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8. Surface alterations and compound release from aligner attachments in vitro.

Author

Iliadi, Anna, Zervou, Sevasti-Kiriaki, Koletsi, Despina, Schätzle, Marc, Hiskia, Anastasia, Eliades, Theodore, and Eliades, George

Subjects
WATER immersion, DENTAL materials, SURFACE texture, COMPOSITE materials, DEBONDING
Abstract

Aim The aim of the present study was to assess the alterations in morphology, roughness, and composition of the surfaces of a conventional and a flowable composite attachment engaged with aligners, and to evaluate the release of resin monomers and their derivatives in an aqueous environment. Methods Zirconia tooth-arch frames (n  = 20) and corresponding thermoformed PET-G aligners with bonded attachments comprising two composite materials (universal—C and flowable—F) were fabricated. The morphological features (stereomicroscopy), roughness (optical profilometry), and surface composition (ATR-FTIR) of the attachments were examined before and after immersion in water. To simulate intraoral use, the aligners were removed and re-seated to the frames four times per day for a 7-day immersion period. After testing, the eluents were analyzed by LC-MS/MS targeting the compounds Bis-GMA, UDMA, 2-HEMA, TEGDMA and BPA and by LC-HRMS for suspect screening of the leached dental material compounds and their degradation products. Results After testing, abrasion-induced defects were found on attachment surfaces such as scratches, marginal cracks, loss of surface texturing, and fractures. The morphological changes and debonding rate were greater in F. Comparisons (before-after testing) revealed a significantly lower Sc roughness parameter in F. The surface composition of the aligners after testing showed minor changes from the control, with insignificant differences in the degree of C = C conversion, except for few cases with strong evidence of hydrolytic degradation. Targeted analysis results revealed a significant difference in the compounds released between Days 1 and 7 in both materials. Insignificant differences were found when C was compared with F in both timeframes. Several degradation products were detected on Day 7, with a strong reduction in the concentration of the targeted compounds. Conclusions The use of aligners affects the surface characteristics and degradation rate of composite attachments in an aqueous environment, releasing monomers, and monomer hydrolysates within 1-week simulated use. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Microbes and us: microbiology literacy in Greece

Author

Karayanni, Hera, primary, Motsiou, Eleni, additional, Sapountzi, Vasiliki, additional, Meggou, Lydia, additional, Pagkoutsou, Maria, additional, Triantafyllidi, Aikaterini, additional, Markouti, Alexandra-Kyparisia, additional, Zervou, Sevasti, additional, Anastasopoulos, Stelios, additional, and Efthimiou, George, additional

Published
2024
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10. Enhancing the Photocatalytic Activity of Immobilized TiO 2 Using Laser-Micropatterned Surfaces.

Author

Giannakis, Theodoros, Zervou, Sevasti-Kiriaki, Triantis, Theodoros M., Christophoridis, Christophoros, Bizani, Erasmia, Starinskiy, Sergey V., Koralli, Panagiota, Mousdis, Georgios, Hiskia, Anastasia, and Kandyla, Maria

Subjects
PHOTOCATALYSTS, ATRAZINE, TITANIUM dioxide, ULTRAVIOLET-visible spectroscopy, RAMAN spectroscopy, SOL-gel processes
Abstract

