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861 results on '"Zeng, Mu-Sheng"'

2. AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation

Author

Dai, Dan-Ling, Xie, Chu, Zhong, Lan-Yi, Liu, Shang-Xin, Zhang, Le-Le, Zhang, Hua, Wu, Xing-Ping, Wu, Zhou-Ming, Kang, Kexin, Li, Yan, Sun, Ya-Meng, Xia, Tian-Liang, Zhang, Chen-Song, Zhang, Ao, Shi, Ming, Sun, Cong, Chen, Mei-Ling, Zhao, Ge-Xin, Bu, Guo-Long, Liu, Yuan-Tao, Huang, Kui-Yuan, Zhao, Zheng, Li, Shu-Xin, Zhang, Xiao-Yong, Yuan, Yun-Fei, Wen, Shi-Jun, Zhang, Lingqiang, Li, Bin-Kui, Zhong, Qian, and Zeng, Mu-Sheng

Published
2024
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11. Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial

Author

Yuan, Li, Jia, Guo-Dong, Lv, Xiao-Fei, Xie, Si-Yi, Guo, Shan-Shan, Lin, Da-Feng, Liu, Li-Ting, Luo, Dong-Hua, Li, Yi-Fu, Deng, Shen-Wen, Guo, Ling, Zeng, Mu-Sheng, Cai, Xiu-Yu, Liu, Sai-Lan, Sun, Xue-Song, Li, Xiao-Yun, Li, Su-Chen, Chen, Qiu-Yan, Tang, Lin-Quan, and Mai, Hai-Qiang

Published
2023
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13. PD-1+CXCR5−CD4+ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma

Author

Li, Jiang-Ping, Wu, Chang-You, Chen, Ming-Yuan, Liu, Shang-Xin, Yan, Shu-Mei, Kang, Yin-Feng, Sun, Cong, Grandis, Jennifer R, Zeng, Mu-Sheng, and Zhong, Qian

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Immunization, Vaccine Related, Cancer, 2.1 Biological and endogenous factors, Inflammatory and immune system, Chemokine CXCL13, Humans, Nasopharyngeal Carcinoma, Programmed Cell Death 1 Receptor, Tertiary Lymphoid Structures, Tumor Microenvironment, head and neck neoplasms, adaptive immunity, tumor microenvironment, lymphocytes, tumor-infiltrating, immunity, cellular, Oncology and carcinogenesis
Abstract

BackgroundA major current challenge is to exploit tertiary lymphoid structures (TLSs) to promote the lymphocyte infiltration, activation and differentiation by tumor antigens to increase antitumor immune responses. The mechanisms that underlie the role of TLS formation in the adaptive immune responses against nasopharyngeal carcinoma (NPC) remain largely unknown.MethodsCell populations and the corresponding markers were identified by single-cell RNA sequencing and fluorescence-activated cell sorting analysis. In vitro differentiation experiments were used to simulate the generation, regulation and function of the Th-CXCL13 cell subset in the tumor microenvironment of NPC. These were followed by histological evaluation of the colocalization of tumor-associated B cells (TABs) and Th-CXCL13 cells within TLSs, and statistical analysis of the relationship between the cells in TLSs and overall survival.ResultsA PD-1+CXCR5-CD4+ Th-CXCL13 cell subset was identified in NPC. This subset was a major source of CXCL13, representing the majority of the CD4+ T cells at levels comparable with Th1 and Tfh cells present in the TLSs. Monocytes activated by toll-like receptor 4 agonists served as the antigen-presenting cells that most efficiently triggered the expansion of Th-CXCL13 cells. Transforming growth factor beta 1 (TGF-β1) stimulation and activation of Sox4 were critical for the induction and polarization of Th-CXCL13 cells in this process. The potential functional contributions of TABs recruited by Th-CXCL13 cells which induced plasma cell differentiation and immunoglobulin production via interleukin-21 and CD84 interactions in the TLSs demonstrated improved survival.ConclusionsInduction of Th-CXCL13 cells links innate inflammation to immune privilege in tumor-associated TLSs and might predict better survival.

