49 results on '"Zeuner, Rainald"'
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2. Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations
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Boztug, Kaan, Brunner, Juergen, Demel, Ulrike F., Förster-Waldl, Elisabeth, Gasteiger, Lukas M., Göschl, Lisa, Kojić, Marina, Schroll, Andrea, Seidel, Markus G., Wintergerst, Uwe, Wisgrill, Lukas, Sharapova, Svetlana O., Goffard, Jean-Christophe, Kerre, Tessa, Meyts, Isabelle, Roosens, Fine, Smet, Julie, Haerynck, Filomeen, Eric, Zelimir Pavle, Milenova, Veneta, Gagro, Alenka, Richter, Darko, Chovancova, Zita, Hlavackova, Eva, Litzman, Jiri, Milota, Tomas, Sediva, Anna, Elaziz, Dalia Abd, Alkady, Radwa Salaheldin, El Sayed El Hawary, Rabab, Eldash, Alia S., Galal, Nermeen, Lotfy, Sohilla, Meshaal, Safa S., Reda, Shereen M., Sobh, Ali, Elmarsafy, Aisha, Seppänen, Mikko R.J., Brosselin, Pauline, Courteille, Virginie, De Vergnes, Nathalie, Kracker, Sven, Pergent, Martine, Randrianomenjanahary, Philippe, Ahrenstorf, Gerrit, Albert, Michael H., Ankermann, Tobias, Atschekzei, Faranaz, Baumann, Ulrich, Becker, Benjamin C., Behrends, Uta, Belohradsky, Bernd H., Biegner, Anika-Kerstin, Binder, Nadine, Bode, Sebastian F.N., Boesecke, Christoph, Boetticher, Benedikt, Borte, Michael, Borte, Stephan, Classen, Carl Friedrich, Dirks, Johannes, Dückers, Gregor, El-Helou, Sabine, Ernst, Diana, Fasshauer, Maria, Fecker, Gisela, Felgentreff, Kerstin, Foell, Dirk, Ghosh, Sujal, Girschick, Hermann J., Goldacker, Sigune, Graf, Norbert, Graf, Dagmar, Greil, Johann, Hanitsch, Leif Gunnar, Hauck, Fabian, Heeg, Maximilian, Heine, Sabine I., Henes, Joerg C., Hoenig, Manfred, Holzer, Ursula, Holzinger, Dirk, Horneff, Gerd, Hundsdoerfer, Patrick, Jablonka, Alexandra, Jakoby, Donate, Joean, Oana, Kaiser-Labusch, Petra, Klemann, Christian, Kobbe, Robin, Körholz, Julia, Kramm, Christof M., Krüger, Renate, Landwehr-Kenzel, Sybille, Lehmberg, Kai, Liese, Johannes G., Lippert, Conrad Ferdinand, Maccari, Maria Elena, Masjosthusmann, Katja, Meinhardt, Andrea, Metzler, Markus, Morbach, Henner, Müller, Ingo, Naumann-Bartsch, Nora, Neubert, Jennifer, Niehues, Tim, Peter, Hans-Hartmut, Rieber, Nikolaus, Ritterbusch, Henrike, Rockstroh, Jürgen Kurt, Roesler, Joachim, Schauer, Uwe, Scheible, Raphael, Schmalzing, Marc, Schmidt, Reinhold Ernst, Schneider, Dominik T., Schreiber, Stefan, Schuetz, Catharina, Schulz, Ansgar, Schulze-Koops, Hendrik, Schulze-Sturm, Ulf, Schuster, Volker, Schwaneck, Eva C., Schwarz, Klaus, Schwarze-Zander, Carolynne, Sirin, Mehtap, Skapenko, Alla, Sogkas, Georgios, Sparber-Sauer, Monika, Speckmann, Carsten, Steinmann, Sandra, Stiehler, Sophie, Tenbrock, Klaus, von Bernuth, Horst, Warnatz, Klaus, Wasmuth, Jan-Christian, Weiss, Michael, Witte, Torsten, Wittke, Kirsten, Wittkowski, Helmut, Zeuner, Rainald A., Farmaki, Evangelia, Hatzistilianou, Maria N., Kakkas, Ioannis, Kanariou, Maria G., Kapousouzi, Androniki, Liatsis, Emmanouil, Maggina, Paraskevi, Papadopoulou-Alataki, Efimia, Raptaki, Maria, Speletas, Matthaios, Tantou, Sofia, Goda, Vera, Kriván, Gergely, Marodi, Laszlo, Abolhassani, Hassan, Aghamohammadi, Asghar, Rezaei, Nima, Feighery, Conleth, Leahy, Timothy Ronan, Ryan, Paul, Batzir, Nurit Assia, Garty, Ben Zion, Tamary, Hannah, Aiuti, Alessandro, Amodio, Donato, Azzari, Chiara, Barzaghi, Federica, Baselli, Lucia A., Cancrini, Caterina, Carrabba, Maria, Cazzaniga, Marco, Cesaro, Simone, Chinello, Matteo, Danieli, Maria Giovanna, Dellepiane, Rosa Maria, Fabio, Giovanna, Gambineri, Eleonora, Lodi, Lorenzo, Lougaris, Vassilios, Marasco, Carolina, Martire, Baldassarre, Marzollo, Antonio, Milito, Cinzia, Moschese, Viviana, Pignata, Claudio, Plebani, Alessandro, Porta, Fulvio, Quinti, Isabella, Ricci, Silvia, Soresina, Annarosa, Tommasini, Alberto, Vacca, Angelo, Vanessa, Clementina, Blažienė, Audra, Sitkauskiene, Brigita, Gowin, Ewelina, Heropolitańska-Pliszka, Edyta, Pietrucha, Barbara, Szaflarska, Anna, Więsik-Szewczyk, Ewa, Wolska-Kuśnierz, Beata, Esteves, Isabel, Faria, Emilia, Marques, Laura Hora, Neves, João Farela, Silva, Susana L., Teixeira, Carla, Pereira da Silva, Sara, Capilna, Brindusa Ruxandra, Guseva, Marina N., Shcherbina, Anna, Bobcakova, Anna, Ciznar, Peter, Gabzdilova, Juliana, Jesenak, Milos, Kapustova, Lenka, Orosova, Jaroslava, Petrovicova, Otilia, Raffac, Stefan, Kopač, Peter, Allende, Luis M., Antolí, Arnau, Blanch, Gemma Rocamora, Carbone, Javier, Dieli-Crimi, Romina, Garcia-Prat, Marina, Gil-Herrera, Juana, Gonzalez-Granado, Luis Ignacio, Agulló, Pilar Llobet, Olbrich, Peter, Parra-Martínez, Alba, Paz-Artal, Estela, Pleguezuelo, Daniel E., Rodríguez, Nerea Salmón, Sánchez-Ramón, Silvia, Santos-Pérez, Juan Luis, Solanich, Xavier, Soler-Palacin, Pere, González-Amores, Miriam, Ekwall, Olov, Fasth, Anders, Bitzenhofer-Grüber, Michaela, Candotti, Fabio, Dimitriou, Florentia, Heininger, Ulrich, Holbro, Andreas, Jandus, Peter, Kolios, Antonios G.A., Marschall, Karin, Schmid, Jana Pachlopnik, Posfay-Barbe, Klara M., Prader, Seraina, Reichenbach, Janine, Steiner, Urs C., Trück, Johannes, Bredius, Robbert G., de Kruijf- Bazen, Suzanne, de Vries, Esther, Henriet, Stefanie S.V., Kuijpers, Taco W., Potjewijd, Judith, Rutgers, Abraham, Stol, Kim, van Aerde, Koen J., Van den Berg, J. Merlijn, van de Ven, Annick A.J.M., Montfrans, Jorisvan, Aydemir, Sezin, Baris, Safa, Dogu, Figen, Ikinciogullari, Aydan, Karakoc-Aydiner, Elif, Kilic, Sara S., Kiykim, Ayca, Kökçü Karadağ, Şefika İlknur, Kutukculer, Necil, Ocak, Suheyla, UNAL, Ekrem, Boyarchuk, Oksana, Hilfanova, Anna, Kostyuchenko, Larysa V., Alachkar, Hana, Arkwright, Peter D., Baxendale, Helen E., Bernatoniene, Jolanta, Coulter, Tanya I., Garcez, Tomaz, Goddard, Sarah, Gompels, Mark M., Grigoriadou, Sofia, Herriot, Richard, Herwadkar, Archana, Huissoon, Aarnoud, Ibberson, Lisa, Nademi, Zoreh, Noorani, Sadia, Parvin, Shahnaz, Steele, Cathal Laurence, Thomas, Moira, Waruiru, Catherine, Yong, Patrick F.K., Bourne, Helen, Thalhammer, Julian, Kindle, Gerhard, Nieters, Alexandra, Rusch, Stephan, Fischer, Alain, Grimbacher, Bodo, Edgar, David, Buckland, Matthew, Mahlaoui, Nizar, and Ehl, Stephan
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- 2021
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3. A case of CLIPPERS syndrome responsive to tocilizumab
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Rempe, Torge, Becktepe, Jos Steffen, Metz, Imke, Brück, Wolfgang, Stürner, Klarissa Hanja, Deuschl, Günther, Berg, Daniela, Baron, Ralf, Zeuner, Rainald, and Leypoldt, Frank
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- 2019
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4. Stark reduzierte Impftiter nach mRNA SARS-CoV-2 Impfung bei Patienten unter TNF-Blocker Therapie
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Geisen, Ulf, Sümbül, Melike, Tran, Florian, Berner, Dennis, Reid, Hayley, Vullriede, Lena, Ciripoi, Maria, Longardt, Ann, Hoff, Paula, Morrison, Peter, Schneider, Verena, Zeuner, Rainald, Schirmer, Jan, Steinbach, Andrea, Nikolaus, Susanna, Gerdes, Sascha, Schreiber, Stefan, and Bacher, Petra
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Medicine and health - Abstract
Einleitung: Impfungen gegen SARS-CoV-2 sind das Mittel der Wahl bei der Bekämpfung der Covid-19-Pandemie. Dennoch gibt es nach der Einführung der neuartigen mRNA Impfstoffe immer noch Unsicherheiten bezüglich der Wirksamkeit bei Patienten mit bestimmten Grunderkrankungen oder Therapien. [zum vollständigen Text gelangen Sie über die oben angegebene URL]
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- 2022
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5. The long term vaccine‐induced anti‐SARS‐CoV‐2 immune response is impaired in quantity and quality under TNFα blockade
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Geisen, Ulf Martin, primary, Rose, Ruben, additional, Neumann, Franziska, additional, Ciripoi, Maria, additional, Vullriede, Lena, additional, Reid, Hayley M., additional, Berner, Dennis Kristopher, additional, Bertoglio, Federico, additional, Hoff, Paula, additional, Hust, Michael, additional, Longardt, Ann Carolin, additional, Lorentz, Thomas, additional, Martini, Gabriela Rios, additional, Saggau, Carina, additional, Schirmer, Jan Henrik, additional, Schubert, Maren, additional, Sümbül, Melike, additional, Tran, Florian, additional, Voß, Mathias, additional, Zeuner, Rainald, additional, Morrison, Peter J., additional, Bacher, Petra, additional, Fickenscher, Helmut, additional, Gerdes, Sascha, additional, Peipp, Matthias, additional, Schreiber, Stefan, additional, Krumbholz, Andi, additional, and Hoyer, Bimba Franziska, additional
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- 2022
