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TP53, functioning as the keeper of the genome, assumes a pivotal function in the inhibition of tumorigenesis. Recent studies have revealed that p53 regulates ferroptosis pathways within tumor cells and is closely related to tumorigenesis. Therefore, we summarize the pathways and mechanisms by which p53 regulates ferroptosis and identify a series of upstream and downstream molecules involved in this process. Furthermore, we construct a p53-ferroptosis network centered on p53. Finally, we present the progress of drugs to prevent wild-type p53 (wtp53) degeneration and restore wtp53, highlighting the deficiencies of drug development and the prospects for p53 in cancer treatment. These findings provide novel strategies and directions for future cancer therapy.

Radiotherapy (RT) has been widely used in the clinical treatment of cancers, but radiotherapy resistance (RR) leads to RT failure, tumor recurrence and metastasis. Many studies have been performed on the potential mechanisms behind RR, and a strong link has been found between RR and DNA damage. RT-induced DNA damage triggers a protective mechanism called the DNA damage response (DDR). DDR consists of several aspects, including the detection of DNA damage and induction of cell cycle checkpoint, DNA repair, and eventual induction of cell death. A large number of studies have shown that DDR inhibition leads to significantly enhanced sensitivity of cancer cells to RT. DDR may be an effective target for radio- and chemo-sensitization during cancer treatment. Therefore, many inhibitors of important enzymes involved in the DDR have been developed, such as PARP inhibitors, DNA-PK inhibitors, and ATM/ATR inhibitors. In addition, DNA damage also triggers the cGAS-STING signaling pathway and the ATM/ATR (CHK)/STAT pathway to induce immune infiltration and T-cell activation. This review discusses the effects of DDR pathway dysregulation on the tumor response to RT and the strategies for targeting these pathways to increase tumor susceptibility to RT. Finally, the potential for the combination treatment of radiation, DDR inhibition, and immunotherapy is described.

Conventional approaches for designing metasurfaces with the desired scattering response are often a time‐consuming and onerous process that heavily relies on the design experience and empirical methods. In this paper, a time and resource‐efficient design method is proposed for the synthesis of multiple metasurface polarizers with an efficient automated data generation process by utilizing the structure validation surrogate model (SVSM). Moreover, a novel attention and space‐to‐depth enhanced adaptive tandem network (ASE‐ATN) is proposed which integrates symmetry‐aware space‐to‐depth (SA‐SPD) along with the attention mechanism for efficient feature extraction. Several design examples of metasurfaces with linear polarization to orthogonal linear polarization (LP‐OLP) and/or linear polarization to circular polarization (LP‐CP) conversion capabilities are provided to verify the performance of the proposed method. The feasibility of the proposed method is demonstrated through the fabrication and measurement of a dual‐band dual‐polarization converter. [ABSTRACT FROM AUTHOR]

Positioning technology is the basis for the application of Internet of Vehicles (IoV). The positioning accuracy is generally very low in infrastructure limited scenarios based on satellites or base stations. In this paper, a vehicle positioning algorithm is proposed that combines the information of vehicle historical trajectory and inertial navigation technology. The simulation results show that the proposed algorithm can significantly improve the positioning accuracy in infrastructure limited scenarios.