Published
2021

14. PD-1+CXCR5-CD4+ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma.

Author

Li, Jiang-Ping, Wu, Chang-You, Chen, Ming-Yuan, Liu, Shang-Xin, Yan, Shu-Mei, Kang, Yin-Feng, Sun, Cong, Grandis, Jennifer R, Zeng, Mu-Sheng, and Zhong, Qian

Subjects
adaptive immunity, cellular, head and neck neoplasms, immunity, lymphocytes, tumor microenvironment, tumor-infiltrating
Abstract

BackgroundA major current challenge is to exploit tertiary lymphoid structures (TLSs) to promote the lymphocyte infiltration, activation and differentiation by tumor antigens to increase antitumor immune responses. The mechanisms that underlie the role of TLS formation in the adaptive immune responses against nasopharyngeal carcinoma (NPC) remain largely unknown.MethodsCell populations and the corresponding markers were identified by single-cell RNA sequencing and fluorescence-activated cell sorting analysis. In vitro differentiation experiments were used to simulate the generation, regulation and function of the Th-CXCL13 cell subset in the tumor microenvironment of NPC. These were followed by histological evaluation of the colocalization of tumor-associated B cells (TABs) and Th-CXCL13 cells within TLSs, and statistical analysis of the relationship between the cells in TLSs and overall survival.ResultsA PD-1+CXCR5-CD4+ Th-CXCL13 cell subset was identified in NPC. This subset was a major source of CXCL13, representing the majority of the CD4+ T cells at levels comparable with Th1 and Tfh cells present in the TLSs. Monocytes activated by toll-like receptor 4 agonists served as the antigen-presenting cells that most efficiently triggered the expansion of Th-CXCL13 cells. Transforming growth factor beta 1 (TGF-β1) stimulation and activation of Sox4 were critical for the induction and polarization of Th-CXCL13 cells in this process. The potential functional contributions of TABs recruited by Th-CXCL13 cells which induced plasma cell differentiation and immunoglobulin production via interleukin-21 and CD84 interactions in the TLSs demonstrated improved survival.ConclusionsInduction of Th-CXCL13 cells links innate inflammation to immune privilege in tumor-associated TLSs and might predict better survival.

Published
2021

16. Protective anti-gB neutralizing antibodies targeting two vulnerable sites for EBV-cell membrane fusion

Author

Zhang, Xiao, Hong, Junping, Zhong, Ling, Wu, Qian, Zhang, Shanshan, Zhu, Qianying, Chen, Haiwen, Wei, Dongmei, Li, Rui, Zhang, Wanlin, Zhang, Xinyu, Wang, Guosong, Zhou, Xiang, Chen, Junyu, Kang, Yinfeng, Zha, Zhenghui, Duan, Xiaobing, Huang, Yang, Sun, Cong, Kong, Xiangwei, Zhou, Yan, Chen, Yanhong, Ye, Xiaoping, Feng, Qisheng, Li, Shaowei, Xiang, Tong, Gao, Song, Zeng, Mu-Sheng, Zheng, Qingbing, Chen, Yixin, Zeng, Yi-Xin, Xia, Ningshao, and Xu, Miao

Published
2022

17. A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV

Author

Sun, Cong, Kang, Yin-Feng, Fang, Xin-Yan, Liu, Yi-Na, Bu, Guo-Long, Wang, Ao-Jie, Li, Yan, Zhu, Qian-Ying, Zhang, Hua, Xie, Chu, Kong, Xiang-Wei, Peng, Yong-Jian, Lin, Wen-Jie, Zhou, Ling, Chen, Xin-Chun, Lu, Zheng-Zhou, Xu, Hui-Qin, Hong, Dong-Chun, Zhang, Xiao, Zhong, Ling, Feng, Guo-Kai, Zeng, Yi-Xin, Xu, Miao, Zhong, Qian, Liu, Zheng, and Zeng, Mu-Sheng

Published
2023
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24. The RARS–MAD1L1 Fusion Gene Induces Cancer Stem Cell–like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma

Author

Zhong, Qian, Liu, Zhi-Hua, Lin, Zhi-Rui, Hu, Ze-Dong, Yuan, Li, Liu, Yan-min, Zhou, Ai-Jun, Xu, Li-Hua, Hu, Li-Juan, Wang, Zi-Feng, Guan, Xin-Yuan, Hao, Jia-Jie, Lui, Vivian WY, Guo, Ling, Mai, Hai-Qiang, Chen, Ming-Yuan, Han, Fei, Xia, Yun-Fei, Grandis, Jennifer R, Zhang, Xing, and Zeng, Mu-Sheng