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6. Multiple effects of TNFα inhibitors on the development of the adaptive immune response after SARS-CoV-2 vaccination
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Geisen, Ulf Martin, primary, Rose, Ruben, additional, Neumann, Franziska, additional, Ciripoi, Maria, additional, Vullriede, Lena, additional, Reid, Hayley M, additional, Berner, Dennis Kristopher, additional, Bertoglio, Federico, additional, Hoff, Paula, additional, Hust, Michael, additional, Longardt, Ann Carolin, additional, Lorentz, Thomas, additional, Rios Martini, Gabriela, additional, Saggau, Carina, additional, Schirmer, Jan Henrik, additional, Schubert, Maren, additional, Suembuel, Melike, additional, Tran, Florian, additional, Voss, Mathias, additional, Zeuner, Rainald, additional, Morrison, Peter J, additional, Bacher, Petra, additional, Fickenscher, Helmut, additional, Gerdes, Sascha, additional, Peipp, Matthias, additional, Schreiber, Stefan, additional, Krumbholz, Andi, additional, and Hoyer, Bimba Franziska, additional
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- 2022
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7. Multilayered Gore-Tex Patch for Temporary Coverage of Deep Noninfectious Corneal Defects: Surgical Procedure and Clinical Experience
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Rüfer, Florian, Eisenack, Johannes, Klettner, Alexa, Zeuner, Rainald, Hillenkamp, Jost, Westphal, Gundolf, Roider, Johann, and Nölle, Bernhard
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- 2011
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8. Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapies
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Geisen, Ulf M, primary, Sümbül, Melike, additional, Tran, Florian, additional, Berner, Dennis K, additional, Reid, Hayley M, additional, Vullriede, Lena, additional, Ciripoi, Maria, additional, Longardt, Ann C, additional, Hoff, Paula, additional, Morrison, Peter J, additional, Schneider, Verena E, additional, Zeuner, Rainald, additional, Schirmer, Jan H, additional, Steinbach, Andrea, additional, Nikolaus, Susanna, additional, Gerdes, S, additional, Schreiber, Stefan, additional, Bacher, Petra, additional, and Hoyer, Bimba F, additional
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- 2021
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9. Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations
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Thalhammer, Julian, primary, Kindle, Gerhard, additional, Nieters, Alexandra, additional, Rusch, Stephan, additional, Seppänen, Mikko R.J., additional, Fischer, Alain, additional, Grimbacher, Bodo, additional, Edgar, David, additional, Buckland, Matthew, additional, Mahlaoui, Nizar, additional, Ehl, Stephan, additional, Boztug, Kaan, additional, Brunner, Juergen, additional, Demel, Ulrike F., additional, Förster-Waldl, Elisabeth, additional, Gasteiger, Lukas M., additional, Göschl, Lisa, additional, Kojić, Marina, additional, Schroll, Andrea, additional, Seidel, Markus G., additional, Wintergerst, Uwe, additional, Wisgrill, Lukas, additional, Sharapova, Svetlana O., additional, Goffard, Jean-Christophe, additional, Kerre, Tessa, additional, Meyts, Isabelle, additional, Roosens, Fine, additional, Smet, Julie, additional, Haerynck, Filomeen, additional, Eric, Zelimir Pavle, additional, Milenova, Veneta, additional, Gagro, Alenka, additional, Richter, Darko, additional, Chovancova, Zita, additional, Hlavackova, Eva, additional, Litzman, Jiri, additional, Milota, Tomas, additional, Sediva, Anna, additional, Elaziz, Dalia Abd, additional, Alkady, Radwa Salaheldin, additional, El Sayed El Hawary, Rabab, additional, Eldash, Alia S., additional, Galal, Nermeen, additional, Lotfy, Sohilla, additional, Meshaal, Safa S., additional, Reda, Shereen M., additional, Sobh, Ali, additional, Elmarsafy, Aisha, additional, Brosselin, Pauline, additional, Courteille, Virginie, additional, De Vergnes, Nathalie, additional, Kracker, Sven, additional, Pergent, Martine, additional, Randrianomenjanahary, Philippe, additional, Ahrenstorf, Gerrit, additional, Albert, Michael H., additional, Ankermann, Tobias, additional, Atschekzei, Faranaz, additional, Baumann, Ulrich, additional, Becker, Benjamin C., additional, Behrends, Uta, additional, Belohradsky, Bernd H., additional, Biegner, Anika-Kerstin, additional, Binder, Nadine, additional, Bode, Sebastian F.N., additional, Boesecke, Christoph, additional, Boetticher, Benedikt, additional, Borte, Michael, additional, Borte, Stephan, additional, Classen, Carl Friedrich, additional, Dirks, Johannes, additional, Dückers, Gregor, additional, El-Helou, Sabine, additional, Ernst, Diana, additional, Fasshauer, Maria, additional, Fecker, Gisela, additional, Felgentreff, Kerstin, additional, Foell, Dirk, additional, Ghosh, Sujal, additional, Girschick, Hermann J., additional, Goldacker, Sigune, additional, Graf, Norbert, additional, Graf, Dagmar, additional, Greil, Johann, additional, Hanitsch, Leif Gunnar, additional, Hauck, Fabian, additional, Heeg, Maximilian, additional, Heine, Sabine I., additional, Henes, Joerg C., additional, Hoenig, Manfred, additional, Holzer, Ursula, additional, Holzinger, Dirk, additional, Horneff, Gerd, additional, Hundsdoerfer, Patrick, additional, Jablonka, Alexandra, additional, Jakoby, Donate, additional, Joean, Oana, additional, Kaiser-Labusch, Petra, additional, Klemann, Christian, additional, Kobbe, Robin, additional, Körholz, Julia, additional, Kramm, Christof M., additional, Krüger, Renate, additional, Landwehr-Kenzel, Sybille, additional, Lehmberg, Kai, additional, Liese, Johannes G., additional, Lippert, Conrad Ferdinand, additional, Maccari, Maria Elena, additional, Masjosthusmann, Katja, additional, Meinhardt, Andrea, additional, Metzler, Markus, additional, Morbach, Henner, additional, Müller, Ingo, additional, Naumann-Bartsch, Nora, additional, Neubert, Jennifer, additional, Niehues, Tim, additional, Peter, Hans-Hartmut, additional, Rieber, Nikolaus, additional, Ritterbusch, Henrike, additional, Rockstroh, Jürgen Kurt, additional, Roesler, Joachim, additional, Schauer, Uwe, additional, Scheible, Raphael, additional, Schmalzing, Marc, additional, Schmidt, Reinhold Ernst, additional, Schneider, Dominik T., additional, Schreiber, Stefan, additional, Schuetz, Catharina, additional, Schulz, Ansgar, additional, Schulze-Koops, Hendrik, additional, Schulze-Sturm, Ulf, additional, Schuster, Volker, additional, Schwaneck, Eva C., additional, Schwarz, Klaus, additional, Schwarze-Zander, Carolynne, additional, Sirin, Mehtap, additional, Skapenko, Alla, additional, Sogkas, Georgios, additional, Sparber-Sauer, Monika, additional, Speckmann, Carsten, additional, Steinmann, Sandra, additional, Stiehler, Sophie, additional, Tenbrock, Klaus, additional, von Bernuth, Horst, additional, Warnatz, Klaus, additional, Wasmuth, Jan-Christian, additional, Weiss, Michael, additional, Witte, Torsten, additional, Wittke, Kirsten, additional, Wittkowski, Helmut, additional, Zeuner, Rainald A., additional, Farmaki, Evangelia, additional, Hatzistilianou, Maria N., additional, Kakkas, Ioannis, additional, Kanariou, Maria G., additional, Kapousouzi, Androniki, additional, Liatsis, Emmanouil, additional, Maggina, Paraskevi, additional, Papadopoulou-Alataki, Efimia, additional, Raptaki, Maria, additional, Speletas, Matthaios, additional, Tantou, Sofia, additional, Goda, Vera, additional, Kriván, Gergely, additional, Marodi, Laszlo, additional, Abolhassani, Hassan, additional, Aghamohammadi, Asghar, additional, Rezaei, Nima, additional, Feighery, Conleth, additional, Leahy, Timothy Ronan, additional, Ryan, Paul, additional, Batzir, Nurit Assia, additional, Garty, Ben Zion, additional, Tamary, Hannah, additional, Aiuti, Alessandro, additional, Amodio, Donato, additional, Azzari, Chiara, additional, Barzaghi, Federica, additional, Baselli, Lucia A., additional, Cancrini, Caterina, additional, Carrabba, Maria, additional, Cazzaniga, Marco, additional, Cesaro, Simone, additional, Chinello, Matteo, additional, Danieli, Maria Giovanna, additional, Dellepiane, Rosa Maria, additional, Fabio, Giovanna, additional, Gambineri, Eleonora, additional, Lodi, Lorenzo, additional, Lougaris, Vassilios, additional, Marasco, Carolina, additional, Martire, Baldassarre, additional, Marzollo, Antonio, additional, Milito, Cinzia, additional, Moschese, Viviana, additional, Pignata, Claudio, additional, Plebani, Alessandro, additional, Porta, Fulvio, additional, Quinti, Isabella, additional, Ricci, Silvia, additional, Soresina, Annarosa, additional, Tommasini, Alberto, additional, Vacca, Angelo, additional, Vanessa, Clementina, additional, Blažienė, Audra, additional, Sitkauskiene, Brigita, additional, Gowin, Ewelina, additional, Heropolitańska-Pliszka, Edyta, additional, Pietrucha, Barbara, additional, Szaflarska, Anna, additional, Więsik-Szewczyk, Ewa, additional, Wolska-Kuśnierz, Beata, additional, Esteves, Isabel, additional, Faria, Emilia, additional, Marques, Laura