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5. Zusammenfassung der Vorträge

Author

Zettl, U. K., Kallwellis, G., Schminke, U., Rieck, K., Gaida-Hommernick, B., Gaab, M. R., Rabending, G., Runge, U., Walter, U., Kloth, A., Benecke, R., Kunesch, E., Wolters, A., Classen, J., Müller, M., Jahns, R., Bauer, B., Nguento, A., Schulz, M., Hartmann, U., Herzer, R., Heinrich, A., Klampe, M., Kuehn, K. U., Schroeder, W., Armbruster, J., Abraham, G., Schattenberg, A., Gaensicke, M., Barnow, S., Herrmann, F. H., Freyberger, H. J., Mundt, B., Stutz, K., Tretzel, H., Ringel, I., Müller-Oerlinghausen, B., Weirich, S., Bischof, S., Broese, T. H., Lüdemann, W., Schicke, M., Schmid, G., Titz, K., Schläfke, D., Dudeck, M., Vogelgesang, S., Röder, H., Kessler, C. H., Fister, A., Steinhagen, V., Michels-Lucht, F., Spitzer, C., Lucht, M., Siebel, U., Bohne, S., Grossmann, A., Buchmann, J., Konnopka, K., Höppner, J., Richter, J., Gierow, W., Irmisch, G., Grabe, H. J., Alte, D., John, U., Göhre, C., Unger, D., Wartemann, U., Hässler, F., Roth, M., Gabriel, S., Vetter, P., Meyer, D.-R., Andresen, R., Zinapold, G., Veit, B., Bock, A., Gold, R., Respondek, E., Greim, B., Ruckert, S., Zettll, U. K., Krüger, T., Schoefer-Timpe, G., Wegmann, K., Stiebler, A., Nichtweiss, M., Schütte, P., Bogun, K.-R., Terstegge, K., Henkes, H., Kirsch, G., Khaw, A. V., Bleiss, A., Drach, L. M., Weidauer, S., Spreer, J., Herminghaus, S., Müller, W., and Nichtweiß, Michael

Published
2001
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23. Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity (Acta Neuropathologica, (2019), 138, 2, (237-250), 10.1007/s00401-019-02026-8)

Author

van der Lee, S. J., Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernandez, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleo, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J., Moreno-Grau, S., Wagner, M., Fortea, J., Keogh, M. J., Blennow, K., Skoog, I., Friese, M. A., Pletnikova, O., Zulaica, M., Lage, C., de Rojas, I., Riedel-Heller, S., Illan-Gala, I., Wei, W., Jeune, B., Orellana, A., Then Bergh, F., Wang, X., Hulsman, M., Beker, N., Tesi, N., Morris, C. M., Indakoetxea, B., Collij, L. E., Scherer, M., Morenas-Rodriguez, E., Ironside, J. W., van Berckel, B. N. M., Alcolea, D., Wiendl, H., Strickland, S. L., Pastor, P., Rodriguez Rodriguez, E., Mead, S., Synofzik, M., van Swieten, J. C., Leber, I., Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Binetti, G., Ghidoni, R., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Blesa, R., Landqvist Waldo, M., Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G. -Y. R., Mann, D. M. A., Grafman, J., Attems, J., Griffiths, T. D., Mckeith, I. G., Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Razquin, C., Ortega-Cubero, S., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., van der Zee, J., Van Broeckhoven, C., Cappa, S. F., Hannequin, D., Golfier, V., Vercelletto, M., Brice, A., Nacmias, B., Sorbi, S., Bagnoli, S., Piaceri, I., Nielsen, J. E., Hjermind, L. E., Riemenschneider, M., Mayhaus, M., Ibach, B., Gasparoni, G., Pichler, S., Gu, W., Rossor, M. N., Fox, N. C., Warren, J. D., Spillantini, M. G., Morris, H. R., Rizzu, P., Snowden, J. S., Rollinson, S., Richardson, A., Gerhard, A., Bruni, A. C., Maletta, R., Frangipane, F., Cupidi, C., Bernardi, L., Anfossi, M., Gallo, M., Conidi, M. E., Smirne, N., Baker, M., Josephs, K. A., Parisi, J. E., Seeley, W. W., Miller, B. L., Karydas, A. M., Rosen, H., Dopper, E. G. P., Seelaar, H., Logroscino, G., Capozzo, R., Novelli, V., Puca, A. A., Franceschi, M., Postiglione, A., Milan, G., Sorrentino, P., Kristiansen, M., Chiang, H. -H., Graff, C., Pasquier, F., Rollin, A., Deramecourt, V., Lebouvier, T., Kapogiannis, D., Ferrucci, L., Pickering-Brown, S., Singleton, A. B., Hardy, J., Momeni, P., Boeve, B. F., Petersen, R. C., Ferman, T. J., van Gerpen, J. A., Reinders, M. J. T., Uitti, R. J., Tarraga, L., Maier, W., Dols-Icardo, O., Kawalia, A., Dalmasso, M. C., Boada, M., Zettl, U. K., van Schoor, N. M., Beekman, M., Allen, M., Masliah, E., de Munain, A. L., Pantelyat, A., Wszolek, Z. K., Ross, O. A., Dickson, D. W., Graff-Radford, N. R., Knopman, D., Rademakers, R., Lemstra, A. W., Pijnenburg, Y. A. L., Scheltens, P., Gasser, T., Chinnery, P. F., Hemmer, B., Huisman, M. A., Troncoso, J., Moreno, F., Nohr, E. A., Sorensen, T. I. A., Heutink, P., Sanchez-Juan, P., Posthuma, D., Coppola, G., Varpetian, A., Foroud, T. M., Levey, A. I., Kukull, W. A., Mendez, M. F., Ringman, J., Chui, H., Cotman, C., Decarli, C., Geschwind, D. H., Clarimon, J., Christensen, K., Ertekin-Taner, N., Scholz, S. W., Ramirez, A., Ruiz, A., Slagboom, E., van der Flier, W. M., Holstege, H., Neurology, Epidemiology and Data Science, Human genetics, APH - Societal Participation & Health, APH - Aging & Later Life, Amsterdam Neuroscience - Complex Trait Genetics, APH - Personalized Medicine, and APH - Methodology