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Genetics, Dental/Oral and Craniofacial Disease, Biotechnology, Rare Diseases, 2.1 Biological and endogenous factors, Animals, Arginine-tRNA Ligase, Biomarkers, Tumor, Cell Cycle Proteins, Cell Line, Tumor, Disease Models, Animal, Drug Resistance, Neoplasm, Gene Knockdown Techniques, Gene Rearrangement, Humans, In Situ Hybridization, Fluorescence, Mice, Nasopharyngeal Carcinoma, Neoplastic Stem Cells, Nuclear Proteins, Oncogene Proteins, Fusion, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins c-myc, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

Purpose: Nasopharyngeal carcinoma (NPC) is the most common head and neck cancer in Southeast Asia. Because local recurrence and distant metastasis are still the main causes of NPC treatment failure, it is urgent to identify new tumor markers and therapeutic targets for advanced NPC.Experimental Design: RNA sequencing (RNA-seq) was applied to look for interchromosome translocation in NPC. PCR, FISH, and immunoprecipitation were used to examine the fusion gene expression at RNA, DNA, and protein levels in NPC biopsies. MTT assay, colony formation assay, sphere formation assay, co-immunoprecipitation, chromatin immunoprecipitation assay, and in vivo chemoresistance assay were applied to explore the function of RARS-MAD1L1 in NPC.Results: We demonstrated that RARS-MAD1L1 was present in 10.03% (35/349) primary NPC biopsies and 10.7% (9/84) in head and neck cancer (HNC) samples. RARS-MAD1L1 overexpression increased cell proliferation, colony formation, and tumorigenicity in vitro, and the silencing of endogenous RARS-MAD1L1 reduced cancer cell growth and colony formation in vitro In addition, RARS-MAD1L1 increased the side population (SP) ratio and induced chemo- and radioresistance. Furthermore RARS-MAD1L1 interacted with AIMP2, which resulted in activation of FUBP1/c-Myc pathway. The silencing of FUBP1 or the administration of a c-Myc inhibitor abrogated the cancer stem cell (CSC)-like characteristics induced by RARS-MAD1L1. The expression of c-Myc and ABCG2 was higher in RARS-MAD1L1-positive HNC samples than in negative samples.Conclusions: Our findings indicate that RARS-MAD1L1 might contribute to tumorigenesis, CSC-like properties, and therapeutic resistance, at least in part, through the FUBP1/c-Myc axis, implying that RARS-MAD1L1 might serve as an attractive target for therapeutic intervention for NPC. Clin Cancer Res; 24(3); 659-73. ©2017 AACR.

Published
2018

29. Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma

Author

Jin, Shanzhao, Li, Ruoyan, Chen, Ming-Yuan, Yu, Chao, Tang, Lin-Quan, Liu, Yan-Min, Li, Jiang-Ping, Liu, Yi-Na, Luo, Yi-Ling, Zhao, Yifan, Zhang, Yu, Xia, Tian-Liang, Liu, Shang-Xin, Liu, Qi, Wang, Guan-Nan, You, Rui, Peng, Jing-Yun, Li, Jiang, Han, Feng, Wang, Jianwei, Chen, Qiu-Yan, Zhang, Li, Mai, Hai-Qiang, Gewurz, Benjamin E., Zhao, Bo, Young, Lawrence S., Zhong, Qian, Bai, Fan, and Zeng, Mu-Sheng

Published
2020
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38. Highly sensitive detection platform-based diagnosis of oesophageal squamous cell carcinoma in China: a multicentre, case–control, diagnostic study

Author

Wang, Yu, Xing, Shan, Xu, Yi-Wei, Xu, Qing-Xia, Ji, Ming-Fang, Peng, Yu-Hui, Wu, Ya-Xian, Wu, Meng, Xue, Ning, Zhang, Biao, Xie, Shang-Hang, Zhu, Rui-Dan, Ou, Xin-Yuan, Huang, Qi, Tian, Bo-Yu, Li, Hui-Lan, Jiang, Yu, Yao, Xiao-Bin, Li, Jian-Pei, Ling, Li, Cao, Su-Mei, Zhong, Qian, Liu, Wan-Li, and Zeng, Mu-Sheng

Abstract

Early detection and screening of oesophageal squamous cell carcinoma rely on upper gastrointestinal endoscopy, which is not feasible for population-wide implementation. Tumour marker-based blood tests offer a potential alternative. However, the sensitivity of current clinical protein detection technologies is inadequate for identifying low-abundance circulating tumour biomarkers, leading to poor discrimination between individuals with and without cancer. We aimed to develop a highly sensitive blood test tool to improve detection of oesophageal squamous cell carcinoma.