Hora, additional, Neves, João Farela, additional, Silva, Susana L., additional, Teixeira, Carla, additional, Pereira da Silva, Sara, additional, Capilna, Brindusa Ruxandra, additional, Guseva, Marina N., additional, Shcherbina, Anna, additional, Bobcakova, Anna, additional, Ciznar, Peter, additional, Gabzdilova, Juliana, additional, Jesenak, Milos, additional, Kapustova, Lenka, additional, Orosova, Jaroslava, additional, Petrovicova, Otilia, additional, Raffac, Stefan, additional, Kopač, Peter, additional, Allende, Luis M., additional, Antolí, Arnau, additional, Blanch, Gemma Rocamora, additional, Carbone, Javier, additional, Dieli-Crimi, Romina, additional, Garcia-Prat, Marina, additional, Gil-Herrera, Juana, additional, Gonzalez-Granado, Luis Ignacio, additional, Agulló, Pilar Llobet, additional, Olbrich, Peter, additional, Parra-Martínez, Alba, additional, Paz-Artal, Estela, additional, Pleguezuelo, Daniel E., additional, Rodríguez, Nerea Salmón, additional, Sánchez-Ramón, Silvia, additional, Santos-Pérez, Juan Luis, additional, Solanich, Xavier, additional, Soler-Palacin, Pere, additional, González-Amores, Miriam, additional, Ekwall, Olov, additional, Fasth, Anders, additional, Bitzenhofer-Grüber, Michaela, additional, Candotti, Fabio, additional, Dimitriou, Florentia, additional, Heininger, Ulrich, additional, Holbro, Andreas, additional, Jandus, Peter, additional, Kolios, Antonios G.A., additional, Marschall, Karin, additional, Schmid, Jana Pachlopnik, additional, Posfay-Barbe, Klara M., additional, Prader, Seraina, additional, Reichenbach, Janine, additional, Steiner, Urs C., additional, Trück, Johannes, additional, Bredius, Robbert G., additional, de Kruijf- Bazen, Suzanne, additional, de Vries, Esther, additional, Henriet, Stefanie S.V., additional, Kuijpers, Taco W., additional, Potjewijd, Judith, additional, Rutgers, Abraham, additional, Stol, Kim, additional, van Aerde, Koen J., additional, Van den Berg, J. Merlijn, additional, van de Ven, Annick A.J.M., additional, Montfrans, Jorisvan, additional, Aydemir, Sezin, additional, Baris, Safa, additional, Dogu, Figen, additional, Ikinciogullari, Aydan, additional, Karakoc-Aydiner, Elif, additional, Kilic, Sara S., additional, Kiykim, Ayca, additional, Kökçü Karadağ, Şefika İlknur, additional, Kutukculer, Necil, additional, Ocak, Suheyla, additional, UNAL, Ekrem, additional, Boyarchuk, Oksana, additional, Hilfanova, Anna, additional, Kostyuchenko, Larysa V., additional, Alachkar, Hana, additional, Arkwright, Peter D., additional, Baxendale, Helen E., additional, Bernatoniene, Jolanta, additional, Coulter, Tanya I., additional, Garcez, Tomaz, additional, Goddard, Sarah, additional, Gompels, Mark M., additional, Grigoriadou, Sofia, additional, Herriot, Richard, additional, Herwadkar, Archana, additional, Huissoon, Aarnoud, additional, Ibberson, Lisa, additional, Nademi, Zoreh, additional, Noorani, Sadia, additional, Parvin, Shahnaz, additional, Steele, Cathal Laurence, additional, Thomas, Moira, additional, Waruiru, Catherine, additional, Yong, Patrick F.K., additional, and Bourne, Helen, additional
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- 2021
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10. Organ-Specific Self-Assessment (OSSA): Ein Fragebogen zur Patienten-basierten Beschreibung des Gesundheitszustandes bei multisystemischen Entzündungserkrankungen
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Zeuner, Rainald, Hübenthal, Matthias, Schrinner, Florian, Schreiber, Stefan, Hoyer, Bimba F., and Franke, Andre
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Rheumatologische Erkrankungen und andere systemische Entzündungserkrankungen (wie Psoriasis oder chronisch entzündlicher Darmerkrankungen) manifestieren sich häufig an verschiedenen Organsystemen. Eine bestmögliche Behandlung erfordert daher eine diagnostische und therapeutische[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
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- 2021
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11. FabryScan: a screening tool for early detection of Fabry disease
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Arning, Kathrin, Naleschinski, Dennis, Maag, Rainer, Biegstraaten, Marieke, Kropp, Peter, Lorenzen, Jürgen, Hollak, Carla E. M., van Schaik, Ivo N., Harten, Pontus, Zeuner, Rainald A., Binder, Andreas, and Baron, Ralf
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- 2012
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12. Complex Regional Pain Syndrome: An Inflammatory Pain Condition? A Case of Fluctuating Presence of Complex Regional Pain Syndrome
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Lassen, Josephine, primary, Zeuner, Rainald, additional, Baron, Ralf, additional, and Gierthmühlen, Janne, additional
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- 2021
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13. Interleukin-6 and Tumour Necrosis Factor-α differentially regulate lincRNA transcripts in cells of the innate immune system in vivo in human subjects with rheumatoid arthritis
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Müller, Nike, Döring, Frank, Klapper, Maja, Neumann, Katrin, Schulte, Dominik M., Türk, Kathrin, Schröder, Johann O., Zeuner, Rainald A., Freitag-Wolf, Sandra, Schreiber, Stefan, and Laudes, Matthias
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- 2014
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14. Complex Regional Pain Syndrome: An Inflammatory Pain Condition? A Case of Fluctuating Presence of Complex Regional Pain Syndrome.
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Lassen, Josephine, Zeuner, Rainald, Baron, Ralf, and Gierthmühlen, Janne
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PAIN , *FEVER , *COMPLEX regional pain syndromes , *PERFUSION imaging , *EDEMA , *PERFUSION - Published
- 2022
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15. Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort
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Geisen, Ulf M, primary, Berner, Dennis K, additional, Tran, Florian, additional, Sümbül, Melike, additional, Vullriede, Lena, additional, Ciripoi, Maria, additional, Reid, Hayley M, additional, Schaffarzyk, Annika, additional, Longardt, Ann C, additional, Franzenburg, Jeanette, additional, Hoff, Paula, additional, Schirmer, Jan H, additional, Zeuner, Rainald, additional, Friedrichs, Anette, additional, Steinbach, Andrea, additional, Knies, Christine, additional, Markewitz, Robert DH, additional, Morrison, Peter J, additional, Gerdes, Sascha, additional, Schreiber, Stefan, additional, and Hoyer, Bimba F, additional
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- 2021
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16. C1qRP (CD93) expression on peripheral blood monocytes in patients with systemic lupus erythematosus
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Moosig, Frank, Fähndrich, Erika, Knorr-Spahr, Anja, Böttcher, Sebastian, Ritgen, Matthias, Zeuner, Rainald, Kneba, Michael, and Schröder, Johann O.
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- 2006
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17. Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases
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Aden, Konrad, primary, Rehman, Ateequr, additional, Waschina, Silvio, additional, Pan, Wei-Hung, additional, Walker, Alesia, additional, Lucio, Marianna, additional, Nunez, Alejandro Mena, additional, Bharti, Richa, additional, Zimmerman, Johannes, additional, Bethge, Johannes, additional, Schulte, Berenice, additional, Schulte, Dominik, additional, Franke, Andre, additional, Nikolaus, Susanna, additional, Schroeder, Johann Oltmann, additional, Vandeputte, Doris, additional, Raes, Jeroen, additional, Szymczak, Silke, additional, Waetzig, Georg H., additional, Zeuner, Rainald, additional, Schmitt-Kopplin, Philippe, additional, Kaleta, Christoph, additional, Schreiber, Stefan, additional, and Rosenstiel, Philip, additional
- Published
- 2019
- Full Text
- View/download PDF
18. High Dose Intravenous Immunoglobulin in Autoimmune Rheumatic Disorders
- Author
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Zeuner, Rainald A., Euler, Hans H., and Schroeder, Johann O.