In the past, the application of TiO2 slurry reactors has faced difficulties concerning the recovery and reusability of the catalyst. In response to these challenges, immobilized photocatalyst systems have been investigated, wherein the catalyst is fixed onto a solid support, frequently with reduced photocatalytic performance. In the present study, thin TiO2 films were developed in the anatase phase by the sol-gel process and spin-cast on laser-microstructured silicon substrates, to form photocatalytic surfaces of increased activity. The TiO2 films were thoroughly characterized using SEM-EDX, XRD, UV–Vis spectroscopy, and Raman spectroscopy. The photocatalytic activity of these surfaces was evaluated by the degradation of atrazine in aqueous solution under UV irradiation. Their photocatalytic activity was found to be significantly enhanced (mean kobs 24.1 × 10−3 min−1) when they are deposited on laser-microstructured silicon compared with flat silicon (mean kobs 4.9 × 10−3 min−1), approaching the photocatalytic activity of sol-gel TiO2 fortified with Degussa P25, used as a reference material (mean kobs 32.7 × 10−3 min−1). During the photocatalytic process, several transformation products (TPs) of atrazine, namely 2-chloro-4-(isopropylamino)-6-amino-s-triazine (CIAT), 2-chloro-4-amino-6-(ethylamino)-s-triazine (CAET), and 2-chloro-4.6-diamino-s-triazine (CAAT), were identified with LC–MS/MS. The stability of the photocatalytic surfaces was also investigated and remained unchanged through multiple cycles of usage. The surfaces were further tested with two other pollutants, i.e., 2,4,6-trichlorophenol and bisphenol-a, showing similar photocatalytic activity as with atrazine. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Supplementary Figure 6 from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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16. Supplementary Figure 5 from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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17. Supplementary Figure 8 from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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18. Supplementary Figure 7 from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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19. Supplementary Figure 3 from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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20. Supplementary Figure 2 from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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21. Data from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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22. Supplemetary Data from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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23. Supplementary Figure 4 from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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24. Authorship Change Form from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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25. Supplementary Figure 1 from Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

Author

Valli, Alessandro, primary, Morotti, Matteo, primary, Zois, Christos E., primary, Albers, Patrick K., primary, Soga, Tomoyoshi, primary, Feldinger, Katharina, primary, Fischer, Roman, primary, Frejno, Martin, primary, McIntyre, Alan, primary, Bridges, Esther, primary, Haider, Syed, primary, Buffa, Francesca M., primary, Baban, Dilair, primary, Rodriguez, Miguel, primary, Yanes, Oscar, primary, Whittington, Hannah J., primary, Lake, Hannah A., primary, Zervou, Sevasti, primary, Lygate, Craig A., primary, Kessler, Benedikt M., primary, and Harris, Adrian L., primary

Published
2023
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28. Water taste and odor (T&O): Challenges, gaps and solutions from a perspective of the WaterTOP network

Author

Akcaalan, Reyhan, primary, Devesa-Garriga, Ricard, additional, Dietrich, Andrea, additional, Steinhaus, Martin, additional, Dunkel, Andreas, additional, Mall, Veronika, additional, Manganelli, Maura, additional, Scardala, Simona, additional, Testai, Emanuela, additional, Codd, Geoffrey A., additional, Kozisek, Frantisek, additional, Antonopoulou, Maria, additional, Ribeiro, Ana Rita Lado, additional, Sampaio, Maria José, additional, Hiskia, Anastasia, additional, Triantis, Theodoros M., additional, Dionysiou, Dionysios D., additional, Puma, Gianluca Li, additional, Lawton, Linda, additional, Edwards, Christine, additional, Andersen, Henrik Rasmus, additional, Fatta-Kassinos, Despo, additional, Karaolia, Popi, additional, Combès, Audrey, additional, Panksep, Kristel, additional, Zervou, Sevasti-Kiriaki, additional, Albay, Meriç, additional, Köker, Latife, additional, Chernova, Ekaterina, additional, Iliakopoulou, Sofia, additional, Varga, Elisabeth, additional, Visser, Petra M., additional, Gialleli, Angelika Ioanna, additional, Zengin, Zuhal, additional, Deftereos, Nikos, additional, Miskaki, Phani, additional, Christophoridis, Christophoros, additional, Paraskevopoulou, Aikaterina, additional, Lin, Tsair-Fuh, additional, Zamyadi, Arash, additional, Dimova, Galina, additional, and Kaloudis, Triantafyllos, additional

Published
2022
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30. Leaching from a 3D-printed aligner resin

Author

Willi, Andreas, primary, Patcas, Raphael, additional, Zervou, Sevasti-Kiriaki, additional, Panayi, Nearchos, additional, Schätzle, Marc, additional, Eliades, George, additional, Hiskia, Anastasia, additional, and Eliades, Theodore, additional

Published
2022
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34. Leaching from a 3D-printed aligner resin.