Published
2024
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41. Identification of a sodium pump Na+/K+ ATPase α1-targeted peptide for PET imaging of breast cancer

Author

Wang, Qian, Li, Shi-Bing, Zhao, Yi-Ying, Dai, Da-Nian, Du, Hui, Lin, Yan-Zhu, Ye, Jia-Cong, Zhao, Jing, Xiao, Wei, Mei, Yan, Xiao, Yi-Tai, Liu, Shi-Chu, Li, Yan, Xia, Yun-Fei, Song, Er-Wei, Tang, Gang-Hua, Zhang, Wei-Guang, Li, Zhi-Jian, Zheng, Xiao-Bin, Cao, De-Hai, Li, Man-Zhi, Zhong, Qian, Chen, Zhong-Ping, Qian, Chao-Nan, Fan, Wei, Feng, Guo-Kai, and Zeng, Mu-Sheng

Published
2018
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44. Genome sequencing analysis identifies Epstein–Barr virus subtypes associated with high risk of nasopharyngeal carcinoma

Author

Xu, Miao, Yao, Youyuan, Chen, Hui, Zhang, Shanshan, Cao, Su-Mei, Zhang, Zhe, Luo, Bing, Liu, Zhiwei, Li, Zilin, Xiang, Tong, He, Guiping, Feng, Qi-Sheng, Chen, Li-Zhen, Guo, Xiang, Jia, Wei-Hua, Chen, Ming-Yuan, Zhang, Xiao, Xie, Shang-Hang, Peng, Roujun, Chang, Ellen T., Pedergnana, Vincent, Feng, Lin, Bei, Jin-Xin, Xu, Rui-Hua, Zeng, Mu-Sheng, Ye, Weimin, Adami, Hans-Olov, Lin, Xihong, Zhai, Weiwei, Zeng, Yi-Xin, and Liu, Jianjun

Published
2019
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46. N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay

Author

Xia, Tian-Liang, Li, Xingyang, Wang, Xueping, Zhu, Yun-Jia, Zhang, Hua, Cheng, Weisheng, Chen, Mei-Ling, Ye, Ying, Li, Yan, Zhang, Ao, Dai, Dan-Ling, Zhu, Qian-Ying, Yuan, Li, Zheng, Jian, Huang, Huilin, Chen, Si-Qi, Xiao, Zhi-Wen, Wang, Hong-Bo, Roy, Gaurab, Zhong, Qian, Lin, Dongxin, Zeng, Yi-Xin, Wang, Jinkai, Zhao, Bo, Gewurz, Benjamin E, Chen, Jianjun, Zuo, Zhixiang, and Zeng, Mu-Sheng

Published
2021
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48. Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection

Author

Hong, Junping, primary, Zhong, Ling, additional, Liu, Liqin, additional, Wu, Qian, additional, Zhang, Wanlin, additional, Chen, Kaiyun, additional, Wei, Dongmei, additional, Sun, Hui, additional, Zhou, Xiang, additional, Zhang, Xinyu, additional, Kang, Yin-Feng, additional, Huang, Yang, additional, Chen, Junyu, additional, Wang, Guosong, additional, Zhou, Yan, additional, Chen, Yanhong, additional, Feng, Qi-Sheng, additional, Yu, Hai, additional, Li, Shaowei, additional, Zeng, Mu-Sheng, additional, Zeng, Yi-Xin, additional, Xu, Miao, additional, Zheng, Qingbing, additional, Chen, Yixin, additional, Zhang, Xiao, additional, and Xia, Ningshao, additional

Published
2023
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49. mRNA‐based Vaccines Targeting the T‐cell Epitope‐rich Domain of Epstein Barr Virus Latent Proteins Elicit Robust Anti‐Tumor Immunity in Mice

Author

Zhao, Ge‐Xin, primary, Bu, Guo‐Long, additional, Liu, Gang‐Feng, additional, Kong, Xiang‐Wei, additional, Sun, Cong, additional, Li, Zi‐Qian, additional, Dai, Dan‐Ling, additional, Sun, Hai‐Xia, additional, Kang, Yin‐Feng, additional, Feng, Guo‐Kai, additional, Zhong, Qian, additional, and Zeng, Mu‐Sheng, additional

Published
2023
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