- Published
- 1997
- Full Text
- View/download PDF
19. Therapie des SLE mit belimumab - Beobachtungen an einer monozentrischen Kohorte über 3 Jahre
- Author
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Sturm, Anna, Zeuner, Rainald, Steinbach, Andrea, and Schröder, Johann Oltmann
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung: Das therapeutische Repertoire für den systemischen Lupus erythematodes (SLE) ist nach wie vor relativ begrenzt. Der Stellenwert mancher Therapieverfahren wird kontrovers diskutiert, möglicherweise auf Grund der Heterogenität der Manifestationen und der Verläufe des SLE.[zum vollständigen Text gelangen Sie über die oben angegebene URL], 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
- Published
- 2019
20. The German National Registry of Primary Immunodeficiencies (2012-2017)
- Author
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El-Helou, Sabine M., Biegner, Anika-Kerstin, Bode, Sebastian, Ehl, Stephan R., Heeg, Maximilian, Maccari, Maria E., Ritterbusch, Henrike, Speckmann, Carsten, Rusch, Stephan, Scheible, Raphael, Warnatz, Klaus, Atschekzei, Faranaz, Beider, Renata, Ernst, Diana, Gerschmann, Stev, Jablonka, Alexandra, Mielke, Gudrun, Schmidt, Reinhold E., Schuermann, Gesine, Sogkas, Georgios, Baumann, Ulrich H., Klemann, Christian, Viemann, Dorothee, von Bernuth, Horst, Krueger, Renate, Hanitsch, Leif G., Scheibenbogen, Carmen M., Wittke, Kirsten, Albert, Michael H., Eichinger, Anna, Hauck, Fabian, Klein, Christoph, Rack-Hoch, Anita, Sollinger, Franz M., Avila, Anne, Borte, Michael, Borte, Stephan, Fasshauer, Maria, Hauenherm, Anja, Kellner, Nils, Mueller, Anna H., Uelzen, Anett, Bader, Peter, Bakhtiar, Shahrzad, Lee, Jae-Yun, Hess, Ursula, Schubert, Ralf, Woelke, Sandra, Zielen, Stefan, Ghosh, Sujal, Laws, Hans-Juergen, Neubert, Jennifer, Oommen, Prasad T., Hoenig, Manfred, Schulz, Ansgar, Steinmann, Sandra, Schwarz, Klaus, Dueckers, Gregor, Lamers, Beate, Langemeyer, Vanessa, Niehues, Tim, Shai, Sonu, Graf, Dagmar, Mueglich, Carmen, Schmalzing, Marc T., Schwaneck, Eva C., Tony, Hans-Peter, Dirks, Johannes, Haase, Gabriele, Liese, Johannes G., Morbach, Henner, Foell, Dirk, Hellige, Antje, Wittkowski, Helmut, Masjosthusmann, Katja, Mohr, Michael, Geberzahn, Linda, Hedrich, Christian M., Mueller, Christiane, Roesen-Wolff, Angela, Roesler, Joachim, Zimmermann, Antje, Behrends, Uta, Rieber, Nikolaus, Schauer, Uwe, Handgretinger, Rupert, Holzer, Ursula, Henes, Joerg, Kanz, Lothar, Boesecke, Christoph, Rockstroh, Juergen K., Schwarze-Zander, Carolynne, Wasmuth, Jan-Christian, Dilloo, Dagmar, Huelsmann, Brigitte, Schoenberger, Stefan, Schreiber, Stefan, Zeuner, Rainald, Ankermann, Tobias, von Bismarck, Philipp, Huppertz, Hans-Iko, Kaiser-Labusch, Petra, Greil, Johann, Jakoby, Donate, Kulozik, Andreas E., Metzler, Markus, Naumann-Bartsch, Nora, Sobik, Bettina, Graf, Norbert, Heine, Sabine, Kobbe, Robin, Lehmberg, Kai, Mueller, Ingo, Herrmann, Friedrich, Horneff, Gerd, Klein, Ariane, Peitz, Joachim, Schmidt, Nadine, Bielack, Stefan, Gross-Wieltsch, Ute, Classen, Carl F., Klasen, Jessica, Deutz, Peter, Kamitz, Dirk, Lassay, Lisa, Tenbrock, Klaus, Wagner, Norbert, Bernbeck, Benedikt, Brummel, Bastian, Lara-Villacanas, Eusebia, Muenstermann, Esther, Schneider, Dominik T., Tietsch, Nadine, Westkemper, Marco, Weiss, Michael, Kramm, Christof, Kuehnle, Ingrid, Kullmann, Silke, Girschick, Hermann, Specker, Christof, Vinnemeier-Laubenthal, Elisabeth, Haenicke, Henriette, Schulz, Claudia, Schweigerer, Lothar, Mueller, Thomas G., Stiefel, Martina, Belohradsky, Bernd H., Soetedjo, Veronika, Kindle, Gerhard, Grimbacher, Bodo, El-Helou, Sabine M., Biegner, Anika-Kerstin, Bode, Sebastian, Ehl, Stephan R., Heeg, Maximilian, Maccari, Maria E., Ritterbusch, Henrike, Speckmann, Carsten, Rusch, Stephan, Scheible, Raphael, Warnatz, Klaus, Atschekzei, Faranaz, Beider, Renata, Ernst, Diana, Gerschmann, Stev, Jablonka, Alexandra, Mielke, Gudrun, Schmidt, Reinhold E., Schuermann, Gesine, Sogkas, Georgios, Baumann, Ulrich H., Klemann, Christian, Viemann, Dorothee, von Bernuth, Horst, Krueger, Renate, Hanitsch, Leif G., Scheibenbogen, Carmen M., Wittke, Kirsten, Albert, Michael H., Eichinger, Anna, Hauck, Fabian, Klein, Christoph, Rack-Hoch, Anita, Sollinger, Franz M., Avila, Anne, Borte, Michael, Borte, Stephan, Fasshauer, Maria, Hauenherm, Anja, Kellner, Nils, Mueller, Anna H., Uelzen, Anett, Bader, Peter, Bakhtiar, Shahrzad, Lee, Jae-Yun, Hess, Ursula, Schubert, Ralf, Woelke, Sandra, Zielen, Stefan, Ghosh, Sujal, Laws, Hans-Juergen, Neubert, Jennifer, Oommen, Prasad T., Hoenig, Manfred, Schulz, Ansgar, Steinmann, Sandra, Schwarz, Klaus, Dueckers, Gregor, Lamers, Beate, Langemeyer, Vanessa, Niehues, Tim, Shai, Sonu, Graf, Dagmar, Mueglich, Carmen, Schmalzing, Marc T., Schwaneck, Eva C., Tony, Hans-Peter, Dirks, Johannes, Haase, Gabriele, Liese, Johannes G., Morbach, Henner, Foell, Dirk, Hellige, Antje, Wittkowski, Helmut, Masjosthusmann, Katja, Mohr, Michael, Geberzahn, Linda, Hedrich, Christian M., Mueller, Christiane, Roesen-Wolff, Angela, Roesler, Joachim, Zimmermann, Antje, Behrends, Uta, Rieber, Nikolaus, Schauer, Uwe, Handgretinger, Rupert, Holzer, Ursula, Henes, Joerg, Kanz, Lothar, Boesecke, Christoph, Rockstroh, Juergen K., Schwarze-Zander, Carolynne, Wasmuth, Jan-Christian, Dilloo, Dagmar, Huelsmann, Brigitte, Schoenberger, Stefan, Schreiber, Stefan, Zeuner, Rainald, Ankermann, Tobias, von Bismarck, Philipp, Huppertz, Hans-Iko, Kaiser-Labusch, Petra, Greil, Johann, Jakoby, Donate, Kulozik, Andreas E., Metzler, Markus, Naumann-Bartsch, Nora, Sobik, Bettina, Graf, Norbert, Heine, Sabine, Kobbe, Robin, Lehmberg, Kai, Mueller, Ingo, Herrmann, Friedrich, Horneff, Gerd, Klein, Ariane, Peitz, Joachim, Schmidt, Nadine, Bielack, Stefan, Gross-Wieltsch, Ute, Classen, Carl F., Klasen, Jessica, Deutz, Peter, Kamitz, Dirk, Lassay, Lisa, Tenbrock, Klaus, Wagner, Norbert, Bernbeck, Benedikt, Brummel, Bastian, Lara-Villacanas, Eusebia, Muenstermann, Esther, Schneider, Dominik T., Tietsch, Nadine, Westkemper, Marco, Weiss, Michael, Kramm, Christof, Kuehnle, Ingrid, Kullmann, Silke, Girschick, Hermann, Specker, Christof, Vinnemeier-Laubenthal, Elisabeth, Haenicke, Henriette, Schulz, Claudia, Schweigerer, Lothar, Mueller, Thomas G., Stiefel, Martina, Belohradsky, Bernd H., Soetedjo, Veronika, Kindle, Gerhard, and Grimbacher, Bodo
- Abstract
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata((R)) and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1-25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0-88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE-syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%-subcutaneous; 29%-intravenous; 1%-unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a m
- Published
- 2019
21. The German national registry of primary immunodeficiencies (2012–2017)
- Author