Author

Willi, Andreas, Patcas, Raphael, Zervou, Sevasti-Kiriaki, Panayi, Nearchos, Schätzle, Marc, Eliades, George, Hiskia, Anastasia, and Eliades, Theodore

Subjects
MOLECULAR structure, LEACHING, MASS spectrometry, DISTILLED water, LIQUID chromatography
Abstract

Aim To quantitatively assess the degree of conversion and the water-leaching targeted compound from 3D-printed aligners. Materials and methods 3D-printed aligners were made of photopolymerized resin (Tera Harz TC85A). The molecular structure and degree of conversion of the set resin were investigated by ATR-FTIR spectroscopy (n = 5). The aligners (n = 10) were immersed in double distilled water for 1 week at 37°C and the eluents were analysed using liquid chromatography/mass spectrometry methods (LC–ESI-MS/MS for urethane dimethacrylate [UDMA] and LC–APCI-MS/MS for bispenol-A [BPA]). Results The resin was composed of aliphatic vinyl ester-urethane monomers, with acrylate and/or methacrylate functionalization. The degree of conversion was estimated as to 83%. There was no detection of BPA in any of the assessed samples (0.25 µg/l). Quantifiable amounts of UDMA were detected in all the exposed samples, ranging from 29 to 96 µg/l. Conclusions Although efficiently polymerized and BPA free, the great variability in the amount of UDMA monomer leached from the examined samples may raise concerns on potential health hazards after repeated intraoral exposure, which is indicated for this class of materials. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Water taste and odor (T&O):Challenges, gaps and solutions from a perspective of the WaterTOP network

Author

Akcaalan, Reyhan, Devesa-Garriga, Ricard, Dietrich, Andrea, Steinhaus, Martin, Dunkel, Andreas, Mall, Veronika, Manganelli, Maura, Scardala, Simona, Testai, Emanuela, Codd, Geoffrey A., Kozisek, Frantisek, Antonopoulou, Maria, Ribeiro, Ana Rita Lado, Sampaio, Maria José, Hiskia, Anastasia, Triantis, Theodoros M., Dionysiou, Dionysios D., Puma, Gianluca Li, Lawton, Linda, Edwards, Christine, Andersen, Henrik Rasmus, Fatta-Kassinos, Despo, Karaolia, Popi, Combès, Audrey, Panksep, Kristel, Zervou, Sevasti-Kiriaki, Albay, Meriç, Köker, Latife, Chernova, Ekaterina, Iliakopoulou, Sofia, Varga, Elisabeth, Visser, Petra M., Gialleli, Angelika Ioanna, Zengin, Zuhal, Deftereos, Nikos, Miskaki, Phani, Christophoridis, Christophoros, Paraskevopoulou, Aikaterina, Lin, Tsair-Fuh, Zamyadi, Arash, Dimova, Galina, Kaloudis, Triantafyllos, Akcaalan, Reyhan, Devesa-Garriga, Ricard, Dietrich, Andrea, Steinhaus, Martin, Dunkel, Andreas, Mall, Veronika, Manganelli, Maura, Scardala, Simona, Testai, Emanuela, Codd, Geoffrey A., Kozisek, Frantisek, Antonopoulou, Maria, Ribeiro, Ana Rita Lado, Sampaio, Maria José, Hiskia, Anastasia, Triantis, Theodoros M., Dionysiou, Dionysios D., Puma, Gianluca Li, Lawton, Linda, Edwards, Christine, Andersen, Henrik Rasmus, Fatta-Kassinos, Despo, Karaolia, Popi, Combès, Audrey, Panksep, Kristel, Zervou, Sevasti-Kiriaki, Albay, Meriç, Köker, Latife, Chernova, Ekaterina, Iliakopoulou, Sofia, Varga, Elisabeth, Visser, Petra M., Gialleli, Angelika Ioanna, Zengin, Zuhal, Deftereos, Nikos, Miskaki, Phani, Christophoridis, Christophoros, Paraskevopoulou, Aikaterina, Lin, Tsair-Fuh, Zamyadi, Arash, Dimova, Galina, and Kaloudis, Triantafyllos

Abstract

Aesthetic aspects of drinking water, such as Taste and Odor (T&O), have significant effects on consumer perceptions and acceptability. Solving unpleasant water T&O episodes in water supplies is challenging, since it requires expertise and know-how in diagnosis, evaluation of impacts and implementation of control measures. We present gaps, challenges and perspectives to advance water T&O science and technology, by identifying key areas in sensory and chemical analysis, risk assessment and water treatment, as articulated by WaterTOP (COST Action CA18225), an interdisciplinary European and international network of researchers, experts, and stakeholders.

