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2. Hydroxyl vacancies in single-walled aluminosilicate and aluminogermanate nanotubes

Author

Teobaldi, G., Beglitis, N. S., Fisher, A. J., Zerbetto, F., and Hofer, W. A.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Other Condensed Matter
Abstract

We report the first theoretical study of hydroxyl vacancies in aluminosilicate and aluminogermanate single-walled metal-oxide nanotubes. The defects are modeled on both sides of the tube walls and lead to occupied and empty states in the band gap which are highly localized both in energy and in real space. We find different magnetization states depending on both the chemical composition and the specific side with respect to the tube cavity. The defect-induced perturbations to the pristine electronic structure are related to the electrostatic polarization across the tube walls and the ensuing change in Br{\o}nsted acid-base reactivity. Finally, the capacity to counterbalance local charge accumulations, a characteristic feature of these systems, is discussed in view of their potential application as insulating coatings for one-dimensional conducting nanodevices., Comment: manuscript: 4 pages, 4 figures

Published
2008
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3. PO-1490 Prostate cancer nodal relapse: impact of CRPC and previous RT on salvage ENRT+PET guided SIB outcome

Author

Fodor, A., primary, Deantoni, C., additional, Giannini, L., additional, Ferrario, F., additional, Villa, S., additional, Mangili, P., additional, Perna, L., additional, Broggi, S., additional, Dell'Oca, I., additional, Zerbetto, F., additional, Chissotti, C., additional, Midulla, M., additional, Torrisi, M., additional, Longobardi, B., additional, Castriconi, R., additional, Del Vecchio, A., additional, Cozzarini, C., additional, Fiorino, C., additional, and Di Muzio, N., additional

Published
2023
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4. PO-1129 Stereotactic re-irradiation of relapsed intracranic lesions: a monoinstitutional experience

Author

Chissotti, C., primary, Torrisi, M., additional, Fodor, A., additional, Deantoni, C.L., additional, Broggi, S., additional, Ferrario, F., additional, Giannini, L., additional, Villa, S.L., additional, Midulla, M., additional, Gigliotti, C.R., additional, Dell'Oca, I., additional, Castriconi, R., additional, Zerbetto, F., additional, Fiorino, C., additional, Del Vecchio, A., additional, Arcangeli, S., additional, and Di Muzio, N.G., additional

Published
2023
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6. PO-1111 Robotic stereotactic radiotherapy for ≥ 10 brain metastases treated with single treatment planning.

Author

Torrisi, M., primary, Chissotti, C., additional, Deantoni, C.L., additional, Fodor, A., additional, Ferrario, F., additional, Giannini, L., additional, Midulla, M., additional, Broggi, S., additional, Tummineri, R., additional, Dell'Oca, I., additional, Castriconi, R., additional, Zerbetto, F., additional, Fiorino, C., additional, Arcangeli, S., additional, and Di Muzio, N.G., additional

Published
2023
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7. PO-1355 Impact of lymphopenia in patients with esophageal cancer after neoadjuvant chemoradiotherapy

Author

SLIM, N., primary, Chissotti, C., additional, Passoni, P., additional, Tummineri, R., additional, Zerbetto, F., additional, Torrisi, M., additional, Giannini, L., additional, Midulla, M., additional, Ferrario, F., additional, Villa, S., additional, Mazza, E., additional, Albarello, L., additional, De Cobelli, F., additional, Rosati, R., additional, Cascinu, S., additional, and Di Muzio, N.G., additional

Published
2023
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9. Modulazione del fenotipo cellulare indotto da radioterapia ipofrazionata in un modello murino di glioma

Author

Granata, S, Valtorta, S, Rainone, P, De Pretis, S, Diprima, S, Zerbetto, F, Villa, S, Di Muzio, N, Moresco, RM, Granata, S, Valtorta, S, Rainone, P, De Pretis, S, Diprima, S, Zerbetto, F, Villa, S, Di Muzio, N, and Moresco, R

