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1,030 results on '"Zeng, Zhu"'

9. Physiological versatility of ANME-1 and Bathyarchaeotoa-8 archaea evidenced by inverse stable isotope labeling

Author

Xiuran Yin, Guowei Zhou, Mingwei Cai, Tim Richter-Heitmann, Qing-Zeng Zhu, Mara Maeke, Ajinkya C. Kulkarni, Rolf Nimzyk, Marcus Elvert, and Michael W. Friedrich

Subjects
Trophic strategy, Inverse labeling, Stable isotope probing, ANME-1, Bathy-8, Microbial ecology, QR100-130
Abstract

Abstract Background The trophic strategy is one key principle to categorize microbial lifestyles, by broadly classifying microorganisms based on the combination of their preferred carbon sources, electron sources, and electron sinks. Recently, a novel trophic strategy, i.e., chemoorganoautotrophy—the utilization of organic carbon as energy source but inorganic carbon as sole carbon source—has been specifically proposed for anaerobic methane oxidizing archaea (ANME-1) and Bathyarchaeota subgroup 8 (Bathy-8). Results To further explore chemoorganoautotrophy, we employed stable isotope probing (SIP) of nucleic acids (rRNA or DNA) using unlabeled organic carbon and 13C-labeled dissolved inorganic carbon (DIC), i.e., inverse stable isotope labeling, in combination with metagenomics. We found that ANME-1 archaea actively incorporated 13C-DIC into RNA in the presence of methane and lepidocrocite when sulfate was absent, but assimilated organic carbon when cellulose was added to incubations without methane additions. Bathy-8 archaea assimilated 13C-DIC when lignin was amended; however, their DNA was derived from both inorganic and organic carbon sources rather than from inorganic carbon alone. Based on SIP results and supported by metagenomics, carbon transfer between catabolic and anabolic branches of metabolism is possible in these archaeal groups, indicating their anabolic versatility. Conclusion We provide evidence for the incorporation of the mixed organic and inorganic carbon by ANME-1 and Bathy-8 archaea in the environment. Video Abstract

Published
2024
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10. CPS1 augments hepatic glucagon response through CaMKII/FOXO1 pathway

Author

Xiao-Meng Sun, Xin Wu, Meng-Guang Wei, Li-Zeng Zhu, Wen-hui Wu, Xin-Yue Zhou, Lian-Wen Qi, and Qun Liu

Subjects
type 2 diabetes, gluconeogenesis, carbamoyl phosphate synthetase 1, CaMKII/FOXO1 pathway, cynarin, Therapeutics. Pharmacology, RM1-950
Abstract

Introduction: Elevated glucagon levels are a characteristic feature of type 2 diabetes. This abnormal increase in glucagon can lead to an accelerated rate of gluconeogenesis. Glucagon also stimulates hepatic metabolism of amino acids, particularly promoting the formation of urea. The specific role of carbamoyl phosphate synthetase 1 (CPS1), a rate-limiting enzyme in the urea cycle, in the development versus the persistence of glucagon-induced hyperglycemia has not been previously established.Methods: The study employed both in vivo and in vitro approaches to assess the impact of CPS1 modulation on glucagon response. CPS1 was knockdown or overexpression to evaluate its influence on hepatic gluconeogenesis. In addition, an in-silico strategy was employed to identify a potential CPS1 inhibitor.Results: Knockdown of CPS1 significantly reduced the glucagon response both in vivo and in vitro. Conversely, overexpression of CPS1 resulted in an overactive hepatic gluconeogenic response. Mechanistically, CPS1 induced the release of calcium ions from the endoplasmic reticulum, which in turn triggered the phosphorylation of CaMKII. The activation of CaMKII then facilitated the dephosphorylation and nuclear translocation of FOXO1, culminating in the enhancement of hepatic gluconeogenesis. Furthermore, cynarin, a natural CPS1 inhibitor derived from the artichoke plant, had the capacity to attenuate the hepatic glucagon response in a CPS1-dependent manner.Discussion: CPS1 played a pivotal role in mediating glucagon-induced hepatic gluconeogenesis. The discovery of cynarin as a natural inhibitor of CPS1 suggested its potential as a therapeutic agent for diabetes treatment.

Published
2024
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11. Bio-inspired Intelligence with Applications to Robotics: A Survey

Author

Li, Junfei, Xu, Zhe, Zhu, Danjie, Dong, Kevin, Yan, Tao, Zeng, Zhu, and Yang, Simon X.

Subjects
Computer Science - Robotics, Electrical Engineering and Systems Science - Systems and Control
Abstract

In the past decades, considerable attention has been paid to bio-inspired intelligence and its applications to robotics. This paper provides a comprehensive survey of bio-inspired intelligence, with a focus on neurodynamics approaches, to various robotic applications, particularly to path planning and control of autonomous robotic systems. Firstly, the bio-inspired shunting model and its variants (additive model and gated dipole model) are introduced, and their main characteristics are given in detail. Then, two main neurodynamics applications to real-time path planning and control of various robotic systems are reviewed. A bio-inspired neural network framework, in which neurons are characterized by the neurodynamics models, is discussed for mobile robots, cleaning robots, and underwater robots. The bio-inspired neural network has been widely used in real-time collision-free navigation and cooperation without any learning procedures, global cost functions, and prior knowledge of the dynamic environment. In addition, bio-inspired backstepping controllers for various robotic systems, which are able to eliminate the speed jump when a large initial tracking error occurs, are further discussed. Finally, the current challenges and future research directions are discussed in this paper.