Published
2022

41. Sublethal exposure to Microcystis aeruginosa extracts during embryonic development reduces aerobic swimming capacity in juvenile zebrafish

Author

Sergi, Emmanolia, primary, Orfanakis, Michail, additional, Dimitriadi, Anastasia, additional, Christou, Maria, additional, Zachopoulou, Anthi, additional, Kourkouta, Chara, additional, Printzi, Alice, additional, Zervou, Sevasti-Kiriaki, additional, Makridis, Pavlos, additional, Hiskia, Anastasia, additional, and Koumoundouros, George, additional

Published
2022
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43. Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse.

Author

Maguire, Mahon L., McAndrew, Debra J., Lake, Hannah A., Ostrowski, Philip J., Zervou, Sevasti, Neubauer, Stefan, Lygate, Craig A., and Schneider, Jurgen E.

Subjects
ADENOSINE triphosphate metabolism, MYOCARDIUM, IN vivo studies, ANIMAL experimentation, CREATINE kinase, NUCLEAR magnetic resonance spectroscopy, CREATINE, PHOSPHOCREATINE, RESEARCH funding, DESCRIPTIVE statistics, MICE
Abstract

Background: Phosphorus cardiovascular magnetic resonance spectroscopy (31P-CMRS) has emerged as an important tool for the preclinical assessment of myocardial energetics in vivo. However, the high rate and diminutive size of the mouse heart is a challenge, resulting in low resolution and poor signal-to-noise. Here we describe a refined high-resolution 31P-CMRS technique and apply it to a novel double transgenic mouse (dTg) with elevated myocardial creatine and creatine kinase (CK) activity. We hypothesised a synergistic effect to augment energetic status, evidenced by an increase in the ratio of phosphocreatine-to-adenosine-triphosphate (PCr/ATP). Methods and results: Single transgenic Creatine Transporter overexpressing (CrT-OE, n = 7) and dTg mice (CrT-OE and CK, n = 6) mice were anaesthetised with isoflurane to acquire 31P-CMRS measurements of the left ventricle (LV) utilising a two-dimensional (2D), threefold under-sampled density-weighted chemical shift imaging (2D-CSI) sequence, which provided high-resolution data with nominal voxel size of 8.5 µl within 70 min. (1H-) cine-CMR data for cardiac function assessment were obtained in the same imaging session. Under a separate examination, mice received invasive haemodynamic assessment, after which tissue was collected for biochemical analysis. Myocardial creatine levels were elevated in all mouse hearts, but only dTg exhibited significantly elevated CK activity, resulting in a 51% higher PCr/ATP ratio in heart (3.01 ± 0.96 vs. 2.04 ± 0.57—mean ± SD; dTg vs. CrT-OE), that was absent from adjacent skeletal muscle. No significant differences were observed for any parameters of LV structure and function, confirming that augmentation of CK activity does not have unforeseen consequences for the heart. Conclusions: We have developed an improved 31P-CMRS methodology for the in vivo assessment of energetics in the murine heart which enabled high-resolution imaging within acceptable scan times. Mice over-expressing both creatine and CK in the heart exhibited a synergistic elevation in PCr/ATP that can now be tested for therapeutic potential in models of chronic heart failure. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure.

Author

McAndrew, Debra J., Lake, Hannah A., Zervou, Sevasti, Schwedhelm, Edzard, Schneider, Jurgen E., Neubauer, Stefan, and Lygate, Craig A.

Subjects
HEART failure, CREATINE, MYOCARDIAL infarction, HEART failure patients
Abstract