Subjects
NGS, Radiotherapy, scRNA-Seq, in vivo, glioblastoma
Abstract

Negli ultimi anni nuove tecnologie, che prendono il nome di Next-generation sequecing (NGS), sono state sviluppate al fine di stabilire il profilo genetico delle singole cellule, permettendo un nuovo approccio allo studio della diversità delle cellule immunitarie. Una di queste tecnologie è il sequenziamento dell'RNA a livello di cellula singola (scRNA-Seq). In questo studio abbiamo valutato l’effetto a lungo termine (21 giorni) dell’esposizione a radioterapia ipo-frazionata (RT) sulle cellule non tumorali in un modello murino di glioma di alto grado. Topi maschi del ceppo C57Bl/6 sono stati divisi in due gruppi e sottoposti a trattamento sham o mediante RT. Due animali per gruppo sono stati selezionati per effettuare il scRNA-Seq a livello del tessuto cerebrale. Per ciascun’analisi 10mila cellule sono state processate tramite la piattaforma Chromium (10X) utilizzando la libreria “Chromium Single Cell 3’”. Le matrici di espressione genica grezza generate con CellRanger (v3.0.2) sono state analizzate mediante il software Seurat R (v4.0.1) e includendo nell’analisi solo le cellule che esprimevano almeno 700 geni (6'931 e 8'186 cellule per veicolo e RT rispettivamente). Le cellule tumorali sono state identificate mediante genotipizzazione utilizzando il softaware Souporcell e rimosse dall'analisi. La tecnica scRNA-Seq ha rivelato la presenza di 25 differenti cluster cellulari (con esclusione di 4 cluster di cellule tumorali). I cluster identificati includevano fenotipi differenti cellule di origine mieloide (macrofagi e microglia), cellule dendritiche, linfociti B e T, natural killer (NK) più cellule endoteliali, podociti, oligodendrociti, neuroni e astrociti. A 21 giorni dall’esposizione a RT si assiste ad un aumento relativo di macrofagi con riduzione dell’espressione di Tgfb1 e TSPO ma non di TREM2 e di linfociti T, soprattutto regolatori, con aumento dell’espressione di trascritti legati a infiammazione e metabolismo. Infine, il trattamento radioterapico induce un aumento di marcatori di reattività astrocitaria, stress cellulare e neuroprotezione come Lgal3, Nupr1 e Igfbpl1. In conclusione, a tre settimane dalla somministrazione di RT sono ancora presenti modificazioni della risposta immunitaria legata a macrofagi e linfociti e modificazioni a carico degli astrociti probabilmente legate al danno cellulare.

Published
2023

11. Effectiveness of synthetic calcite doped with Fe-EDDHSA as a slow-release Fe source: In-vitro experiment on kiwifruit (Actinidia chinensis var. deliciosa) plants

Author

BALDI E., MARINO G., MUZZI E., MARZADORI C., CIAVATTA C., TAVONI M., Di GIOSIA M., CALVARESI M., FALINI G., ZERBETTO F., TOSELLI M., and BALDI E., MARINO G., MUZZI E., MARZADORI C., CIAVATTA C., TAVONI M., Di GIOSIA M., CALVARESI M., FALINI G., ZERBETTO F., TOSELLI M.

Subjects
in-vitro culture, Fe-chelates| in-vitro culture| pH| alkaline growing media| EDDHSA/CaCO3, pH, Fe-chelate, EDDHSA/CaCO3, alkaline growing media, lcsh:Agriculture (General), lcsh:S1-972
Abstract

Doped calcite (Fe-EDDHSA/CaCO3) was experimentally produced. The hypothesis of the present experiment is that, when roots get in contact with Fe-EDDHSA/CaCO3, the extrusion of H+ decreases the pH and dissolves calcite with subsequent release of Fe that becomes available for roots. The aim of the experiment was to determine whether doped calcite might represent a slow-release Fe source for in-vitro grown kiwifruit plantlets. The root elongation media used in the experiment had pH 8.0 and differed from each other for Fe supply as follow: Control medium that contained complete Murashige and Skoog salt mixture, including FeSO4 and Na2EDTA; calcite medium enriched with Fe-EDDHSA/CaCO3 as the only Fe source; −Fe medium without Fe. The absence of FeSO4 in the medium caused a reduction of plantlet growth. The final pH was higher with calcite medium than in control and −Fe. The addition of Fe-EDDHSA/CaCO3 increased Fe shoot concentration when compared with the −Fe medium. The data of the present experiment show the potential Fe slow release ability of Fe-EDDHSA/CaCO3; however, further investigation on Fe containing fertilizers should be conducted on potted plants to validate our results.