Subjects
education
Abstract

The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once.

Published
2020

47. Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS

Author

Schrewe, L., Lill, C. M., Liu, T., Salmen, A., Gerdes, L. A., Guillot-Noel, L., Akkad, D. A., Blaschke, P., Graetz, C., Hoffjan, S., Kroner, A., Demir, S., Böhme, A., Rieckmann, P., Elali, A., Hagemann, N., Hermann, D. M., Cournu-Rebeix, I., Zipp, F., Kümpfel, T., Buttmann, M., Zettl, U. K., Fontaine, B., Bertram, L., Gold, R., Chan, A., St. Josef Hospital, Ruhr-University Bochum, Max-Planck-Institut für Molekulare Genetik (MPIMG), Max-Planck-Gesellschaft, Platform for Genome Analytics, University Medical Center of the Johannes Gutenberg University Mainz, Max Planck Institute for Human Development, Institute for Clinical Neuroimmunology, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Human Genetics, Ruhr-Universität Bochum [Bochum], Department of Neurology, McGill University Health Center [Montreal] (MUHC), Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Neuroscience Axis, Research Center of CHU de Québec—CHUL, Universität Duisburg-Essen [Essen], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imperial College of Science, Technology and Medicine (IMPERIAL COLLEGE), Queen Mary University of London (QMUL)-Imperial College of Science, Technology and Medicine, HAL-UPMC, Gestionnaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Rostock, Julius-Maximilians-Universität Würzburg (JMU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), and Universität Duisburg-Essen = University of Duisburg-Essen [Essen]

Subjects
Male, Encephalomyelitis, Autoimmune, Experimental, Genotype, Immunology, Medizin, Fluorescent Antibody Technique, Real-Time Polymerase Chain Reaction, Multiple sclerosis, Cellular and Molecular Neuroscience, Mice, apoE, Apolipoproteins E, Sex Factors, INFLAMMATION, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, ddc:610, ALZHEIMER-DISEASE, Mice, Knockout, Science & Technology, Neurology & Neurosurgery, Research, Neurosciences, Gender, CNS DISEASE, 1103 Clinical Sciences, MULTIPLE-SCLEROSIS, ASSOCIATION, COGNITIVE FUNCTION, Mice, Inbred C57BL, Neurology, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, 1107 Immunology, DISEASE SEVERITY, IMMUNE-SYSTEM, Female, lipids (amino acids, peptides, and proteins), MSSS, Association studies in genetics, Neurosciences & Neurology, 1109 Neurosciences, Life Sciences & Biomedicine
Abstract