Aims: Low levels of homoarginine and creatine are associated with heart failure severity in humans, but it is unclear to what extent they contribute to pathophysiology. Both are synthesized via L‐arginine:glycine amidinotransferase (AGAT), such that AGAT−/− mice have a combined creatine and homoarginine deficiency. We hypothesized that this would be detrimental in the setting of chronic heart failure. Methods and results: Study 1: homoarginine deficiency—female AGAT−/− and wild‐type mice were given creatine‐supplemented diet so that both had normal myocardial creatine levels, but only AGAT−/− had low plasma homoarginine. Myocardial infarction (MI) was surgically induced and left ventricular (LV) structure and function assessed at 6–7 weeks by in vivo imaging and haemodynamics. Study 2: homoarginine and creatine‐deficiency—as before, but AGAT−/− mice were given creatine‐supplemented diet until 1 week post‐MI, when 50% were changed to a creatine‐free diet. Both groups therefore had low homoarginine levels, but one group also developed lower myocardial creatine levels. In both studies, all groups had LV remodelling and dysfunction commensurate with the development of chronic heart failure, for example, LV dilatation and mean ejection fraction <20%. However, neither homoarginine deficiency alone or in combination with creatine deficiency had a significant effect on mortality, LV remodelling, or on any indices of contractile and lusitropic function. Conclusions: Low levels of homoarginine and creatine do not worsen chronic heart failure arguing against a major causative role in disease progression. This suggests that it is unnecessary to correct hArg deficiency in patients with heart failure, although supra‐physiological levels may still be beneficial. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Stratification strength and light climate explain variation in chlorophyll a at the continental scale in a European multilake survey in a heatwave summer