Published
2019
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13. MO-0553 ENRT+ PET-guided SIB for prostate cancer lymph nodal relapses: long-term outcomes

Author

Fodor, A., primary, Deantoni, C.L., additional, Fiorino, C., additional, Cozzarini, C., additional, Dell'Oca, I., additional, Mangili, P., additional, Tummineri, R., additional, Zerbetto, F., additional, Sanchez Galvan, A., additional, Mandurino, G., additional, Villa, S.L., additional, Baroni, S., additional, Saddi, J., additional, Pacifico, P., additional, Perna, L., additional, Broggi, S., additional, Del Vecchio, A., additional, Picchio, M., additional, Gianolli, L., additional, and Di Muzio, N., additional

Published
2022
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14. PO-1100 Impact of sarcopenia in oropharyngeal cancer patients treated with radical chemo-radiotherapy

Author

deantoni, C.L., primary, Chiara, A., additional, Mirabile, A., additional, Broggi, S., additional, Fiorino, C., additional, Fodor, A., additional, Pasetti, M., additional, Tummineri, R., additional, Zerbetto, F., additional, Baroni, S., additional, Sanchez Galvan, A., additional, Gregorc, V., additional, Dell'Oca, I., additional, and Di Muzio, N.G., additional

Published
2022
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15. MO-0717 Radiation Therapy and Cardiovascular Implanted Electronic Devices: a single center years expierence

Author

Baroni, S., primary, Gulletta, S., additional, Pasetti, M., additional, Vergara, P., additional, Broggi, S., additional, Tummineri, R., additional, Deantoni, C.L., additional, Zerbetto, F., additional, Fodor, A., additional, Mandurino, G., additional, Sanchez Galvan, A., additional, Fierro, N., additional, Dell'Oca, I., additional, Arcangeli, S., additional, and Di Muzio, N.G., additional

Published
2022
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19. PET imaging and single-cell RNA sequencing glioma microenvironment assessment after RT combined therapy

Author

Granata, S, Valtorta, S, Zerbetto, F, Todde, S, Iannone, M, Coliva, T, Spinelli, A, Bertoli, G, de Pretis, S, Diprima, S, Villa, S, DI MUZIO, N, Moresco, R, Silvia Granata, Silvia Valtorta, Flavia Zerbetto, Sergio Todde, Marco Iannone, Angela Coliva, Antonello Spinelli, Gloria Bertoli, Stefano de Pretis, Santo Diprima, Stefano Villa, Nadia Di Muzio, Rosa Maria Moresco, Granata, S, Valtorta, S, Zerbetto, F, Todde, S, Iannone, M, Coliva, T, Spinelli, A, Bertoli, G, de Pretis, S, Diprima, S, Villa, S, DI MUZIO, N, Moresco, R, Silvia Granata, Silvia Valtorta, Flavia Zerbetto, Sergio Todde, Marco Iannone, Angela Coliva, Antonello Spinelli, Gloria Bertoli, Stefano de Pretis, Santo Diprima, Stefano Villa, Nadia Di Muzio, and Rosa Maria Moresco