Published
2022
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22. S100A4 mediates the accumulation and functions of myeloid-derived suppressor cells via GP130/JAK2/STAT3 signaling in acute myeloid leukemia

Author

Peng, Yuhui, Zhang, Jian, Zhang, Ting, Wang, Chanjuan, Bai, Jingdi, Li, Yi, Duan, Juanjuan, Fan, Daogui, Fu, Wenli, Liang, Xinming, Xie, Xin, Qi, Xiaolan, Hong, Wei, He, Yan, Wu, ChangXue, Zhou, Jing, Chen, Pingping, Zeng, Hongmei, Dai, Yun, Yu, Wenfeng, Bai, Hua, Guo, Pengxiang, Zeng, Zhu, and Zhang, Qifang

Published
2025
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23. IRF4 rearrangement may predict favorable prognosis in children and young adults with primary head and neck large B‐cell lymphoma

Author

Xiang‐Nan Jiang, Fang Yu, Tian Xue, Qing‐Xin Xia, Qian‐Ming Bai, Bao‐Hua Yu, Ruo‐Hong Shui, Xiao‐Yan Zhou, Xiong‐Zeng Zhu, Jun‐Ning Cao, Xiao‐Nan Hong, and Xiao‐Qiu Li

Subjects
children and young adults, head and neck, IRF4 rearrangement, large B‐cell lymphoma, therapeutic strategy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Purpose Large B‐cell lymphoma with IRF4 rearrangement (LBCL, IRF4+) has been recently recognized as a specific entity that is frequently associated with young age and favorable prognosis. However, whether the good outcome of the disease is due to IRF4+ or other factors remains obscure. We thus analyzed 100 young patients with primary head and neck LBCL to see the clinicopathologic correlates of IRF4+. Methods The histopathology, immunophenotype, IRF4 status of the tumors, and clinical data were reviewed. Results Twenty‐one tumors were diagnosed as LBCL, IRF4+, which were more frequently associated with a follicular growth pattern, medium‐sized blastoid cytology, germinal center B‐cell‐like, and CD5+ phenotype, compared with IRF4− ones. While most of the patients received chemotherapy with or without radiation, eight IRF4+ patients received mere surgical resection of the tumor and exhibited excellent outcome. IRF4+ cases featured a significantly higher complete remission rate, and better survivals compared with IRF4− ones. Multivariate analysis confirmed IRF4+ correlates with a better survival. Conclusion Our work confirmed the unique clinicopathologic features of LBCL, IRF4+, and disclosed for the first time the independent favorable prognostic impact of IRF4+. These findings may further unravel the heterogeneity of LBCL occurring in youth, and aid in risk stratification and tailoring the therapeutic strategy.

Published
2023
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31. The Algorithms of Predicting Bacterial Essential Genes and NcRNAs by Machine Learning

Author

Ye, Yuannong, Liang, Dingfa, Zeng, Zhu, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Liu, Qi, editor, Liu, Xiaodong, editor, Chen, Bo, editor, Zhang, Yiming, editor, and Peng, Jiansheng, editor

Published
2022
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49. Most Probable Phase Portraits of Stochastic Differential Equations and its Numerical Simulation

Author

Yang, Bing, Zeng, Zhu, and Wang, Ling

Subjects
Mathematics - Probability
Abstract

A practical and accessible introduction to most probable phase portraits is given. The reader is assumed to be familiar with stochastic differential equations and Euler-Maruyama method in numerical simulation. The article first introduce the method to obtain most probable phase portraits and then give its numerical simulation which is based on Euler-Maruyama method. All of these are given by examples and easy to understand.

Published
2017

50. High-dose radiation-induced immunogenic cell death of bladder cancer cells leads to dendritic cell activation.

Author

Zeng, Xianlin, Luo, Daiqin, Zhang, Shuai, Cui, Zhonghui, Wang, Yun, Chen, Jin, Zhang, Shichao, Teng, Lijing, Hu, Zuquan, Liu, Lina, Zhou, Shi, Zeng, Zhu, and Long, Jinhua

Abstract

Radiotherapy is a commonly used method in the treatment of bladder cancers (BC). Radiation-induced immunogenic cell death (ICD) is related to the immune response against cancers and their prognoses. Even though dendritic cells (DC) act as powerful antigen-presenting cells in the body, their precise role in this ICD process remains unclear. Accordingly, an in vitro study was undertaken to ascertain whether high-dose radiation-induced ICD of BC cells could regulate the immune response of DC. The results indicated that high-dose radiation treatments of BC cells significantly increased their levels of apoptosis, blocked their cell cycle in the G2/M phase, increased their expression of ICD-related proteins, and upregulated their secretion of CCL5 and CCL21 which control the directed migration of DC. It was also noted that expression of CD80, CD86, CCR5, and CCR7 on DC was upregulated in the medium containing the irradiated cells. In conclusion, the present findings illustrate that high-dose radiation can induce the occurrence of ICD within BC cells, concomitantly resulting in the activation of DC. Such findings could be of great significance in increasing the understanding how radiotherapy of BC may work to bring about reductions in cell activity and how these processes in turn lead to immunoregulation of the function of DC. [ABSTRACT FROM AUTHOR]

Published
2024
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