Author

Donis, Daphne, primary, Mantzouki, Evanthia, additional, McGinnis, Daniel F., additional, Vachon, Dominic, additional, Gallego, Irene, additional, Grossart, Hans‐Peter, additional, de Senerpont Domis, Lisette N., additional, Teurlincx, Sven, additional, Seelen, Laura, additional, Lürling, Miquel, additional, Verstijnen, Yvon, additional, Maliaka, Valentini, additional, Fonvielle, Jeremy, additional, Visser, Petra M., additional, Verspagen, Jolanda, additional, van Herk, Maria, additional, Antoniou, Maria G., additional, Tsiarta, Nikoletta, additional, McCarthy, Valerie, additional, Perello, Victor C., additional, Machado‐Vieira, Danielle, additional, de Oliveira, Alinne Gurjão, additional, Maronić, Dubravka Špoljarić, additional, Stević, Filip, additional, Pfeiffer, Tanja Žuna, additional, Vucelić, Itana Bokan, additional, Žutinić, Petar, additional, Udovič, Marija Gligora, additional, Plenković‐Moraj, Anđelka, additional, Bláha, Luděk, additional, Geriš, Rodan, additional, Fránková, Markéta, additional, Christoffersen, Kirsten Seestern, additional, Warming, Trine Perlt, additional, Feldmann, Tõnu, additional, Laas, Alo, additional, Panksep, Kristel, additional, Tuvikene, Lea, additional, Kangro, Kersti, additional, Koreivienė, Judita, additional, Karosienė, Jūratė, additional, Kasperovičienė, Jūratė, additional, Savadova‐Ratkus, Ksenija, additional, Vitonytė, Irma, additional, Häggqvist, Kerstin, additional, Salmi, Pauliina, additional, Arvola, Lauri, additional, Rothhaupt, Karl, additional, Avagianos, Christos, additional, Kaloudis, Triantafyllos, additional, Gkelis, Spyros, additional, Panou, Manthos, additional, Triantis, Theodoros, additional, Zervou, Sevasti‐Kiriaki, additional, Hiskia, Anastasia, additional, Obertegger, Ulrike, additional, Boscaini, Adriano, additional, Flaim, Giovanna, additional, Salmaso, Nico, additional, Cerasino, Leonardo, additional, Haande, Sigrid, additional, Skjelbred, Birger, additional, Grabowska, Magdalena, additional, Karpowicz, Maciej, additional, Chmura, Damian, additional, Nawrocka, Lidia, additional, Kobos, Justyna, additional, Mazur‐Marzec, Hanna, additional, Alcaraz‐Párraga, Pablo, additional, Wilk‐Woźniak, Elżbieta, additional, Krztoń, Wojciech, additional, Walusiak, Edward, additional, Gagala‐Borowska, Ilona, additional, Mankiewicz‐Boczek, Joana, additional, Toporowska, Magdalena, additional, Pawlik‐Skowronska, Barbara, additional, Niedźwiecki, Michał, additional, Pęczuła, Wojciech, additional, Napiórkowska‐Krzebietke, Agnieszka, additional, Dunalska, Julita, additional, Sieńska, Justyna, additional, Szymański, Daniel, additional, Kruk, Marek, additional, Budzyńska, Agnieszka, additional, Goldyn, Ryszard, additional, Kozak, Anna, additional, Rosińska, Joanna, additional, Szeląg‐Wasielewska, Elżbieta, additional, Domek, Piotr, additional, Jakubowska‐Krepska, Natalia, additional, Kwasizur, Kinga, additional, Messyasz, Beata, additional, Pełechata, Aleksandra, additional, Pełechaty, Mariusz, additional, Kokocinski, Mikolaj, additional, Madrecka‐Witkowska, Beata, additional, Kostrzewska‐Szlakowska, Iwona, additional, Frąk, Magdalena, additional, Bańkowska‐Sobczak, Agnieszka, additional, Wasilewicz, Michał, additional, Ochocka, Agnieszka, additional, Pasztaleniec, Agnieszka, additional, Jasser, Iwona, additional, Antão‐Geraldes, Ana M., additional, Leira, Manel, additional, Vasconcelos, Vitor, additional, Morais, Joao, additional, Vale, Micaela, additional, Raposeiro, Pedro M., additional, Gonçalves, Vítor, additional, Aleksovski, Boris, additional, Krstić, Svetislav, additional, Nemova, Hana, additional, Drastichova, Iveta, additional, Chomova, Lucia, additional, Remec‐Rekar, Spela, additional, Elersek, Tina, additional, Hansson, Lars‐Anders, additional, Urrutia‐Cordero, Pablo, additional, Bravo, Andrea G., additional, Buck, Moritz, additional, Colom‐Montero, William, additional, Mustonen, Kristiina, additional, Pierson, Don, additional, Yang, Yang, additional, Richardson, Jessica, additional, Edwards, Christine, additional, Cromie, Hannah, additional, Delgado‐Martín, Jordi, additional, García, David, additional, Cereijo, Jose Luís, additional, Gomà, Joan, additional, Trapote, Mari Carmen, additional, Vegas‐Vilarrúbia, Teresa, additional, Obrador, Biel, additional, García‐Murcia, Ana, additional, Real, Monserrat, additional, Romans, Elvira, additional, Noguero‐Ribes, Jordi, additional, Duque, David Parreño, additional, Fernández‐Morán, Elísabeth, additional, Úbeda, Bárbara, additional, Gálvez, José Ángel, additional, Catalán, Núria, additional, Pérez‐Martínez, Carmen, additional, Ramos‐Rodríguez, Eloísa, additional, Cillero‐Castro, Carmen, additional, Moreno‐Ostos, Enrique, additional, Blanco, José María, additional, Rodríguez, Valeriano, additional, Montes‐Pérez, Jorge Juan, additional, Palomino, Roberto L., additional, Rodríguez‐Pérez, Estela, additional, Hernández, Armand, additional, Carballeira, Rafael, additional, Camacho, Antonio, additional, Picazo, Antonio, additional, Rochera, Carlos, additional, Santamans, Anna C., additional, Ferriol, Carmen, additional, Romo, Susana, additional, Soria, Juan Miguel, additional, Özen, Arda, additional, Karan, Tünay, additional, Demir, Nilsun, additional, Beklioğlu, Meryem, additional, Filiz, Nur, additional, Levi, Eti, additional, Iskin, Uğur, additional, Bezirci, Gizem, additional, Tavşanoğlu, Ülkü Nihan, additional, Çelik, Kemal, additional, Ozhan, Koray, additional, Karakaya, Nusret, additional, Koçer, Mehmet Ali Turan, additional, Yilmaz, Mete, additional, Maraşlıoğlu, Faruk, additional, Fakioglu, Özden, additional, Soylu, Elif Neyran, additional, Yağcı, Meral Apaydın, additional, Çınar, Şakir, additional, Çapkın, Kadir, additional, Yağcı, Abdulkadir, additional, Cesur, Mehmet, additional, Bilgin, Fuat, additional, Bulut, Cafer, additional, Uysal, Rahmi, additional, Latife, Köker, additional, Akçaalan, Reyhan, additional, Albay, Meriç, additional, Alp, Mehmet Tahir, additional, Özkan, Korhan, additional, Sevindik, Tuğba Ongun, additional, Tunca, Hatice, additional, Önem, Burçin, additional, Paerl, Hans, additional, Carey, Cayelan C., additional, and Ibelings, Bastiaan W., additional