Abstract

Introduction Glioblastoma (GBM) is the most common primary brain tumour in adults with a median survival of 11-12 months. Standard therapy consists of radiotherapy (RT) plus chemotherapy with temozolomide (TMZ), and no alternative treatment is available. Using multimodal imaging and single-cell RNA-sequencing (scRNA-seq), we investigated the role of RT associated with TMZ and metformin (MET) in tumour response in a syngenic murine GBM model. Methods GL261 GBM cell line was orthotopically injected into C57Bl/6 mice. Animals were randomly divided into four groups: vehicle, RT alone, RT with TMZ, and RT with TMZ plus MET. The therapy response was monitored using Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) with [ 18 F]FLT (cell proliferation). Immunofluorescence, scRNA- seq analysis and PCR analysis were carried out on brain samples collected after 4 weeks of treatment. Results RT alone greatly increased survival (40.5 days) compared to vehicle (26.5 days), and when combined with drugs this effect was potentiated (148 days). At 4 weeks, the addition of TMZ alone or with MET significantly decreased tumour sizes visible at MRI and [ 18 F]FLT uptake compared to RT alone-treated mice. Through IF we observed modifications of different inflammatory markers and downregulation of IBA1 in the peri-tumoural area when RT was combined with drugs. RT alone decreased GFAP levels intra-tumourally. scRNA-seq revealed different clusters of cells including tumor cells, glioma associated macrophages and microglia, dendritic cells, natural killer and B and T lymphocytes. RT drugs combination reduced cluster signals more than RT alone. On the basis of cell cycle analysis cancer cells were classified in two sub-clusters: one in phase G2/M and the other in phase S that was more susceptible to RT alone. Globally, RT alone increased the inflammatory milieu as shown by the modification in TAM cluster composition. This response was attenuated by the combination of RT w

Published
2022

21. PO-1069 Multiple Brain Metastases concomitantly treated with robotic SRS/SRT

Author

Sanchez Galvan, A., primary, Deli, A.M., additional, Fodor, A., additional, Tummineri, R., additional, Villa, S.L., additional, Baroni, S., additional, Mandurino, G., additional, Pacifico, P., additional, Deantoni, C.L., additional, Slim, N., additional, Zerbetto, F., additional, Fiorino, C., additional, Broggi, S., additional, Del Vecchio, A., additional, Arcangeli, S., additional, and Di Muzio, N.G., additional

Published
2021
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25. PO-1131 Primary tumors observed in 1325 consecutive breast cancer patients treated with whole breast RT

Author

Fodor, A., primary, Brombin, C., additional, Mangili, P., additional, Tummineri, R., additional, Zerbetto, F., additional, Pasetti, M., additional, Longobardi, B., additional, Esposito, P.G., additional, Castriconi, R., additional, Dell’Oca, I., additional, Deantoni, C.L., additional, Broggi, S., additional, Deli, A.M., additional, Fiorino, C., additional, Del Vecchio, A., additional, Di Serio, M.S., additional, and Di Muzio, N.G., additional

Published
2021
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26. PO-1300 Stereotactic Body Radiation Therapy for oligometastatic lymph-nodal relapses in gynecological cancer

Author

Mandurino, G., primary, Fodor, A., additional, Villa, S.L., additional, Baroni, S., additional, Sanchez Galvan, A., additional, Tummineri, R., additional, Pacifico, P., additional, Zerbetto, F., additional, Deantoni, C.L., additional, Mangili, P., additional, Del Vecchio, A., additional, Arcangeli, S., additional, and Di Muzio, N.G., additional

Published
2021
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27. PO-1354 Time Dependence of PSADT prognostic threshold in men treated with post-prostatectomy salvage RT

Author

Cozzarini, C., primary, Magli, A., additional, Cante, D., additional, Andreoli, L., additional, Pastorino, A., additional, Faiella, A., additional, Fodor, A., additional, Deantoni, C., additional, Zerbetto, F., additional, Tonetto, F., additional, Noris Chiorda, B., additional, Piva, C., additional, Olivetta, E., additional, Avuzzi, B., additional, Gandaglia, G., additional, Fossati, N., additional, Fiorino, C., additional, Sanguineti, G., additional, Valdagni, R., additional, Briganti, A., additional, Montorsi, F., additional, and Di Muzio, N., additional

Published
2021
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34. PO-0955: Molecular subtypes and local control in 1054 breast cancer patients treated with de-escalated 3DCRT

Author

Fodor, A., primary, Mangili, P., additional, Brombin, C., additional, Zerbetto, F., additional, Longobardi, B., additional, Borroni, F., additional, Tummineri, R., additional, Pasetti, M., additional, Rancoita, P., additional, Perna, L., additional, Dell'Oca, I., additional, Deantoni, C.L., additional, Esposito, P.G., additional, Deli, A.M., additional, Rossi, E., additional, Chiara, A., additional, Broggi, S., additional, Slim, N., additional, Passoni, P., additional, Cattaneo, M., additional, Bolognesi, A., additional, Fiorino, C., additional, Di Serio, M.S., additional, and Di Muzio, N.G., additional