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Al-Herz, Waleed, El-Helou, Sabine M., Biegner, Anika-Kerstin, Bode, Sebastian, Ehl, Stephan, Heeg, Maximilian, Maccari, Maria E., Ritterbusch, Henrike, Speckmann, Carsten, Rusch, Stephan, Scheible, Raphael, Warnatz, Klaus, Atschekzei, Faranaz, Beider, Renata, Ernst, Diana, Gerschmann, Stev, Jablonka, Alexandra, Mielke, Gudrun, Schmidt, Reinhold E., Schürmann, Gesine, Sogkas, Georgios, Baumann, Ulrich, Klemann, Christian, Viemann, Dorothee, Bernuth, Horst von, Krüger, Renate, Hanitsch, Leif Gunnar, Scheibenbogen, Carmen, Wittke, Kirsten, Albert, Michael H., Eichinger, Anna, Hauck, Fabian, Klein, Christoph, Rack-Hoch, Anita, Sollinger, Franz, Avila, Anne, Borte, Michael, Borte, Stephan, Fasshauer, Maria, Hauenherm, Anja, Kellner, Nils, Müller, Anna H., Ülzen, Anett, Bader, Peter, Bakhtiar, Shahrzad, Lee, Jae-Yun, Heß, Ursula, Schubert, Ralf, Wölke, Sandra, Zielen, Stefan, Ghosh, Sujal, Laws, Hans-Jürgen, Neubert, Jennifer, Oommen, Prasad Thomas, Hönig, Manfred, Schulz, Ansgar, Steinmann, Sandra, Schwarz, Klaus, Dückers, Gregor, Lamers, Beate, Langemeyer, Vanessa, Niehues, Tim, Shai, Sonu, Graf, Dagmar, Müglich, Carmen, Schmalzing, Marc, Schwaneck, Eva C., Tony, Hans-Peter, Dirks, Johannes, Haase, Gabriele, Liese, Johannes G., Morbach, Henner, Föll, Dirk, Hellige, Antje, Wittkowski, Helmut, Masjosthusmann, Katja, Mohr, Michael, Geberzahn, Linda, Hedrich, Christian Michael, Müller, Christiane, Rösen-Wolff, Angela, Roesler, Joachim, Zimmermann, Antje, Behrends, Uta, Rieber, Nikolaus, Schauer, Uwe, Handgretinger, Rupert, Holzer, Ursula, Henes, Jörg Christoph, Kanz, Lothar, Boesecke, Christoph, Rockstroh, Jürgen, Schwarze-Zander, Carolynne, Wasmuth, Jan-Christian, Dilloo, Dagmar, Hülsmann, Brigitte, Schönberger, Stefan, Schreiber, Stefan, Zeuner, Rainald, Ankermann, Tobias, Bismarck, Philipp von, Huppertz, Hans-Iko, Kaiser-Labusch, Petra, Greil, Johann, Jakoby, Donate, Kulozik, Andreas, Metzler, Markus, Naumann-Bartsch, Nora, Sobik, Bettina, Graf, Norbert, Heine, Sabine, Kobbe, Robin, Lehmberg, Kai, Müller, Ingo, Herrmann, Friedrich, Horneff, Gerd, Klein, Ariane, Peitz, Joachim, Schmidt, Nadine, Bielack, Stefan S., Groß-Wieltsch, Ute, Classen, Carl Friedrich, Klasen, Jessica, Deutz, Peter, Kamitz, Dirk, Lassay, Lisa, Tenbrock, Klaus, Wagner, Norbert, Bernbeck, Benedikt, Brummel, Bastian, Lara-Villacanas, Eusebia, Münstermann, Esther, Schneider, Dominik T., Tietsch, Nadine, Westkemper, Marco, Weiß, Michael, Kramm, Christof M., Kühnle, Ingrid, Kullman, Silke, Girschick, Hermann, Specker, Christof, Vinnemeier-Laubenthal, Elisabeth, Haenicke, Henriette, Schulz, Claudia, Schweigerer, Lothar, Müller, Thomas G., Stiefel, Martina, Belohradsky, Bernd H., Soetedjo, Veronika, Kindle, Gerhard, Grimbacher, Bodo, Al-Herz, Waleed, El-Helou, Sabine M., Biegner, Anika-Kerstin, Bode, Sebastian, Ehl, Stephan, Heeg, Maximilian, Maccari, Maria E., Ritterbusch, Henrike, Speckmann, Carsten, Rusch, Stephan, Scheible, Raphael, Warnatz, Klaus, Atschekzei, Faranaz, Beider, Renata, Ernst, Diana, Gerschmann, Stev, Jablonka, Alexandra, Mielke, Gudrun, Schmidt, Reinhold E., Schürmann, Gesine, Sogkas, Georgios, Baumann, Ulrich, Klemann, Christian, Viemann, Dorothee, Bernuth, Horst von, Krüger, Renate, Hanitsch, Leif Gunnar, Scheibenbogen, Carmen, Wittke, Kirsten, Albert, Michael H., Eichinger, Anna, Hauck, Fabian, Klein, Christoph, Rack-Hoch, Anita, Sollinger, Franz, Avila, Anne, Borte, Michael, Borte, Stephan, Fasshauer, Maria, Hauenherm, Anja, Kellner, Nils, Müller, Anna H., Ülzen, Anett, Bader, Peter, Bakhtiar, Shahrzad, Lee, Jae-Yun, Heß, Ursula, Schubert, Ralf, Wölke, Sandra, Zielen, Stefan, Ghosh, Sujal, Laws, Hans-Jürgen, Neubert, Jennifer, Oommen, Prasad Thomas, Hönig, Manfred, Schulz, Ansgar, Steinmann, Sandra, Schwarz, Klaus, Dückers, Gregor, Lamers, Beate, Langemeyer, Vanessa, Niehues, Tim, Shai, Sonu, Graf, Dagmar, Müglich, Carmen, Schmalzing, Marc, Schwaneck, Eva C., Tony, Hans-Peter, Dirks, Johannes, Haase, Gabriele, Liese, Johannes G., Morbach, Henner, Föll, Dirk, Hellige, Antje, Wittkowski, Helmut, Masjosthusmann, Katja, Mohr, Michael, Geberzahn, Linda, Hedrich, Christian Michael, Müller, Christiane, Rösen-Wolff, Angela, Roesler, Joachim, Zimmermann, Antje, Behrends, Uta, Rieber, Nikolaus, Schauer, Uwe, Handgretinger, Rupert, Holzer, Ursula, Henes, Jörg Christoph, Kanz, Lothar, Boesecke, Christoph, Rockstroh, Jürgen, Schwarze-Zander, Carolynne, Wasmuth, Jan-Christian, Dilloo, Dagmar, Hülsmann, Brigitte, Schönberger, Stefan, Schreiber, Stefan, Zeuner, Rainald, Ankermann, Tobias, Bismarck, Philipp von, Huppertz, Hans-Iko, Kaiser-Labusch, Petra, Greil, Johann, Jakoby, Donate, Kulozik, Andreas, Metzler, Markus, Naumann-Bartsch, Nora, Sobik, Bettina, Graf, Norbert, Heine, Sabine, Kobbe, Robin, Lehmberg, Kai, Müller, Ingo, Herrmann, Friedrich, Horneff, Gerd, Klein, Ariane, Peitz, Joachim, Schmidt, Nadine, Bielack, Stefan S., Groß-Wieltsch, Ute, Classen, Carl Friedrich, Klasen, Jessica, Deutz, Peter, Kamitz, Dirk, Lassay, Lisa, Tenbrock, Klaus, Wagner, Norbert, Bernbeck, Benedikt, Brummel, Bastian, Lara-Villacanas, Eusebia, Münstermann, Esther, Schneider, Dominik T., Tietsch, Nadine, Westkemper, Marco, Weiß, Michael, Kramm, Christof M., Kühnle, Ingrid, Kullman, Silke, Girschick, Hermann, Specker, Christof, Vinnemeier-Laubenthal, Elisabeth, Haenicke, Henriette, Schulz, Claudia, Schweigerer, Lothar, Müller, Thomas G., Stiefel, Martina, Belohradsky, Bernd H., Soetedjo, Veronika, Kindle, Gerhard, and Grimbacher, Bodo
- Abstract
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more
- Published
- 2019
22. Regulation of CpG-Induced Immune Activation by Suppressive Oligodeoxynucleotides
- Author
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KLINMAN, DENNIS M., ZEUNER, RAINALD, YAMADA, HIROSHI, GURSEL, MAYDA, CURRIE, DEBBIE, and GURSEL, IHSAN
- Published
- 2003
23. Influence of Stimulatory and Suppressive DNA Motifs on Host Susceptibility to Inflammatory Arthritis
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Zeuner, Rainald A., Verthelyi, Daniela, Gursel, Mayda, Ishii, Ken J., and Klinman, Dennis M.
- Published
- 2003
24. One Foot Away
- Author
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Zeuner, Rainald A.
- Published
- 2002
- Full Text
- View/download PDF
25. Reduction of CpG-Induced Arthritis by Suppressive Oligodeoxynucleotides
- Author
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Zeuner, Rainald A., Ishii, Ken J., Lizak, Martin J., Gursel, Ihsan, Yamada, Hiroshi, Klinman, Dennis M., and Verthelyi, Daniela
- Published
- 2002
26. Differential signaling by CpG DNA in DCs and B cells: not just TLR9
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Verthelyi, Daniela and Zeuner, Rainald A
- Published
- 2003
- Full Text
- View/download PDF
27. Manifestation einer Immundysbalance insbesondere im otologischen und sinunasalen Bereich auf Basis eines Therapieschadens bei Autoimmunerkrankung(en).