Published
2021
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46. Investigation of the Occurrence of Cyanotoxins in Lake Karaoun (Lebanon) by Mass Spectrometry, Bioassays and Molecular Methods

Author

Hammoud, Noura Alice, primary, Zervou, Sevasti-Kiriaki, additional, Kaloudis, Triantafyllos, additional, Christophoridis, Christophoros, additional, Paraskevopoulou, Aikaterina, additional, Triantis, Theodoros M., additional, Slim, Kamal, additional, Szpunar, Joanna, additional, Fadel, Ali, additional, Lobinski, Ryszard, additional, and Hiskia, Anastasia, additional

Published
2021
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48. Cyanobacterial Toxins and Peptides in Lake Vegoritis, Greece

Author

Zervou, Sevasti-Kiriaki, primary, Moschandreou, Kimon, additional, Paraskevopoulou, Aikaterina, additional, Christophoridis, Christophoros, additional, Grigoriadou, Elpida, additional, Kaloudis, Triantafyllos, additional, Triantis, Theodoros M., additional, Tsiaoussi, Vasiliki, additional, and Hiskia, Anastasia, additional

Published
2021
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49. Alien plants of Europe: introduction pathways, gateways and time trends

Author

Arianoutsou, Margarita, primary, Bazos, Ioannis, additional, Christopoulou, Anastasia, additional, Kokkoris, Yannis, additional, Zikos, Andreas, additional, Zervou, Sevasti, additional, Delipetrou, Pinelopi, additional, Cardoso, Ana Cristina, additional, Deriu, Ivan, additional, Gervasini, Eugenio, additional, and Tsiamis, Konstantinos, additional

Published
2021
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50. Temperature effects explain continental scale distribution of cyanobacterial toxins

