight carriers. The incidence of NAFLD was associated with concurrent type 2 diabetes mellitus (DM) (HR, 1.88; 95%CI, 1.15-3.08). However, no associations between viral factors with NAFLD incidence rate were identified. In a subgroup of participants with concurrent type 2 DM, detectable HBV DNA levels were negatively associated with the development of NAFLD (HR, 0.37; 95%CI, 0.14-0.98). There was super-multiplicative interaction between BMI and gender with respect to incidence of NAFLD, with an ROR of 2.08 (95%CI, 1.02-4.23).ConclusionMetabolic factors play an important role in the presence of NAFLD among Chinese CHB patients. However, viral replication factors are not related to NAFLD except among those with concurrent type 2 DM.

Published
2019

9. Additional file 1 of A booster hepatitis B vaccine for children with maternal HBsAg positivity before 2 years of age could effectively prevent vaccine breakthrough infections

Author

Song, Yarong, Zhang, Xin, Liu, Minmin, Zhai, Xiangjun, Liu, Jianxun, Li, Yi, Li, Lili, Xiao, Yiwei, Duan, Zhongping, Jiang, Jing, Ding, Feng, Zhu, Liguo, Jiang, Jie, Zou, Huaibin, Zhuang, Hui, Wang, Jie, and Li, Jie

Abstract

Additional file 1: Fig. S1. Enrolment and follow-up of participants. Table S1. Comparison of the baseline characteristics of children followed up and lost to follow-up and those of their mothers. Table S2. Comparison of baseline characteristics of children with different anti-HBs levels at the age of 7 months and those of their mothers. Table S3. Genotype, subtype, homology and S region mutation comparisons of infected mother-child HBV pairs. Table S4. Comparison of the baseline characteristics of children with and without HBV VBIs and those of their mothers.

Published
2022
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10. The Dynamic Changes of HBV Quasispecies Diversity in Infancy after Immunoprophylaxis Failure: A Prospective Cohort Study

Author

Li, Yi, primary, Xiao, Yiwei, additional, Li, Lili, additional, Song, Yarong, additional, Zhai, Xiangjun, additional, Liu, Jianxun, additional, Duan, Zhongping, additional, Yan, Ling, additional, Ding, Feng, additional, Liu, Jia, additional, Zhu, Liguo, additional, Jiang, Jie, additional, Zou, Huaibin, additional, Li, Lingxiang, additional, Liang, Caihong, additional, Wang, Jie, additional, and Li, Jie, additional

Published
2021
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16. Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus

Author

Lu, Ying, primary, Song, Yarong, additional, Zhai, Xiangjun, additional, Zhu, Fengcai, additional, Liu, Jianxun, additional, Chang, Zhanjun, additional, Li, Yi, additional, Xiao, Yiwei, additional, Li, Lili, additional, Liu, Minmin, additional, Liu, Jia, additional, Duan, Zhongping, additional, Zou, Huaibin, additional, Zhuang, Hui, additional, Wang, Jie, additional, and Li, Jie, additional

Published
2021
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22. Reduction of the occurrence of occult HBV infection in infants by increasing the dose of hepatitis B vaccine: a large prospective cohort study

Author

Li, Yi, primary, Liu, Zhixiu, additional, Song, Yarong, additional, Xiao, Yiwei, additional, Jiang, Jing, additional, Li, Lili, additional, Zhai, Xiangjun, additional, Liu, Jianxun, additional, Duan, Zhongping, additional, Ding, Feng, additional, Liu, Jia, additional, Zhuang, Hui, additional, Zhu, Liguo, additional, Jiang, Jie, additional, Zou, Huaibin, additional, Wang, Jie, additional, and Li, Jie, additional

Published
2020
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26. Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance and seroconversion in hepatitis B e antigen‐negative chronic infection patients: A population‐based prospective cohort

Author

Zhu, Liguo, primary, Zhai, Xiangjun, additional, Wang, Qungang, additional, Jiang, Jie, additional, Peng, Hong, additional, Song, Ci, additional, Ge, Zijun, additional, Qian, Jiao, additional, Zhou, MingHao, additional, Zhou, Yan, additional, Xu, Jianfang, additional, Liu, Hongjian, additional, Hang, Dong, additional, Hu, Zhibin, additional, Shen, Hongbin, additional, and Zhu, Fengcai, additional

Published
2018
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27. Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis

Author

Liu Jiyong, Jin Guangfu, Wang Xuechen, Wang Shui, Qin Jianwei, Tang Jinhai, Hu Zhibin, Gao Jun, Zhai Xiangjun, Chen Wenshen, Chen Feng, Wang Xinru, Wei Qingyi, and Shen Hongbing