Background Despite pleiotropic immunomodulatory effects of apolipoprotein E (apoE) in vitro, its effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) are still controversial. As sex hormones modify immunomodulatory apoE functions, they may explain contentious findings. This study aimed to investigate sex-specific effects of apoE on disease course of EAE and MS. Methods MOG35-55 induced EAE in female and male apoE-deficient mice was assessed clinically and histopathologically. apoE expression was investigated by qPCR. The association of the MS severity score (MSSS) and APOE rs429358 and rs7412 was assessed across 3237 MS patients using linear regression analyses. Results EAE disease course was slightly attenuated in male apoE-deficient (apoE−/−) mice compared to wildtype mice (cumulative median score: apoE−/− = 2 [IQR 0.0–4.5]; wildtype = 4 [IQR 1.0–5.0]; n = 10 each group, p = 0.0002). In contrast, EAE was more severe in female apoE−/− mice compared to wildtype mice (cumulative median score: apoE−/− = 3 [IQR 2.0–4.5]; wildtype = 3 [IQR 0.0–4.0]; n = 10, p = 0.003). In wildtype animals, apoE expression during the chronic EAE phase was increased in both females and males (in comparison to naïve animals; p

Published
2015

48. Exome Array GWAS in 10,000 Germans Identifies Association between MUC22 and Multiple Sclerosis

Author

Dankowski, T., Buck, D., Andlauer, T. F., Antony, G., Bayas, A., Bechmann, Lars Peter, Berthele, A., Bettecken, T., Chan, A., Franke, A., Gold, R., Graetz, C., Haas, J., Hecker, M., Herms, S., Hohlfeld, R., Infante-Duarte, C., Jöckel, Karl-Heinz, Kieseier, B. C., Knier, B., Knop, M., Lichtner, P., Lieb, W., Lill, C. M., Limmroth, V., Linker, R. A., Loleit, V., Meuth, S., Moebus, Susanne, Mueller-Myhsok, B., Nischwitz, S., Noethen, M. M., Friedemann, P., Pütz, Martin, Ruck, T., Salmen, A., Stangel, M., Stellmann, J. -. P., Strauch, K., Stuerner, K. H., Tackenberg, B., Bergh, F. T. h. e. n., Tumani, H., Waldenberger, M., Weber, F., Wiend, H., Wildemann, B., Zettl, U. K., Ziemann, U., Zipp, F., Hemmer, B., and Ziegler, A.

Subjects
Medizin
Published
2015

49. The sphingosine analog fingolimod (FTY720) enhances tone and contractility of rat gastric fundus smooth muscle.

Author

Kraft, M., Zettl, U. K., Noack, T., and Patejdl, R.

Subjects
*SPHINGOSINE, *FINGOLIMOD, *GASTRIC fundus, *SMOOTH muscle, *LABORATORY rats, *INDOMETHACIN, *CALCIUM in the body
Abstract

Background: Sphingosine and its metabolite sphingosine phosphate (S1P) regulate a multitude of biological functions, including the contractile state of smooth. Gastrointestinal side effects have been reported in patients treated with FTY720, a sphingosine analog that is approved for the treatment of multiple sclerosis. The aim of this study was to characterize the effects of FTY720 on rat gastric fundus smooth muscle under basal conditions and during activation induced by high‐K+ solution. Methods: Isometric contractions of isolated circular strips of gastric fundus smooth muscle were recorded using the organ bath method. The effects of FTY720 or vehicle were recorded under control conditions and in the presence of indomethacin, L‐NAME, HA‐1100, nifedipine, JTE‐013, and suramin. Tone and contractions recorded in the presence of FTY720 or vehicle are reported as % of the amplitude of an initial high‐K+ contraction obtained under control conditions. Key Results: From a concentration of 10 μmol L−1 onwards, FTY720 increased the tone, reaching 8.9% ± 7.5% at 100 μmol L−1 (P < .05). With indomethacin in the solution, the effects of FTY720 were enhanced (32.1% ± 7.7%; P < .001). The FTY720‐induced increase in tone was abolished in the absence of extracellular Ca2+ and reduced by nifedipine, HA‐1100, JTE‐013, and suramin. Furthermore, FTY720 increased high‐K+ contractions in the presence of indomethacin. Conclusions & Inferences: FTY720 increases tone and contractile responses to depolarization in gastric fundus smooth muscle by triggering calcium entry and calcium sensitization in a S1P receptor‐dependent manner. Taken together, the experimental results presented in this work suggest that FTY720 may increase gastric tone and contractility in patients. [ABSTRACT FROM AUTHOR]

Published
2018
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