- Author
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Schanze, Leonard, Zeuner, Rainald, Bacher, Petra, Schreiber, Stefan, Kahl, Sarah, and Laudien, Martin
- Published
- 2024
- Full Text
- View/download PDF
28. The German National Registry of Primary Immunodeficiencies (2012–2017)
- Author
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El-Helou, Sabine M., primary, Biegner, Anika-Kerstin, additional, Bode, Sebastian, additional, Ehl, Stephan R., additional, Heeg, Maximilian, additional, Maccari, Maria E., additional, Ritterbusch, Henrike, additional, Speckmann, Carsten, additional, Rusch, Stephan, additional, Scheible, Raphael, additional, Warnatz, Klaus, additional, Atschekzei, Faranaz, additional, Beider, Renata, additional, Ernst, Diana, additional, Gerschmann, Stev, additional, Jablonka, Alexandra, additional, Mielke, Gudrun, additional, Schmidt, Reinhold E., additional, Schürmann, Gesine, additional, Sogkas, Georgios, additional, Baumann, Ulrich H., additional, Klemann, Christian, additional, Viemann, Dorothee, additional, von Bernuth, Horst, additional, Krüger, Renate, additional, Hanitsch, Leif G., additional, Scheibenbogen, Carmen M., additional, Wittke, Kirsten, additional, Albert, Michael H., additional, Eichinger, Anna, additional, Hauck, Fabian, additional, Klein, Christoph, additional, Rack-Hoch, Anita, additional, Sollinger, Franz M., additional, Avila, Anne, additional, Borte, Michael, additional, Borte, Stephan, additional, Fasshauer, Maria, additional, Hauenherm, Anja, additional, Kellner, Nils, additional, Müller, Anna H., additional, Ülzen, Anett, additional, Bader, Peter, additional, Bakhtiar, Shahrzad, additional, Lee, Jae-Yun, additional, Heß, Ursula, additional, Schubert, Ralf, additional, Wölke, Sandra, additional, Zielen, Stefan, additional, Ghosh, Sujal, additional, Laws, Hans-Juergen, additional, Neubert, Jennifer, additional, Oommen, Prasad T., additional, Hönig, Manfred, additional, Schulz, Ansgar, additional, Steinmann, Sandra, additional, Schwarz, Klaus, additional, Dückers, Gregor, additional, Lamers, Beate, additional, Langemeyer, Vanessa, additional, Niehues, Tim, additional, Shai, Sonu, additional, Graf, Dagmar, additional, Müglich, Carmen, additional, Schmalzing, Marc T., additional, Schwaneck, Eva C., additional, Tony, Hans-Peter, additional, Dirks, Johannes, additional, Haase, Gabriele, additional, Liese, Johannes G., additional, Morbach, Henner, additional, Foell, Dirk, additional, Hellige, Antje, additional, Wittkowski, Helmut, additional, Masjosthusmann, Katja, additional, Mohr, Michael, additional, Geberzahn, Linda, additional, Hedrich, Christian M., additional, Müller, Christiane, additional, Rösen-Wolff, Angela, additional, Roesler, Joachim, additional, Zimmermann, Antje, additional, Behrends, Uta, additional, Rieber, Nikolaus, additional, Schauer, Uwe, additional, Handgretinger, Rupert, additional, Holzer, Ursula, additional, Henes, Jörg, additional, Kanz, Lothar, additional, Boesecke, Christoph, additional, Rockstroh, Jürgen K., additional, Schwarze-Zander, Carolynne, additional, Wasmuth, Jan-Christian, additional, Dilloo, Dagmar, additional, Hülsmann, Brigitte, additional, Schönberger, Stefan, additional, Schreiber, Stefan, additional, Zeuner, Rainald, additional, Ankermann, Tobias, additional, Bismarck, Philipp von, additional, Huppertz, Hans-Iko, additional, Kaiser-Labusch, Petra, additional, Greil, Johann, additional, Jakoby, Donate, additional, Kulozik, Andreas E., additional, Metzler, Markus, additional, Naumann-Bartsch, Nora, additional, Sobik, Bettina, additional, Graf, Norbert, additional, Heine, Sabine, additional, Kobbe, Robin, additional, Lehmberg, Kai, additional, Müller, Ingo, additional, Herrmann, Friedrich, additional, Horneff, Gerd, additional, Klein, Ariane, additional, Peitz, Joachim, additional, Schmidt, Nadine, additional, Bielack, Stefan, additional, Groß-Wieltsch, Ute, additional, Classen, Carl F., additional, Klasen, Jessica, additional, Deutz, Peter, additional, Kamitz, Dirk, additional, Lassay, Lisa, additional, Tenbrock, Klaus, additional, Wagner, Norbert, additional, Bernbeck, Benedikt, additional, Brummel, Bastian, additional, Lara-Villacanas, Eusebia, additional, Münstermann, Esther, additional, Schneider, Dominik T., additional, Tietsch, Nadine, additional, Westkemper, Marco, additional, Weiß, Michael, additional, Kramm, Christof, additional, Kühnle, Ingrid, additional, Kullmann, Silke, additional, Girschick, Hermann, additional, Specker, Christof, additional, Vinnemeier-Laubenthal, Elisabeth, additional, Haenicke, Henriette, additional, Schulz, Claudia, additional, Schweigerer, Lothar, additional, Müller, Thomas G., additional, Stiefel, Martina, additional, Belohradsky, Bernd H., additional, Soetedjo, Veronika, additional, Kindle, Gerhard, additional, and Grimbacher, Bodo, additional
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- 2019
- Full Text
- View/download PDF
29. Monoclonal Cryo-Antifibrinogenemia
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Euler, Hans H., Zeuner, Rainald A., Beress, Rosemarie, Gutschmidt, Hans J., Christophers, Enno, and Schroeder, Johann O.
- Published
- 1996
30. Anti-Tnf Therapy Systematically Influences Intestinal Microbial Community Structure in Chronic Inflammatory Diseases
- Author
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Aden, Konrad, primary, Rehman, Ateequr, additional, Pan, Wei-Hung, additional, Bethge, Johannes, additional, Franke, Andre, additional, Nikolaus, Susanna, additional, Zeuner, Rainald, additional, Schreiber, Stefan, additional, and Rosenstiel, Philip, additional
- Published
- 2017
- Full Text
- View/download PDF
31. Sa2004 Biological Therapy Modulates Gut Microbiota - A Longitudinal Study Across Chronic Inflammatory Diseases
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Aden, Konrad, primary, Rehman, Ateequr, additional, Bethge, Johannes, additional, Nikolaus, Susanna, additional, Zeuner, Rainald, additional, Schröder, Johann O., additional, Rosenstiel, Philip, additional, and Schreiber, Stefan, additional
- Published
- 2016
- Full Text
- View/download PDF
32. Successful therapy with tocilizumab in a patient with therapy-refractory relapsing polychondritis.
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Karakitsos, Ilias, Zeuner, Rainald, Hoffmann, Markus, and Laudien, Martin
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- 2023
- Full Text
- View/download PDF
33. Erfolgreiche Therapie mit Tocilizumab bei einer Patientin mit therapierefraktärer rezidievierender polychondritis.
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Karakitsos, Ilias, Zeuner, Rainald, Hoffmann, Markus, and Laudien, Martin
- Published
- 2023
- Full Text
- View/download PDF
34. Tocilizumab and steroid boli for treatment-resistant anterior necrotizing scleritis
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Tode, Jan, primary, Zeuner, Rainald, additional, Saeger, Mark, additional, Roider, Johann, additional, and Nölle, Bernhard, additional
- Published
- 2015
- Full Text
- View/download PDF
35. IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans
- Author
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Müller, Nike, primary, Schulte, Dominik M., additional, Türk, Kathrin, additional, Freitag-Wolf, Sandra, additional, Hampe, Jochen, additional, Zeuner, Rainald, additional, Schröder, Johann O., additional, Gouni-Berthold, Ioanna, additional, Berthold, Heiner K., additional, Krone, Wilhelm, additional, Rose-John, Stefan, additional, Schreiber, Stefan, additional, and Laudes, Matthias, additional
- Published
- 2015
- Full Text
- View/download PDF
36. B Lymphocyte Stimulator (BLyS) Is Expressed in Human Adipocytes In Vivo and Is Related to Obesity but Not to Insulin Resistance
- Author
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Mueller, Nike, Schulte, Dominik M., Hillebrand, Susann, Tuerk, Kathrin, Hampe, Jochen, Schafmayer, Clemens, Brosch, Mario, von Schoenfels, Witigo, Ahrens, Markus, Zeuner, Rainald, Schroeder, Johann O., Blueher, Matthias, Gutschow, Christian, Freitag-Wolf, Sandra, Stelmach-Mardas, Marta, Saggau, Carina, Schreiber, Stefan, Laudes, Matthias, Mueller, Nike, Schulte, Dominik M., Hillebrand, Susann, Tuerk, Kathrin, Hampe, Jochen, Schafmayer, Clemens, Brosch, Mario, von Schoenfels, Witigo, Ahrens, Markus, Zeuner, Rainald, Schroeder, Johann O., Blueher, Matthias, Gutschow, Christian, Freitag-Wolf, Sandra, Stelmach-Mardas, Marta, Saggau, Carina, Schreiber, Stefan, and Laudes, Matthias
- Abstract
Inflammation and metabolism have been shown to be evolutionary linked and increasing evidence exists that pro-inflammatory factors are involved in the pathogenesis of obesity and type 2 diabetes. Until now, most data suggest that within adipose tissue these factors are secreted by cells of the innate immune system, e. g. macrophages. In the present study we demonstrate that B lymphocyte stimulator (BLyS) is increased in human obesity. In contrast to several pro-inflammatory factors, we found the source of BLyS in human adipose tissue to be the adipocytes rather than immune cells. In grade 3 obese human subjects, expression of BLyS in vivo in adipose tissue is significantly increased (p<0.001). Furthermore, BLyS serum levels are elevated in grade 3 human obesity (862.5+222.0 pg/ml vs. 543.7+60.7 pg/ml in lean controls, p<0.001) and are positively correlated to the BMI (r = 0.43, p<0.0002). In the present study, bariatric surgery significantly altered serum BLyS concentrations. In contrast, weight loss due to a very-low-calorie-formula-diet (800 kcal/d) had no such effect. To examine metabolic activity of BLyS, in a translational research approach, insulin sensitivity was measured in human subjects in vivo before and after treatment with the human recombinant anti-BLyS antibody belimumab. Since BLyS is known to promote B-cell proliferation and immunoglobulin secretion, the present data suggest that adipocytes of grade 3 obese human subjects are able to activate the adaptive immune system, suggesting that in metabolic inflammation in humans both, innate and adaptive immunity, are of pathophysiological relevance.