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Accumulative evidence suggests that low folate intake is associated with increased risk of breast cancer. Polymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, and thus individual susceptibility to cancer. Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP in the process of DNA synthesis. Two potentially functional polymorphisms [a 28-bp tandem repeat in the TYMS 5'-untranslated enhanced region (TSER) and a 6-bp deletion/insertion in the TYMS 3'-untranslated region (TS 3'-UTR)] were suggested to be correlated with alteration of thymidylate synthase expression and associated with cancer risk. Methods To test the hypothesis that polymorphisms of the TYMS gene are associated with risk of breast cancer, we genotyped these two polymorphisms in a case-control study of 432 incident cases with invasive breast cancer and 473 cancer-free controls in a Chinese population. Results We found that the distribution of TS3'-UTR (1494del6) genotype frequencies were significantly different between the cases and controls (P = 0.026). Compared with the TS3'-UTR del6/del6 wild-type genotype, a significantly reduced risk was associated with the ins6/ins6 homozygous variant genotype (adjusted OR = 0.58, 95% CI = 0.35–0.97) but not the del6/ins6 genotype (OR = 1.09, 95% CI = 0.82–1.46). Furthermore, breast cancer risks associated with the TS3'-UTR del6/del6 genotype were more evident in older women, postmenopausal subjects, individuals with a younger age at first-live birth and individuals with an older age at menarche. However, there was no evidence for an association between the TSER polymorphism and breast cancer risks. Conclusion These findings suggest that the TS3'-UTR del6 polymorphism may play a role in the etiology of breast cancer. Further larger population-based studies as well as functional evaluation of the variants are warranted to confirm our findings.

Published
2006
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29. Hepatitis B virus infection and risk of non-alcoholic fatty liver disease: A population-based cohort study

Author

Zhu, Liguo, primary, Jiang, Jie, additional, Zhai, Xiangjun, additional, Baecker, Aileen, additional, Peng, Hong, additional, Qian, Jiao, additional, Zhou, MingHao, additional, Song, Ci, additional, Zhou, Yan, additional, Xu, Jianfang, additional, Liu, Hongjian, additional, Hang, Dong, additional, Hu, Zhibin, additional, Shen, Hongbin, additional, Zhang, Zuo-Feng, additional, and Zhu, Fengcai, additional

Published
2018
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32. Identification of GRP75 as a novel PreS1 binding protein using a proteomics strategy

Author

Cui, Lunbiao, Ge, Yiyue, Qi, Yuhua, Shi, Zhiyang, Jiao, Yongjun, Qi, Xian, Zhai, Xiangjun, and Wang, Hua

Subjects
Proteomics, PreS1, HBV, GRP75, lcsh:QR1-502, General Microbiology, Microbiology, lcsh:Microbiology, Research Paper
Abstract

The PreS1 region of the L protein is important in cell attachment and consequently in hepatitis B virus (HBV) infectivity. To identify novel PreS1 interacting protein, we performed Glutathione-S-transferase (GST) pull-down, two-dimensional gel electrophoresis (2-DE) and mass spectrometry assays. Glucose-regulated proteins (GRP) 78 and 75 were found to bind PreS1. The interactions between PreS1 and GRP75 were confirmed by a co-immunoprecipitation experiment. GRP78 and GRP75 may play important roles in mediating HBV virion entering into hepatocyte and regulating proper folding of the L protein due to their critical functions in protein folding and trafficking. The finding of novel PreS1 binding protein enriches our knowledge about molecular mechanism of HBV infection.

Published
2010

34. Fine mapping the MHC region identified four independent variants modifying susceptibility to chronic hepatitis B in Han Chinese

Author

Zhu, Meng, primary, Dai, Juncheng, additional, Wang, Cheng, additional, Wang, Yuzhuo, additional, Qin, Na, additional, Ma, Hongxia, additional, Song, Ci, additional, Zhai, Xiangjun, additional, Yang, Yuan, additional, Liu, Jibin, additional, Liu, Li, additional, Li, Shengping, additional, Liu, Jianjun, additional, Yang, Haitao, additional, Zhu, Fengcai, additional, Shi, Yongyong, additional, Shen, Hongbing, additional, Jin, Guangfu, additional, Zhou, Weiping, additional, and Hu, Zhibin, additional

Published
2016
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35. Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study

Author

Wen, Juan, primary, Song, Ci, additional, Jiang, Deke, additional, Jin, Tianbo, additional, Dai, Juncheng, additional, Zhu, Liguo, additional, An, Jiaze, additional, Liu, Yao, additional, Ma, Shijie, additional, Qin, Na, additional, Liang, Cheng, additional, Chen, Jiaping, additional, Jiang, Yue, additional, Yang, Linlin, additional, Liu, Jibin, additional, Liu, Li, additional, Geng, Tingting, additional, Chen, Chao, additional, Jiang, Jie, additional, Chen, Jianguo, additional, Zhu, Fengcai, additional, Zhu, Yefei, additional, Yu, Long, additional, Shen, Hongbing, additional, Zhai, Xiangjun, additional, Xu, Jianfeng, additional, and Hu, Zhibin, additional

Published
2015
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38. Expression Quantitative Trait Loci for CARD8 Contributes to Risk of Two Infection-Related Cancers—Hepatocellular Carcinoma and Cervical Cancer