Author

Mantzouki, Evanthia, Lürling, Miquel, Fastner, Jutta, Domis, Lisette de Senerpont, Wilk-Woźniak, Elżbieta, Koreiviene, Judita, Seelen, Laura, Teurlincx, Sven, Verstijnen, Yvon, Krztoń, Wojciech, Walusiak, Edward, Karosienė, Jūratė, Kasperovičienė, Jūratė, Savadova, Ksenija, Vitonytė, Irma, Cillero-Castro, Carmen, Budzyńska, Agnieszka, Goldyn, Ryszard, Kozak, Anna, Rosińska, Joanna, Szeląg-Wasielewska, Elżbieta, Domek, Piotr, Jakubowska-Krepska, Natalia, Kwasizur, Kinga, Messyasz, Beata, Pełechata, Aleksandra, Pełechaty, Mariusz, Kokocinski, Mikolaj, García-Murcia, Ana, Real, Monserrat, Romans, Elvira, Noguero-Ribes, Jordi, Duque, David Parreño, Fernández-Morán, Elísabeth, Karakaya, Nusret, Häggqvist, Kerstin, Beklioğlu, Meryem, Filiz, Nur, Levi, Eti E., Iskin, Uğur, Bezirci, Gizem, Tavşanoğlu, Ülkü Nihan, Özhan, Koray, Gkelis, Spyros, Panou, Manthos, Fakioglu, Özden, Avagianos, Christos, Kaloudis, Triantafyllos, Çelik, Kemal, Yilmaz, Mete, Marcé, Rafael, Catalán, Nuria, Bravo, Andrea G., Buck, Moritz, Colom-Montero, William, Mustonen, Kristiina, Pierson, Don, Yang, Yang, Raposeiro, Pedro M., Gonçalves, Vítor, Antoniou, Maria G., Tsiarta, Nikoletta, McCarthy, Valerie, Perello, Victor C., Feldmann, Tõnu, Laas, Alo, Panksep, Kristel, Tuvikene, Lea, Gagala, Ilona, Mankiewicz-Boczek, Joana, Yağcı, Meral Apaydın, Çınar, Şakir, Çapkın, Kadir, Yağcı, Abdulkadir, Cesur, Mehmet, Bilgin, Fuat, Bulut, Cafer, Uysal, Rahmi, Obertegger, Ulrike, Boscaini, Adriano, Flaim, Giovanna, Salmaso, Nico, Cerasino, Leonardo, Richardson, Jessica, Visser, Petra M., Verspagen, Jolanda M. H., Karan, Tünay, Soylu, Elif Neyran, Maraşlıoğlu, Faruk, Napiórkowska-Krzebietke, Agnieszka, Ochocka, Agnieszka, Pasztaleniec, Agnieszka, Antão-Geraldes, Ana M., Vasconcelos, Vitor, Morais, João, Vale, Micaela, Köker, Latife, Akçaalan, Reyhan, Albay, Meriç, Maronić, Dubravka Špoljarić, Stević, Filip, Pfeiffer, Tanja Žuna, Fonvielle, Jeremy, Straile, Dietmar, Rothhaupt, Karl-Otto, Hansson, Lars-Anders, Urrutia-Cordero, Pablo, Bláha, Luděk, Geriš, Rodan, Fránková, Markéta, Koçer, Mehmet Ali Turan, Alp, Mehmet Tahir, Remec-Rekar, Spela, Elersek, Tina, Triantis, Theodoros, Zervou, Sevasti-Kiriaki, Hiskia, Anastasia, Haande, Sigrid, Skjelbred, Birger, Madrecka, Beata, Nemova, Hana, Drastichova, Iveta, Chomova, Lucia, Edwards, Christine, Sevindik, Tuğba Ongun, Tunca, Hatice, Önem, Burçin, Aleksovski, Boris, Krstić, Svetislav, Vucelić, Itana Bokan, Nawrocka, Lidia, Salmi, Pauliina, Machado-Vieira, Danielle, Oliveira, Alinne Gurjão De, Delgado-Martín, Jordi, García, David, Cereijo, Jose Luís, Gomà, Joan, Trapote, Mari Carmen, Vegas-Vilarrúbia, Teresa, Obrador, Biel, Grabowska, Magdalena, Karpowicz, Maciej, Chmura, Damian, Úbeda, Bárbara, Gálvez, José Ángel, Özen, Arda, Christoffersen, Kirsten Seestern, Warming, Trine Perlt, Kobos, Justyna, Mazur-Marzec, Hanna, Pérez-Martínez, Carmen, Ramos-Rodríguez, Eloísa, Arvola, Lauri, Alcaraz-Párraga, Pablo, Toporowska, Magdalena, Pawlik-Skowronska, Barbara, Niedźwiecki, Michał, Pęczuła, Wojciech, Leira, Manel, Hernández, Armand, Moreno-Ostos, Enrique, Blanco, José María, Rodríguez, Valeriano, Montes-Pérez, Jorge Juan, Palomino, Roberto L., Rodríguez-Pérez, Estela, Carballeira, Rafael, Camacho, Antonio, Picazo, Antonio, Rochera, Carlos, Santamans, Anna C., Ferriol, Carmen, Romo, Susana, Soria, Juan Miguel, Dunalska, Julita, Sieńska, Justyna, Szymański, Daniel, Kruk, Marek, Kostrzewska-Szlakowska, Iwona, Jasser, Iwona, Žutinić, Petar, Udovič, Marija Gligora, Plenković-Moraj, Anđelka, Frąk, Magdalena, Bańkowska-Sobczak, Agnieszka, Wasilewicz, Michał, Özkan, Korhan, Maliaka, Valentini, Kangro, Kersti, Grossart, Hans-Peter, Paerl, Hans W., Carey, Cayelan C., and Ibelings, Bas W.

Subjects
ddc:610, 610 Medizin und Gesundheit, Institut für Biochemie und Biologie
Abstract

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect effects of temperature were the main drivers of the spatial distribution in the toxins produced by the cyanobacterial community, the toxin concentrations and toxin quota. Generalized linear models showed that a Toxin Diversity Index (TDI) increased with latitude, while it decreased with water stability. Increases in TDI were explained through a significant increase in toxin variants such as MC-YR, anatoxin and cylindrospermopsin, accompanied by a decreasing presence of MC-LR. While global warming continues, the direct and indirect effects of increased lake temperatures will drive changes in the distribution of cyanobacterial toxins in Europe, potentially promoting selection of a few highly toxic species or strains., Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1105

Published
2021
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