Published
2020
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37. PO-1173: Long term results of IG-IMRT in high risk prostate cancer patients: a monoinstitutional experience

Author

Di Muzio, N., primary, Deantoni, C.L., additional, Cozzarini, C., additional, Dell'Oca, I., additional, Zerbetto, F., additional, Mangili, P., additional, Broggi, S., additional, Pasetti, M., additional, Chiara, A., additional, Borroni, F., additional, Tummineri, R., additional, Perna, L., additional, Calandrino, R., additional, Fiorino, C., additional, and Fodor, A., additional

Published
2020
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39. 13C NMR patterns of odd-numbered C119 fullerenes

Author

Heine, T., Zerbetto, F., Seifert, G., and Fowler, P.W.

Subjects
Carbon allotropes -- Research, Nuclear magnetic resonance -- Usage, Chemicals, plastics and rubber industries
Abstract

Calculations for 13C NMR chemical shifts and relative energies of eight C119 isomers within the density-functional-based tight-binding and the individual gauge for local orbitals models are presented. The calculated 13C NMR chemical shifts are compatible with the experimental spectrum.

Published
2000

40. A tight-binding treatment for (super)13 C NMR spectra of fullerenes

Author

Heine, T., Seifert, G., Fowler, P.W., and Zerbetto, F.

Subjects
Chemistry, Physical and theoretical -- Research, Carbon allotropes -- Research, Chemicals, plastics and rubber industries
Abstract

Simulation of (super)13 C NMR spectra of fullerenes and fullerene molecules has been performed by means of a density-functional based tight-binding method. The authors discuss the correlation between local geometry and calculated shift for atoms in pentagon sites.

Published
1999

42. Nuclear motions of an inclusion complex of cali[4]arene

Author

Paci, B., Deleuze, M.S., Caciuffo, R., Tomkinson, J., Ugozzoli, F., and Zerbetto, F.

Subjects
Nuclear spectroscopy -- Usage, Molecular structure -- Research, Neutrons -- Spectra, Chemicals, plastics and rubber industries
Abstract

The integrated application of experimentation, inelastic neutron scattering and the computational molecular mechanics (MM3) model were used to evaluate the 2:1 inclusion complex of calixarenes. Results show different spectral signatures between the 2:1 inclusion complex of p-tert-butylcalix[4]arene and p-xylene and the hypothetical 1:1 complex. The variation is attributed to the intense band identified only with p-xylene.

Published
1998

43. Structural predictions for the C116 molecule

Author

Achiba, Y., Fowler, P.W., Mitchell, D., and Zerbetto, F.

Subjects
Carbon allotropes -- Research, Quantum theory -- Analysis, Molecular dynamics -- Research, Chemicals, plastics and rubber industries
Abstract

A study was conducted to determine the energetically favored isomer set for the C116 fullerene using combined topological and quantum mechanical methods. The adjacency matrices were determined using spiral codes for the complete set of isomeric C116 fullerene structures. Results indicated that C116 parallels C84 wherein two isomers are almost isoenergetic. Findings also suggested that the most stable isomer of the fullerene supports the hexagon-neighbor rule.

Published
1998

47. EP-1303 Hypofractionated adjuvant radiotherapy in elderly low risk breast cancer patients: loss or gain?

Author

Fodor, A., primary, Pasetti, M., additional, Mangili, P., additional, Longobardi, B., additional, Zerbetto, F., additional, Perna, L., additional, Dell'Oca, I., additional, Signorotto, P., additional, Tummineri, R., additional, Borroni, F., additional, Deantoni, C.L., additional, Deli, A.M., additional, Slim, N., additional, Chiara, A., additional, Passoni, P., additional, Foti, S., additional, Azizi, M., additional, Fiorino, C., additional, Bolognesi, A., additional, and Di Muzio, N.G., additional

Published
2019
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