Author

Yin, Jian, primary, Wen, Juan, additional, Hang, Dong, additional, Han, Jing, additional, Jiang, Jie, additional, Song, Ci, additional, Liu, Yao, additional, Liu, Jibin, additional, Liu, Li, additional, Zhu, Liguo, additional, Chen, Jianguo, additional, Zhai, Xiangjun, additional, Xie, Shuanghua, additional, Hu, Zhibin, additional, Shen, Hongbing, additional, Dai, Min, additional, and Li, Ni, additional

Published
2015
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42. New loci associated with chronic hepatitis B virus infection in Han Chinese

Author

Hu, Zhibin, primary, Liu, Yao, additional, Zhai, Xiangjun, additional, Dai, Juncheng, additional, Jin, Guangfu, additional, Wang, Li, additional, Zhu, Liguo, additional, Yang, Yuan, additional, Liu, Jibin, additional, Chu, Minjie, additional, Wen, Juan, additional, Xie, Kaipeng, additional, Du, Guoming, additional, Wang, Qungang, additional, Zhou, Yuchun, additional, Cao, Minquan, additional, Liu, Li, additional, He, Yisha, additional, Wang, Ying, additional, Zhou, Gangqiao, additional, Jia, Weihua, additional, Lu, Jiachun, additional, Li, Shengping, additional, Liu, Jianjun, additional, Yang, Haitao, additional, Shi, Yongyong, additional, Zhou, Weiping, additional, and Shen, Hongbing, additional

Published
2013
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44. Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.

Author

Song, Ci, Liu, Yao, Xu, Lu, Wen, Juan, Jiang, Deke, Chen, Jianguo, Zhai, Xiangjun, Hu, Zhibin, Liu, Li, and Liu, Jibin

Subjects
HEPATITIS B treatment, CANCER risk factors, IMMUNOREGULATION, LIVER cancer, VIRAL mutation, GENE expression, GENETICS
Abstract

Previously we identified that HBV(Hepatitis B virus) sequence variation, which may interact with host human leukocyte antigen ( HLA) genetic variation, could influence host risk of hepatocellular carcinoma ( HCC). More HBV-host interactions need to be identified. Protein tyrosine phosphatase nonreceptor type 12 ( PTPN12), serves as an antagonist to tyrosine kinase signaling, may play integral roles in immune response against HBV infection and the development of HCC. Rs11485985 was an expression quantitative trait loci ( eQTL) for PTPN12 by bioinformatics analyses. In this study, we genotyped the PTPN12 eQTL and sequenced the HBV region Enh II/ BCP/ PC in a case-control cohort including 1507 HBV-related HCC cases and 1560 HBV persistent carriers as controls. The variant genotype GG of rs11489585 increased HCC risk compared to the HBV persistent carriers (adjusted OR = 2.03, 95% confidence interval [ CIs] = 1.30-3.18). We also detected borderline significant associations of PTPN12 eQTL rs11489585 with HBV mutations ( P = 0.05 for G1799C). Taken together, PTPN12 may influence HCC risk accompanied by HBV mutations. [ABSTRACT FROM AUTHOR]

Published
2016
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45. GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers

Author

Li, Shengping, primary, Qian, Ji, additional, Yang, Yuan, additional, Zhao, Wanting, additional, Dai, Juncheng, additional, Bei, Jin-Xin, additional, Foo, Jia Nee, additional, McLaren, Paul J., additional, Li, Zhiqiang, additional, Yang, Jingmin, additional, Shen, Feng, additional, Liu, Li, additional, Yang, Jiamei, additional, Li, Shuhong, additional, Pan, Shandong, additional, Wang, Yi, additional, Li, Wenjin, additional, Zhai, Xiangjun, additional, Zhou, Boping, additional, Shi, Lehua, additional, Chen, Xinchun, additional, Chu, Minjie, additional, Yan, Yiqun, additional, Wang, Jun, additional, Cheng, Shuqun, additional, Shen, Jiawei, additional, Jia, Weihua, additional, Liu, Jibin, additional, Yang, Jiahe, additional, Wen, Zujia, additional, Li, Aijun, additional, Zhang, Ying, additional, Zhang, Guoliang, additional, Luo, Xianrong, additional, Qin, Hongbo, additional, Chen, Minshan, additional, Wang, Hua, additional, Jin, Li, additional, Lin, Dongxin, additional, Shen, Hongbing, additional, He, Lin, additional, de Bakker, Paul I. W., additional, Wang, Hongyang, additional, Zeng, Yi-Xin, additional, Wu, Mengchao, additional, Hu, Zhibin, additional, Shi, Yongyong, additional, Liu, Jianjun, additional, and Zhou, Weiping, additional

Published
2012
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50. Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population

Author

Zhi, Hong, primary, Wang, Hua, additional, Ren, Liqun, additional, Shi, Zhiyang, additional, Peng, Haiyan, additional, Cui, Lunbiao, additional, Ma, Genshan, additional, Ye, Xingzhou, additional, Feng, Yi, additional, Shen, Chengxing, additional, Zhai, Xiangjun, additional, Zhang, Chenyu, additional, Zen, Ke, additional, and Liu, Naifeng, additional

Published
2009
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