- Published
- 2014
37. Tu1870 - Anti-Tnf Therapy Systematically Influences Intestinal Microbial Community Structure in Chronic Inflammatory Diseases
- Author
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Aden, Konrad, Rehman, Ateequr, Pan, Wei-Hung, Bethge, Johannes, Franke, Andre, Nikolaus, Susanna, Zeuner, Rainald, Schreiber, Stefan, and Rosenstiel, Philip
- Published
- 2017
- Full Text
- View/download PDF
38. B Lymphocyte Stimulator (BLyS) Is Expressed in Human Adipocytes In Vivo and Is Related to Obesity but Not to Insulin Resistance
- Author
-
Müller, Nike, primary, Schulte, Dominik M., additional, Hillebrand, Susann, additional, Türk, Kathrin, additional, Hampe, Jochen, additional, Schafmayer, Clemens, additional, Brosch, Mario, additional, von Schönfels, Witigo, additional, Ahrens, Markus, additional, Zeuner, Rainald, additional, Schröder, Johann O., additional, Blüher, Matthias, additional, Gutschow, Christian, additional, Freitag-Wolf, Sandra, additional, Stelmach-Mardas, Marta, additional, Saggau, Carina, additional, Schreiber, Stefan, additional, and Laudes, Matthias, additional
- Published
- 2014
- Full Text
- View/download PDF
39. Biologics as Treatment for Systemic Lupus: Great Efforts, Sobering Results, New Challenges
- Author
-
Schroder, Johann, primary and Zeuner, Rainald, additional
- Published
- 2009
- Full Text
- View/download PDF
40. B Lymphocyte Stimulator (BLyS) Is Expressed in Human Adipocytes In Vivo and Is Related to Obesity but Not to Insulin Resistance.
- Author
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Müller, Nike, Schulte, Dominik M., Hillebrand, Susann, Türk, Kathrin, Hampe, Jochen, Schafmayer, Clemens, Brosch, Mario, von Schönfels, Witigo, Ahrens, Markus, Zeuner, Rainald, Schröder, Johann O., Blüher, Matthias, Gutschow, Christian, Freitag-Wolf, Sandra, Stelmach-Mardas, Marta, Saggau, Carina, Schreiber, Stefan, and Laudes, Matthias
- Subjects
LYMPHOCYTES ,B cells ,FAT cells ,OBESITY ,INSULIN resistance ,MACROPHAGES ,PHYSIOLOGY - Abstract
Inflammation and metabolism have been shown to be evolutionary linked and increasing evidence exists that pro-inflammatory factors are involved in the pathogenesis of obesity and type 2 diabetes. Until now, most data suggest that within adipose tissue these factors are secreted by cells of the innate immune system, e. g. macrophages. In the present study we demonstrate that B lymphocyte stimulator (BLyS) is increased in human obesity. In contrast to several pro-inflammatory factors, we found the source of BLyS in human adipose tissue to be the adipocytes rather than immune cells. In grade 3 obese human subjects, expression of BLyS in vivo in adipose tissue is significantly increased (p<0.001). Furthermore, BLyS serum levels are elevated in grade 3 human obesity (862.5+222.0 pg/ml vs. 543.7+60.7 pg/ml in lean controls, p<0.001) and are positively correlated to the BMI (r = 0.43, p<0.0002). In the present study, bariatric surgery significantly altered serum BLyS concentrations. In contrast, weight loss due to a very-low-calorie-formula-diet (800 kcal/d) had no such effect. To examine metabolic activity of BLyS, in a translational research approach, insulin sensitivity was measured in human subjects in vivo before and after treatment with the human recombinant anti-BLyS antibody belimumab. Since BLyS is known to promote B-cell proliferation and immunoglobulin secretion, the present data suggest that adipocytes of grade 3 obese human subjects are able to activate the adaptive immune system, suggesting that in metabolic inflammation in humans both, innate and adaptive immunity, are of pathophysiological relevance. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
41. Plasma exchange in systemic lupus erythematosus
- Author
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Euler, Hans H., primary, Zeuner, Rainald A., additional, and Schroeder, Johann O., additional
- Published
- 1996
- Full Text
- View/download PDF
42. Treatment‐free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide
- Author
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Euler, Hans H., primary, Schroeder, Johann O., additional, Harten, Pontus, additional, Zeuner, Rainald A., additional, and Gutschmidt, Hans J., additional
- Published
- 1994
- Full Text
- View/download PDF
43. Letter to the Editor.
- Author
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Moosig, Frank, Graf, Demian, Knorr-Spahr, Anja, and Zeuner, Rainald A.
- Subjects
MONOCYTES ,GRANULOCYTES - Abstract
Analyzes the monocyte phagocytosis of complement opsonized Escherichia coli in patients with systemic lupus erythematosus (SLE). Examination of the seriological characteristics of SLE; Observation of the significant differences between monocytes and granulocytes of healthy controls and of SLE patients.
- Published
- 2003
44. The German National Registry of Primary Immunodeficiencies (2012-2017)
- Author
-
El-Helou, Sabine M., Biegner, Anika-Kerstin, Bode, Sebastian, Ehl, Stephan R., Heeg, Maximilian, Maccari, Maria E., Ritterbusch, Henrike, Speckmann, Carsten, Rusch, Stephan, Scheible, Raphael, Warnatz, Klaus, Atschekzei, Faranaz, Beider, Renata, Ernst, Diana, Gerschmann, Stev, Jablonka, Alexandra, Mielke, Gudrun, Schmidt, Reinhold E., Schürmann, Gesine, Sogkas, Georgios, Baumann, Ulrich H., Klemann, Christian, Viemann, Dorothee, Von Bernuth, Horst, Krüger, Renate, Hanitsch, Leif G., Scheibenbogen, Carmen M., Wittke, Kirsten, Albert, Michael H., Eichinger, Anna, Hauck, Fabian, Klein, Christoph, Rack-Hoch, Anita, Sollinger, Franz M., Avila, Anne, Borte, Michael, Borte, Stephan, Fasshauer, Maria, Hauenherm, Anja, Kellner, Nils, Müller, Anna H., Ülzen, Anett, Bader, Peter, Bakhtiar, Shahrzad, Lee, Jae-Yun, Heß, Ursula, Schubert, Ralf, Wölke, Sandra, Zielen, Stefan, Ghosh, Sujal, Laws, Hans-Juergen, Neubert, Jennifer, Oommen, Prasad T., Hönig, Manfred, Schulz, Ansgar, Steinmann, Sandra, Schwarz, Klaus, Dückers, Gregor, Lamers, Beate, Langemeyer, Vanessa, Niehues, Tim, Shai, Sonu, Graf, Dagmar, Müglich, Carmen, Schmalzing, Marc T., Schwaneck, Eva C., Tony, Hans-Peter, Dirks, Johannes, Haase, Gabriele, Liese, Johannes G., Morbach, Henner, Foell, Dirk, Hellige, Antje, Wittkowski, Helmut, Masjosthusmann, Katja, Mohr, Michael, Geberzahn, Linda, Hedrich, Christian M., Müller, Christiane, Rösen-Wolff, Angela, Roesler, Joachim, Zimmermann, Antje, Behrends, Uta, Rieber, Nikolaus, Schauer, Uwe, Handgretinger, Rupert, Holzer, Ursula, Henes, Jörg, Kanz, Lothar, Boesecke, Christoph, Rockstroh, Jürgen K., Schwarze-Zander, Carolynne, Wasmuth, Jan-Christian, Dilloo, Dagmar, Hülsmann, Brigitte, Schönberger, Stefan, Schreiber, Stefan, Zeuner, Rainald, Ankermann, Tobias, Von Bismarck, Philipp, Huppertz, Hans-Iko, Kaiser-Labusch, Petra, Greil, Johann, Jakoby, Donate, Kulozik, Andreas E., Metzler, Markus, Naumann-Bartsch, Nora, Sobik, Bettina, Graf, Norbert, Heine, Sabine, Kobbe, Robin, Lehmberg, Kai, Müller, Ingo, Herrmann, Friedrich, Horneff, Gerd, Klein, Ariane, Peitz, Joachim, Schmidt, Nadine, Bielack, Stefan, Groß-Wieltsch, Ute, Classen, Carl F., Klasen, Jessica, Deutz, Peter, Kamitz, Dirk, Lassay, Lisa, Tenbrock, Klaus, Wagner, Norbert, Bernbeck, Benedikt, Brummel, Bastian, Lara-Villacanas, Eusebia, Münstermann, Esther, Schneider, Dominik T., Tietsch, Nadine, Westkemper, Marco, Weiß, Michael, Kramm, Christof, Kühnle, Ingrid, Kullmann, Silke, Girschick, Hermann, Specker, Christof, Vinnemeier-Laubenthal, Elisabeth, Haenicke, Henriette, Schulz, Claudia, Schweigerer, Lothar, Müller, Thomas G., Stiefel, Martina, Belohradsky, Bernd H., Soetedjo, Veronika, Kindle, Gerhard, and Grimbacher, Bodo
- Subjects
3. Good health - Abstract
Frontiers in immunology 10, 1272 (2019). doi:10.3389/fimmu.2019.01272, Published by Frontiers Media, Lausanne
45. Veränderung des sensorischen Phänotyps von Patienten mit Arthrose vor und nach Gelenkersatz
- Author
-
Höper, Johanna, Hüllemann, Philipp, and Zeuner, Rainald
- Subjects
Sensorischer Phänotyp, Arthrose ,doctoral thesis ,Abschlussarbeit ,ddc:610 ,ddc:6XX - Abstract
Die Osteoarthrose ist eine der häufigsten chronischen, degenerativen Erkrankungen des Bewegungsapparates. Eine konservative Therapie kann bislang keine langfristige Symptomlinderung erreichen und den Krankheitsprozess nicht aufhalten. Bislang wurde angenommen, dass die Schmerzentstehung der Arthrose rein nozizeptiv ist. Eine genaue Analyse des somatosensorischen Phänotyps insichtlich Funktionsverlust oder Sensitivierung ermöglicht die Quantitativ Sensorische Testung (QST) und erlaubt Rückschlüsse auf die zugrunde liegende Pathophysiologie. Ziel dieser Arbeit war die Charakterisierung des sensorischen Phänotyps und Analyse hinsichtlich Schmerzintensität, demographischen Charakteristika, Funktionalität, Lebensqualität und psychischer Gesundheit von Patienten mit Arthrose. Weiterhin sollten Unterschiede zwischen Patienten mit und ohne zentrale Schmerzsensibilisierungsprozesse sowie die konservativ und operativ behandelten Patienten, einerseits innerhalb der Gruppen longitudinal und andererseits im Gruppenvergleich, analysiert werden. Die Studie bestand aus zwei Untersuchungszeitpunkten (Visite 1 und Visite 2), an denen nach Erhebung der Anamnese, demographischen Daten und Schmerzintensität, eine QST im Areal des übertragenden Schmerzes am Oberschenkel durchgeführt wurde. Weiterhin wurden validierte Fragebögen eingesetzt zur Erfassung der Funktionalität, gesundheitsbezogenen Lebensqualität, psychischen Gesundheit, Qualität des Schlafs und Schmerzcharakteristika. 49 Patienten mit Coxoder Gonarthrose haben an dieser Studie teilgenommen. 31 der Patienten haben auch an Visite 2, teilgenommen; 13 dieser Patienten erhielten zwischenzeitlich eine Gelenkersatzoperation, deren Indikation unabhängig von dieser Studie gestellt wurde. Das somatosensorische Profil der Arthrosepatienten war charakterisiert durch eine Sensibilisierung im Sinne einer thermischen und/oder mechanischen Hyperalgesie. Fast die Hälfte der untersuchten Patienten wiesen Zeichen einer zentralen Schmerzsensibilisierung auf. Diese Patienten hatten stärkere Schmerzen als Patienten ohne zentrale Sensibilisierung. Hinsichtlich Erkrankungsdauer, Häufigkeiten der charakteristisch neuropathischen Symptome, Funktionseinschränkung, Schlafstörungen, Psychische Gesundheit sowie Lebensqualität fanden sich keine Unterschiede. Die Patienten, die im Verlauf eine Gelenkersatzoperation erhielten, hatten bei Visite 1 mehr Schmerzen und stärkere Funktionseinschränkungen als die Patienten mit konservativer Therapie; Unterschiede der Lebensqualität oder psychischen Gesundheit sowie im sensorischen Profil der Patientengruppen konnten nicht gefunden werden. Nach Gelenkersatzoperation nahmen die Schmerzintensität und die zentrale Sensibilisierung ab. Anhand dieses Ergebnisses und dem Vergleich der Patienten mit und ohne zentrale Sensibilisierung ist anzunehmen, dass die Schmerzintensität ein Hauptfaktor in der Generierung dieser zentralen Sensibilisierungsprozesse ist und analog die Verminderung der Schmerzintensität eine zentrale Rolle bei der Reduktion zentraler Sensibilisierung spielt. Für die Patienten mit konservativer Therapie konnte, abgesehen von einer verminderten Kälteschmerzschwelle und einer verminderten taktilen Wahrnehmung, keine Veränderung im Verlauf in den Ergebnissen der QST und den Fragebogenergebnissen gefunden werden. Bemerkenswert ist, dass sich ein Zusammenhang mit der subjektiven Zufriedenheit mit dem Gelenkersatz und dem Ausmaß der Funktionsverbesserung nach der Behandlung fand, aber nicht mit der Schmerzreduktion oder den Schmerzen nach der Behandlung. Das Vorhandensein einer depressiven Störung bei Visite 1 war mit einer geringeren Schmerzreduktion nach operativer Behandlung und somit einem geringeren Behandlungsansprechen verbunden. Zusammenfassend fand sich bei Arthrosepatienten hinsichtlich der sensorischen Auffälligkeiten insbesondere eine Überempfindlichkeit gegen Hitze und mechanische Reize, wobei ein substanzieller Prozentsatz der Patienten Zeichen einer zentralen Sensibilisierung aufwies und dies mit der angegebenen Schmerzintensität korrelierte.
- Published
- 2020
46. Manifestationen der Granulomatose mit Polyangiitis im Kopf-Hals-Bereich - eine monozentrische Kohortenbeschreibung
- Author
-
Kühn, Dominik, Laudien, Martin, Zeuner, Rainald, Priv.-Doz. Dr. Martin Laudien, and Priv.-Doz. Dr. Rainald Zeuner
- Subjects
doctoral thesis ,Abschlussarbeit ,Granulomatose mit Polyangiitis ,Medizinische Fakultät ,HNO ,ddc:610 ,GPA ,ddc:6XX ,Faculty of Medicine ,Morbus Wegener ,GPA, HNO, Morbus Wegener, Granulomatose mit Polyangiitis - Abstract
Die Granulomatose mit Polyangiitis (GPA) ist eine seltene Autoimmunerkrankung aus der Gruppe der anti-neutrophilen zytoplasmatischen Autoantikörper-assoziierten primären Vaskulitiden. Eine Beteiligung des Kopf-Hals-Bereichs ist bisher nur in kleinen Fallserien und Fallberichten beschrieben worden. Das Ziel dieser Kohortenbeschreibung ist eine systematische Charakterisierung der HNO-Beteiligungen einer großen Anzahl von GPAPatienten und eine Korrelation lokaler und systemischer Krankheitsaktivität.
- Published
- 2019
47. Lebensqualität, Gesundheitszustand und Therapiezufriedenheit bei erfolgreich langzeitbehandelten HIV-infizierten Patienten
- Author
-
Sonntag, Ina Alwine Petra Andrea, Hoffmann, Christian, and Zeuner, Rainald
- Subjects
Abschlussarbeit ,HIV ,Therapiezufriedenheit ,Faculty of Medicine ,doctoral thesis ,SF-12 ,ASDM ,Medizinische Fakultät ,Gesundheitszustand ,ddc:610 ,ddc:6XX ,ART ,HIV Lebensqualität Gesundheitszustand Therapiezufriedenheit ART SF-12 ASDM ,Lebensqualität - Abstract
LEBENSQUALITÄT, GESUNDHEITSZUSTAND UND THERAPIEZUFRIEDENHEIT BEI ERFOLGREICH LANGZEITBEHANDELTEN HIV-INFIZIERTEN PATIENTEN
- Published
- 2018
48. Vergleich des Adhäsionsverhaltens verschiedener Staphylococcus aureus Stämme von Patienten mit Granulomatose mit Polyangiits und Normalkontrollen an einer immortalen nasalen Epithelzelllinie
- Author
-
Rolfs, Kari, Laudien, Martin, Zeuner, Rainald, PD Dr. Martin Laudien, and PD Dr. Rainald Zeuner
- Subjects
doctoral thesis ,Zelllinie ,Abschlussarbeit ,Medizinische Fakultät ,ddc:000 ,ddc:0XX ,Adhäsionsverhalten ,S. aureus, Adhäsionsverhalten, GPA, Zelllinie ,GPA ,S. aureus ,Faculty of Medicine - Abstract
Vergleich des Adhäsionsverhaltens verschiedener Staphylococcus aureus Stämme von Patienten mit Granulomatose mit Polyangiits und Normalkontrollen an einer immortalen nasalen Epithelzelllinie (RPMI 2650 Zelllinie)
- Published
- 2018
49. Monocyte and granulocyte phagocytosis of Escherichia coil particles in systemic lupus erythematosus is not reduced when compared to healthy controls.
- Author
-
Moosig F, Graf D, Knorr-Spahr A, Zeuner RA, Böttcher S, and Schröder JO
- Subjects
- Adult, Case-Control Studies, Female, Flow Cytometry, Granulocytes immunology, Granulocytes physiology, Humans, Lupus Erythematosus, Systemic diagnosis, Middle Aged, Monocytes immunology, Monocytes physiology, Phagocytosis immunology, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Escherichia coli, Lupus Erythematosus, Systemic blood, Phagocytosis physiology
- Published
- 2003
- Full Text
- View/download PDF
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